{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:33:00Z","timestamp":1790544780121,"version":"4.1.0"},"reference-count":86,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,4,15]],"date-time":"2015-04-15T00:00:00Z","timestamp":1429056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005865","name":"Mochida Memorial Foundation for Medical and Pharmaceutical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007263","name":"Astellas Foundation for Research on Metabolic Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004330","name":"Smoking Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.intimp.2015.04.015","type":"journal-article","created":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T21:12:22Z","timestamp":1429564342000},"page":"127-134","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":102,"title":["Non-neuronal cholinergic system in regulation of immune function with a focus on \u03b17 nAChRs"],"prefix":"10.1016","volume":"29","author":[{"given":"Koichiro","family":"Kawashima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Moriwaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidemi","family":"Misawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhide","family":"Horiguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2015.04.015_bb0005","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.lfs.2012.10.004","article-title":"The non-neuronal cholinergic system: Basic science, therapeutic implications and new perspectives","volume":"91","author":"Grando","year":"2012","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2015.04.015_bb0010","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1254\/jphs.FM0070073","article-title":"Basic and clinical aspects of non-neuronal acetylcholine: Overview of non-neuronal cholinergic systems and their biological significance","volume":"106","author":"Kawashima","year":"2008","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.intimp.2015.04.015_bb0015","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/S0024-3205(02)02478-5","article-title":"Evolutional study on acetylcholine expression","volume":"72","author":"Horiuchi","year":"2003","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2015.04.015_bb0020","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1038\/bjp.2008.185","article-title":"Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans","volume":"154","author":"Wessler","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.intimp.2015.04.015_bb0025","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1042\/bj0231064","article-title":"Observations on acetylcholine","volume":"23","author":"Dudley","year":"1929","journal-title":"Biochem. J."},{"key":"10.1016\/j.intimp.2015.04.015_bb0030","first-page":"1788","article-title":"On the physiological action of certain choline derivatives and new methods for detecting choline","volume":"2","author":"Hunt","year":"1906","journal-title":"Br. Med. J."},{"key":"10.1016\/j.intimp.2015.04.015_bb0035","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1136\/bmj.1.2001.1082","article-title":"The physiological action of choline and neurine","volume":"1","author":"Mott","year":"1899","journal-title":"Br. Med. J."},{"key":"10.1016\/j.intimp.2015.04.015_bb0040","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/0024-3205(95)00013-V","article-title":"The background of the muscarinic system","volume":"56","author":"Burgen","year":"1995","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2015.04.015_bb0045","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1042\/bj0080044","article-title":"Acetylcholine, a new active principle of ergot","volume":"8","author":"Ewins","year":"1914","journal-title":"Biochem. J."},{"key":"10.1016\/j.intimp.2015.04.015_bb0050","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0022-3565(25)08268-0","article-title":"The action of certain esters and ethers of choline, and their relation to muscarine","volume":"6","author":"Dale","year":"1914","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.intimp.2015.04.015_bb0055","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.jocn.2008.01.001","article-title":"John Eccles (1903\u201397) and the experiment that proved chemical synaptic transmission in the central nervous system","volume":"15","author":"Todman","year":"2008","journal-title":"J. Clin. Neurosci."},{"key":"10.1016\/j.intimp.2015.04.015_bb0060","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF01738910","article-title":"Uber humorale Ubertragbarkeit der Herznwirkung","volume":"189","author":"Loewi","year":"1921","journal-title":"Pfl\u00fcgers Arch. ges Physiol."