{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T03:47:35Z","timestamp":1784951255359,"version":"3.55.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81302903"],"award-info":[{"award-number":["81302903"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.intimp.2016.02.003","type":"journal-article","created":{"date-parts":[[2016,2,24]],"date-time":"2016-02-24T09:45:39Z","timestamp":1456307139000},"page":"44-52","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":92,"special_numbering":"C","title":["Protective effect of wedelolactone against CCl 4 -induced acute liver injury in mice"],"prefix":"10.1016","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4709-7359","authenticated-orcid":false,"given":"Yang","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DongMei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ShanBo","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XiFang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AiDong","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JingWen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2016.02.003_bb0005","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/0717-6287-47-59","article-title":"Proteomic analysis of the regenerating liver following 2\/3 partial hepatectomy in rats","volume":"47","author":"Chen","year":"2014","journal-title":"Biol. Res."},{"key":"10.1016\/j.intimp.2016.02.003_bb0010","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/jcp.21172","article-title":"Liver regeneration","volume":"213","author":"Michalopoulos","year":"2007","journal-title":"J. Cell. Physiol."},{"issue":"8","key":"10.1016\/j.intimp.2016.02.003_bb0015","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.3109\/13880209.2014.967782","article-title":"Ameliorative effect of methanol extract of Rumex vesicarius on CCl4-induced liver damage in Wistar albino rats","volume":"53","author":"Ganaie","year":"2015","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.intimp.2016.02.003_bb0020","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1016\/j.lfs.2004.02.030","article-title":"Molecular process in acute liver injury and regeneration induced by carbon tetrachloride","volume":"75","author":"Taniguchi","year":"2004","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2016.02.003_bb0025","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1006\/taap.1996.0316","article-title":"The role of inflammatory cells and cytochrome P450 in the potentiation of CCl4-induced liver injury by a single dose of retinol","volume":"141","author":"Badger","year":"1996","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.intimp.2016.02.003_bb0030","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1248\/yakushi.126.885","article-title":"Learning toxicology from carbon tetrachloride induced hepatotoxicity","volume":"126","author":"Masuda","year":"2006","journal-title":"Yakugaku Zasshi"},{"key":"10.1016\/j.intimp.2016.02.003_bb0035","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ejphar.2013.06.012","article-title":"Wedelolactone exhibits anti-fibrotic effects on human hepatic stellate cell line LX- 2","volume":"714","author":"Xia","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2016.02.003_bb0040","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/j.1742-7843.2008.00350.x","article-title":"Inhibition of snake venoms and phospholipases A(2) by extracts from native and genetically modified Eclipta alba: isolation of active coumestans","volume":"104","author":"Diogo","year":"2009","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.intimp.2016.02.003_bb0045","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1158\/1535-7163.MCT-09-0133","article-title":"Pharmacologic inhibitors of IkappaB kinase suppress growth and migration of mammary carcinosarcoma cells in vitro and prevent osteolytic bone metastasis in vivo","volume":"8","author":"Idris","year":"2009","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.intimp.2016.02.003_bb0050","doi-asserted-by":"crossref","first-page":"5435","DOI":"10.1158\/1078-0432.CCR-09-0298","article-title":"Herbal extract of Wedelia chinensis attenuates androgen receptor activity and orthotopic growth of prostate cancer in nude mice","volume":"15","author":"Tsai","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.intimp.2016.02.003_bb0055","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1055\/s-2007-969188","article-title":"Coumestans as the main active principles of the liver drugs Eclipta alba and Wedelia calendulacea","volume":"5","author":"Wagner","year":"1986","journal-title":"Planta Med."},{"key":"10.1016\/j.intimp.2016.02.003_bb0060","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1093\/carcin\/bgm137","article-title":"Compounds from Wedelia chinensis synergistically suppress androgen activity and growth in prostate cancer cells","volume":"28","author":"Lin","year":"2007","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.intimp.2016.02.003_bb0065","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1002\/ptr.2252","article-title":"HIV-1 protease and HIV-1 integrase inhibitory substances from Eclipta prostrata","volume":"21","author":"Tewtrakul","year":"2007","journal-title":"Phytother. Res."},{"issue":"3","key":"10.1016\/j.intimp.2016.02.003_bb0070","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3109\/08958378.2013.872213","article-title":"Adenovirus delivered angiopoietin-1 suppresses NF-k B and p38 MAPK and attenuates inflammatory responses in phosgene-induced acute lung injury","volume":"26","author":"He","year":"2014","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.intimp.2016.02.003_bb0075","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nri915","article-title":"Anti-inflammatory lipid mediators and insights into the resolution of inflammation","volume":"2","author":"Lawrence","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.intimp.2016.02.003_bb0080","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1016\/j.cellsig.2006.05.004","article-title":"ERK1\/2 and p38-MAPK signaling pathways, through MSK1, are involved in NF-kappaB transactivation during oxidative stress in skeletal myoblasts","volume":"18","author":"Kefaloyianni","year":"2006","journal-title":"Cell. Signal."},{"key":"10.1016\/j.intimp.2016.02.003_bb0085","doi-asserted-by":"crossref","first-page":"4685","DOI":"10.1182\/blood-2005-01-0191","article-title":"Srchomology 2 domain-containing inositol-5-phosphatase 1 (SHIP1) negatively regulates TLR4-mediated LPS response primarily through a phosphatase activityand PI-3K-independent mechanism","volume":"105","author":"An","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.intimp.2016.02.003_bb0090","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1056\/NEJM199704103361506","article-title":"Nuclear factor-kappa B: a pivotal transcription factor in chronic inflammatory diseases","volume":"336","author":"Barnes","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.intimp.2016.02.003_bb0095","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jhazmat.2011.08.027","article-title":"Protective effect of Panax ginseng against serum biochemical changes and apoptosis in liver of rats treated with carbon tetrachloride (CCl4)","volume":"195","author":"Karakus","year":"2011","journal-title":"J. Hazard. Mater."