{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T03:55:18Z","timestamp":1776138918860,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.intimp.2012.08.013","type":"journal-article","created":{"date-parts":[[2012,8,30]],"date-time":"2012-08-30T05:00:16Z","timestamp":1346302816000},"page":"410-421","source":"Crossref","is-referenced-by-count":56,"title":["Glycyrrhizin regulates CD4+T cell response during liver fibrogenesis via JNK, ERK and PI3K\/AKT pathway"],"prefix":"10.1016","volume":"14","author":[{"given":"Chuan-tao","family":"Tu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu-ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-yao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2012.08.013_bb0005","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1172\/JCI30542","article-title":"Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ","volume":"117","author":"Iredale","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.intimp.2012.08.013_bb0010","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1053\/j.gastro.2008.03.003","article-title":"Mechanisms of hepatic fibrogenesis","volume":"134","author":"Friedman","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.intimp.2012.08.013_bb0015","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1096\/fj.03-1273rev","article-title":"TGF-beta signaling and the fibrotic response","volume":"18","author":"Leask","year":"2004","journal-title":"FASEB J"},{"key":"10.1016\/j.intimp.2012.08.013_bb0020","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bpg.2011.02.005","article-title":"Mechanisms of hepatic fibrogenesis","volume":"25","author":"Lee","year":"2011","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.1016\/j.intimp.2012.08.013_bb0025","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1365-2249.2011.04393.x","article-title":"Modulation of CD4\u207a T cell responses following splenectomy in hepatitis C virus-related liver cirrhosis","volume":"165","author":"Hashimoto","year":"2011","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.intimp.2012.08.013_bb0030","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1002\/hep.24764","article-title":"Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice","volume":"55","author":"Heymann","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2012.08.013_bb0035","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1586\/17474124.2.2.233","article-title":"Chemokine-directed immune cell infiltration in acute and chronic liver disease","volume":"2","author":"Karlmark","year":"2008","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.intimp.2012.08.013_bb0040","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.cell.2010.02.021","article-title":"Th17 and regulatory T cells in mediating and restraining inflammation","volume":"140","author":"Littman","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2012.08.013_bb0045","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1056\/NEJMra0707449","article-title":"Interleukin-17 and type 17 helper T cells","volume":"361","author":"Miossec","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.intimp.2012.08.013_bb0050","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.coi.2007.10.006","article-title":"Starring stellate cells in liver immunology","volume":"20","author":"Winau","year":"2008","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.intimp.2012.08.013_bb0055","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1002\/hep.1840380418","article-title":"Human hepatic stellate cells show features of antigen-presenting cells and stimulate lymphocyte proliferation","volume":"38","author":"Vinas","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2012.08.013_bb0060","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3109\/08830189609061756","article-title":"Immunoglobulin deficient mice generated by gene targeting as models for studying the immune response","volume":"13","author":"Bot","year":"1996","journal-title":"Int Rev Immunol"},{"key":"10.1016\/j.intimp.2012.08.013_bb0065","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00281-009-0169-0","article-title":"Mononuclear cells in liver fibrosis","volume":"31","author":"Marra","year":"2009","journal-title":"Semin Immunopathol"},{"key":"10.1016\/j.intimp.2012.08.013_bb0070","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1365-2567.2007.02691.x","article-title":"Circulating CD4+CD25+ regulatory T cells correlate with chronic hepatitis B infection","volume":"123","author":"Peng","year":"2008","journal-title":"Immunology"},{"key":"10.1016\/j.intimp.2012.08.013_bb0075","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/hep.23273","article-title":"Interleukin-17-producing CD4 (+) T cells increase with severity of liver damage in patients with chronic