},{"key":"10.1016\/j.intimp.2015.04.015_bb0065","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1007\/BF01741946","article-title":"Uber hormonale Ubertragbarkeit der Herznervenwirkung. (Mitteilung X). Uber das Schicksal des Vagusstoff","volume":"214","author":"Loewi","year":"1926","journal-title":"Pfl\u00fcgers Arch. ges Physiol."},{"key":"10.1016\/j.intimp.2015.04.015_bb0070","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1113\/jphysiol.1929.sp002598","article-title":"The presence of histamine and acetylcholine in the spleen of the ox and the horse","volume":"68","author":"Dale","year":"1929","journal-title":"J. Physiol. Lond."},{"key":"10.1016\/j.intimp.2015.04.015_bb0075","first-page":"10-11P","article-title":"Nomenclature of fibres in the autonomic system and their effects","volume":"80","author":"Dale","year":"1934","journal-title":"J. Physiol. Lond."},{"key":"10.1016\/j.intimp.2015.04.015_bb0080","first-page":"319","article-title":"Pharmacology and nerve-endings","volume":"28","author":"Dale","year":"1935","journal-title":"Proc. R. Soc. Med."},{"key":"10.1016\/j.intimp.2015.04.015_bb0085","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.lfs.2003.09.037","article-title":"The lymphocytic cholinergic system and its contribution to the regulation of immune function","volume":"74","author":"Kawashima","year":"2003","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2015.04.015_bb0090","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.2741\/1390","article-title":"Expression of non-neuronal acetylcholine in lymphocytes and its contribution to the regulation of immune function","volume":"9","author":"Kawashima","year":"2004","journal-title":"Front. Biosci."},{"key":"10.1016\/j.intimp.2015.04.015_bb0095","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1126\/science.1209985","article-title":"Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit","volume":"334","author":"Rosas-Ballina","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.intimp.2015.04.015_bb0100","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1084\/jem.23.3.265","article-title":"The reactions between bacteria and animal tissues under conditions of artificial cultivation. II. Bactericidal actions in tissue cultures","volume":"23","author":"Smyth","year":"1916","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.intimp.2015.04.015_bb0105","first-page":"87","article-title":"The differentiation of cells as a criterion for cell identification, considered in relation to the small cortical cell of the thymus","volume":"27","author":"Danchakoff","year":"1919","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.intimp.2015.04.015_bb0110","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1515\/bchm2.1930.191.3-4.179","article-title":"Acetylcholin und Cholin aus tierischen Organen","volume":"191","author":"Kapfhammer","year":"1930","journal-title":"Z. Physiol. Chem."},{"key":"10.1016\/j.intimp.2015.04.015_bb0115","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1515\/bchm2.1931.200.4-6.153","article-title":"Acetylcholin im Rinderblut","volume":"200","author":"Bischoff","year":"1931","journal-title":"Z. Physiol. Chem."},{"key":"10.1016\/j.intimp.2015.04.015_bb0120","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1113\/jphysiol.1933.sp003048","article-title":"The alleged occurrence of acetylcholine in ox blood","volume":"79","author":"Dudley","year":"1933","journal-title":"J. Physiol."},{"key":"10.1016\/j.intimp.2015.04.015_bb0125","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1113\/jphysiol.1934.sp003165","article-title":"The alleged occurrence of acetylcholine in normal ox blood","volume":"82","author":"Loach","year":"1934","journal-title":"J. Physiol."},{"key":"10.1016\/j.intimp.2015.04.015_bb0130","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0160-5402(80)90022-4","article-title":"Radioimmunoassay for acetylcholine in the rat brain","volume":"3","author":"Kawashima","year":"1980","journal-title":"J. Pharmacol. Methods"},{"key":"10.1016\/j.intimp.2015.04.015_bb0135","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0304-3940(87)90478-2","article-title":"Plasma concentration of acetylcholine in young women","volume":"80","author":"Kawashima","year":"1987","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.intimp.2015.04.015_bb0140","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0304-3940(95)12180-3","article-title":"Species differences in the acetylcholine content in blood and plasma","volume":"201","author":"Fujii","year":"1995","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.intimp.2015.04.015_bb0145","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0304-3940(97)00287-5","article-title":"Maintenance of constant blood acetylcholine content before and after feeding in young