{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:13:31Z","timestamp":1761585211085,"version":"build-2065373602"},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100010002","name":"Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.intimp.2014.02.005","type":"journal-article","created":{"date-parts":[[2014,2,22]],"date-time":"2014-02-22T12:00:35Z","timestamp":1393070435000},"page":"12-23","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Formulated extract from multiple citrus peels impairs dendritic cell functions and attenuates allergic contact hypersensitivity"],"prefix":"10.1016","volume":"20","author":[{"given":"Shiming","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Chin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Tang","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping-Yi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiko","family":"Suzawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin-Chieh","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Liang","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Der-Yuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Chen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2014.02.005_bb0005","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1207\/S15327914NC372_7","article-title":"Citrus peel use is associated with reduced risk of squamous cell carcinoma of the skin","volume":"37","author":"Hakim","year":"2000","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.intimp.2014.02.005_bb0010","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.lwt.2008.09.015","article-title":"Antifungal activity and chemical composition of Citrus reticulata Blanco essential oil against phytopathogens from North East India","volume":"42","author":"Chutia","year":"2009","journal-title":"LWT-Food Sci Technol"},{"key":"10.1016\/j.intimp.2014.02.005_bb0015","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1271\/bbb.68.1690","article-title":"Characteristic odor components of Citrus reticulata Blanco (ponkan) cold-pressed oil","volume":"68","author":"Sawamura","year":"2004","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.1016\/j.intimp.2014.02.005_bb0020","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.foodcont.2010.11.021","article-title":"Chemical composition of commercial citrus fruit essential oils and evaluation of their antimicrobial activity acting alone or in combined processes","volume":"22","author":"Espina","year":"2011","journal-title":"Food Control"},{"key":"10.1016\/j.intimp.2014.02.005_bb0025","doi-asserted-by":"crossref","first-page":"7976","DOI":"10.1021\/jf801434c","article-title":"Investigation of heat treating conditions for enhancing the anti-inflammatory activity of citrus fruit (Citrus reticulata) peels","volume":"56","author":"Ho","year":"2008","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.intimp.2014.02.005_bb0030","first-page":"145","article-title":"Auraptene: phytochemical and pharmacological properties","author":"Epifano","year":"2008","journal-title":"Phytochem Res Prog"},{"key":"10.1016\/j.intimp.2014.02.005_bb0035","first-page":"152","article-title":"Screening of antibacterial activity of six plant essential oils against pathogenic bacterial strains","volume":"2","author":"Upadhyay","year":"2010","journal-title":"Asian J Med Sci"},{"key":"10.1016\/j.intimp.2014.02.005_bb0040","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1556\/AMicr.57.2010.1.2","article-title":"Inhibitory effects of Fortunella japonica var. margarita and Citrus sunki essential oils on nitric oxide production and skin pathogens","volume":"57","author":"Yang","year":"2010","journal-title":"Acta Microbiol Immunol Hung"},{"key":"10.1016\/j.intimp.2014.02.005_bb0045","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1177\/0040517510373633","article-title":"A novel bioactive fabric dyed with unripe Citrus grandis Osbeck extract part 1: dyeing properties and antimicrobial activity on cotton knit fabrics","volume":"80","author":"Yi","year":"2010","journal-title":"Text Res J"},{"key":"10.1016\/j.intimp.2014.02.005_bb0050","doi-asserted-by":"crossref","first-page":"6185","DOI":"10.1021\/jf8006568","article-title":"Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity","volume":"56","author":"Benavente-Garcia","year":"2008","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.intimp.2014.02.005_bb0055","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s11745-004-1212-8","article-title":"Modulation of HepG2 cell net apolipoprotein B secretion by the citrus polymethoxyflavone, tangeretin","volume":"39","author":"Kurowska","year":"2004","journal-title":"Lipids"},{"key":"10.1016\/j.intimp.2014.02.005_bb0060","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2174\/0929867013373723","article-title":"Biological properties of citrus flavonoids pertaining to cancer and inflammation","volume":"8","author":"Manthey","year":"2001","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.intimp.2014.02.005_bb0065","doi-asserted-by":"crossref","first-page":"5239","DOI":"10.1021\/jf990176o","article-title":"Antimutagenic activity of polymethoxyflavonoids from Citrus aurantium","volume":"47","author":"Miyazawa","year":"1999","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.intimp.2014.02.005_bb0070","first-page":"44","article-title":"Effect of citrus flavonoids and tocotrienols