{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T22:09:51Z","timestamp":1770674991017,"version":"3.49.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Prairie of Inner Mongolia, PR China"},{"name":"Natural Science Foundation of Inner Mongolia Autonomous Region of China","award":["2015MS0307"],"award-info":[{"award-number":["2015MS0307"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.intimp.2015.07.024","type":"journal-article","created":{"date-parts":[[2015,10,24]],"date-time":"2015-10-24T15:49:05Z","timestamp":1445701745000},"page":"901-907","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":61,"title":["A novel Lactobacillus plantarum strain P-8 activates beneficial immune response of broiler chickens"],"prefix":"10.1016","volume":"29","author":[{"given":"Lifeng","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caihong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuo","family":"Ya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiqiang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2015.07.024_bb0005","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1081\/ABIO-120005768","article-title":"Antibiotics as growth promotants: mode of action","volume":"13","author":"Gaskins","year":"2002","journal-title":"Anim. Biotechnol."},{"key":"10.1016\/j.intimp.2015.07.024_bb0010","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2014.00033","article-title":"Antibiotic growth promoters enhance animal production by targeting intestinal bile salt hydrolase and its producers","volume":"5","author":"Lin","year":"2014","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.intimp.2015.07.024_bb0015","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.tvjl.2010.03.003","article-title":"An update on alternatives to antimicrobial growth promoters for broilers","volume":"187","author":"Huyghebaert","year":"2011","journal-title":"Vet. J."},{"key":"10.1016\/j.intimp.2015.07.024_bb0020","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.mib.2003.09.009","article-title":"Antibiotics in animal feed and their role in resistance development","volume":"6","author":"Wegener","year":"2003","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.intimp.2015.07.024_bb0025","doi-asserted-by":"crossref","DOI":"10.1079\/PAVSNNR20138032","article-title":"Alternatives to antibiotics for farm animals","volume":"8","author":"Papatsiros","year":"2013","journal-title":"CAB Rev."},{"key":"10.1016\/j.intimp.2015.07.024_bb0030","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1128\/CMR.00002-11","article-title":"Food animals and antimicrobials: impacts on human health","volume":"24","author":"Marshall","year":"2011","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.intimp.2015.07.024_bb0035","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3389\/fmicb.2014.00217","article-title":"Antibiotic alternatives: the substitution of antibiotics in animal husbandry?","volume":"5","author":"Cheng","year":"2014","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.intimp.2015.07.024_bb0040","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1017\/S1466252313000030","article-title":"Alternatives to antibiotics: a symposium on the challenges and solutions for animal production","volume":"14","author":"Seal","year":"2013","journal-title":"Anim. Health Res. Rev."},{"key":"10.1016\/j.intimp.2015.07.024_bb0045","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.tim.2012.11.001","article-title":"Treatment, promotion, commotion: antibiotic alternatives in food-producing animals","volume":"21","author":"Allen","year":"2013","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.intimp.2015.07.024_bb0050","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2014.00217","article-title":"Antibiotic alternatives: the substitution of antibiotics in animal husbandry?","volume":"5","author":"Cheng","year":"2014","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.intimp.2015.07.024_bb0055","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1016\/j.intimp.2011.08.013","article-title":"Lactobacillus plantarum strain YU from fermented foods activates Th1 and protective immune responses","volume":"11","author":"Kawashima","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2015.07.024_bb0060","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.ijfoodmicro.2007.10.011","article-title":"Immunomodulatory effect of halophilic lactic acid bacterium Tetragenococcus halophilus Th221 from soy sauce moromi grown in high-salt medium","volume":"121","author":"Masuda","year":"2008","journal-title":"Int. J. Food Microbiol."},{"key":"10.1016\/j.intimp.2015.07.024_bb0065","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1271\/bbb.64.2706","article-title":"Effects of a fermented milk drink containing Lactobacillus casei strain Shirota on the immune system in healthy human subjects","volume":"64","author":"Nagao","year":"2000","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.intimp.2015.07.024_bb0070","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1111\/j.1365-2672.2006.02963.x","article-title":"Probiotics and their fermented food products are beneficial for health","volume":"100","author":"Parvez","year":"2006","journal-title":"J. Appl. Microbiol."},{"issue":"Suppl. 