{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T20:01:14Z","timestamp":1762459274589,"version":"3.41.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.intimp.2015.02.030","type":"journal-article","created":{"date-parts":[[2015,2,28]],"date-time":"2015-02-28T21:17:14Z","timestamp":1425158234000},"page":"518-527","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Molecular attributes of conjugate antigen influence function of antibodies induced by anti-nicotine vaccine in mice and non-human primates"],"prefix":"10.1016","volume":"25","author":[{"given":"Michael J.","family":"McCluskie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Thorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul R.","family":"Mehelic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parag","family":"Kolhe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keshab","family":"Bhattacharya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jari I.","family":"Finneman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Stead","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele Bailey","family":"Piatchek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ningli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghania","family":"Chikh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janna","family":"Cartier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana M.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R.","family":"Merson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather L.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2015.02.030_bb0005","series-title":"2011: warning about the dangers of tobacco","article-title":"WHO report on the global tobacco epidemic","author":"World Health Organization","year":"2011"},{"year":"2014","series-title":"Tobacco","author":"World Health Organization","key":"10.1016\/j.intimp.2015.02.030_bb0010"},{"issue":"1","key":"10.1016\/j.intimp.2015.02.030_bb0015","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1360-0443.2004.00540.x","article-title":"Shape of the relapse curve and long-term abstinence among untreated smokers","volume":"99","author":"Hughes","year":"2004","journal-title":"Addiction"},{"issue":"6","key":"10.1016\/j.intimp.2015.02.030_bb0020","doi-asserted-by":"crossref","first-page":"664","DOI":"10.5993\/AJHB.32.6.10","article-title":"Varenicline versus bupropion SR or placebo for smoking cessation: a pooled analysis","volume":"32","author":"Nides","year":"2008","journal-title":"Am J Health Behav"},{"issue":"9629","key":"10.1016\/j.intimp.2015.02.030_bb0025","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1016\/S0140-6736(08)60871-5","article-title":"Tobacco addiction","volume":"371","author":"Hatsukami","year":"2008","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.intimp.2015.02.030_bb0030","first-page":"11","article-title":"Therapeutic vaccines for nicotine dependence","volume":"8","author":"Maurer","year":"2006","journal-title":"Curr Opin Mol Ther"},{"issue":"3","key":"10.1016\/j.intimp.2015.02.030_bb0035","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/clpt.2010.317","article-title":"Immunogenicity and smoking-cessation outcomes for a novel nicotine immunotherapeutic","volume":"89","author":"Hatsukami","year":"2011","journal-title":"Clin Pharmacol Ther"},{"issue":"6","key":"10.1016\/j.intimp.2015.02.030_bb0040","doi-asserted-by":"crossref","first-page":"e2547","DOI":"10.1371\/journal.pone.0002547","article-title":"A vaccine against nicotine for smoking cessation: a randomized controlled trial","volume":"3","author":"Cornuz","year":"2008","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.intimp.2015.02.030_bb0045","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1176\/appi.ajp.2012.12060793","article-title":"Effect of a nicotine vaccine on nicotine binding to beta2*-nicotinic acetylcholine receptors in vivo in human tobacco smokers","volume":"170","author":"Esterlis","year":"2013","journal-title":"Am J Psychiatry"},{"issue":"8","key":"10.1016\/j.intimp.2015.02.030_bb0050","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1111\/add.12577","article-title":"Treatment with a nicotine vaccine does not lead to changes in brain activity during smoking cue exposure or a working memory task","volume":"109","author":"Havermans","year":"2014","journal-title":"Addiction"},{"issue":"11","key":"10.1016\/j.intimp.2015.02.030_bb0055","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1016\/j.intimp.2008.07.001","article-title":"Enhanced immunogenicity of a bivalent nicotine vaccine","volume":"8","author":"Keyler","year":"2008","journal-title":"Int Immunopharmacol"},{"issue":"24","key":"10.1016\/j.intimp.2015.02.030_bb0060","doi-asserted-by":"crossref","first-page":"7164","DOI":"10.1021\/ja034805t","article-title":"A new strategy for improved nicotine vaccines using conformationally constrained haptens","volume":"125","author":"Meijler","year":"2003","journal-title":"J Am Chem Soc"},{"issue":"47","key":"10.1016\/j.intimp.2015.02.030_bb0065","doi-asserted-by":"crossref","first-page":"6665","DOI":"10.1016\/j.vaccine.2012.08.064","article-title":"Probing