{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T18:39:45Z","timestamp":1777574385836,"version":"3.51.4"},"reference-count":47,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.intimp.2015.06.032","type":"journal-article","created":{"date-parts":[[2015,7,7]],"date-time":"2015-07-07T01:45:28Z","timestamp":1436233528000},"page":"382-389","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Tanshinone IIA represses inflammatory response and reduces radiculopathic pain by inhibiting IRAK-1 and NF-\u03baB\/p38\/JNK signaling"],"prefix":"10.1016","volume":"28","author":[{"given":"Wei","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuiyan","family":"Xing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2015.06.032_bb0005","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.spinee.2007.10.005","article-title":"A systematic review of low back pain cost of illness studies in the United States and internationally","volume":"8","author":"Dagenais","year":"2008","journal-title":"Spine J.Off.J. North Am. Spine Soc."},{"key":"10.1016\/j.intimp.2015.06.032_bb0010","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1097\/01.brs.0000154619.38122.47","article-title":"Metabolism of the intervertebral disc: effects of low levels of oxygen, glucose, and pH on rates of energy metabolism of bovine nucleus pulposus cells","volume":"30","author":"Bibby","year":"2005","journal-title":"Spine"},{"key":"10.1016\/j.intimp.2015.06.032_bb0015","doi-asserted-by":"crossref","first-page":"R45","DOI":"10.1186\/ar2198","article-title":"Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration","volume":"9","author":"Le Maitre","year":"2007","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.intimp.2015.06.032_bb0020","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.spinee.2012.02.027","article-title":"Expression and regulation of metalloproteinases and their inhibitors in intervertebral disc aging and degeneration","volume":"13","author":"Vo","year":"2013","journal-title":"Spine J. Off. J. North Am. Spine Soc."},{"key":"10.1016\/j.intimp.2015.06.032_bb0025","first-page":"1033","article-title":"Intervertebral disc biology, degeneration and novel tissue engineering and regenerative medicine therapies","volume":"22","author":"Richardson","year":"2007","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.intimp.2015.06.032_bb0030","doi-asserted-by":"crossref","first-page":"R732","DOI":"10.1186\/ar1732","article-title":"The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration","volume":"7","author":"Le Maitre","year":"2005","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.intimp.2015.06.032_bb0035","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1002\/art.27444","article-title":"Proinflammatory cytokine expression profile in degenerated and herniated human intervertebral disc tissues","volume":"62","author":"Shamji","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2015.06.032_bb0040","doi-asserted-by":"crossref","first-page":"103","DOI":"10.22203\/eCM.v023a08","article-title":"Inflammatory and catabolic signalling in intervertebral discs: the roles of NF-kappaB and MAP kinases","volume":"23","author":"Wuertz","year":"2012","journal-title":"Eur. Cell. Mater."},{"key":"10.1016\/j.intimp.2015.06.032_bb0045","first-page":"1009","article-title":"Immune cascades in human intervertebral disc: the pros and cons","volume":"6","author":"Sun","year":"2013","journal-title":"Int. J. Clin. Exp. Pathol."},{"issue":"Suppl. 2","key":"10.1016\/j.intimp.2015.06.032_bb0050","first-page":"68","article-title":"Pathology and possible mechanisms of nervous system response to disc degeneration","volume":"88","author":"Brisby","year":"2006","journal-title":"J. Bone Joint Surg. (Am. Vol.)"},{"key":"10.1016\/j.intimp.2015.06.032_bb0055","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/01.brs.0000251651.61844.2d","article-title":"Autoimmune properties of nucleus pulposus: an experimental study in pigs","volume":"32","author":"Geiss","year":"2007","journal-title":"Spine"},{"key":"10.1016\/j.intimp.2015.06.032_bb0060","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1097\/01.brs.0000201324.45537.46","article-title":"Possible pathogenesis of painful intervertebral disc degeneration","volume":"31","author":"Peng","year":"2006","journal-title":"Spine"},{"key":"10.1016\/j.intimp.2015.06.032_bb0065","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1097\/00007632-200107150-00004","article-title":"Influence of macrophage infiltration of herniated disc tissue on the production of matrix metalloproteinases leading to disc resorption","volume":"26","author":"Doita","year":"2001","journal-title":"Spine"},{"key":"10.1016\/j.intimp.2015.06.032_bb0070","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1097\/BRS.0b013e3181ebdb43","article-title":"Attenuation of inflammatory events in human intervertebral disc cells with a tumor necrosis factor antagonist","volume":"36","author":"Sinclair","year":"2011","journal-title":"Spine"},{"key":"10.1016\/j.intimp.2015.06.032_bb0075","doi-asserted-by":"crossref","first-page":"E1373","DOI":"10.1097\/BRS.0b013e318221e655","article-title":"The red wine polyphenol resveratrol shows promising potential for the treatment of nucleus pulposus-mediated pain in vitro and in vivo","volume":"36","author":"Wuertz","year":"2011","journal-title":"Spine"},{"key":"10.1016\/j.intimp.2015.06.032_bb0080","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.ejphar.2007.04.031","article-title":"Tanshinone