chimpanzees","volume":"227","author":"Fujii","year":"1997","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.intimp.2015.04.015_bb0150","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/0304-3940(89)90599-5","article-title":"Extraneuronal localization of acetylcholine and its release upon nicotine stimulation","volume":"104","author":"Kawashima","year":"1989","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.intimp.2015.04.015_bb0155","first-page":"251","article-title":"Presence of acetylcholine in human blood and its localization in circulating mononuclear leukocytes","volume":"9","author":"Kawashima","year":"1993","journal-title":"Biog Amine"},{"key":"10.1016\/j.intimp.2015.04.015_bb0160","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0304-3940(97)00188-2","article-title":"Oral administration of KW-5092, a novel gastroprokinetic agent with acetylcholinesterase inhibitory and acetylcholine release enhancing activities, causes a dose-dependent increase in the blood acetylcholine content of beagle dogs","volume":"225","author":"Yamada","year":"1997","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.intimp.2015.04.015_bb0165","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1471-4159.1975.tb11895.x","article-title":"A rapid radiochemical methods for the determination of choline acetyltransferase","volume":"24","author":"Fonnum","year":"1975","journal-title":"J. Neurochem."},{"issue":"Suppl. I","key":"10.1016\/j.intimp.2015.04.015_bb0170","doi-asserted-by":"crossref","first-page":"194P","DOI":"10.1016\/S0021-5198(19)38592-0","article-title":"Determination of acetylcholine content and choline acetyltransferase activity in rabbit blood cells obtained from buffy coat layer","volume":"55","author":"Kajiyama","year":"1991","journal-title":"Jpn. J. Pharmacol."},{"issue":"Suppl. I","key":"10.1016\/j.intimp.2015.04.015_bb0175","doi-asserted-by":"crossref","first-page":"59P","DOI":"10.1016\/S0021-5198(19)48675-7","article-title":"Localization of acetylcholine and choline acetyltransferase activity in human mononuclear leukocytes","volume":"58","author":"Kajiyama","year":"1992","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.intimp.2015.04.015_bb0180","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/jnr.490350209","article-title":"Detection of choline-acetyltransferase activity in lymphocytes","volume":"35","author":"Rinner","year":"1993","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.intimp.2015.04.015_bb0185","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1113\/jphysiol.1982.sp014022","article-title":"The synthesis of acetylcholine in skeletal muscle of the rat","volume":"322","author":"Tucek","year":"1982","journal-title":"J. Physiol."},{"key":"10.1016\/j.intimp.2015.04.015_bb0190","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/(SICI)1097-4547(19960401)44:1<66::AID-JNR9>3.0.CO;2-G","article-title":"Localization and synthesis of acetylcholine in human leukemic T-cell lines","volume":"44","author":"Fujii","year":"1996","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.intimp.2015.04.015_bb0195","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0165-5728(97)00195-1","article-title":"Induction of choline acetyltransferase mRNA in human mononuclear leukocytes stimulated by phytohemagglutinin, a T-cell activator","volume":"82","author":"Fujii","year":"1998","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.intimp.2015.04.015_bb0200","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0304-3940(98)00921-5","article-title":"Constitutive expression of mRNA for the same choline acetyltransferase as that in the nervous system, an acetylcholine-synthesizing enzyme, in human leukemic T-cell lines","volume":"259","author":"Fujii","year":"1999","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.intimp.2015.04.015_bb0205","doi-asserted-by":"crossref","first-page":"231","DOI":"10.2183\/pjab.71.231","article-title":"Expression of choline acetyltransferase mRNA and protein in T-lymphocytes","volume":"71B","author":"Fujii","year":"1995","journal-title":"Proc. Jpn Acad."},{"key":"10.1016\/j.intimp.2015.04.015_bb0210","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0165-5728(97)00155-0","article-title":"Rat lymphocytes produce and secrete acetylcholine in dependence of differentiation and activation","volume":"81","author":"Rinner","year":"1998","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.intimp.2015.04.015_bb0215","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1254\/jphs.FM0070109","article-title":"Basic and clinical aspects of non-neuronal acetylcholine: Expression of an independent, non-neuronal cholinergic system in lymphocytes and its clinical significance in