the protective effects of a conformationally constrained nicotine vaccine","volume":"30","author":"Moreno","year":"2012","journal-title":"Vaccine"},{"issue":"10","key":"10.1016\/j.intimp.2015.02.030_bb0070","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1016\/j.vaccine.2009.12.051","article-title":"Nicotine hapten structure, antibody selectivity and effect relationships: results from a nicotine vaccine screening procedure","volume":"28","author":"de Villiers","year":"2010","journal-title":"Vaccine"},{"issue":"4","key":"10.1016\/j.intimp.2015.02.030_bb0075","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.bcp.2011.11.004","article-title":"Structurally distinct nicotine immunogens elicit antibodies with non-overlapping specificities","volume":"83","author":"Pravetoni","year":"2012","journal-title":"Biochem Pharmacol"},{"issue":"10","key":"10.1016\/j.intimp.2015.02.030_bb0080","doi-asserted-by":"crossref","first-page":"e76557","DOI":"10.1371\/journal.pone.0076557","article-title":"Selection of a novel anti-nicotine vaccine: influence of antigen design on antibody function in mice","volume":"8","author":"Pryde","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.intimp.2015.02.030_bb0085","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.intimp.2013.03.021","article-title":"Enhancing immunogenicity of a 3\u2032aminomethylnicotine-DT-conjugate anti-nicotine vaccine with CpG adjuvant in mice and non-human primates","volume":"16","author":"McCluskie","year":"2013","journal-title":"Int Immunopharmacol"},{"issue":"6","key":"10.1016\/j.intimp.2015.02.030_bb0090","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s10875-004-6244-3","article-title":"CPG 7909, an immunostimulatory TLR9 agonist oligodeoxynucleotide, as adjuvant to Engerix-B((R)) HBV vaccine in healthy adults: a double-blind phase I\/II study","volume":"24","author":"Cooper","year":"2004","journal-title":"J Clin Immunol"},{"issue":"7","key":"10.1016\/j.intimp.2015.02.030_bb0095","doi-asserted-by":"crossref","first-page":"e22271","DOI":"10.1371\/journal.pone.0022271","article-title":"Impact on malaria parasite multiplication rates in infected volunteers of the protein-in-adjuvant vaccine AMA1-C1\/Alhydrogel+CPG 7909","volume":"6","author":"Duncan","year":"2011","journal-title":"PLoS One"},{"issue":"31","key":"10.1016\/j.intimp.2015.02.030_bb0100","doi-asserted-by":"crossref","first-page":"4104","DOI":"10.1016\/j.vaccine.2009.04.077","article-title":"A phase 1 study of the blood-stage malaria vaccine candidate AMA1-C1\/alhydrogel with CPG 7909, using two different formulations and dosing intervals","volume":"27","author":"Ellis","year":"2009","journal-title":"Vaccine"},{"issue":"37","key":"10.1016\/j.intimp.2015.02.030_bb0105","doi-asserted-by":"crossref","first-page":"6313","DOI":"10.1016\/j.vaccine.2011.05.047","article-title":"Marked enhancement of the immune response to BioThrax(R) (Anthrax Vaccine Adsorbed) by the TLR9 agonist CPG 7909 in healthy volunteers","volume":"29","author":"Rynkiewicz","year":"2011","journal-title":"Vaccine"},{"issue":"5","key":"10.1016\/j.intimp.2015.02.030_bb0110","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.vaccine.2004.07.014","article-title":"Co-administration of CpG oligonucleotides enhances the late affinity maturation process of human anti-hepatitis B vaccine response","volume":"23","author":"Siegrist","year":"2004","journal-title":"Vaccine"},{"issue":"1","key":"10.1016\/j.intimp.2015.02.030_bb0115","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/eji.200324032","article-title":"Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities","volume":"34","author":"Vollmer","year":"2004","journal-title":"Eur J Immunol"},{"issue":"4","key":"10.1016\/j.intimp.2015.02.030_bb0120","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/clpt.1984.67","article-title":"Daily intake of nicotine during cigarette smoking","volume":"35","author":"Benowitz","year":"1984","journal-title":"Clin Pharmacol Ther"},{"issue":"1","key":"10.1016\/j.intimp.2015.02.030_bb0125","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.vaccine.2012.10.069","article-title":"High immunogenicity of nicotine vaccines obtained by intradermal delivery with safe adjuvants","volume":"31","author":"Chen","year":"2012","journal-title":"Vaccine"},{"issue":"4","key":"10.1016\/j.intimp.2015.02.030_bb0130","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.bmcl.2012.12.048","article-title":"Enhancing nicotine vaccine immunogenicity with liposomes","volume":"23","author":"Lockner","year":"2013","journal-title":"Bioorg Med Chem Lett"},{"issue":"1","key":"10.1016\/j.intimp.2015.02.030_bb0135","doi-asserted-by":"crossref","first-page":"64","DOI":"10.4161\/hv.26635","article-title":"A novel and efficient nicotine vaccine using nano-lipoplex as a delivery vehicle","volume":"10","author":"Hu","year":"2014","journal-title":"Hum Vaccin Immunother"},{"issue":"12","key":"10.1016\/j.intimp.2015.02.030_bb0140","doi-asserted-by":"crossref","first-page":"e82557","DOI":"10.1371\/journal.pone.0082557","article-title":"Immunogenicity