{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T12:16:11Z","timestamp":1778328971469,"version":"3.51.4"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.intimp.2015.06.031","type":"journal-article","created":{"date-parts":[[2015,7,10]],"date-time":"2015-07-10T17:17:24Z","timestamp":1436548644000},"page":"409-413","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Natural killer cell activity in patients with major depressive disorder treated with escitalopram"],"prefix":"10.1016","volume":"28","author":[{"given":"E-Jin","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Je-Hoon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dea-Chul","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Ick","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang-Whan","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2015.06.031_bb0005","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1001\/archpsyc.1991.01810260079012","article-title":"Depression, the immune system, and health and illness","volume":"48","author":"Stein","year":"1991","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.intimp.2015.06.031_bb0010","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1037\/0033-2909.113.3.472","article-title":"Depression and immunity: a meta-analytic review","volume":"113","author":"Herbert","year":"1993","journal-title":"Psychol. Bull."},{"key":"10.1016\/j.intimp.2015.06.031_bb0015","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.bbi.2007.01.010","article-title":"Depressive disorders and immunity: 20years of progress and discovery","volume":"21","author":"Irwin","year":"2007","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.intimp.2015.06.031_bb0020","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S0022-3999(02)00309-4","article-title":"Depression and immune function: central pathways to morbidity and mortality","volume":"53","author":"Kiecolt-Glaser","year":"2002","journal-title":"J. Psychosom. Res."},{"key":"10.1016\/j.intimp.2015.06.031_bb0025","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.biopsych.2005.05.001","article-title":"Mood disorders in the medically ill: scientific review and recommendations","volume":"58","author":"Evans","year":"2005","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.intimp.2015.06.031_bb0030","first-page":"547","article-title":"Leukocyte subsets in treatment-resistant major depression","volume":"51","author":"Kubera","year":"1999","journal-title":"Pol. J. Pharmacol."},{"key":"10.1016\/j.intimp.2015.06.031_bb0035","first-page":"38","article-title":"Assessment of the immune system activity in Iranian patients with major depression disorder (MDD)","volume":"4","author":"Farid Hosseini","year":"2007","journal-title":"Iran. J. Immunol."},{"key":"10.1016\/j.intimp.2015.06.031_bb0040","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1159\/000026555","article-title":"Antidepressants augment natural killer cell activity: in vivo and in vitro","volume":"39","author":"Frank","year":"1999","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.intimp.2015.06.031_bb0045","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.psychres.2006.05.013","article-title":"Natural killer T cells in patients with major depressive disorder","volume":"144","author":"Park","year":"2006","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.intimp.2015.06.031_bb0050","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0278-5846(94)00101-M","article-title":"Evidence for an immune response in major depression: a review and hypothesis","volume":"19","author":"Maes","year":"1995","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.intimp.2015.06.031_bb0055","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.euroneuro.2009.11.005","article-title":"Evaluation of the effect of selective serotonin-reuptake inhibitors on lymphocyte subsets in patients with a major depressive disorder","volume":"20","author":"Hernandez","year":"2010","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.intimp.2015.06.031_bb0060","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/0006-3223(95)00038-I","article-title":"Depression and immunity: the biochemical interrelationship between the central nervous system and immune system","volume":"37","author":"Kook","year":"1995","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.intimp.2015.06.031_bb0065","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0165-5728(99)00144-7","article-title":"Comparison of the effects of dopaminergic and serotonergic activity in the CNS on the activity of the immune system","volume":"101","author":"Mizruchin","year":"1999","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.intimp.2015.06.031_bb0070","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.psychres.2004.05.001","article-title":"Potential psychosocial mechanisms linking depression to immune function in elderly subjects","volume":"127","author":"Bouhuys","year":"2004","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.intimp.2015.06.031_bb0075","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1097\/00006842-199511000-00008","article-title":"Lymphocyte subsets associated with major depression and dysthymia: modification by antidepressant treatment","volume":"57","author":"Ravindran","year":"1995","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.intimp.2015.06.031_bb0080","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0165-1781(98)00133-4","article-title":"Depression and immunity: clinical factors and therapeutic course","volume":"85","author":"Schleifer","year":"1999","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.intimp.2015.06.031_bb0085","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1096\/fasebj.5.15.1743441","article-title":"Neuropeptide Y and natural killer cell activity: findings in depression and Alzheimer caregiver stress","volume":"5","author":"Irwin","year":"1991","journal-title":"FASEB J."