{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T22:30:25Z","timestamp":1781908225987,"version":"3.54.5"},"reference-count":28,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470672"],"award-info":[{"award-number":["81470672"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271060"],"award-info":[{"award-number":["81271060"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30973281"],"award-info":[{"award-number":["30973281"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.intimp.2014.10.017","type":"journal-article","created":{"date-parts":[[2014,10,25]],"date-time":"2014-10-25T12:45:34Z","timestamp":1414241134000},"page":"642-648","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Ca2+-activated K+ channel-3.1 blocker TRAM-34 alleviates murine allergic rhinitis"],"prefix":"10.1016","volume":"23","author":[{"given":"Hai","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunquan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl. 1","key":"10.1016\/j.intimp.2014.10.017_bb0145","doi-asserted-by":"crossref","first-page":"S112","DOI":"10.2500\/aap.2012.33.9001","article-title":"The burden of allergic rhinitis on patients' quality of life","volume":"33","author":"Bellanti","year":"2012","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/j.intimp.2014.10.017_bb0010","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.intimp.2010.10.002","article-title":"Beneficial effects of chelidonic acid on a model of allergic rhinitis","volume":"11","author":"Oh","year":"2011","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.intimp.2014.10.017_bb0150","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.jaci.2011.11.026","article-title":"The effects of an H3 receptor antagonist (PF-03654746) with fexofenadine on reducing allergic rhinitis symptoms","volume":"129","author":"Stokes","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.intimp.2014.10.017_bb0020","doi-asserted-by":"crossref","first-page":"472","DOI":"10.2500\/aap.2011.32.3474","article-title":"Efficacy and safety of fluticasone furoate nasal spray in Chinese adult and adolescent subjects with intermittent or persistent allergic rhinitis","volume":"32","author":"Han","year":"2011","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/j.intimp.2014.10.017_bb0025","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.intimp.2013.04.011","article-title":"Comparison of the efficacy of KOB03, ketotifen, and montelukast in an experimental mouse model of allergic rhinitis","volume":"16","author":"Jung","year":"2013","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.intimp.2014.10.017_bb0030","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.intimp.2013.04.025","article-title":"Therapeutic potential of curcumin in experimentally induced allergic rhinitis in guinea pigs","volume":"17","author":"Thakare","year":"2013","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.intimp.2014.10.017_bb0035","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.intimp.2009.02.011","article-title":"Effect of histamine H4 receptor antagonist on allergic rhinitis in mice","volume":"9","author":"Takahashi","year":"2009","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.intimp.2014.10.017_bb0040","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1185\/03007995.2013.821055","article-title":"Efficacy, safety, and optimal dose selection of beclomethasone dipropionate nasal aerosol for seasonal allergic rhinitis in adolescents and adults","volume":"29","author":"Raphael","year":"2013","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/j.intimp.2014.10.017_bb0045","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.intimp.2011.12.008","article-title":"Potential role of store-operated Ca2+ entry in Th2 response induced by histamine in human monocyte-derived dendritic cells","volume":"12","author":"Geng","year":"2012","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.intimp.2014.10.017_bb0050","doi-asserted-by":"crossref","first-page":"5512","DOI":"10.4049\/jimmunol.180.8.5512","article-title":"Homeostatic intracellular-free Ca2+ is permissive for Rap1-mediated constitutive activation of alpha4 integrins on eosinophils","volume":"180","author":"Ulfman","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2014.10.017_bb0055","doi-asserted-by":"crossref","first-page":"e61595","DOI":"10.1371\/journal.pone.0061595","article-title":"The Orai-1 and STIM-1 complex controls human dendritic cell maturation","volume":"8","author":"Felix","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2014.10.017_bb0060","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/B978-0-12-407870-3.00002-0","article-title":"STIM-ORAI interactions that control the CRAC channel","volume":"71","author":"Gudlur","year":"2013","journal-title":"Curr Top Membr"},{"key":"10.1016\/j.intimp.2014.10.017_bb0065","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.anai.2011.09.013","article-title":"Influence of Orai1 intervention on mouse airway epithelium reactions in vivo and in vitro","volume":"108","author":"Lin","year":"2012","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.intimp.2014.10.017_bb0070","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3858\/emm.2012.44.3.013","article-title":"Downregulation of Orai1 expression in the airway alleviates murine allergic