hepatitis B","volume":"51","author":"Zhang","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2012.08.013_bb0080","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/nri2660","article-title":"Interplay between the TH17 and TReg cell lineages: a (co-)evolutionary perspective","volume":"9","author":"Weaver","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.intimp.2012.08.013_bb0085","doi-asserted-by":"crossref","first-page":"e13869","DOI":"10.1371\/journal.pone.0013869","article-title":"Decreased ratio of Treg cells to Th17 correlates with HBV DNA suppression in chronic hepatitis B patients undergoing entecavir treatment","volume":"5","author":"Zhang","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2012.08.013_bb0090","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1471-2172-12-47","article-title":"The balance between intrahepatic IL-17+ T cells and Foxp3+ regulatory T cells plays an important role in HBV-related end-stage liver disease","volume":"12","author":"Niu","year":"2011","journal-title":"BMC Immunol"},{"key":"10.1016\/j.intimp.2012.08.013_bb0095","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.bbamcr.2010.12.012","article-title":"The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation","volume":"1813","author":"Plotnikov","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.intimp.2012.08.013_bb0100","doi-asserted-by":"crossref","first-page":"e28232","DOI":"10.1371\/journal.pone.0028232","article-title":"B7-H4 treatment of T cells inhibits ERK, JNK, p38, and AKT activation","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2012.08.013_bb0105","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/(SICI)1099-081X(199711)18:8<717::AID-BDD54>3.0.CO;2-U","article-title":"The pharmacokinetics of glycyrrhizin and its restorative effect on hepatic function in patients with chronic hepatitis and in chronically carbon-tetrachloride-intoxicated rats","volume":"18","author":"Yamamura","year":"1997","journal-title":"Biopharm Drug Dispos"},{"key":"10.1016\/j.intimp.2012.08.013_bb0110","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1002\/(SICI)1097-0142(19970415)79:8<1494::AID-CNCR8>3.0.CO;2-B","article-title":"The long term efficacy of glycyrrhizin in chronic hepatitis C patients","volume":"79","author":"Arase","year":"1997","journal-title":"Cancer"},{"key":"10.1016\/j.intimp.2012.08.013_bb0115","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0166-3542(96)00942-4","article-title":"Therapeutic basis of glycyrrhizin on chronic hepatitis B","volume":"30","author":"Sato","year":"1996","journal-title":"Antiviral Res"},{"key":"10.1016\/j.intimp.2012.08.013_bb0120","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/ptr.2295","article-title":"Antiviral effects of Glycyrrhiza species","volume":"22","author":"Fiore","year":"2008","journal-title":"Phytother Res"},{"key":"10.1016\/j.intimp.2012.08.013_bb0125","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.dld.2006.11.004","article-title":"Herbal medicine in the treatment of liver diseases","volume":"39","author":"Stickel","year":"2007","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.intimp.2012.08.013_bb0130","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1053\/jhep.2001.27445","article-title":"Complementary and alternative medicine in chronic liver disease","volume":"34","author":"Seeff","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2012.08.013_bb0135","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1440-1746.2005.04083.x","article-title":"Clinical features of hepatocellular carcinoma that occur after sustained virological response to interferon for chronic hepatitis C","volume":"21","author":"Ikeda","year":"2006","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.intimp.2012.08.013_bb0140","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1600-0676.1998.tb00147.x","article-title":"Inhibitory effect of glycyrrhizin on NF-kappaB binding activity in CCl4- plus ethanol-induced liver cirrhosis in rats","volume":"18","author":"Wang","year":"1998","journal-title":"Liver"},{"key":"10.1016\/j.intimp.2012.08.013_bb0145","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jss.2007.01.024","article-title":"The mechanism of how anti-IL-18 prevents concanavalin-A-induced hepatic fibrosis on a mouse model","volume":"142","author":"Zhang","year":"2007","journal-title":"J Surg Res"},{"key":"10.1016\/j.intimp.2012.08.013_bb0150","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1053\/gast.2001.25480","article-title":"Angiotensin-converting enzyme inhibition attenuates the progression of rat hepatic fibrosis","volume":"121","author":"Jonsson","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.intimp.2012.08.013_bb0155","first-page":"8","article-title":"Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of