{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T23:52:14Z","timestamp":1776988334016,"version":"3.51.4"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Baili Research Fund III of Chinese Journal of Pediatrics","award":["cjp012-002"],"award-info":[{"award-number":["cjp012-002"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.intimp.2014.12.028","type":"journal-article","created":{"date-parts":[[2015,1,6]],"date-time":"2015-01-06T15:33:14Z","timestamp":1420558394000},"page":"106-111","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["The effects of baicalin on the TLR2\/4 signaling pathway in the peripheral blood mononuclear cells of a lipopolysaccharide-induced rat fever model"],"prefix":"10.1016","volume":"25","author":[{"given":"Li","family":"Ye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8074-4170","authenticated-orcid":false,"given":"Yuhong","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yamei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2014.12.028_bb0005","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jep.2010.01.006","article-title":"The genus Scutellaria: an ethnopharmacological and phytochemical review","volume":"128","author":"Shang","year":"2010","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.intimp.2014.12.028_bb0010","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1016\/j.chroma.2008.03.059","article-title":"Simple preparation of baicalin from Scutellariae radix","volume":"1216","author":"Ohkoshi","year":"2009","journal-title":"J Chromatogr A"},{"key":"10.1016\/j.intimp.2014.12.028_bb0015","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.neuropharm.2006.05.010","article-title":"The antipyretic effects of baicalin in lipopolysaccharide-evoked fever in rabbits","volume":"51","author":"Tsai","year":"2006","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.intimp.2014.12.028_bb0020","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1142\/S0192415X04002521","article-title":"A new approach to investigate the pharmacokinetics of traditional Chinese medicine YL2000","volume":"32","author":"Zhao","year":"2004","journal-title":"Am J Chin Med"},{"key":"10.1016\/j.intimp.2014.12.028_bb0025","first-page":"1068","article-title":"Effect of baicalin on antipyresis and influence on cytokine","volume":"35","author":"Li","year":"2010","journal-title":"Zhong guo Zhong Yao Za Zhi"},{"key":"10.1016\/j.intimp.2014.12.028_bb0030","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1126\/science.1085536","article-title":"Toll-like receptor signaling pathways","volume":"300","author":"Barton","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.intimp.2014.12.028_bb0035","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1100\/tsw.2010.50","article-title":"Fever","volume":"10","author":"Bartfai","year":"2010","journal-title":"Scientific World Journal"},{"key":"10.1016\/j.intimp.2014.12.028_bb0040","doi-asserted-by":"crossref","first-page":"R147","DOI":"10.1016\/S0960-9822(99)80085-2","article-title":"Fever: links with an ancient receptor","volume":"9","author":"Dinarello","year":"1999","journal-title":"Curr Biol"},{"key":"10.1016\/j.intimp.2014.12.028_bb0045","doi-asserted-by":"crossref","first-page":"4000","DOI":"10.1182\/blood-2005-11-4743","article-title":"Bacterial lipopolysaccharide fever is initiated via Toll-like receptor 4 on hematopoietic cells","volume":"107","author":"Steiner","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.intimp.2014.12.028_bb0050","doi-asserted-by":"crossref","first-page":"R1316","DOI":"10.1152\/ajpregu.00301.2006","article-title":"Circulating interleukin-6 induces fever through a STAT3-linked activation of COX-2 in the brain","volume":"291","author":"Rummel","year":"2006","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.intimp.2014.12.028_bb0055","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1472-6750-7-76","article-title":"Characterization of EvaGreen and the implication of its physicochemical properties for qPCR applications","volume":"7","author":"Mao","year":"2007","journal-title":"BMC Biotechnol"},{"key":"10.1016\/j.intimp.2014.12.028_bb0060","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1186\/1471-2164-9-474","article-title":"Differential gene expression profiles are dependent upon method of peripheral blood collection and RNA isolation","volume":"9","author":"Asare","year":"2008","journal-title":"BMC Genomics"},{"key":"10.1016\/j.intimp.2014.12.028_bb0065","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.intimp.2014.12.028_bb0070","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1002\/elps.201400025","article-title":"Total protein quantitation using the bicinchoninic acid assay and gradient elution moving boundary electrophoresis","volume":"35","author":"Kralj","year":"2014","journal-title":"Electrophoresis"},{"key":"10.1016\/j.intimp.2014.12.028_bb0075","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.molmed.2007.09.002","article-title":"Signaling to NF-kappaB by Toll-like receptors","volume":"13","author":"Kawai","year":"2007","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.intimp.2014.12.028_bb0080","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.bbi.2013.10.013","article-title":"Toll-like receptors 2 and 4 modulate autonomic control of heart rate and energy metabolism","volume":"36","author":"Okun","year":"2014","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.intimp.2014.12.028_bb0085","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.4161\/cc.5.19.3321","article-title":"Cells that trigger fever","volume":"5","author":"Omanovsky","year":"2006","journal-title":"Cell Cycle"},{"key":"10.1016\/j.intimp.2014.12.028_bb0090","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.2741\/1341","article-title":"Cytokines