{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T23:20:23Z","timestamp":1772839223325,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["23610008"],"award-info":[{"award-number":["23610008"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004024","name":"Jinan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013286","name":"Specialized Research Fund for the Doctoral Program of Higher Education of China","doi-asserted-by":"publisher","award":["20104401120003"],"award-info":[{"award-number":["20104401120003"]}],"id":[{"id":"10.13039\/501100013286","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1016\/j.intimp.2014.03.014","type":"journal-article","created":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T06:15:35Z","timestamp":1396419335000},"page":"377-382","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Protective effects of apocynin nitrone on acute lung injury induced by lipopolysaccharide in rats"],"prefix":"10.1016","volume":"20","author":[{"given":"Lipeng","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongmei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sainan","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2014.03.014_bb0005","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1089\/ars.2009.2599","article-title":"NOX enzymes and pulmonary disease","volume":"11","author":"Griffith","year":"2009","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.intimp.2014.03.014_bb0010","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1365-2613.2007.00566.x","article-title":"Toll\u2010like receptor and tumour necrosis factor dependent endotoxin\u2010induced acute lung injury","volume":"88","author":"Togbe","year":"2007","journal-title":"Int J Exp Pathol"},{"key":"10.1016\/j.intimp.2014.03.014_bb0015","doi-asserted-by":"crossref","first-page":"L379","DOI":"10.1152\/ajplung.00010.2008","article-title":"Animal models of acute lung injury","volume":"295","author":"Matute-Bello","year":"2008","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.intimp.2014.03.014_bb0020","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1440-1681.2006.04320.x","article-title":"N\u2010acetylcysteine abrogates acute lung injury induced by endotoxin","volume":"33","author":"Kao","year":"2006","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.intimp.2014.03.014_bb0025","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.3181\/0712-RM-354","article-title":"Regulatory effects of hydrogen sulfide on IL-6, IL-8 and IL-10 levels in the plasma and pulmonary tissue of rats with acute lung injury","volume":"233","author":"Li","year":"2008","journal-title":"Exp Biol Med"},{"key":"10.1016\/j.intimp.2014.03.014_bb0030","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/1465-9921-7-125","article-title":"Role of TNFalpha in pulmonary pathophysiology","volume":"7","author":"Mukhopadhyay","year":"2006","journal-title":"Respir Res"},{"key":"10.1016\/j.intimp.2014.03.014_bb0035","first-page":"165","article-title":"The role of oxygen free radicals in occupational and environmental lung diseases","volume":"105","author":"Vallyathan","year":"1997","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.intimp.2014.03.014_bb0040","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.bbrc.2005.08.210","article-title":"Molecular composition and regulation of the Nox family NAD (P) H oxidases","volume":"338","author":"Sumimoto","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.intimp.2014.03.014_bb0045","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1016\/j.ejmech.2011.03.056","article-title":"Synthesis and biological evaluations of novel apocynin analogues","volume":"46","author":"Lu","year":"2011","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.intimp.2014.03.014_bb0050","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/10623320213638","article-title":"Inhibition of NADPH oxidase activation in endothelial cells by ortho-methoxy-substituted catechols","volume":"9","author":"Johnson","year":"2002","journal-title":"Endothelium"},{"key":"10.1016\/j.intimp.2014.03.014_bb0055","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1097\/CCM.0b013e31819fb507","article-title":"Use of corticosteroids in acute lung injury and acute respiratory distress syndrome: a systematic review and meta-analysis*","volume":"37","author":"Tang","year":"2009","journal-title":"Crit Care Med"},{"key":"10.1016\/j.intimp.2014.03.014_bb0060","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.bbrc.2004.09.066","article-title":"Accelerated CuZn-SOD-mediated oxidation and reduction in the presence of hydrogen peroxide","volume":"324","author":"Johnson","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.intimp.2014.03.014_bb0065","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s00011-007-7037-y","article-title":"Mannose prevents lipopolysaccharide-induced acute lung injury in rats","volume":"57","author":"Xu","year":"2008","journal-title":"Inflamm Res"},{"key":"10.1016\/j.intimp.2014.03.014_bb0070","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1002\/bjs.4938","article-title":"C5 complement inhibition attenuates shock and acute lung injury in an experimental model of ruptured abdominal aortic aneurysm","volume":"92","author":"Harkin","year":"2005","journal-title":"Br J Surg"},{"key":"10.1016\/j.intimp.2014.03.014_bb0075","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/S0076-6879(78)53044-9","article-title":"Preparation and assay of superoxide dismutases","volume":"53","author":"Crapo","year":"1977","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.intimp.2014.03.014_bb0080","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1161\/HYPERTENSIONAHA.108.116467","article-title":"Role