coxsackievirus b3-induced viral myocarditis reduces myocardium inflammation","volume":"14","author":"Fan","year":"2011","journal-title":"Virol J"},{"key":"10.1016\/j.intimp.2012.08.013_bb0160","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.intimp.2007.05.011","article-title":"Diammoniumgly-cyrrhizinate, a component of traditional Chinese medicine Gan-Cao, prevents murine T-cell-mediated fulminant hepatitis in IL- 10- and IL-6-dependent manners","volume":"7","author":"Feng","year":"2007","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.intimp.2012.08.013_bb0165","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1440-1746.1997.tb00416.x","article-title":"Effects of glycyrrhizin on immune-mediated cytotoxicity","volume":"12","author":"Yoshikawa","year":"1997","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.intimp.2012.08.013_bb0170","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1440-1746.1992.tb00927.x","article-title":"Effect of glycyrrhizin on lysis of hepatocyte membranes induced by anti-liver cell membrane antibody","volume":"7","author":"Shiki","year":"1992","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.intimp.2012.08.013_bb0175","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1743-422X-3-68","article-title":"Natural products that reduce rotavirus infectivity identified by a cell-based moderate-throughput screening assay","volume":"3","author":"Shaneyfelt","year":"2006","journal-title":"Virol J"},{"key":"10.1016\/j.intimp.2012.08.013_bb0180","doi-asserted-by":"crossref","first-page":"BR24","DOI":"10.12659\/MSM.882196","article-title":"18\u03b1-glycyrrhizin induces apoptosis and suppresses activation of rat hepatic stellate cells","volume":"18","author":"Qu","year":"2012","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.intimp.2012.08.013_bb0185","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1101\/gr.6.4.300","article-title":"A tandem duplication within the fibrillin 1 gene is associated with the mouse tight skin mutation","volume":"6","author":"Siracusa","year":"1996","journal-title":"Genome Res"},{"key":"10.1016\/j.intimp.2012.08.013_bb0190","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/376594a0","article-title":"An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection","volume":"376","author":"Wynn","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2012.08.013_bb0195","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.4049\/jimmunol.1004077","article-title":"Obstructive jaundice expands intrahepatic regulatory T cells, which impair liver T lymphocyte function but modulate liver cholestasis and fibrosis","volume":"187","author":"Katz","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2012.08.013_bb0200","doi-asserted-by":"crossref","first-page":"17444","DOI":"10.1073\/pnas.1107023108","article-title":"Macrophage migration inhibitory factor (MIF) exerts antifibrotic effects in experimental liver fibrosis via CD74","volume":"108","author":"Heinrichs","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.intimp.2012.08.013_bb0205","doi-asserted-by":"crossref","first-page":"129","DOI":"10.2220\/biomedres.17.129","article-title":"Kinetics and localization of lymphoblasts that proliferate in the murine liver after Concanavalin A administration","volume":"17","author":"Fujikura","year":"1996","journal-title":"Biomed Res"},{"key":"10.1016\/j.intimp.2012.08.013_bb0210","first-page":"149","article-title":"Glycyrrhizin protects mice from concanavalin A-induced hepatitis without affecting cytokine expression","volume":"4","author":"Okamoto","year":"1999","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.intimp.2012.08.013_bb0215","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1007\/s00535-003-1179-7","article-title":"Glycyrrhizin enhances interleukin-10 production by liver dendritic cells in mice with hepatitis","volume":"38","author":"Abe","year":"2003","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.intimp.2012.08.013_bb0220","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/labinvest.2011.157","article-title":"HBcAg induces PD-1 upregulation on CD4+T cells through activation of JNK, ERK and PI3K\/AKT pathways in chronic hepatitis-B-infected patients","volume":"92","author":"Li","year":"2012","journal-title":"Lab Invest"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757691200255X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757691200255X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T05:33:22Z","timestamp":1542778402000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156757691200255X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S156757691200255X"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2012.08.013","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}