{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:05:18Z","timestamp":1762430718149},"reference-count":40,"publisher":"Elsevier BV","issue":"1","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.intimp.2013.03.013","type":"journal-article","created":{"date-parts":[[2013,3,27]],"date-time":"2013-03-27T09:16:08Z","timestamp":1364375768000},"page":"27-34","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Cucurbitacin IIa induces caspase-3-dependent apoptosis and enhances autophagy in lipopolysaccharide-stimulated RAW 264.7 macrophages"],"prefix":"10.1016","volume":"16","author":[{"given":"Jian","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-hui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-yun","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian-hui","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2013.03.013_bb0005","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/ptr.2650090302","article-title":"Cucurbitacins and their pharmacological effects","volume":"9","author":"Miro","year":"1995","journal-title":"Phytother Res"},{"key":"10.1016\/j.intimp.2013.03.013_bb0010","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1093\/abbs\/gmr042","article-title":"Cucurbitacin B induces rapid depletion of the G-actin pool through reactive oxygen species-dependent actin aggregation in melanoma cells","volume":"43","author":"Zhang","year":"2011","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"10.1016\/j.intimp.2013.03.013_bb0015","doi-asserted-by":"crossref","first-page":"952762","DOI":"10.1155\/2012\/952762","article-title":"Cucurbitacin E induces G(2)\/M phase arrest through STAT3\/p53\/p21 signaling and provokes apoptosis via Fas\/CD95 and mitochondria-dependent pathways in human bladder cancer T24 cells","volume":"2012","author":"Huang","year":"2012","journal-title":"Evid Based Complement Altern Med"},{"key":"10.1016\/j.intimp.2013.03.013_bb0020","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1038\/sj.jid.5701246","article-title":"Cucurbitacin I inhibits Stat3 and induces apoptosis in Sezary cells","volume":"128","author":"van Kester","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.intimp.2013.03.013_bb0025","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.intimp.2009.01.006","article-title":"Cucurbitacin D isolated from Trichosanthes kirilowii induces apoptosis in human hepatocellular carcinoma cells in vitro","volume":"9","author":"Takahashi","year":"2009","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.intimp.2013.03.013_bb0030","doi-asserted-by":"crossref","first-page":"3236","DOI":"10.1038\/sj.onc.1208470","article-title":"Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity","volume":"24","author":"Sun","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.intimp.2013.03.013_bb0035","first-page":"1270","article-title":"Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase\/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice","volume":"63","author":"Blaskovich","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.intimp.2013.03.013_bb0040","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1124\/jpet.106.107003","article-title":"Cucurbitacin R reduces the inflammation and bone damage associated with adjuvant arthritis in Lewis rats by suppression of tumor necrosis factor-alpha in T lymphocytes and macrophages","volume":"320","author":"Escandell","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.intimp.2013.03.013_bb0045","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.bcp.2008.05.004","article-title":"Activated kRas protects colon cancer cells from cucurbitacin-induced apoptosis: the role of p53 and p21","volume":"76","author":"Escandell","year":"2008","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.intimp.2013.03.013_bb0050","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/j.fitote.2011.08.002","article-title":"Anti-inflammatory activities of cucurbitacin E isolated from Citrullus lanatus var. citroides: role of reactive nitrogen species and cyclooxygenase enzyme inhibition","volume":"82","author":"Abdelwahab","year":"2011","journal-title":"Fitoterapia"},{"key":"10.1016\/j.intimp.2013.03.013_bb0055","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1124\/jpet.103.063693","article-title":"Inhibition of nitric oxide generation by 23,24-dihydrocucurbitacin D in mouse peritoneal macrophages","volume":"309","author":"Park","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.intimp.2013.03.013_bb0060","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1016\/S0024-3205(03)00602-7","article-title":"Nitric oxide and cyclooxygenase may participate in the analgesic and anti-inflammatory effect of the cucurbitacins fraction from Wilbrandia ebracteata","volume":"73","author":"Peters","year":"2003","journal-title":"Life Sci"},{"key":"10.1016\/j.intimp.2013.03.013_bb0065","first-page":"115","article-title":"The reseach history and present status on the chemical components of genus Hemsleya (Cucurtibaceae)","volume":"8","author":"Ruilin","year":"1986","journal-title":"Acta Bot Yunnan"},{"key":"10.1016\/j.intimp.2013.03.013_bb0070","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/bjc.2011.10","article-title":"Cucurbitacin IIa: a novel class of anti-cancer drug inducing non-reversible actin aggregation and inhibiting survivin independent of JAK2\/STAT3 phosphorylation","volume":"104","author":"Boykin","year":"2011","journal-title":"Br J Cancer"},{"key":"10.1016\/j.intimp.2013.03.013_bb0075","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1100\/tsw.2010.44","article-title":"Cucurbitacin: ancient compound shedding new light on cancer treatment","volume":"10","author":"Lee","year":"2010","journal-title":"Sci World J"},{"key":"10.1016\/j.intimp.2013.03.013_bb0080","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.bbapap.2005.08.017","article-title":"MAPK signalling pathways as molecular targets for anti-inflammatory therapy\u2014from molecular mechanisms to therapeutic benefits","volume":"1754","author":"Kaminska","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.intimp.2013.03.013_bb0085","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.cell.2008.01.020","article-title":"Shared principles in NF-kappaB signaling","volume":"132","author":"Hayden","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2013.03.013_bb0090","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/sj.cdd.4400476","article-title":"Emerging roles of caspase-3 in apoptosis","volume":"6","author":"Porter","year":"1999","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.intimp.2013.03.013_bb0095","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0968-0004(97)01085-2","article-title":"Caspases: killer