immunotherapy","volume":"106","author":"Fujii","year":"2008","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.intimp.2015.04.015_bb0220","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.lfs.2012.04.031","article-title":"Regulatory mechanisms of acetylcholine synthesis and release by T cells","volume":"91","author":"Fujii","year":"2012","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2015.04.015_bb0225","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1023\/A:1022840416292","article-title":"Up-regulation of mRNA encoding the M5 muscarinic acetylcholine receptor in human T- and B-lymphocytes during immunological responses","volume":"28","author":"Fujii","year":"2003","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.intimp.2015.04.015_bb0230","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jneuroim.2011.12.022","article-title":"Mediatophore regulates acetylcholine release from T cells","volume":"244","author":"Fujii","year":"2012","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.intimp.2015.04.015_bb0235","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.1749-6632.2008.04000.x","article-title":"Exocytosis, mediatophore, and vesicular Ca2+\/H+ antiport in rapid neurotransmission","volume":"1152","author":"Dunant","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.intimp.2015.04.015_bb0240","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0163-7258(99)00071-6","article-title":"Extraneuronal cholinergic system in lymphocytes","volume":"86","author":"Kawashima","year":"2000","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.intimp.2015.04.015_bb0245","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.lfs.2012.05.006","article-title":"Critical roles of acetylcholine and the muscarinic and nicotinic acetylcholine receptors in the regulation of immune function","volume":"91","author":"Kawashima","year":"2012","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2015.04.015_bb0250","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1749-6632.2012.06516.x","article-title":"Reconciling neuronally and non-neuronally derived acetylcholine in the regulation of immune function","volume":"1261","author":"Kawashima","year":"2012","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.intimp.2015.04.015_bb0255","series-title":"Immunopharmacology of lymphocytes","first-page":"169","article-title":"Hormones, neurotransmitters and neruopeptides as modulators of lymphocyte functions","author":"Homo-Delarche","year":"1994"},{"key":"10.1016\/j.intimp.2015.04.015_bb0260","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0889-1591(89)90001-9","article-title":"Cholinergic receptors of lymphocytes","volume":"3","author":"Maslinski","year":"1989","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.intimp.2015.04.015_bb0265","first-page":"303","article-title":"Neuroreceptor changes in Alzheimer disease","volume":"4","author":"Nordberg","year":"1992","journal-title":"Cerebrovasc. Brain Metab. Rev."},{"key":"10.1016\/j.intimp.2015.04.015_bb0270","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev.iy.05.040187.003201","article-title":"Lymphocyte hormone receptors","volume":"5","author":"Plaut","year":"1987","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.intimp.2015.04.015_bb0275","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0304-3940(99)00259-1","article-title":"Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines","volume":"266","author":"Sato","year":"1999","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.intimp.2015.04.015_bb0280","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1016\/j.lfs.2007.02.036","article-title":"Expression and function of genes encoding cholinergic components in murine immune cells","volume":"80","author":"Kawashima","year":"2007","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2015.04.015_bb0285","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/gene.2010.72","article-title":"Plasticity of the murine spleen T-cell cholinergic receptors and their role in in vitro differentiation of na\u00efve CD4 T cells toward the Th1, Th2 and Th17 lineages","volume":"12","author":"Qian","year":"2011","journal-title":"Genes Immun."},{"key":"10.1016\/j.intimp.2015.04.015_bb0290","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.1471-4159.2007.04498.x","article-title":"Evaluating the suitability of nicotinic acetylcholine receptor antibodies for standard immunodetection procedures","volume":"102","author":"Moser","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.intimp.2015.04.015_bb0295","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s002100000251","article-title":"Calcium oscillation is induced by muscarinic acetylcholine receptor stimulation in human leukemic T- and B-cell lines","volume":"362","author":"Fujii","year":"2000","journal-title":"Naunyn Schmiedeberg's Arch. Pharmacol."