{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T10:59:34Z","timestamp":1783508374132,"version":"3.55.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,15]],"date-time":"2016-01-15T00:00:00Z","timestamp":1452816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"The Wellcome Trust","doi-asserted-by":"crossref","award":["085903"],"award-info":[{"award-number":["085903"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.intimp.2016.01.003","type":"journal-article","created":{"date-parts":[[2016,1,21]],"date-time":"2016-01-21T16:54:15Z","timestamp":1453395255000},"page":"87-95","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["The role of the Annexin-A1\/FPR2 system in the regulation of mast cell degranulation provoked by compound 48\/80 and in the inhibitory action of nedocromil"],"prefix":"10.1016","volume":"32","author":[{"given":"Ajantha","family":"Sinniah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia","family":"Yazid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Perretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egle","family":"Solito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.J.","family":"Flower","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2016.01.003_bb0005","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/bjp.2008.252","article-title":"Annexin-A1: a pivotal regulator of the innate and adaptive immune systems","volume":"155","author":"D'Acquisto","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.intimp.2016.01.003_bb0010","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nri2470","article-title":"Annexin A1 and glucocorticoids as effectors of the resolution of inflammation","volume":"9","author":"Perretti","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.intimp.2016.01.003_bb0015","first-page":"27","article-title":"Studies on the structural properties of lipocortin-1 and the regulation of its synthesis by steroids","volume":"349","author":"Browning","year":"1990","journal-title":"Prog. Clin. Biol. Res."},{"key":"10.1016\/j.intimp.2016.01.003_bb0020","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1096\/fj.05-5319fje","article-title":"Post-translational modification plays an essential role in the translocation of annexin A1 from the cytoplasm to the cell surface","volume":"20","author":"Solito","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.intimp.2016.01.003_bb0025","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.4049\/jimmunol.0903526","article-title":"Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation","volume":"184","author":"Dufton","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2016.01.003_bb0030","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1038\/nm786","article-title":"Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor","volume":"8","author":"Perretti","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.intimp.2016.01.003_bb0035","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S1097-2765(00)80323-8","article-title":"A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR","volume":"5","author":"Walther","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.intimp.2016.01.003_bb0040","doi-asserted-by":"crossref","first-page":"18232","DOI":"10.1073\/pnas.1308253110","article-title":"Ligand-specific conformational change of the G-protein-coupled receptor ALX\/FPR2 determines proresolving functional responses","volume":"110","author":"Cooray","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.intimp.2016.01.003_bb0045","unstructured":"Oliani SM, Perretti M. Cell localization of the anti-inflammatory protein annexin 1 during experimental inflammatory response. Ital. J. Anat. Embryol. = Arch. Ital. Anat. Embriol. 2001;106:69\u201377."},{"key":"10.1016\/j.intimp.2016.01.003_bb0050","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1038\/labinvest.3780150","article-title":"An immunocytochemical and in situ hybridization analysis of annexin 1 expression in rat mast cells: modulation by inflammation and dexamethasone","volume":"80","author":"SM","year":"2000","journal-title":"Lab. Investig."},{"key":"10.1016\/j.intimp.2016.01.003_bb0055","doi-asserted-by":"crossref","first-page":"4410","DOI":"10.4049\/jimmunol.176.7.4410","article-title":"Spatial and temporal profiles for anti-inflammatory gene expression in leukocytes during a resolving model of peritonitis","volume":"176","author":"Damazo","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2016.01.003_bb0060","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1007\/s00011-008-7222-7","article-title":"Fluctuation of annexin-A1 positive mast cells in chronic granulomatous inflammation","volume":"57","author":"Oliani","year":"2008","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.intimp.2016.01.003_bb0065","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.mce.2013.05.014","article-title":"Molecular mechanisms of glucocorticoid action in mast cells","volume":"380","author":"Oppong","year":"2013","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.intimp.2016.01.003_bb0070","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1161\/ATVBAHA.110.209536","article-title":"Antiallergic cromones inhibit neutrophil recruitment onto vascular endothelium via annexin-A1 mobilization","volume":"30","author":"Yazid","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.intimp.2016.01.003_bb0075","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1016\/j.bcp.2009.03.010","article-title":"Cromoglycate drugs suppress eicosanoid generation in U937 cells by promoting the release of Anx-A1","volume":"77","author":"Yazid","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.intimp.2016.01.003_bb0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0058963","article-title":"Anti-allergic cromones inhibit histamine and eicosanoid release from activated human and murine mast cells by releasing Annexin A1","volume":"8","author":"Yazid","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.intimp.2016.01.003_bb0085","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.1210\/endo.143.8.8965","article-title":"Annexin 