proteases","volume":"22","author":"Nicholson","year":"1997","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.intimp.2013.03.013_bb0100","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/40901","article-title":"X-linked IAP is a direct inhibitor of cell-death proteases","volume":"388","author":"Deveraux","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2013.03.013_bb0105","doi-asserted-by":"crossref","first-page":"6914","DOI":"10.1093\/emboj\/16.23.6914","article-title":"The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases","volume":"16","author":"Roy","year":"1997","journal-title":"EMBO J"},{"key":"10.1016\/j.intimp.2013.03.013_bb0110","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/ncb1204","article-title":"IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms","volume":"7","author":"Tenev","year":"2005","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.intimp.2013.03.013_bb0115","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1038\/nrm2529","article-title":"Autophagic cell death: the story of a misnomer","volume":"9","author":"Kroemer","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.intimp.2013.03.013_bb0120","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cell.2007.12.018","article-title":"Autophagy in the pathogenesis of disease","volume":"132","author":"Levine","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2013.03.013_bb0125","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1083\/jcb.152.4.657","article-title":"Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells","volume":"152","author":"Mizushima","year":"2001","journal-title":"J Cell Biol"},{"key":"10.1016\/j.intimp.2013.03.013_bb0130","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature09782","article-title":"Autophagy in immunity and inflammation","volume":"469","author":"Levine","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2013.03.013_bb0135","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.immuni.2007.05.022","article-title":"Toll-like receptor 4 is a sensor for autophagy associated with innate immunity","volume":"27","author":"Xu","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2013.03.013_bb0140","doi-asserted-by":"crossref","first-page":"315","DOI":"10.4161\/auto.7.3.14044","article-title":"Lipopolysaccaride induces autophagic signaling in macrophages via a TLR4, heme oxygenase-1 dependent pathway","volume":"7","author":"Rao","year":"2011","journal-title":"Autophagy"},{"key":"10.1016\/j.intimp.2013.03.013_bb0145","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1093\/emboj\/18.3.501","article-title":"Leukocyte polarization in cell migration and immune interactions","volume":"18","author":"Sanchez-Madrid","year":"1999","journal-title":"EMBO J"},{"key":"10.1016\/j.intimp.2013.03.013_bb0150","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/j.bcp.2008.05.028","article-title":"Actin-targeting natural compounds as tools to study the role of actin cytoskeleton in signal transduction","volume":"76","author":"Kustermans","year":"2008","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.intimp.2013.03.013_bb0155","doi-asserted-by":"crossref","first-page":"4468","DOI":"10.1167\/iovs.08-1781","article-title":"Suppression of activation and induction of apoptosis in RAW264.7 cells by amniotic membrane extract","volume":"49","author":"He","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.intimp.2013.03.013_bb0160","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.cyto.2008.01.006","article-title":"LPS\/TLR4 signal transduction pathway","volume":"42","author":"Lu","year":"2008","journal-title":"Cytokine"},{"key":"10.1016\/j.intimp.2013.03.013_bb0165","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1042\/CS20020240","article-title":"The inflammatory macrophage: a story of Jekyll and Hyde","volume":"104","author":"Duffield","year":"2003","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.intimp.2013.03.013_bb0170","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1126\/science.7878464","article-title":"Apoptosis in the pathogenesis and treatment of disease","volume":"267","author":"Thompson","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.intimp.2013.03.013_bb0175","doi-asserted-by":"crossref","first-page":"6480","DOI":"10.4049\/jimmunol.177.9.6480","article-title":"Decreased alveolar macrophage apoptosis is associated with increased pulmonary inflammation in a murine model of pneumococcal pneumonia","volume":"177","author":"Marriott","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2013.03.013_bb0180","doi-asserted-by":"crossref","first-page":"732798","DOI":"10.1155\/2011\/732798","article-title":"Autophagy in inflammatory diseases","volume":"2011","author":"Choi","year":"2011","journal-title":"Int J Cell Biol"},{"key":"10.1016\/j.intimp.2013.03.013_bb0185","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1089\/ars.2010.3485","article-title":"Autophagy shapes inflammation","volume":"14","author":"Fesus","year":"2011","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.intimp.2013.03.013_bb0190","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/nature07383","article-title":"Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1\u03b2 production","volume":"456","author":"Saitoh","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2013.03.013_bb0195","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.immuni.2009.02.009","article-title":"Autophagy is an essential component of Drosophila immunity against vesicular stomatitis virus","volume":"30","author":"Shelly","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2013.03.013_bb0200","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/ni.1634","article-title":"Autophagic control of listeria through intracellular innate immune recognition in Drosophila","volume":"9","author":"Yano","year":"2008","journal-title":"Nat Immunol"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576913000982?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576913000982?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T18:03:28Z","timestamp":1539799408000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576913000982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["S1567576913000982"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2013.03.013","relation":{},"ISSN":["1567-5769"],"issn-type":[{"type":"print","value":"1567-5769"}],"subject":[],"published":{"date-parts":[[2013,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cucurbitacin IIa induces caspase-3-dependent apoptosis and enhances autophagy in lipopolysaccharide-stimulated RAW 264.7 macrophages","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2013.03.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}