},{"key":"10.1016\/j.intimp.2015.04.015_bb0300","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jneuroim.2005.03.018","article-title":"Regulation of CD8+ cytolytic T lymphocyte differentiation by a cholinergic pathway","volume":"164","author":"Zimring","year":"2005","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.intimp.2015.04.015_bb0305","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1016\/j.lfs.2007.01.001","article-title":"Analysis of CD8+ T cell-mediated anti-viral responses in mice with targeted deletions of the M1 or M5 muscarinic cholinergic receptors","volume":"80","author":"Vezys","year":"2007","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2015.04.015_bb0310","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jneuroim.2007.05.017","article-title":"Diminished antigen-specific IgG1 and interleukin-6 production and acetylcholinesterase expression in combined M1 and M5 muscarinic acetylcholine receptor knockout mice","volume":"188","author":"Fujii","year":"2007","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.intimp.2015.04.015_bb0315","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1016\/S0024-3205(03)00077-8","article-title":"Nicotine-induced Ca2+ signaling and down-regulation of nicotinic acetylcholine receptor subunit expression in the CEM human leukemic T-cell line","volume":"72","author":"Kimura","year":"2003","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2015.04.015_bb0320","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.4049\/jimmunol.179.5.2889","article-title":"T cells express alpha7-nicotinic acetylcholine receptor subunits that require a functional TCR and leukocyte-specific protein tyrosine kinase for nicotine-induced Ca2+ response","volume":"179","author":"Razani-Boroujerdi","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2015.04.015_bb0325","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jneuroim.2013.12.003","article-title":"SLURP-1, an endogenous \u03b17 nicotinic acetylcholine receptor allosteric ligand, is expressed in CD205+ dendritic cells in human tonsils and potentiates lymphocytic cholinergic activity","volume":"267","author":"Fujii","year":"2014","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.intimp.2015.04.015_bb0330","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature01339","article-title":"Nicotinic acetylcholine receptor \u03b17 subunit is an essential regulator of inflammation","volume":"421","author":"Wang","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2015.04.015_bb0335","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/nature01321","article-title":"The inflammatory reflex","volume":"420","author":"Tracey","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2015.04.015_bb0340","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jneuroim.2007.07.003","article-title":"Enhanced serum antigen-specific IgG1 and proinflammatory cytokine production in nicotinic acetylcholine receptor \u03b17 subunit gene knockout mice","volume":"189","author":"Fujii","year":"2007","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.intimp.2015.04.015_bb0345","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1110\/ps.8.4.810","article-title":"Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6\/uPAR protein superfamily","volume":"8","author":"Adermann","year":"1999","journal-title":"Protein Sci."},{"key":"10.1016\/j.intimp.2015.04.015_bb0350","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1093\/hmg\/ddg320","article-title":"Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda","volume":"12","author":"Chimienti","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.intimp.2015.04.015_bb0355","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1111\/j.0022-202X.2005.23973.x","article-title":"Biological effects of SLURP-1 on human keratinocyte","volume":"125","author":"Arredondo","year":"2005","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.intimp.2015.04.015_bb0360","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1093\/hmg\/10.8.875","article-title":"Mutations in the gene encoding SLURP-1 in Mal de Meleda","volume":"10","author":"Fischer","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.intimp.2015.04.015_bb0365","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1016\/j.lfs.2006.12.028","article-title":"Immune system expression of SLURP-1 and SLURP-2, two endogenous nicotinic acetylcholine receptor ligands","volume":"80","author":"Moriwaki","year":"2007","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2015.04.015_bb0370","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1365-2133.2010.10059.x","article-title":"SLURP-1 mutation-impaired T-cell activation in a family with mal de