},{"issue":"5","key":"10.1016\/j.intimp.2016.02.003_bb0100","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1002\/hep.26763","article-title":"Poly(ADP-ribose) polymerase-1 is a key mediator of liver inflammation and fibrosis","volume":"59","author":"Mukhopadhyay","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2016.02.003_bb0105","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1248\/bpb.35.980","article-title":"The role of Kupffer cells in carbon tetrachloride intoxication in mice","volume":"35","author":"Kiso","year":"2012","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.intimp.2016.02.003_bb0110","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1006\/taap.1993.1069","article-title":"The involvement of Kupffer cells in carbon tetrachloride toxicity","volume":"119","author":"Edwards","year":"1993","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"4","key":"10.1016\/j.intimp.2016.02.003_bb0115","doi-asserted-by":"crossref","first-page":"L622","DOI":"10.1152\/ajplung.00477.2005","article-title":"NF-kappa B activation as a pathological mechanism of septic shock and inflammation","volume":"290","author":"Liu","year":"2006","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"issue":"2","key":"10.1016\/j.intimp.2016.02.003_bb0120","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S0925-4439(00)00098-3","article-title":"Evaluation of oxidative stress during apoptosis and necrosis caused by carbon tetrachloride in rat liver","volume":"1535","author":"Sun","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.intimp.2016.02.003_bb0125","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/713611034","article-title":"Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model","volume":"33","author":"Weber","year":"2003","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.intimp.2016.02.003_bb0130","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1515\/znc-2001-7-826","article-title":"Mechanism of carbon tetrachloride-induced hepatotoxicity. Hepatocellular damage by reactive carbon tetrachloride metabolites","volume":"56","author":"Boll","year":"2001","journal-title":"Z. Naturforsch. C."},{"key":"10.1016\/j.intimp.2016.02.003_bb0135","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1093\/clinchem\/43.7.1209","article-title":"Plasma malondialdehyde as biomarker for oxidative stress: reference interval and effects of life-style factors","volume":"43","author":"Nielsen","year":"1997","journal-title":"Clin. Chem."},{"key":"10.1016\/j.intimp.2016.02.003_bb0140","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jchromb.2005.06.035","volume":"827","author":"Mateos","year":"2005","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.intimp.2016.02.003_bb0145","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1111\/j.1471-4159.1993.tb07478.x","article-title":"Superoxide dismutase activity, oxidative damage, and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis","volume":"61","author":"Bowling","year":"1993","journal-title":"J. Neurochem."},{"key":"10.1016\/j.intimp.2016.02.003_bb0150","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.fct.2012.11.022","article-title":"Antioxidant and hepatoprotective effects of Schisandra chinensis pollen extract on CCl4-induced acute liver damage in mice","volume":"55","author":"Cheng","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.intimp.2016.02.003_bb0155","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/0885-4505(88)90102-8","article-title":"Hepatic antioxidant enzymes and lipid peroxidation in carbon tetrachloride-induced liver cirrhosis in rats","volume":"40","author":"Nadkarni","year":"1988","journal-title":"Biochem. Med. Metab. Biol."},{"key":"10.1016\/j.intimp.2016.02.003_bb0160","first-page":"20","article-title":"MAP kinases in immune responses","volume":"2","author":"Zhang","year":"2005","journal-title":"Cell Mol. Immunol."},{"key":"10.1016\/j.intimp.2016.02.003_bb0165","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0898-6568(00)00149-2","article-title":"LPS induction of gene expression in human monocytes","volume":"13","author":"Guha","year":"2001","journal-title":"Cell. Signal."},{"key":"10.1016\/j.intimp.2016.02.003_bb0170","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.jep.2012.01.016","article-title":"Anti-inflammatory effects of dichloromethane fraction from Orostachys japonicus in RAW 264.7 cells: suppression of NF-kappaB activation and MAPK signaling","volume":"140","author":"Lee","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2016.02.003_bb0175","doi-asserted-by":"crossref","first-page":"637512","DOI":"10.1155\/2012\/637512","article-title":"Oleifolioside A, a new active compound, attenuates LPS-stimulated iNOS and COX-2 expression through the downregulation of NF-kappaB and MAPK activities in RAW 264.7 macrophages","volume":"2012","author":"Yu","year":"2012","journal-title":"Evid. Based Complement. Alternat. Med."},{"issue":"1","key":"10.1016\/j.intimp.2016.02.003_bb0180","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jep.2012.08.041","article-title":"Nitidine chloride inhibits LPS induced inflammatory cytokines production via MAPK and NF-kappaB pathway in RAW 264.7 cells","volume":"144","author":"Wang","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2016.02.003_bb0185","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.ejmech.2012.07.041","article-title":"Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice","volume":"56","author":"Lee","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.intimp.2016.02.003_bb0190","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/35160","article-title":"Bcl-2 prolongs cell survival after Bax-induced release of cytochromec","volume":"391","author":"Rosse","year":"1998","journal-title":"Nature"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576916300388?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576916300388?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T01:08:17Z","timestamp":1600218497000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576916300388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":38,"alternative-id":["S1567576916300388"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2016.02.003","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effect of wedelolactone against CCl4-induced acute liver injury in mice","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2016.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}