of Menkes ATPase in angiotensin II-induced hypertension a key modulator for extracellular superoxide dismutase function","volume":"52","author":"Qin","year":"2008","journal-title":"Hypertension"},{"key":"10.1016\/j.intimp.2014.03.014_bb0085","doi-asserted-by":"crossref","first-page":"e10189","DOI":"10.1371\/journal.pone.0010189","article-title":"Extracellular SOD-derived H2O2 promotes VEGF signaling in caveolae\/lipid rafts and post-ischemic angiogenesis in mice","volume":"5","author":"Oshikawa","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2014.03.014_bb0090","doi-asserted-by":"crossref","first-page":"377","DOI":"10.7150\/ijms.5224","article-title":"Curcumin attenuates diabetic neuropathic pain by downregulating TNF-\u03b1 in a rat model","volume":"10","author":"Li","year":"2013","journal-title":"Int J Med Sci"},{"key":"10.1016\/j.intimp.2014.03.014_bb0095","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1620\/tjem.193.27","article-title":"Changes in the tissue and plasma superoxide dismutase (SOD) levels in a burned rat model","volume":"193","author":"Ohno","year":"2001","journal-title":"Tohoku J Exp Med"},{"key":"10.1016\/j.intimp.2014.03.014_bb0100","doi-asserted-by":"crossref","first-page":"e42078","DOI":"10.1371\/journal.pone.0042078","article-title":"Molecular hydrogen reduces LPS-induced neuroinflammation and promotes recovery from sickness behaviour in mice","volume":"7","author":"Spulber","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2014.03.014_bb0105","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.taap.2012.12.012","article-title":"The antiestrogen endoxifen protects rat liver mitochondria from permeability transition pore opening and oxidative stress at concentrations that do not affect the phosphorylation efficiency","volume":"267","author":"Ribeiro","year":"2013","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.intimp.2014.03.014_bb0110","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/labinvest.3700388","article-title":"Lethal endotoxic shock using \u03b1-galactosylceramide sensitization as a new experimental model of septic shock","volume":"86","author":"Ito","year":"2006","journal-title":"Lab Invest"},{"key":"10.1016\/j.intimp.2014.03.014_bb0115","first-page":"691","article-title":"A low level of TNF-mediates hemorrhage-induced acute lung injury via p55 TNF receptor","volume":"83","author":"Song","year":"2003","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"10.1016\/j.intimp.2014.03.014_bb0120","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1474-9726.2006.00189.x","article-title":"Nitrones as therapeutics in age\u2010related diseases","volume":"5","author":"Floyd","year":"2006","journal-title":"Aging Cell"},{"key":"10.1016\/j.intimp.2014.03.014_bb0125","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.taap.2009.09.008","article-title":"Sprague\u2013Dawley rats display sex-linked differences in the pharmacokinetics of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolite 3,4-methylenedioxyamphetamine (MDA)","volume":"241","author":"Fonsart","year":"2009","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.intimp.2014.03.014_bb0130","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.taap.2006.11.021","article-title":"Melanoma differentiation associated gene-7\/interleukin-24 (mda-7\/IL-24): novel gene therapeutic for metastatic melanoma","volume":"224","author":"Fisher","year":"2007","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.intimp.2014.03.014_bb0135","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1093\/rheumatology\/38.11.1088","article-title":"Apocynin, a plant-derived, cartilage-saving drug, might be useful in the treatment of rheumatoid arthritis","volume":"38","author":"Lafeber","year":"1999","journal-title":"Rheumatology"},{"key":"10.1016\/j.intimp.2014.03.014_bb0140","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0014-2999(01)01516-3","article-title":"Effects of methoxylation of apocynin and analogs on the inhibition of reactive oxygen species production by stimulated human neutrophils","volume":"433","author":"Van den Worm","year":"2001","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.intimp.2014.03.014_bb0145","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.taap.2009.07.022","article-title":"NADPH oxidase and lipid raft-associated redox signaling are required for PCB153-induced upregulation of cell adhesion molecules in human brain endothelial cells","volume":"240","author":"Eum","year":"2009","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.intimp.2014.03.014_bb0150","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.taap.2008.04.018","article-title":"Increased accumulation of neutrophils and decreased fibrosis in the lung of NADPH oxidase-deficient C57BL\/6 mice exposed to carbon nanotubes","volume":"231","author":"Shvedova","year":"2008","journal-title":"Toxicol Appl Pharmacol"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576914001179?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576914001179?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:06:23Z","timestamp":1761584783000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576914001179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["S1567576914001179"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2014.03.014","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effects of apocynin nitrone on acute lung injury induced by lipopolysaccharide in rats","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2014.03.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}