},{"key":"10.1016\/j.intimp.2015.06.031_bb0090","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/0166-2236(95)93942-Q","article-title":"Do antidepressants stabilize mood through actions on the hypothalamic\u2013pituitary\u2013adrenocortical system?","volume":"18","author":"Barden","year":"1995","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.intimp.2015.06.031_bb0095","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/0192-0561(94)90107-4","article-title":"Expression of a high-affinity serotonin transporter in human lymphocytes","volume":"16","author":"Faraj","year":"1994","journal-title":"Int. J. Immunopharmacol."},{"key":"10.1016\/j.intimp.2015.06.031_bb0100","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0008-8749(90)90125-B","article-title":"Enhancement of human natural killer cell cytotoxicity by serotonin: Role of non-T\/CD16+ NK cells, accessory monocytes, and 5-HT1a receptors","volume":"127","author":"Hellstrand","year":"1990","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.intimp.2015.06.031_bb0105","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0006-3223(01)01145-3","article-title":"Second generation SSRIs. Human monoamine transporter binding profile of escitalopram and R-fluoxetine","volume":"50","author":"Owens","year":"2001","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.intimp.2015.06.031_bb0110","series-title":"Structured Clinical Interview for DSM-IV Axis I Disorders-Clinician Version (SCID-CV)","author":"First","year":"1996"},{"key":"10.1016\/j.intimp.2015.06.031_bb0115","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.2044-8260.1967.tb00530.x","article-title":"Development of a rating scale for primary depressive illness","volume":"6","author":"Hamilton","year":"1967","journal-title":"Br. J. Soc. Clin. Psychol."},{"key":"10.1016\/j.intimp.2015.06.031_bb0120","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1192\/bjp.134.4.382","article-title":"A new depression scale designed to be sensitive to change","volume":"134","author":"Montgomery","year":"1979","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.intimp.2015.06.031_bb0125","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s00213-004-1865-z","article-title":"Escitalopram versus citalopram: the surprising role of the R-enantiomer","volume":"174","author":"S\u00e1nchez","year":"2004","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.intimp.2015.06.031_bb0130","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.euroneuro.2004.08.008","article-title":"The S-enantiomer of R, S citalopram, increases inhibitor binding to the human serotonin transporter by an allosteric mechanism. Comparison with other serotonin transporter inhibitors","volume":"15","author":"Chen","year":"2005","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.intimp.2015.06.031_bb0135","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/sj.bjp.0705738","article-title":"R-citalopram functionally antagonises escitalopram in vivo and in vitro: evidence for kinetic interaction at the serotonin transporter","volume":"142","author":"St\u00f3rustovu","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.intimp.2015.06.031_bb0140","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/01.yic.0000194377.88330.1d","article-title":"A double-blind, randomized, parallel-group, flexible-dose study to evaluate the tolerability, efficacy and effects of treatment discontinuation with escitalopram and paroxetine in patients with major depressive disorder","volume":"21","author":"Baldwin","year":"2006","journal-title":"Int. Clin. Psychopharmacol."},{"key":"10.1016\/j.intimp.2015.06.031_bb0145","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/0014-5793(91)80736-M","article-title":"Hormone specific regulation of natural killer cells by cortisol. Direct inactivation of the cytotoxic function of cloned human NK cells without an effect on cellular proliferation","volume":"285","author":"Callewaert","year":"1991","journal-title":"FEBS Lett."},{"key":"10.1016\/j.intimp.2015.06.031_bb0150","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.biopsych.2007.08.012","article-title":"Selective serotonin reuptake inhibitor and substance P antagonist enhancement of natural killer cell innate immunity in human immunodeficiency virus\/acquired immunodeficiency syndrome","volume":"63","author":"Evans","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.intimp.2015.06.031_bb0155","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/S0006-3223(00)00927-6","article-title":"Increase of NK T cells in aged depressed patients not treated with antidepressive drugs","volume":"48","author":"Flantge","year":"2000","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.intimp.2015.06.031_bb0160","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/bio.1170100107","article-title":"The influence of age and sex on phagocyte chemiluminescence","volume":"10","author":"McCafferty","year":"1995","journal-title":"J. Biolumin. Chemilumin."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576915300102?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576915300102?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:39:26Z","timestamp":1755650366000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576915300102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S1567576915300102"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2015.06.031","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Natural killer cell activity in patients with major depressive disorder treated with escitalopram","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2015.06.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}