{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T21:44:25Z","timestamp":1762551865437,"version":"build-2065373602"},"reference-count":33,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81001016"],"award-info":[{"award-number":["81001016"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.intimp.2015.07.014","type":"journal-article","created":{"date-parts":[[2015,7,26]],"date-time":"2015-07-26T23:45:12Z","timestamp":1437954312000},"page":"560-570","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Antitumor effect and underlying mechanism of RGD-modified adenovirus mediated IL-24 expression on myeloid leukemia cells"],"prefix":"10.1016","volume":"28","author":[{"given":"Xin","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Blumenfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jicheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingcheng","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zong-jiang","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2015.07.014_bb0005","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s11033-010-0121-3","article-title":"Antitumor activity of an adenovirus harboring human IL-24 in colon cancer","volume":"38","author":"Chang","year":"2011","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.intimp.2015.07.014_bb0010","first-page":"195","article-title":"mda-7\/IL-24 induces apoptosis in human GBC-SD gall bladder carcinoma cells via mitochondrial apoptotic pathway","volume":"25","author":"Jia","year":"2011","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.intimp.2015.07.014_bb0015","doi-asserted-by":"crossref","first-page":"561","DOI":"10.3727\/096504010X12767359113929","article-title":"Ad.mda-7(IL-24) selectively induces apoptosis in hepatocellular carcinoma cell lines, suppresses metastasis, and enhances the effect of doxorubicin on xenograft tumors","volume":"18","author":"Wang","year":"2010","journal-title":"Oncol. Res."},{"key":"10.1016\/j.intimp.2015.07.014_bb0020","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/s12185-010-0654-1","article-title":"Enhanced cytotoxicity of IL-24 gene-modified dendritic cells co-cultured with cytokine-induced killer cells to hepatocellular carcinoma cells","volume":"92","author":"Yu","year":"2010","journal-title":"Int. J. Hematol."},{"key":"10.1016\/j.intimp.2015.07.014_bb0025","doi-asserted-by":"crossref","first-page":"7552","DOI":"10.1038\/sj.onc.1208911","article-title":"Unique aspects of mda-7\/IL-24 antitumor bystander activity: establishing a role for secretion of MDA-7\/IL-24 protein by normal cells","volume":"24","author":"Su","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.intimp.2015.07.014_bb0030","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.pharmthera.2005.11.005","article-title":"mda-7\/IL-24: multifunctional cancer-specific apoptosis-inducing cytokine","volume":"111","author":"Gupta","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.intimp.2015.07.014_bb0035","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.1158\/0008-5472.CAN-04-0200","article-title":"Melanoma differentiation associated gene-7\/interleukin-24 promotes tumor cell-specific apoptosis through both secretory and nonsecretory pathways","volume":"64","author":"Sauane","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.intimp.2015.07.014_bb0040","first-page":"310","article-title":"Recombinant human IL-24 suppresses lung carcinoma cell growth via induction of cell apoptosis and inhibition of tumor angiogenesis","volume":"23","author":"Xie","year":"2008","journal-title":"Cancer Biother. Radiopharm."},{"key":"10.1016\/j.intimp.2015.07.014_bb0045","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3109\/07357900903095672","article-title":"Recombinant human interleukin-24 suppresses gastric carcinoma cell growth in vitro and in vivo","volume":"28","author":"Yan","year":"2010","journal-title":"Cancer Invest."},{"key":"10.1016\/j.intimp.2015.07.014_bb0050","first-page":"425","article-title":"Inhibition of pancreatic carcinoma growth by adenovirus-mediated human interleukin-24 expression in animal model","volume":"23","author":"Pan","year":"2008","journal-title":"Cancer Biother. Radiopharm."},{"key":"10.1016\/j.intimp.2015.07.014_bb0055","first-page":"29","article-title":"The in vitro and in vivo antitumor activity of adenovirus-mediated interleukin-24 expression for laryngocarcinoma","volume":"25","author":"Liu","year":"2010","journal-title":"Cancer Biother. Radiopharm."},{"key":"10.1016\/j.intimp.2015.07.014_bb0060","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1634\/stemcells.18-3-176","article-title":"Maturation and lineage-specific expression of the coxsackie and adenovirus receptor in hematopoietic cells","volume":"18","author":"Rebel","year":"2000","journal-title":"Stem Cells"},{"key":"10.1016\/j.intimp.2015.07.014_bb0065","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0945-053X(03)00083-0","article-title":"The RGD, story: a personal account","volume":"22","author":"Ruoslahti","year":"2003","journal-title":"Matrix Biol."},{"key":"10.1016\/j.intimp.2015.07.014_bb0070","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1021\/bi002101f","article-title":"Solution structures and integrin binding activities of an RGD peptide with two isomers","volume":"40","author":"Assa-Munt","year":"2001","journal-title":"Biochemistry"},{"key":"10.1016\/j.intimp.2015.07.014_bb0075","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1158\/0008-5472.CAN-03-1753","article-title":"Coupling tumor necrosis factor-alpha with alphaV integrin ligands improves its antineoplastic activity","volume":"64","author":"Curnis","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.intimp.2015.07.014_bb0080","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/BF03401847","article-title":"Melanoma differentiation associated gene-7 (mda-7): a novel anti-tumor gene for cancer gene therapy","volume":"7","author":"Mhashilkar","year":"2001","journal-title":"Mol. Med."