IIA protects cardiac myocytes against oxidative stress-triggered damage and apoptosis","volume":"568","author":"Fu","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2015.06.032_bb0085","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1097\/FJC.0b013e3181671439","article-title":"Sodium tanshinone IIA sulfonate protects cardiomyocytes against oxidative stress-mediated apoptosis through inhibiting JNK activation","volume":"51","author":"Yang","year":"2008","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.intimp.2015.06.032_bb0090","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1078\/094471103322004776","article-title":"Neuroprotective effects of tanshinones in transient focal cerebral ischemia in mice","volume":"10","author":"Lam","year":"2003","journal-title":"Phytomedicine : Int. J. Phytother. Phytopharmacol."},{"key":"10.1016\/j.intimp.2015.06.032_bb0095","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1177\/0091270005282630","article-title":"Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use","volume":"45","author":"Zhou","year":"2005","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.intimp.2015.06.032_bb0100","first-page":"79","article-title":"Tanshinone IIA protects neonatal rat cardiomyocytes from adriamycin-induced apoptosis","volume":"151","author":"Gao","year":"2008","journal-title":"Transl. Res. J. Lab. CLin. Med."},{"key":"10.1016\/j.intimp.2015.06.032_bb0105","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jsbmb.2009.01.011","article-title":"The anti-inflammatory activities of Tanshinone IIA, an active component of TCM, are mediated by estrogen receptor activation and inhibition of iNOS","volume":"113","author":"Fan","year":"2009","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.intimp.2015.06.032_bb0110","first-page":"681","article-title":"Anti-inflammatory effects of tanshinone IIA on radiation-induced microglia BV-2 cells inflammatory response","volume":"24","author":"Dong","year":"2009","journal-title":"Cancer Biother. Radiopharm."},{"key":"10.1016\/j.intimp.2015.06.032_bb0115","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ejphar.2008.10.034","article-title":"Tanshinone IIA suppresses inflammatory bone loss by inhibiting the synthesis of prostaglandin E2 in osteoblasts","volume":"601","author":"Kwak","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2015.06.032_bb0120","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.intimp.2014.07.002","article-title":"Sodium tanshinone IIA sulfonate prolongs the survival of skin allografts by inhibiting inflammatory cell infiltration and T cell proliferation","volume":"22","author":"Yu","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2015.06.032_bb0125","doi-asserted-by":"crossref","first-page":"e38381","DOI":"10.1371\/journal.pone.0038381","article-title":"Tanshinone IIA attenuates the inflammatory response and apoptosis after traumatic injury of the spinal cord in adult rats","volume":"7","author":"Yin","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.intimp.2015.06.032_bb0130","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/aps.2014.112","article-title":"Tanshinone IIA therapeutically reduces LPS-induced acute lung injury by inhibiting inflammation and apoptosis in mice","volume":"36","author":"Xu","year":"2015","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.intimp.2015.06.032_bb0135","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1523\/JNEUROSCI.4288-04.2005","article-title":"Activity-dependent neuroprotection and cAMP response element-binding protein (CREB): kinase coupling, stimulus intensity, and temporal regulation of CREB phosphorylation at serine 133","volume":"25","author":"Lee","year":"2005","journal-title":"J. Neurosc. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.intimp.2015.06.032_bb0140","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0079-6123(02)37006-7","article-title":"Cell death in models of spinal cord injury","volume":"137","author":"Beattie","year":"2002","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.intimp.2015.06.032_bb0145","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.biomaterials.2012.10.017","article-title":"Protective effects of cationic bovine serum albumin-conjugated PEGylated tanshinone IIA nanoparticles on cerebral ischemia","volume":"34","author":"Liu","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.intimp.2015.06.032_bb0150","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S1097-2765(03)00053-4","article-title":"Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members","volume":"11","author":"Janssens","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1016\/j.intimp.2015.06.032_bb0155","doi-asserted-by":"crossref","first-page":"L895","DOI":"10.1152\/ajplung.2000.279.5.L895","article-title":"SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung","volume":"279","author":"Underwood","year":"2000","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.intimp.2015.06.032_bb0160","doi-asserted-by":"crossref","first-page":"372","DOI":"10.22203\/eCM.v028a26","article-title":"Epigallocatechin 3-gallate suppresses interleukin-1beta-induced inflammatory responses in intervertebral disc cells in vitro and reduces radiculopathic pain in rats","volume":"28","author":"Krupkova","year":"2014","journal-title":"Eur. Cell. Mater."