1","key":"10.1016\/j.intimp.2015.07.024_bb0075","doi-asserted-by":"crossref","first-page":"S90","DOI":"10.1017\/S0007114507832983","article-title":"Immunomodulatory effects of probiotics in different stages of life","volume":"98","author":"Nova","year":"2007","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.intimp.2015.07.024_bb0080","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1007\/s13213-011-0377-4","article-title":"In vitro screen of Lactobacillus plantarum as probiotic bacteria and their fermented characteristics in soymilk","volume":"62","author":"Bao","year":"2012","journal-title":"Ann. Microbiol."},{"key":"10.1016\/j.intimp.2015.07.024_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.nut.2013.11.018","article-title":"Effect of oral consumption of probiotic Lactobacillus plantarum P-8 on fecal microbiota, SIgA, SCFAs, and TBAs of adults of different ages","volume":"30","author":"Wang","year":"2014","journal-title":"Nutrition"},{"key":"10.1016\/j.intimp.2015.07.024_bb0090","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jbiotec.2014.11.011","article-title":"Complete genome sequence of probiotic Lactobacillus plantarum P-8 with antibacterial activity","volume":"193","author":"Zhang","year":"2015","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.intimp.2015.07.024_bb0095","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.anaerobe.2011.06.003","article-title":"Novel probiotic Enterococcus faecium IS-27526 supplementation increased total salivary sIgA level and bodyweight of pre-school children: a pilot study","volume":"17","author":"Surono","year":"2011","journal-title":"Anaerobe"},{"key":"10.1016\/j.intimp.2015.07.024_bb0100","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3382\/ps.2009-00418","article-title":"Effects of direct-fed microbials on growth performance, gut morphometry, and immune characteristics in broiler chickens","volume":"89","author":"Lee","year":"2010","journal-title":"Poult. Sci."},{"key":"10.1016\/j.intimp.2015.07.024_bb0105","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.intimp.2015.07.024_bb0110","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1600-0463.2005.apm_204.x","article-title":"Pathological and clinical significance of increased intraepithelial lymphocytes (IELs) in small bowel mucosa","volume":"113","author":"Chang","year":"2005","journal-title":"APMIS"},{"key":"10.1016\/j.intimp.2015.07.024_bb0115","doi-asserted-by":"crossref","first-page":"663","DOI":"10.3382\/ps.2012-02813","article-title":"Effects of probiotic-supplemented diets on growth performance and intestinal immune characteristics of broiler chickens","volume":"92","author":"Bai","year":"2013","journal-title":"Poult. Sci."},{"key":"10.1016\/j.intimp.2015.07.024_bb0120","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.vetimm.2013.09.002","article-title":"Effect of Lactobacillus brevis ATCC 8287 as a feeding supplement on the performance and immune function of piglets","volume":"158","author":"L\u00e4hteinen","year":"2014","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.intimp.2015.07.024_bb0125","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1439-0442.2005.00736.x","article-title":"The effects of probiotic and mannanoligosaccharide on some haematological and immunological parameters in turkeys","volume":"52","author":"Cetin","year":"2005","journal-title":"J. Vet. Med. A Physiol. Pathol. Clin. Med."},{"key":"10.1016\/j.intimp.2015.07.024_bb0130","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1080\/17450390701431540","article-title":"Impact of the probiotic bacteria Enterococcus faecium NCIMB 10415 (SF68) and Bacillus cereus var. toyoi NCIMB 40112 on the development of serum IgG and faecal IgA of sows and their piglets","volume":"61","author":"Scharek","year":"2007","journal-title":"Arch. Anim. Nutr."},{"key":"10.1016\/j.intimp.2015.07.024_bb0135","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1097\/MOG.0b013e32833dccf8","article-title":"Update on mucosal immunoglobulin A in gastrointestinal disease","volume":"26","author":"Brandtzaeg","year":"2010","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.intimp.2015.07.024_bb0140","doi-asserted-by":"crossref","first-page":"1046S","DOI":"10.1093\/ajcn\/69.5.1046s","article-title":"Influences of microbiota on intestinal immune system development","volume":"69","author":"Cebra","year":"1999","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.intimp.2015.07.024_bb0145","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.it.2014.07.010","article-title":"Modulation of immune development and function by intestinal microbiota","volume":"35","author":"Kabat","year":"2014","journal-title":"Trends Immunol."