},{"key":"10.1016\/j.intimp.2015.07.014_bb0085","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s11010-011-0898-y","article-title":"Analysis of rpoS and bolA gene expression under various stress induced environments in planktonic and biofilm phase using 2\u2212\u0394\u0394Ct method","volume":"357","author":"Adnan","year":"2011","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.intimp.2015.07.014_bb0090","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/sj.cgt.7700618","article-title":"Enhanced tumor immunogenicity through coupling cytokine expression with antigen presentation","volume":"10","author":"He","year":"2003","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.intimp.2015.07.014_bb0095","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.3892\/ijmm.2013.1319","article-title":"Potential implication of IL-24 in lymphangiogenesis of human breast cancer","volume":"31","author":"Frewer","year":"2013","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.intimp.2015.07.014_bb0100","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1007\/s13277-013-0792-1","article-title":"Adenovirus arming human IL-24 inhibits neuroblastoma cell proliferation in vitro and xenograft tumor growth in vivo","volume":"34","author":"Zhuo","year":"2013","journal-title":"Tumour Biol."},{"key":"10.1016\/j.intimp.2015.07.014_bb0105","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.canlet.2014.10.045","article-title":"Adeno-associated virus-mediated cancer gene therapy: current status","volume":"356","author":"Luo","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.intimp.2015.07.014_bb0110","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2174\/1566523213666131125095046","article-title":"Adenovirus vectors for gene therapy, vaccination and cancer gene therapy","volume":"13","author":"Wold","year":"2013","journal-title":"Curr. Gene Ther."},{"key":"10.1016\/j.intimp.2015.07.014_bb0115","first-page":"65","article-title":"Endoplasmic reticulum stress response in cancer: molecular mechanism and therapeutic potential","volume":"2","author":"Wang","year":"2010","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.intimp.2015.07.014_bb0120","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.pharmthera.2010.08.001","article-title":"The development of MDA-7\/IL-24 as a cancer therapeutic","volume":"128","author":"Dent","year":"2010","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.intimp.2015.07.014_bb0125","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.ccr.2012.02.028","article-title":"Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependency","volume":"21","author":"Wei","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.intimp.2015.07.014_bb0130","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/nature08822","article-title":"The landscape of somatic copy-number alteration across human cancers","volume":"463","author":"Beroukhim","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2015.07.014_bb0135","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nature09779","article-title":"Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7","volume":"471","author":"Wertz","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2015.07.014_bb0140","doi-asserted-by":"crossref","first-page":"22551","DOI":"10.1074\/jbc.M702673200","article-title":"Translational repression of MCL-1 couples stress-induced eIF2 alpha phosphorylation to mitochondrial apoptosis initiation","volume":"282","author":"Fritsch","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2015.07.014_bb0145","doi-asserted-by":"crossref","first-page":"5034","DOI":"10.1158\/0008-5472.CAN-10-0563","article-title":"Mechanism by which Mcl-1 regulates cancer-specific apoptosis triggered by mda-7\/IL-24, an IL-10-related cytokine","volume":"70","author":"Dash","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.intimp.2015.07.014_bb0150","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.cellsig.2006.08.019","article-title":"The pro-inflammatory oxidant hypochlorous acid induces Bax-dependent mitochondrial permeabilisation and cell death through AIF-\/EndoGdependent pathways","volume":"19","author":"Whiteman","year":"2007","journal-title":"Cell. Signal."},{"key":"10.1016\/j.intimp.2015.07.014_bb0155","doi-asserted-by":"crossref","first-page":"5328","DOI":"10.1073\/pnas.0400053101","article-title":"All-trans retinoic acid\/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia","volume":"101","author":"Shen","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.intimp.2015.07.014_bb0160","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.canlet.2014.10.018","article-title":"The protein kinase C agonist prostratin induces differentiation of human myeloid leukemia cells and enhances cellular differentiation by chemotherapeutic agents","volume":"356","author":"Shen","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.intimp.2015.07.014_bb0165","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1182\/blood-2007-07-102798","article-title":"Acute promyelocytic leukemia: from highly fatal to highly curable","volume":"111","author":"Wang","year":"2008","journal-title":"Blood"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757691530028X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757691530028X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T21:41:57Z","timestamp":1762551717000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156757691530028X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S156757691530028X"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2015.07.014","relation":{},"ISSN":["1567-5769"],"issn-type":[{"type":"print","value":"1567-5769"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antitumor effect and underlying mechanism of RGD-modified adenovirus mediated IL-24 expression on myeloid leukemia cells","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2015.07.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}