and fever","volume":"9","author":"Conti","year":"2004","journal-title":"Front Biosci"},{"key":"10.1016\/j.intimp.2014.12.028_bb0095","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1182\/blood-2008-07-019307","article-title":"TLRs and innate immunity","volume":"113","author":"Beutler","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.intimp.2014.12.028_bb0100","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S0022-3565(24)29528-8","article-title":"Pharmacokinetic\/pharmacodynamic modeling of antipyretic and anti-inflammatory effects of naproxen in the rat","volume":"297","author":"Josa","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.intimp.2014.12.028_bb0105","doi-asserted-by":"crossref","first-page":"10689","DOI":"10.1074\/jbc.274.16.10689","article-title":"Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction","volume":"274","author":"Chow","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.intimp.2014.12.028_bb0110","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/26239","article-title":"Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling","volume":"395","author":"Yang","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2014.12.028_bb0115","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1371\/journal.ppat.0020067","article-title":"Shield as signal: lipopolysaccharides and the evolution of immunity to gram-negative bacteria","volume":"2","author":"Munford","year":"2006","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.intimp.2014.12.028_bb0120","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S1074-7613(00)80119-3","article-title":"Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components","volume":"11","author":"Takeuchi","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2014.12.028_bb0125","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.imlet.2006.11.008","article-title":"Hyperthermia differentially regulates TLR4 and TLR2-mediated innate immune response","volume":"108","author":"Zhao","year":"2007","journal-title":"Immunol Lett"},{"key":"10.1016\/j.intimp.2014.12.028_bb0130","first-page":"2639","article-title":"Effect of baicalin on pattern recognition receptor TLR2\/4-NOD2 and its significance of drug ability","volume":"38","author":"Chai","year":"2013","journal-title":"Zhong guo Zhong Yao Za Zhi"},{"key":"10.1016\/j.intimp.2014.12.028_bb0135","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/ptr.3003","article-title":"The anti-inflammatory effect of baicalin on hypoxia\/reoxygenation and TNF-alpha induced injury in cultural rat cardiomyocytes","volume":"24","author":"Lin","year":"2010","journal-title":"Phytother Res"},{"key":"10.1016\/j.intimp.2014.12.028_bb0140","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.intimp.2012.10.013","article-title":"Baicalin attenuates proinflammatory cytokine production in oxygen-glucose deprived challenged rat microglial cells by inhibiting TLR4 signaling pathway","volume":"14","author":"Hou","year":"2012","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.intimp.2014.12.028_bb0145","first-page":"1586","article-title":"Role of baicalin in regulating Toll-like receptor 2\/4 after ischemic neuronal injury","volume":"125","author":"Li","year":"2012","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.intimp.2014.12.028_bb0150","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s10753-010-9254-8","article-title":"Baicalin inhibits TLR2\/4 signaling pathway in rat brain following permanent cerebral ischemia","volume":"34","author":"Tu","year":"2011","journal-title":"Inflammation"},{"key":"10.1016\/j.intimp.2014.12.028_bb0155","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1142\/S0192415X08005783","article-title":"Therapeutic effects of baicalin on lipopolysaccharide-induced acute lung injury in rats","volume":"36","author":"Huang","year":"2008","journal-title":"Am J Chin Med"},{"key":"10.1016\/j.intimp.2014.12.028_bb0160","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1472-6882-14-19","article-title":"The protective effect of baicalin against renal ischemia-reperfusion injury through inhibition of inflammation and apoptosis","volume":"14","author":"Lin","year":"2014","journal-title":"BMC Complement Altern Med"},{"key":"10.1016\/j.intimp.2014.12.028_bb0165","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.taap.2011.10.005","article-title":"Effect of baicalin on toll-like receptor 4-mediated ischemia\/reperfusion inflammatory responses in alcoholic fatty liver condition","volume":"258","author":"Kim","year":"2012","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.intimp.2014.12.028_bb0170","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.biopha.2008.01.003","article-title":"Up-regulation of Toll-like receptor 4 was suppressed by emodin and baicalin in the setting of acute pancreatitis","volume":"63","author":"Li","year":"2009","journal-title":"Biomed Pharmacother"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576914005062?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576914005062?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T02:06:24Z","timestamp":1747361184000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576914005062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["S1567576914005062"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2014.12.028","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effects of baicalin on the TLR2\/4 signaling pathway in the peripheral blood mononuclear cells of a lipopolysaccharide-induced rat fever model","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2014.12.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}