},{"key":"10.1016\/j.intimp.2015.07.024_bb0150","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1128\/CVI.13.2.219-226.2006","article-title":"The probiotic bacterium Lactobacillus casei induces activation of the gut mucosal immune system through innate immunity","volume":"13","author":"Galdeano","year":"2006","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.intimp.2015.07.024_bb0155","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1471-230X-11-64","article-title":"Impact of a probiotic fermented milk in the gut ecosystem and in the systemic immunity using a non-severe protein-energy-malnutrition model in mice","volume":"11","author":"Maldonado Galdeano","year":"2011","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.intimp.2015.07.024_bb0160","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1080\/10408398.2011.619671","article-title":"Immune system stimulation by probiotic microorganisms","volume":"54","author":"Ashraf","year":"2014","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.intimp.2015.07.024_bb0165","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1128\/AEM.70.2.1176-1181.2004","article-title":"Colonization and immunomodulation by Lactobacillus reuteri ATCC 55730 in the human gastrointestinal tract","volume":"70","author":"Valeur","year":"2004","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.intimp.2015.07.024_bb0170","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.vetimm.2006.01.017","article-title":"Effect of orally administered probiotic E. coli strain Nissle 1917 on intestinal mucosal immune cells of healthy young pigs","volume":"111","author":"Duncker","year":"2006","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.intimp.2015.07.024_bb0175","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1007\/s12265-013-9496-6","article-title":"T helper cell polarization in healthy people: implications for cardiovascular disease","volume":"6","author":"Olson","year":"2013","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"10.1016\/j.intimp.2015.07.024_bb0180","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3389\/fphys.2013.00206","article-title":"Cellular and population plasticity of helper CD4(+) T cell responses","volume":"4","author":"Magombedze","year":"2013","journal-title":"Front. Physiol."},{"key":"10.1016\/j.intimp.2015.07.024_bb0185","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1053\/gast.2000.9370","article-title":"Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: a double-blind, placebo-controlled trial","volume":"119","author":"Gionchetti","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.intimp.2015.07.024_bb0190","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1016\/S0140-6736(03)13490-3","article-title":"Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial","volume":"361","author":"Kalliomaki","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.intimp.2015.07.024_bb0195","doi-asserted-by":"crossref","first-page":"5570","DOI":"10.3748\/wjg.14.5570","article-title":"Potentially probiotic bacteria induce efficient maturation but differential cytokine production in human monocyte-derived dendritic cells","volume":"14","author":"Latvala","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.intimp.2015.07.024_bb0200","doi-asserted-by":"crossref","first-page":"171","DOI":"10.4049\/jimmunol.168.1.171","article-title":"Lactobacilli differentially modulate expression of cytokines and maturation surface markers in murine dendritic cells","volume":"168","author":"Christensen","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2015.07.024_bb0205","first-page":"62","article-title":"Immuno-modulation and anti-inflammatory effects of antibiotics growth promoters versus probiotics in the intestinal tract","volume":"2","author":"Menconi","year":"2014","journal-title":"J. Microbiol. Res. Rev."},{"key":"10.1016\/j.intimp.2015.07.024_bb0210","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1757-4749-3-14","article-title":"Non-therapeutic administration of a model antimicrobial growth promoter modulates intestinal immune responses","volume":"3","author":"Costa","year":"2011","journal-title":"Gut Pathog."},{"key":"10.1016\/j.intimp.2015.07.024_bb0215","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1128\/AAC.01052-10","article-title":"Anti-Inflammatory benefits of antibiotic-induced neutrophil apoptosis: tulathromycin induces caspase-3-dependent neutrophil programmed cell death and inhibits NF-kappaB signaling and CXCL8 transcription","volume":"55","author":"Fischer","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.intimp.2015.07.024_bb0220","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1136\/thx.2005.052399","article-title":"Evaluation of airway inflammation by quantitative Th1\/Th2 cytokine mRNA measurement in sputum of asthma patients","volume":"61","author":"Truyen","year":"2006","journal-title":"Thorax"},{"key":"10.1016\/j.intimp.2015.07.024_bb0225","unstructured":"Perkel J. Distinguishing Th1 and Th2 Cells. The Scientist. 2001:http:\/\/www.thescientist.com\/?articles.view\/articleNo\/13377\/title\/Distinguishing-Th1-and-Th2-Cells\/."},{"key":"10.1016\/j.intimp.2015.07.024_bb0230","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1128\/CVI.00406-06","article-title":"Proposed model: mechanisms of immunomodulation induced by probiotic bacteria","volume":"14","author":"Galdeano","year":"2007","journal-title":"Clin. Vaccine Immunol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576915300369?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576915300369?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T18:22:49Z","timestamp":1567275769000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576915300369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S1567576915300369"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2015.07.024","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel Lactobacillus plantarum strain P-8 activates beneficial immune response of broiler chickens","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2015.07.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}