{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T11:08:24Z","timestamp":1761217704461},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Key Programs of China","award":["2012ZX09101103-017"],"award-info":[{"award-number":["2012ZX09101103-017"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.intimp.2014.05.012","type":"journal-article","created":{"date-parts":[[2014,5,24]],"date-time":"2014-05-24T11:00:47Z","timestamp":1400929247000},"page":"261-268","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Protective effect of SKLB010 against d-galactosamine\/lipopolysaccharide-induced acute liver failure via nuclear factor-\u03baB signaling pathway in macrophages"],"prefix":"10.1016","volume":"21","author":[{"given":"Caifeng","family":"Xie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang","family":"Jingjing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aihua","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2014.05.012_bb0005","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1002\/hep.22177","article-title":"Acute liver failure: summary of a workshop","volume":"47","author":"Lee","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2014.05.012_bb0010","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1002\/hep.20703","article-title":"AASLD position paper: the management of acute liver failure","volume":"41","author":"Polson","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2014.05.012_bb0015","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1021\/jm901183d","article-title":"Discovery of (Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione, a readily available and orally active glitazone for the treatment of concanavalin A-induced acute liver injury of BALB\/c mice","volume":"53","author":"Luo","year":"2010","journal-title":"J Med Chem"},{"key":"10.1016\/j.intimp.2014.05.012_bb0020","doi-asserted-by":"crossref","first-page":"654","DOI":"10.3748\/wjg.v18.i7.654","article-title":"(Z)-5-(4-Methoxybenzylidene)thiazolidine-2,4-dione protects rats from carbon tetrachloride-induced liver injury and fibrogenesis","volume":"18","author":"Chen","year":"2012","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.intimp.2014.05.012_bb0025","first-page":"319","article-title":"The role of the liver in the response to LPS: experimental and clinical findings","volume":"8","author":"Jirillo","year":"2002","journal-title":"J Endotoxin Res"},{"key":"10.1016\/j.intimp.2014.05.012_bb0030","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.ejphar.2008.02.081","article-title":"Protective effect of baicalin against lipopolysaccharide\/d-galactosamine-induced liver injury in mice by upregulation of heme oxygenase-1","volume":"587","author":"Wan","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.intimp.2014.05.012_bb0035","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1053\/jhep.2001.24561","article-title":"Etoposide prevents apoptosis in mouse liver with d-galactosamine\/lipopolysaccharide-induced fulminant hepatic failure resulting in reduction of lethality","volume":"33","author":"Nakama","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2014.05.012_bb0040","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1053\/j.gastro.2008.03.002","article-title":"Cellular and molecular mechanisms of liver injury","volume":"134","author":"Malhi","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.intimp.2014.05.012_bb0045","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1128\/IAI.67.3.1018-1024.1999","article-title":"Role of nitric oxide in lipopolysaccharide-induced hepatic injury in d-galactosamine-sensitized mice as an experimental endotoxic shock model","volume":"67","author":"Morikawa","year":"1999","journal-title":"Infect Immun"},{"key":"10.1016\/j.intimp.2014.05.012_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0898-6568(99)00071-6","article-title":"The p38 signal transduction pathway: activation and function","volume":"12","author":"Ono","year":"2000","journal-title":"Cell Signal"},{"key":"10.1016\/j.intimp.2014.05.012_bb0055","doi-asserted-by":"crossref","first-page":"30858","DOI":"10.1074\/jbc.274.43.30858","article-title":"The p38MAPK mitogen-activated protein kinase is required for NF-kappaB-dependent gene expression. The role of TATA-binding protein (TBP)","volume":"274","author":"Carter","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.intimp.2014.05.012_bb0060","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/TP.0b013e31821cdea5","article-title":"Erythropoietin increases survival and attenuates fulminant hepatic failure injury induced by d-galactosamine\/lipopolysaccharide in mice","volume":"92","author":"Ben-Ari","year":"2011","journal-title":"Transplantation"},{"key":"10.1016\/j.intimp.2014.05.012_bb0065","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1136\/gut.2007.141986","article-title":"Nuclear factor-kappaB inhibition and non-alcoholic steatohepatitis: inflammation as a target for therapy","volume":"57","author":"Marra","year":"2008","journal-title":"Gut"},{"key":"10.1016\/j.intimp.2014.05.012_bb0070","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1136\/gut.2008.165647","article-title":"A novel technique for selective NF-kappaB inhibition in Kupffer cells: contrary effects in fulminant hepatitis and ischaemia-reperfusion","volume":"58","author":"Hoffmann","year":"2009","journal-title":"Gut"},{"key":"10.1016\/j.intimp.2014.05.012_bb0075","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/34178","article-title":"The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation","volume":"391","author":"Ricote","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2014.05.012_bb0080","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.pharmthera.2005.08.007","article-title":"Peroxisome