},{"key":"10.1016\/j.intimp.2015.06.032_bb0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jor.21206","article-title":"Interleukin-17 synergizes with IFNgamma or TNFalpha to promote inflammatory mediator release and intercellular adhesion molecule-1 (ICAM-1) expression in human intervertebral disc cells","volume":"29","author":"Gabr","year":"2011","journal-title":"J. Orthop. Res. Off. Publ. Orthop. Res. Soc."},{"key":"10.1016\/j.intimp.2015.06.032_bb0170","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1055\/s-0033-1347299","article-title":"Inflammatory mediators in intervertebral disk degeneration and discogenic pain","volume":"3","author":"Wuertz","year":"2013","journal-title":"Glob. Spine J."},{"key":"10.1016\/j.intimp.2015.06.032_bb0175","doi-asserted-by":"crossref","first-page":"e68273","DOI":"10.1371\/journal.pone.0068273","article-title":"Axial low back pain: one painful area--many perceptions and mechanisms","volume":"8","author":"Forster","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.intimp.2015.06.032_bb0180","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1185\/03007995.2010.534446","article-title":"Pharmacotherapy of low back pain: targeting nociceptive and neuropathic pain components","volume":"27","author":"Morlion","year":"2011","journal-title":"Curr. Med. Res. Opin."},{"key":"10.1016\/j.intimp.2015.06.032_bb0185","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1097\/BRS.0b013e318294edb1","article-title":"Regulation of nerve growth factor by anti-inflammatory drugs, a steroid, and a selective cyclooxygenase 2 inhibitor in human intervertebral disc cells stimulated with interleukin-1","volume":"38","author":"Alimasi","year":"2013","journal-title":"Spine"},{"key":"10.1016\/j.intimp.2015.06.032_bb0190","doi-asserted-by":"crossref","first-page":"e47735","DOI":"10.1371\/journal.pone.0047735","article-title":"Degenerate human nucleus pulposus cells promote neurite outgrowth in neural cells","volume":"7","author":"Richardson","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.intimp.2015.06.032_bb0195","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.gene.2012.06.004","article-title":"Toll-like receptor adaptor signaling molecule MyD88 on intervertebral disk homeostasis: in vitro, ex vivo studies","volume":"505","author":"Ellman","year":"2012","journal-title":"Gene"},{"key":"10.1016\/j.intimp.2015.06.032_bb0200","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1097\/BRS.0b013e31815b757a","article-title":"p38 MAPK inhibition in nucleus pulposus cells: a potential target for treating intervertebral disc degeneration","volume":"32","author":"Studer","year":"2007","journal-title":"Spine"},{"key":"10.1016\/j.intimp.2015.06.032_bb0205","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1002\/jor.20604","article-title":"p38 MAPK inhibition modulates rabbit nucleus pulposus cell response to IL-1","volume":"26","author":"Studer","year":"2008","journal-title":"J. Orthop. Res. Off. Publ. Orthop. Res. Soc."},{"key":"10.1016\/j.intimp.2015.06.032_bb0210","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/path.1608","article-title":"Localization of degradative enzymes and their inhibitors in the degenerate human intervertebral disc","volume":"204","author":"Le Maitre","year":"2004","journal-title":"J. Pathol."},{"key":"10.1016\/j.intimp.2015.06.032_bb0215","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0304-3959(93)90124-8","article-title":"Nitric oxide (NO) and nociceptive processing in the spinal cord","volume":"52","author":"Meller","year":"1993","journal-title":"Pain"},{"key":"10.1016\/j.intimp.2015.06.032_bb0220","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/01.brs.0000255097.18246.bc","article-title":"Anti-TNF-alpha antibody reduces pain-behavioral changes induced by epidural application of nucleus pulposus in a rat model depending on the timing of administration","volume":"32","author":"Sasaki","year":"2007","journal-title":"Spine"},{"key":"10.1016\/j.intimp.2015.06.032_bb0225","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1097\/BRS.0b013e318173298b","article-title":"Participation of 5-hydroxytryptamine in pain-related behavior induced by nucleus pulposus applied on the nerve root in rats","volume":"33","author":"Kato","year":"2008","journal-title":"Spine"},{"key":"10.1016\/j.intimp.2015.06.032_bb0230","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1097\/BRS.0b013e3181696132","article-title":"Do corticosteroids produce additional benefit in nerve root infiltration for lumbar disc herniation?","volume":"33","author":"Tachihara","year":"2008","journal-title":"Spine"},{"key":"10.1016\/j.intimp.2015.06.032_bb0235","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/rheumatology\/ken396","article-title":"The cellular pathobiology of the degenerate intervertebral disc and discogenic back pain","volume":"48","author":"Freemont","year":"2009","journal-title":"Rheumatology"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576915300114?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576915300114?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:39:10Z","timestamp":1755650350000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576915300114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S1567576915300114"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2015.06.032","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tanshinone IIA represses inflammatory response and reduces radiculopathic pain by inhibiting IRAK-1 and NF-\u03baB\/p38\/JNK signaling","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2015.06.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}