Meleda","volume":"164","author":"Tjiu","year":"2011","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.intimp.2015.04.015_bb0375","doi-asserted-by":"crossref","first-page":"e116023","DOI":"10.1371\/journal.pone.0116023","article-title":"Ubiquitous transgene expression of the glucosylceramide-synthesizing enzyme accelerates glucosylceramide accumulation and storage cells in a Gaucher disease mouse model","volume":"9","author":"Barnes","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.intimp.2015.04.015_bb0380","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.1073\/pnas.1320924111","article-title":"Marginal zone CD169+ macrophages coordinate apoptotic cell-driven cellular recruitment and tolerance","volume":"111","author":"Ravishankar","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.intimp.2015.04.015_bb0385","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1034\/j.1399-0039.2002.590608.x","article-title":"The HLA-DOB gene displays limited polymorphism with only one amino acid substitution","volume":"59","author":"Naruse","year":"2002","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.intimp.2015.04.015_bb0390","doi-asserted-by":"crossref","first-page":"11288","DOI":"10.1073\/pnas.1202208109","article-title":"Conditional ablation of CD205+ conventional dendritic cells impacts the regulation of T-cell immunity and homeostasis in vivo","volume":"109","author":"Fukuya","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.intimp.2015.04.015_bb0395","doi-asserted-by":"crossref","first-page":"609086","DOI":"10.1155\/2014\/609086","article-title":"Anti-inflammatory effects of the nicotinergic peptides SLURP-1 and SLURP-2 on human intestinal epithelial cells and immunocytes","volume":"2014","author":"Chernyavsky","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.intimp.2015.04.015_bb0400","doi-asserted-by":"crossref","first-page":"539","DOI":"10.2119\/molmed.2011.00405","article-title":"\u03b17 nicotinic acetylcholine receptor (\u03b17nAChR) expression in bone marrow-derived non-T cells is required for the inflammatory reflex","volume":"18","author":"Olofsson","year":"2012","journal-title":"Mol. Med."},{"key":"10.1016\/j.intimp.2015.04.015_bb0405","doi-asserted-by":"crossref","first-page":"C903","DOI":"10.1152\/ajpcell.00216.2010","article-title":"Upregulation of nuclear factor-\u03baB expression by SLURP-1 is mediated by \u03b17-nicotinic acetylcholine receptor and involves both ionic events and activation of protein kinases","volume":"299","author":"Chernyavsky","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.intimp.2015.04.015_bb0410","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1600-065X.2008.00628.x","article-title":"Th17 cells in human disease","volume":"223","author":"Tesmer","year":"2008","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.intimp.2015.04.015_bb0415","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1172\/JCI46125","article-title":"Evidence for a stepwise program of extrathymic T cell development within the human tonsil","volume":"122","author":"McClory","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.intimp.2015.04.015_bb0420","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1016\/j.lfs.2007.02.005","article-title":"The roles of nicotinic receptors in B-lymphocyte development and activation","volume":"80","author":"Skok","year":"2007","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2015.04.015_bb0425","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1016\/S0028-3908(00)00124-6","article-title":"Mixed nicotinic\u2013muscarinic properties of the \u03b19 nicotinic cholinergic receptor","volume":"39","author":"Verbitsky","year":"2000","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.intimp.2015.04.015_bb0430","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1093\/molehr\/gah245","article-title":"Acetylcholine causes an increase of intracellular calcium in human sperm","volume":"11","author":"Bray","year":"2005","journal-title":"Mol. Hum. Reprod."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576915001708?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576915001708?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T19:38:07Z","timestamp":1747942687000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576915001708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":86,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["S1567576915001708"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2015.04.015","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Non-neuronal cholinergic system in regulation of immune function with a focus on \u03b17 nAChRs","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2015.04.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}