on serum cholesterol levels in hypercholesterolemic subjects","volume":"13","author":"Roza","year":"2007","journal-title":"Altern Ther Health Med"},{"key":"10.1016\/j.intimp.2014.02.005_bb0075","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/mnfr.200800057","article-title":"Monodemethylated polymethoxyflavones from sweet orange (Citrus sinensis) peel inhibit growth of human lung cancer cells by apoptosis","volume":"53","author":"Xiao","year":"2009","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.intimp.2014.02.005_bb0080","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/mnfr.201200606","article-title":"Effective suppression of azoxymethane-induced aberrant crypt foci formation in mice with citrus peel flavonoids","volume":"57","author":"Lai","year":"2013","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.intimp.2014.02.005_bb0085","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.fshw.2012.09.001","article-title":"Inhibition of citrus flavonoids on 12-O-tetradecanoylphorbol 13-acetate-induced skin inflammation and tumorigenesis in mice","volume":"1","author":"Pan","year":"2012","journal-title":"Food Sci Human Wellness"},{"key":"10.1016\/j.intimp.2014.02.005_bb0090","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1039\/c3fo60037h","article-title":"Potent anti-cancer effects of citrus peel flavonoids in human prostate xenograft tumors","volume":"4","author":"Lai","year":"2013","journal-title":"Food Funct"},{"key":"10.1016\/j.intimp.2014.02.005_bb0095","doi-asserted-by":"crossref","first-page":"242","DOI":"10.31989\/ffhd.v3i6.50","article-title":"Inhibitory effect of a formulated extract from multiple citrus peels on LPS-induced inflammation in RAW 246.7 macrophages","volume":"3","author":"Etoh","year":"2013","journal-title":"Funct Foods Health Dis"},{"key":"10.1016\/j.intimp.2014.02.005_bb0100","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1007\/s00018-008-8009-2","article-title":"Central role of dendritic cells in the regulation and deregulation of immune responses","volume":"65","author":"Granucci","year":"2008","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.intimp.2014.02.005_bb0105","first-page":"17","article-title":"Dendritic cells: translating innate to adaptive immunity","volume":"311","author":"Steinman","year":"2006","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1016\/j.intimp.2014.02.005_bb0110","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1615\/CritRevImmunol.v32.i2.30","article-title":"Crosstalk between T lymphocytes and dendritic cells","volume":"32","author":"Hivroz","year":"2012","journal-title":"Crit Rev Immunol"},{"key":"10.1016\/j.intimp.2014.02.005_bb0115","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.it.2012.02.007","article-title":"Lymph node homing of T cells and dendritic cells via afferent lymphatics","volume":"33","author":"F\u00f6rster","year":"2012","journal-title":"Trends Immunol"},{"key":"10.1016\/j.intimp.2014.02.005_bb0120","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1189\/jlb.1106694","article-title":"The cross-talk between dendritic and regulatory T cells: good or evil?","volume":"82","author":"Hubert","year":"2007","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.intimp.2014.02.005_bb0125","first-page":"125643","article-title":"Dextromethorphan inhibits activations and functions in dendritic cells","author":"Chen","year":"2013","journal-title":"Clin Dev Immunol"},{"key":"10.1016\/j.intimp.2014.02.005_bb0130","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1007\/s00262-011-1016-4","article-title":"A novel adjuvant Ling Zhi-8 enhances the efficacy of DNA cancer vaccine by activating dendritic cells","volume":"60","author":"Lin","year":"2011","journal-title":"Cancer Immunol Immunother"},{"key":"10.1016\/j.intimp.2014.02.005_bb0135","doi-asserted-by":"crossref","first-page":"6815","DOI":"10.4049\/jimmunol.0903991","article-title":"Immunosuppressive effect of quercetin on dendritic cell activation and function","volume":"184","author":"Huang","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2014.02.005_bb0140","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1248\/bpb.27.1656","article-title":"Proteoglycan isolated from Phellinus linteus induces toll-like receptors 2- and 4-mediated maturation of murine dendritic cells via activation of ERK, p38, and NF-\u03baB","volume":"27","author":"Kim","year":"2004","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.intimp.2014.02.005_bb0145","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1084\/jem.188.11.2175","article-title":"Dendritic cell survival and maturation are regulated by different signaling pathways","volume":"188","author":"Rescigno","year":"1998","journal-title":"J Exp Med"},{"key":"10.1016\/j.intimp.2014.02.005_bb0150","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jdermsci.2008.08.009","article-title":"Adjuvant effect of lipopolysaccharide on the induction of contact hypersensitivity to haptens in mice","volume":"53","author":"Yokoi","year":"2009","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.intimp.2014.02.005_bb0155","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1080\/10428190500085255","article-title":"Anti-CD 40 monoclonal antibody","volume":"46","author":"Geldart","year":"2005","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.intimp.2014.02.005_bb0160","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/nri727","article-title":"The