{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T02:06:07Z","timestamp":1783130767117,"version":"3.54.6"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Natural Science Research General Program of Jiangsu Higher Education Institutions","award":["15KJB310011"],"award-info":[{"award-number":["15KJB310011"]}]},{"name":"Natural Science Preliminary Research Foundation of Nanjing University of Chinese Medicine","award":["14XYY04"],"award-info":[{"award-number":["14XYY04"]}]},{"name":"Priority Academic Program Development of Jiangsu Higher Education Institutions, China","award":["14PAPDJS"],"award-info":[{"award-number":["14PAPDJS"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.intimp.2015.11.010","type":"journal-article","created":{"date-parts":[[2015,11,27]],"date-time":"2015-11-27T06:00:11Z","timestamp":1448604011000},"page":"36-42","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Suppressive effect of Sanmiao formula on experimental gouty arthritis by inhibiting cartilage matrix degradation: An  in vivo  and  in vitro  study"],"prefix":"10.1016","volume":"30","author":[{"given":"Fangfang","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leilei","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangji","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2015.11.010_bb0005","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1002\/art.30520","article-title":"Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition Examination Survey 2007\u20132008","volume":"63","author":"Zhu","year":"2011","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2015.11.010_bb0010","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/art.23177","article-title":"Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part I","volume":"58","author":"Helmick","year":"2008","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2015.11.010_bb0015","first-page":"12-1","article-title":"Comparative effectiveness of urate lowering with febuxostat versus allopurinol in gout: analyses from large U.S. managed care cohort","volume":"17","author":"Singh","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.intimp.2015.11.010_bb0020","doi-asserted-by":"crossref","first-page":"756","DOI":"10.7326\/0003-4819-131-10-199911160-00007","article-title":"Synovial fluid analysis for diagnosis of intercritical gout","volume":"131","author":"Pascual","year":"1999","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.intimp.2015.11.010_bb0025","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1471-2474-12-42","article-title":"Effect of nitric oxide on mitochondrial activity of human synovial cells","volume":"12","author":"Cillero-Pastor","year":"2011","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.intimp.2015.11.010_bb0030","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.joca.2008.05.010","article-title":"Inhibition of cyclooxygenase 2 expression by diallyl sulfide on joint inflammation induced by urate crystal and IL-1beta","volume":"17","author":"Lee","year":"2009","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.intimp.2015.11.010_bb0035","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1136\/ard.2003.015743","article-title":"Severe gouty arthritis refractory to anti-inflammatory drugs: treatment with anti-tumour necrosis factor alpha as a new therapeutic option","volume":"63","author":"Tausche","year":"2004","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.intimp.2015.11.010_bb0040","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.imbio.2008.11.005","article-title":"Cytokine secretion in macrophages and other cells: pathways and mediators","volume":"214","author":"Stow","year":"2009","journal-title":"Immunobiology"},{"key":"10.1016\/j.intimp.2015.11.010_bb0045","first-page":"2429","article-title":"Colchicine for prophylaxis of acute flares when initiating allopurinol for chronic gouty arthritis","volume":"31","author":"Borstad","year":"2004","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.intimp.2015.11.010_bb0050","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1042\/bj1950159","article-title":"Purification of rabbit bone inhibitor of collagenase","volume":"195","author":"Cawston","year":"1981","journal-title":"Biochem. J."},{"key":"10.1016\/j.intimp.2015.11.010_bb0055","doi-asserted-by":"crossref","first-page":"146","DOI":"10.4082\/kjfm.2015.36.3.146","article-title":"Advanced erosive gout as a cause of fever of unknown origin","volume":"36","author":"Kato","year":"2015","journal-title":"Korean J. Fam. Med."},{"key":"10.1016\/j.intimp.2015.11.010_bb0060","series-title":"Pharmacopoeia of People's Republic of China [M]. Part 1","author":"National Pharmacopoeia Committee","year":"2010"},{"key":"10.1016\/j.intimp.2015.11.010_bb0065","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.3892\/etm.2014.1862","article-title":"Sanmiao formula inhibits chondrocyte apoptosis and cartilage matrix degradation in a rat model of osteoarthritis","volume":"8","author":"Xu","year":"2014","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.intimp.2015.11.010_bb0070","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jep.2009.12.035","article-title":"The dual actions of Sanmiao wan as a hypouricemic agent: down-regulation of hepatic XOD and renal mURAT1 in hyperuricemic mice","volume":"128","author":"Xing","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2015.11.010_bb0075","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1089\/rej.2013.1439","article-title":"Treatment with SiMiaoFang, an anti-arthritis Chinese herbal formula, inhibits cartilage matrix degradation in osteoarthritis rat model","volume":"16","author":"Xu","year":"2013","journal-title":"Rejuvenation Res."