rhinitis","volume":"44","author":"Wang","year":"2012","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.intimp.2014.10.017_bb0075","doi-asserted-by":"crossref","first-page":"G873","DOI":"10.1152\/ajpgi.00156.2013","article-title":"Upregulation of KCa3.1K(+) channel in mesenteric lymph node CD4(+) T lymphocytes from a mouse model of dextran sodium sulfate-induced inflammatory bowel disease","volume":"306","author":"Ohya","year":"2014","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.intimp.2014.10.017_bb0155","doi-asserted-by":"crossref","first-page":"e773","DOI":"10.1038\/cddis.2013.279","article-title":"KCa3.1 channels are involved in the infiltrative behavior of glioblastoma in vivo","volume":"4","author":"D'Alessandro","year":"2013","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.intimp.2014.10.017_bb0085","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.2337\/db13-0135","article-title":"Blockade of KCa3.1 ameliorates renal fibrosis through the TGF-beta1\/Smad pathway in diabetic mice","volume":"62","author":"Huang","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.intimp.2014.10.017_bb0090","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ejphar.2014.06.061","article-title":"Targeting of microglial KCa3.1 channels by TRAM-34 exacerbates hippocampal neurodegeneration and does not affect ictogenesis and epileptogenesis in chronic temporal lobe epilepsy models","volume":"740","author":"Ongerth","year":"2014","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.intimp.2014.10.017_bb0095","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1165\/rcmb.2012-0236OC","article-title":"Targeted inhibition of KCa3.1 channel attenuates airway inflammation and remodeling in allergic asthma","volume":"48","author":"Yu","year":"2013","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.intimp.2014.10.017_bb0100","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1165\/rcmb.2012-0103OC","article-title":"Ca(2+)-activated K(+) channel-3.1 blocker TRAM-34 attenuates airway remodeling and eosinophilia in a murine asthma model","volume":"48","author":"Girodet","year":"2013","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.intimp.2014.10.017_bb0105","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.jep.2012.05.039","article-title":"Antiallergic effect of KOB03, a polyherbal medicine, on mast cell-mediated allergic responses in ovalbumin-induced allergic rhinitis mouse and human mast cells","volume":"142","author":"Won Jung","year":"2012","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.intimp.2014.10.017_bb0110","first-page":"358","article-title":"Interleukin-17 producing T cells could be a marker for patients with allergic rhinitis","volume":"16","author":"Tsvetkova-Vicheva","year":"2014","journal-title":"Isr Med Assoc J"},{"key":"10.1016\/j.intimp.2014.10.017_bb0115","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/2045-7022-4-3","article-title":"IL-17 producing T cells correlate with polysensitization but not with bronchial hyperresponsiveness in patients with allergic rhinitis","volume":"4","author":"Tsvetkova-Vicheva","year":"2014","journal-title":"Clin Transl Allergy"},{"key":"10.1016\/j.intimp.2014.10.017_bb0120","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.jcma.2012.07.003","article-title":"Effect of Tong Qiao drops on the expression of eotaxin, IL-13 in the nasal mucosa of rats with allergic rhinitis","volume":"75","author":"Xu","year":"2012","journal-title":"J Chin Med Assoc"},{"key":"10.1016\/j.intimp.2014.10.017_bb0125","first-page":"188","article-title":"Total antioxidant status and oxidative stress and their relationship to total IgE levels and eosinophil counts in children with allergic rhinitis","volume":"22","author":"Emin","year":"2012","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1016\/j.intimp.2014.10.017_bb0130","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.4049\/jimmunol.1300104","article-title":"Functional KCa3.1 channels regulate steroid insensitivity in bronchial smooth muscle cells","volume":"191","author":"Chachi","year":"2013","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2014.10.017_bb0135","doi-asserted-by":"crossref","first-page":"e95173","DOI":"10.1371\/journal.pone.0095173","article-title":"High glucose induces CCL20 in proximal tubular cells via activation of the KCa3.1 channel","volume":"9","author":"Huang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2014.10.017_bb0140","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1073\/pnas.0910133107","article-title":"Inhibition of the K+ channel KCa3.1 ameliorates T cell-mediated colitis","volume":"107","author":"Di","year":"2010","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576914003993?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576914003993?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T07:22:46Z","timestamp":1538119366000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576914003993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S1567576914003993"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2014.10.017","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ca2+-activated K+ channel-3.1 blocker TRAM-34 alleviates murine allergic rhinitis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2014.10.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}