B7-CD28 superfamily","volume":"2","author":"Sharpe","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.intimp.2014.02.005_bb0165","doi-asserted-by":"crossref","first-page":"5791","DOI":"10.4049\/jimmunol.158.12.5791","article-title":"IL-6 rescues resting mouse T cells from apoptosis","volume":"158","author":"Teague","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2014.02.005_bb0170","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.clim.2008.08.018","article-title":"The effects of IL-6 on CD4 T cell responses","volume":"130","author":"Dienz","year":"2009","journal-title":"Clin Immunol"},{"key":"10.1016\/j.intimp.2014.02.005_bb0175","doi-asserted-by":"crossref","first-page":"3637","DOI":"10.4049\/jimmunol.169.7.3637","article-title":"IL-12 provides proliferation and survival signals to murine CD4+ T cells through phosphatidylinositol 3-kinase\/Akt signaling pathway","volume":"169","author":"Yoo","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2014.02.005_bb0180","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1084\/jem.182.6.1759","article-title":"T helper type 1\/T helper type 2 cytokines and T cell death: preventive effect of interleukin 12 on activation-induced and CD95 (FAS\/APO-1)-mediated apoptosis of CD4+ T cells from human immunodeficiency virus-infected persons","volume":"182","author":"Estaquier","year":"1995","journal-title":"J Exp Med"},{"key":"10.1016\/j.intimp.2014.02.005_bb0185","doi-asserted-by":"crossref","first-page":"7233","DOI":"10.4049\/jimmunol.162.12.7233","article-title":"Extinction of IL-12 signaling promotes Fas-mediated apoptosis of antigen-specific T cells","volume":"162","author":"Marth","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2014.02.005_bb0190","doi-asserted-by":"crossref","first-page":"5735","DOI":"10.2174\/138161212803530763","article-title":"NF-\u03baB as a target for modulating inflammatory responses","volume":"18","author":"Gasparini","year":"2012","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.intimp.2014.02.005_bb0195","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1084\/jem.188.11.2175","article-title":"Dendritic cell survival and maturation are regulated by different signaling pathways","volume":"188","author":"Rescigno","year":"1998","journal-title":"J Exp Med"},{"key":"10.1016\/j.intimp.2014.02.005_bb0200","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1248\/bpb.27.1656","article-title":"Proteoglycan isolated from Phellinus linteus induces toll-like receptors 2- and 4- mediated maturation of murine dendritic cells via activation of ERK, p38, and NF-\u03baB","volume":"27","author":"Kim","year":"2004","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.intimp.2014.02.005_bb0205","doi-asserted-by":"crossref","first-page":"6777","DOI":"10.4049\/jimmunol.178.11.6777","article-title":"Distinct roles of different NF-kappa B subunits in regulating inflammatory and T cell stimulatory gene expression in dendritic cells","volume":"178","author":"Wang","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2014.02.005_bb0210","first-page":"223","article-title":"Th1\/Th2 balance: the hypothesis, its limitations, and implications for health and disease","volume":"8","author":"Kidd","year":"2003","journal-title":"Altern Med Rev"},{"key":"10.1016\/j.intimp.2014.02.005_bb0215","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1146\/annurev.immunol.16.1.495","article-title":"The interleukin-12\/interleukin-12-receptor system: role in normal and pathologic immune responses","volume":"16","author":"Gately","year":"1998","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.intimp.2014.02.005_bb0220","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1189\/jlb.70.2.185","article-title":"Insights into molecular mechanisms of contact hypersensitivity gained from gene knockout studies","volume":"70","author":"Wang","year":"2001","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.intimp.2014.02.005_bb0225","doi-asserted-by":"crossref","first-page":"4817","DOI":"10.2741\/3041","article-title":"Role of Toll like receptor-activated dendritic cells in the development of autoimmunity","volume":"13","author":"Granucci","year":"2008","journal-title":"Front Biosci"},{"key":"10.1016\/j.intimp.2014.02.005_bb0230","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.coi.2010.12.015","article-title":"Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses","volume":"23","author":"Barber","year":"2011","journal-title":"Curr Opin Immunol"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576914000526?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576914000526?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:06:31Z","timestamp":1761584791000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576914000526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S1567576914000526"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2014.02.005","relation":{},"ISSN":["1567-5769"],"issn-type":[{"type":"print","value":"1567-5769"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Formulated extract from multiple citrus peels impairs dendritic cell functions and attenuates allergic contact hypersensitivity","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2014.02.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}