of individual vaccine components in a bivalent nicotine vaccine differ according to vaccine formulation and administration conditions","volume":"8","author":"Cornish","year":"2013","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.intimp.2015.02.030_bb0145","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1159\/000067433","article-title":"Preclinical development of a vaccine \u2018against smoking\u2019","volume":"25","author":"Cerny","year":"2002","journal-title":"Onkologie"},{"issue":"3","key":"10.1016\/j.intimp.2015.02.030_bb0150","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1021\/bc500016k","article-title":"Investigating hapten clustering as a strategy to enhance vaccines against drugs of abuse","volume":"25","author":"Collins","year":"2014","journal-title":"Bioconjug Chem"},{"issue":"52","key":"10.1016\/j.intimp.2015.02.030_bb0155","doi-asserted-by":"crossref","first-page":"6185","DOI":"10.1016\/j.vaccine.2013.10.051","article-title":"Increased efficacy of a trivalent nicotine vaccine compared to a dose-matched monovalent vaccine when formulated with alum","volume":"31","author":"de Villiers","year":"2013","journal-title":"Vaccine"},{"issue":"14","key":"10.1016\/j.intimp.2015.02.030_bb0160","doi-asserted-by":"crossref","first-page":"5221","DOI":"10.1021\/jm2004943","article-title":"Synthesis of mercapto-(+)-methamphetamine haptens and their use for obtaining improved epitope density on (+)-methamphetamine conjugate vaccines","volume":"54","author":"Carroll","year":"2011","journal-title":"J Med Chem"},{"issue":"2","key":"10.1016\/j.intimp.2015.02.030_bb0165","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/S0022-3565(25)22078-X","article-title":"Antibodies against arylcyclohexylamines and their similarities in binding specificity with the phencyclidine receptor","volume":"246","author":"Owens","year":"1988","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.intimp.2015.02.030_bb0170","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/B978-0-12-420118-7.00014-7","article-title":"New directions in nicotine vaccine design and use","volume":"69","author":"Pentel","year":"2014","journal-title":"Adv Pharmacol"},{"key":"10.1016\/j.intimp.2015.02.030_bb0175","series-title":"19th Annual Meeting of the Society for Research on Nicotine and Tobacco, Boston, MA, USA. March, 2013","article-title":"Nic7-001, A novel anti-nicotine vaccine, shows significantly superior function in non-human primates (NHP) compared to a CYT002-NicQb mimetic","author":"McCluskie","year":"2013"},{"issue":"1","key":"10.1016\/j.intimp.2015.02.030_bb0180","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.vaccine.2005.05.041","article-title":"Relationships among physico-chemical and biological tests for a synthetic Hib-TT conjugate vaccine","volume":"25","author":"Cuervo","year":"2007","journal-title":"Vaccine"},{"issue":"23\u201324","key":"10.1016\/j.intimp.2015.02.030_bb0185","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1016\/S0264-410X(01)00024-X","article-title":"Effect of physico-chemical modification on the immunogenicity of Haemophilus influenzae type b oligosaccharide\u2013CRM(197) conjugate vaccines","volume":"19","author":"Bolgiano","year":"2001","journal-title":"Vaccine"},{"issue":"18","key":"10.1016\/j.intimp.2015.02.030_bb0190","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1016\/j.vaccine.2008.01.022","article-title":"Physicochemical characterisation of glycoconjugate vaccines for prevention of meningococcal diseases","volume":"26","author":"Bardotti","year":"2008","journal-title":"Vaccine"},{"issue":"8","key":"10.1016\/j.intimp.2015.02.030_bb0195","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1021\/bc9001486","article-title":"Carbodiimide EDC induces cross-links that stabilize RNase A C-dimer against dissociation: EDC adducts can affect protein net charge, conformation, and activity","volume":"20","author":"Lopez-Alonso","year":"2009","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.intimp.2015.02.030_bb0200","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1128\/CVI.00427-07","article-title":"Related to the diluent used for aluminum hydroxide adjuvant","volume":"15","author":"Lin","year":"2008","journal-title":"Clin. Vaccine Immunol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576915000867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576915000867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T15:23:40Z","timestamp":1747754620000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576915000867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["S1567576915000867"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2015.02.030","relation":{},"ISSN":["1567-5769"],"issn-type":[{"type":"print","value":"1567-5769"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular attributes of conjugate antigen influence function of antibodies induced by anti-nicotine vaccine in mice and non-human primates","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2015.02.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}