},{"key":"10.1016\/j.intimp.2015.11.010_bb0080","first-page":"54","article-title":"Experimental inflammation induced by naturally occurring microcrystalline salts","volume":"3","author":"Denko","year":"1976","journal-title":"J. Rheumatolol."},{"key":"10.1016\/j.intimp.2015.11.010_bb0085","first-page":"25","article-title":"Effect of cold water bath on the induced gout arthritis in rats","volume":"26","author":"Le","year":"2012","journal-title":"Chin. Pharmacol. Toxicol."},{"key":"10.1016\/j.intimp.2015.11.010_bb0090","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1053\/joca.2000.0397","article-title":"Quantitation of chondroitin-sulfates, disaccharides and hyaluronan in normal, early and advanced osteoarthritic sheep temporomandibular joints","volume":"9","author":"Ishimaru","year":"2001","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.intimp.2015.11.010_bb0095","first-page":"39","article-title":"Method for the replication of persistent hyperuricemia model in rats","volume":"34","author":"Li","year":"2008","journal-title":"Shandong Med."},{"key":"10.1016\/j.intimp.2015.11.010_bb0100","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1023\/A:1003945902473","article-title":"Stromelysin-1 (MMP-3) in forming enamel and predentine in rat incisor-coordinated distribution with proteoglycans suggests a functional role","volume":"31","author":"Hall","year":"1999","journal-title":"Histochem. J."},{"issue":"Pt 3","key":"10.1016\/j.intimp.2015.11.010_bb0105","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1042\/bj2790733","article-title":"Metalloproteinase digestion of cartilage proteoglycan. Pattern of cleavage by stromelysin and susceptibility to collagenase","volume":"279","author":"Hughes","year":"1991","journal-title":"Biochem. J."},{"key":"10.1016\/j.intimp.2015.11.010_bb0110","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1136\/ard.2003.006510","article-title":"Dual effects of 17beta-oestradiol on interleukin 1beta-induced proteoglycan degradation in chondrocytes","volume":"63","author":"Richette","year":"2004","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.intimp.2015.11.010_bb0115","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/art.1780260110","article-title":"Collagenase and collagenolytic activity in human osteoarthritic cartilage","volume":"26","author":"Pelletier","year":"1983","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2015.11.010_bb0120","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1002\/art.1780360906","article-title":"The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis","volume":"36","author":"Lohmander","year":"1993","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2015.11.010_bb0125","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0167-4838(99)00279-4","article-title":"Tissue inhibitors of metalloproteinases: evolution, structure and function","volume":"1477","author":"Brew","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.intimp.2015.11.010_bb0130","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1089\/dna.1996.15.1039","article-title":"Regulation of tissue inhibitor of metalloproteinases-3 gene expression by transforming growth factor-beta and dexamethasone in bovine and human articular chondrocytes","volume":"15","author":"Su","year":"1996","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.intimp.2015.11.010_bb0135","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1053\/joca.2000.0406","article-title":"Effects of non-steroidal antiinflammatory drugs and dexamethasone on the activity and expression of matrix metalloproteinase-1, matrix metalloproteinase-3 and tissue inhibitor of metalloproteinases-1 by bovine articular chondrocytes","volume":"9","author":"Sadowski","year":"2001","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.intimp.2015.11.010_bb0140","doi-asserted-by":"crossref","first-page":"39096","DOI":"10.1074\/jbc.M006201200","article-title":"Age-related changes in aggrecan glycosylation affect cleavage by aggrecanase","volume":"275","author":"Pratta","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2015.11.010_bb0145","doi-asserted-by":"crossref","first-page":"13372","DOI":"10.1074\/jbc.M009737200","article-title":"Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4","volume":"276","author":"Sandy","year":"2001","journal-title":"J. Biol. Chem."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757691530179X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757691530179X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T14:50:59Z","timestamp":1531752659000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156757691530179X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":29,"alternative-id":["S156757691530179X"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2015.11.010","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Suppressive effect of Sanmiao formula on experimental gouty arthritis by inhibiting cartilage matrix degradation: An in vivo and in vitro study","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2015.11.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}