1-dependent actions of glucocorticoids in the anterior pituitary gland: roles of the N-terminal domain and protein kinase C","volume":"143","author":"John","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.intimp.2016.01.003_bb0090","doi-asserted-by":"crossref","first-page":"32785","DOI":"10.1074\/jbc.271.51.32785","article-title":"12-O-tetradecanoylphorbol-13-acetate-induced dephosphorylation of protein kinase Calpha correlates with the presence of a membrane-associated protein phosphatase 2 A heterotrimer","volume":"271","author":"Hansra","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2016.01.003_bb0095","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1006\/bbrc.1997.6874","article-title":"Cooperation between the Fc epsilonR1 and formyl peptide receptor signaling pathways in RBL(FPR) cells: the contribution of receptor-specific Ca2+ mobilization responses","volume":"235","author":"Lee","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2016.01.003_bb0100","doi-asserted-by":"crossref","first-page":"6760","DOI":"10.4049\/jimmunol.169.12.6760","article-title":"Regulation of N-formyl peptide-mediated degranulation by receptor phosphorylation","volume":"169","author":"Vines","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2016.01.003_bb0105","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1159\/000084226","article-title":"Differential role for mitogen-activated protein kinases in IgE-dependent signaling in human peripheral blood basophils: in contrast to p38 MAPK, c-Jun N-terminal kinase is poorly expressed and does not appear to control mediator release","volume":"136","author":"Gibbs","year":"2005","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.intimp.2016.01.003_bb0110","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/all.12122","article-title":"Cinnamon extract inhibits degranulation and de novo synthesis of inflammatory mediators in mast cells","volume":"68","author":"Hagenlocher","year":"2013","journal-title":"Allergy"},{"key":"10.1016\/j.intimp.2016.01.003_bb0115","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1006\/cyto.2002.0879","article-title":"Involvement of p38 and JNK MAPKs pathways in Substance P-induced production of TNF-alpha by peritoneal mast cells","volume":"18","author":"Azzolina","year":"2002","journal-title":"Cytokine"},{"key":"10.1016\/j.intimp.2016.01.003_bb0120","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1038\/jid.2010.152","article-title":"Induction of prostaglandin D2 through the p38 MAPK pathway is responsible for the antipruritic activity of sertaconazole nitrate","volume":"130","author":"Kaur","year":"2010","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.intimp.2016.01.003_bb0125","doi-asserted-by":"crossref","first-page":"6144","DOI":"10.1074\/jbc.275.9.6144","article-title":"Transient translocation and activation of protein phosphatase 2 A during mast cell secretion","volume":"275","author":"Ludowyke","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2016.01.003_bb0130","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.pharmthera.2006.04.011","article-title":"Mast cell function: regulation of degranulation by serine\/threonine phosphatases","volume":"112","author":"Sim","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.intimp.2016.01.003_bb0135","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1126\/science.6153130","article-title":"Antiallergic drug cromolyn may inhibit histamine secretion by regulating phosphorylation of a mast cell protein","volume":"207","author":"Theoharides","year":"1980","journal-title":"Science"},{"key":"10.1016\/j.intimp.2016.01.003_bb0140","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/S0022-3565(24)39140-2","article-title":"Cloning and cellular localization of the rat mast cell 78-kDa protein phosphorylated in response to the mast cell \u201cstabilizer\u201d cromolyn","volume":"294","author":"Theoharides","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.intimp.2016.01.003_bb0145","first-page":"413","article-title":"Coupling of receptors to G proteins, pharmacological implications","volume":"46","author":"Bockaert","year":"1991","journal-title":"Therapie"},{"key":"10.1016\/j.intimp.2016.01.003_bb0150","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1476-5381.1981.tb09974.x","article-title":"The inhibition by hydrocortisone of prostaglandin biosynthesis in rat peritoneal leucocytes is correlated with intracellular macrocortin levels","volume":"74","author":"Carnuccio","year":"1981","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.intimp.2016.01.003_bb0155","doi-asserted-by":"crossref","first-page":"5665","DOI":"10.4049\/jimmunol.1102306","article-title":"Regulation of cytosolic phospholipase A2 phosphorylation by proteolytic cleavage of annexin A1 in activated mast cells","volume":"188","author":"Kwon","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2016.01.003_bb0160","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s10735-014-9595-y","article-title":"The intricate role of mast cell proteases and the annexin A1\u2013FPR1 system in abdominal wall endometriosis","volume":"46","author":"Paula","year":"2015","journal-title":"J. Mol. Histol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576916300042?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576916300042?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T05:58:12Z","timestamp":1748757492000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576916300042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":32,"alternative-id":["S1567576916300042"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2016.01.003","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of the Annexin-A1\/FPR2 system in the regulation of mast cell degranulation provoked by compound 48\/80 and in the inhibitory action of nedocromil","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2016.01.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}