{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:04:26Z","timestamp":1791353066046,"version":"4.3.1"},"reference-count":21,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Catholic Medical Center Research Foundation"},{"name":"Seoul St. Mary's Hospital Clinical Medicine Research Program"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.intimp.2015.03.017","type":"journal-article","created":{"date-parts":[[2015,3,30]],"date-time":"2015-03-30T09:18:57Z","timestamp":1427707137000},"page":"103-111","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":67,"title":["Digoxin ameliorates autoimmune arthritis via suppression of Th17 differentiation"],"prefix":"10.1016","volume":"26","author":[{"given":"Jennifer","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungye","family":"Baek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaeseon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juhyun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Gun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi-Kyung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi-La","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Hwan","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Ki","family":"Kwok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2015.03.017_bb0005","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0092-8674(00)81109-5","article-title":"Rheumatoid arthritis","volume":"85","author":"Feldmann","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2015.03.017_bb0010","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1002\/art.1780391103","article-title":"Invasive fibroblast-like synoviocytes in rheumatoid arthritis. Passive responders or transformed aggressors?","volume":"39","author":"Firestein","year":"1996","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2015.03.017_bb0015","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nature01661","article-title":"Evolving concepts of rheumatoid arthritis","volume":"423","author":"Firestein","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2015.03.017_bb0020","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1056\/NEJMra1004965","article-title":"The pathogenesis of rheumatoid arthritis","volume":"365","author":"McInnes","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.intimp.2015.03.017_bb0025","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1002\/art.24075","article-title":"Promotion of the local differentiation of murine Th17 cells by synovial macrophages during acute inflammatory arthritis","volume":"58","author":"Egan","year":"2008","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2015.03.017_bb0030","doi-asserted-by":"crossref","first-page":"14292","DOI":"10.1073\/pnas.1009234107","article-title":"Proinflammatory T helper type 17 cells are effective B-cell helpers","volume":"107","author":"Mitsdoerffer","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.intimp.2015.03.017_bb0035","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.4049\/jimmunol.170.5.2655","article-title":"IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-kappa B ligand\/osteoprotegerin balance","volume":"170","author":"Lubberts","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2015.03.017_bb0040","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/art.38267","article-title":"Gene-associated retinoid-interferon-induced mortality 19 (GRIM-19) attenuates autoimmune arthritis by regulation of Th17 and Treg cells","volume":"66","author":"Moon","year":"2014","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2015.03.017_bb0045","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1002\/art.38305","article-title":"STA-21, a promising STAT3 inhibitor that reciprocally regulates Th17 and Treg, inhibits osteoclastogenesis and alleviates autoimmune inflammation","volume":"66","author":"Park","year":"2014","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2015.03.017_bb0050","doi-asserted-by":"crossref","first-page":"4417","DOI":"10.4049\/jimmunol.1300514","article-title":"JAK2-STAT3 blockade by AG490 suppresses autoimmune arthritis in mice via reciprocal regulation of regulatory T cells and Th17 cells","volume":"192","author":"Park","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2015.03.017_bb0055","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.immuni.2007.11.016","article-title":"T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma","volume":"28","author":"Yang","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2015.03.017_bb0060","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1056\/NEJM199702203360801","article-title":"The effect of digoxin on mortality and morbidity in patients with heart failure","volume":"336","year":"1997","journal-title":"N. Engl. J. Med."},{"issue":"Suppl. 1","key":"10.1016\/j.intimp.2015.03.017_bb0065","first-page":"87","article-title":"Na, K-ATPase expression in normal and failing human left ventricle","volume":"87","author":"Allen","year":"1992","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.intimp.2015.03.017_bb0070","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/nature09978","article-title":"Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORgammat activity","volume":"472","author":"Huh","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2015.03.017_bb0075","doi-asserted-by":"crossref","first-page":"31409","DOI":"10.1074\/jbc.M111.254003","article-title":"Structural basis of digoxin that antagonizes RORgamma t receptor activity and suppresses Th17 cell differentiation and interleukin (IL)-17 production","volume":"286","author":"Fujita-Sato","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2015.03.017_bb0080","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.autrev.2012.02.022","article-title":"Effective treatment of rat adjuvant-induced arthritis by celastrol","volume":"11","author":"Cascao","year":"2012","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.intimp.2015.03.017_bb0085","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/1529-0131(199802)41:2<290::AID-ART13>3.0.CO;2-R","article-title":"Treatment of rheumatoid arthritis with oral type II collagen. Results of a multicenter, double-blind, placebo-controlled trial","volume":"41","author":"Barnett","year":"1998","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2015.03.017_bb0090","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1038\/nm1284","article-title":"Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis","volume":"11","author":"Camps","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.intimp.2015.03.017_bb0095","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.immuni.2009.05.001","article-title":"Plasticity of CD4+ T cell lineage differentiation","volume":"30","author":"Zhou","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2015.03.017_bb0100","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/ni.1995","article-title":"Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5","volume":"12","author":"Yang","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.intimp.2015.03.017_bb0105","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1084\/jem.20120994","article-title":"The origins, function, and regulation of T follicular helper cells","volume":"209","author":"Ma","year":"2012","journal-title":"J. Exp. Med."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576915001113?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576915001113?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T12:34:51Z","timestamp":1566477291000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576915001113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["S1567576915001113"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2015.03.017","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Digoxin ameliorates autoimmune arthritis via suppression of Th17 differentiation","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2015.03.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}