proliferator-activated receptors and inflammation","volume":"110","author":"Moraes","year":"2006","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.intimp.2014.05.012_bb0085","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1016\/j.lfs.2004.10.042","article-title":"Inhibition of inducible nitric oxide synthase and cyclooxygenase II by Platycodon grandiflorum saponins via suppression of nuclear factor-kappaB activation in RAW 264.7 cells","volume":"76","author":"Ahn","year":"2005","journal-title":"Life Sci"},{"key":"10.1016\/j.intimp.2014.05.012_bb0090","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.ejphar.2008.02.044","article-title":"Anti-inflammatory activity of 4-methoxyhonokiol is a function of the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via NF-kappaB, JNK and p38MAPK inactivation","volume":"586","author":"Zhou","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.intimp.2014.05.012_bb0095","doi-asserted-by":"crossref","first-page":"13622","DOI":"10.1073\/pnas.0501758102","article-title":"The kinase inhibitor imatinib mesylate inhibits TNF-{alpha} production in vitro and prevents TNF-dependent acute hepatic inflammation","volume":"102","author":"Wolf","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.intimp.2014.05.012_bb0100","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1016\/S0002-9440(10)65076-6","article-title":"Depletion of hepatic glutathione prevents death receptor-dependent apoptotic and necrotic liver injury in mice","volume":"156","author":"Hentze","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1016\/j.intimp.2014.05.012_bb0105","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.4049\/jimmunol.171.4.1994","article-title":"Nramp1 functionality increases inducible nitric oxide synthase transcription via stimulation of IFN regulatory factor 1 expression","volume":"171","author":"Fritsche","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2014.05.012_bb0110","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.lfs.2006.02.020","article-title":"Inhibition of lipopolysaccharide-induced iNOS and COX-2 expression by dehydroevodiamine through suppression of NF-kappaB activation in RAW 264.7 macrophages","volume":"79","author":"Noh","year":"2006","journal-title":"Life Sci"},{"key":"10.1016\/j.intimp.2014.05.012_bb0115","doi-asserted-by":"crossref","first-page":"F1141","DOI":"10.1152\/ajprenal.00288.2005","article-title":"Thiazolidinedione ameliorates renal injury in experimental diabetic rats through anti-inflammatory effects mediated by inhibition of NF-kappaB activation","volume":"292","author":"Ohga","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.intimp.2014.05.012_bb0120","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1046\/j.1523-1755.2002.00476.x","article-title":"Effects of different PPARgamma-agonists on MCP-1 expression and monocyte recruitment in experimental glomerulonephritis","volume":"62","author":"Panzer","year":"2002","journal-title":"Kidney Int"},{"key":"10.1016\/j.intimp.2014.05.012_bb0125","doi-asserted-by":"crossref","first-page":"5939","DOI":"10.1073\/pnas.76.11.5939","article-title":"Galactosamine-induced sensitization to the lethal effects of endotoxin","volume":"76","author":"Galanos","year":"1979","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.intimp.2014.05.012_bb0130","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1084\/jem.165.3.657","article-title":"Lethal toxicity of lipopolysaccharide and tumor necrosis factor in normal and d-galactosamine-treated mice","volume":"165","author":"Lehmann","year":"1987","journal-title":"J Exp Med"},{"key":"10.1016\/j.intimp.2014.05.012_bb0135","doi-asserted-by":"crossref","first-page":"4705","DOI":"10.1016\/S0021-9258(17)37600-7","article-title":"Role of transcription factor NF-kappa B\/Rel in induction of nitric oxide synthase","volume":"269","author":"Xie","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.intimp.2014.05.012_bb0140","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1159\/000232940","article-title":"Role of cytokines in the pathophysiology of acute-on-chronic liver failure","volume":"28","author":"Liu","year":"2009","journal-title":"Blood Purif"},{"key":"10.1016\/j.intimp.2014.05.012_bb0145","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1016\/j.freeradbiomed.2011.02.021","article-title":"Cannabidiol protects against hepatic ischemia\/reperfusion injury by attenuating inflammatory signaling and response, oxidative\/nitrative stress, and cell death","volume":"50","author":"Mukhopadhyay","year":"2011","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.intimp.2014.05.012_bb0150","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1038\/embor.2008.149","article-title":"p38 alpha MAPK inhibits JNK activation and collaborates with IkappaB kinase 2 to prevent endotoxin-induced liver failure","volume":"9","author":"Heinrichsdorff","year":"2008","journal-title":"EMBO Rep"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576914001842?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576914001842?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T15:34:23Z","timestamp":1649086463000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576914001842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S1567576914001842"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2014.05.012","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effect of SKLB010 against d-galactosamine\/lipopolysaccharide-induced acute liver failure via nuclear factor-\u03baB signaling pathway in macrophages","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2014.05.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}