{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T14:10:39Z","timestamp":1781014239896,"version":"3.54.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T00:00:00Z","timestamp":1493164800000},"content-version":"am","delay-in-days":299,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"name":"National Construction Project of Clinical Key Specialized Department","award":["[2013] 544"],"award-info":[{"award-number":["[2013] 544"]}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"publisher","award":["81170967"],"award-info":[{"award-number":["81170967"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"publisher","award":["81570975"],"award-info":[{"award-number":["81570975"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.intimp.2016.03.035","type":"journal-article","created":{"date-parts":[[2016,4,27]],"date-time":"2016-04-27T12:01:28Z","timestamp":1461758488000},"page":"106-110","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Clinical observation on the treatment of oral lichen planus with total glucosides of paeony capsule combined with corticosteroids"],"prefix":"10.1016","volume":"36","author":[{"given":"Leilei","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyi","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanhuan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3980-5012","authenticated-orcid":false,"given":"Guoyao","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2016.03.035_bb0005","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1111\/j.1365-2133.2012.10821.x","article-title":"Interventions for treating oral lichen planus: a systematic review","volume":"166","author":"Lodi","year":"2012","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.intimp.2016.03.035_bb0010","doi-asserted-by":"crossref","first-page":"370","DOI":"10.2741\/e712","article-title":"Oral lichen planus: a narrative review","volume":"6","author":"Di Stasio","year":"2014","journal-title":"Front. Biosci."},{"key":"10.1016\/j.intimp.2016.03.035_bb0015","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1601-0825.2008.01441.x","article-title":"Oral lichen planus: controversies surrounding malignant transformation","volume":"14","author":"Gonzalez-Moles","year":"2008","journal-title":"Oral Dis."},{"key":"10.1016\/j.intimp.2016.03.035_bb0020","first-page":"E12","article-title":"Oral lichen planus with malignant transformation to invasive squamous cell carcinoma","volume":"96","author":"Braun","year":"2015","journal-title":"Cutis"},{"key":"10.1016\/j.intimp.2016.03.035_bb0025","doi-asserted-by":"crossref","first-page":"45","DOI":"10.14219\/jada.2013.10","article-title":"The malignant transformation of oral lichen planus and oral lichenoid lesions: a systematic review","volume":"145","author":"Fitzpatrick","year":"2014","journal-title":"J. Am. Dent. Assoc."},{"key":"10.1016\/j.intimp.2016.03.035_bb0030","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.archoralbio.2013.04.004","article-title":"Oral lichen planus: focus on etiopathogenesis","volume":"58","author":"Payeras","year":"2013","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.intimp.2016.03.035_bb0035","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1034\/j.1600-0714.2003.00173.x","article-title":"Systemic and topical corticosteroid treatment of oral lichen planus: a comparative study with long-term follow-up","volume":"32","author":"Carbone","year":"2003","journal-title":"J. Oral Pathol. Med."},{"key":"10.1016\/j.intimp.2016.03.035_bb0040","first-page":"893","article-title":"Topical application of drugs used in treatment of oral lichen planus lesions","volume":"22","author":"Radwan-Oczko","year":"2013","journal-title":"Adv. Clin. Exp. Med."},{"key":"10.1016\/j.intimp.2016.03.035_bb0045","first-page":"43","article-title":"A review on the pharmacology of Paeonia lactiflora and its chemical components","volume":"10","author":"Wu","year":"1985","journal-title":"Zhong Yao Tong Bao"},{"key":"10.1016\/j.intimp.2016.03.035_bb0050","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.jep.2011.03.045","article-title":"Effects of total glucosides from paeony (Paeonia lactiflora Pall) roots on experimental atherosclerosis in rats","volume":"135","author":"Li","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2016.03.035_bb0055","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.intimp.2015.08.008","article-title":"Total glucosides of paeony can reduce the hepatotoxicity caused by methotrexate and leflunomide combination treatment of active rheumatoid arthritis","volume":"28","author":"Xiang","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2016.03.035_bb0060","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.jcms.2012.11.042","article-title":"Effects of total glucosides of paeony for delaying onset of Sjogren's syndrome: an animal study","volume":"41","author":"Li","year":"2013","journal-title":"J. Craniomaxillofac. Surg."},{"key":"10.1016\/j.intimp.2016.03.035_bb0065","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.intimp.2013.01.021","article-title":"Reduced hepatotoxicity by total glucosides of paeony in combination treatment with leflunomide and methotrexate for patients with active rheumatoid arthritis","volume":"15","author":"Chen","year":"2013","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2016.03.035_bb0070","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s11655-010-0504-2","article-title":"Clinical observation on the treatment of chronic urticaria with total glucosides of paeony capsule combined with citirizine","volume":"16","author":"Long","year":"2010","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.intimp.2016.03.035_bb0075","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.clim.2012.02.002","article-title":"Total glucosides of paeony induces regulatory CD4(+)CD25(+) T cells by increasing Foxp3 demethylation in lupus CD4(+) T cells","volume":"143","author":"Zhao","year":"2012","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.intimp.2016.03.035_bb0080","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1089\/apc.2007.0160","article-title":"Antifungal effect of mouth rinses on oral Candida counts and salivary flow in treatment-naive HIV-infected patients","volume":"22","author":"Patel","year":"2008","journal-title":"AIDS Patient Care STDs"},{"key":"10.1016\/j.intimp.2016.03.035_bb0085","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1111\/ijd.12918","article-title":"Oral lichen planus: an update on its pathogenesis","volume":"54","author":"Nogueira","year":"2015","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.intimp.2016.03.035_bb0090","doi-asserted-by":"crossref","first-page":"492","DOI":"10.12968\/hmed.2014.75.9.492","article-title":"Aetiology, diagnosis and treatment of oral lichen planus","volume":"75","author":"Ryan","year":"2014","journal-title":"Br. J. Hosp. Med."},{"key":"10.1016\/j.intimp.2016.03.035_bb0095","doi-asserted-by":"crossref","first-page":"S158","DOI":"10.4103\/0975-7406.155873","article-title":"Oral lichen planus: an overview","volume":"7","author":"Krupaa","year":"2015","journal-title":"J. Pharm. Bio. Sci."},{"key":"10.1016\/j.intimp.2016.03.035_bb0100","first-page":"151","article-title":"Effect of cedar honey in the treatment of oral lichen planus","volume":"26","author":"Sanatkhani","year":"2014","journal-title":"Iran. J. Otorhinolaryngol."},{"key":"10.1016\/j.intimp.2016.03.035_bb0105","first-page":"3","article-title":"Oral lichen planus: clinical features, etiology, treatment and management; a review of literature","volume":"4","author":"Boorghani","year":"2010","journal-title":"J. Dent. Res. Dent. Clin. Dent. Prosp."},{"key":"10.1016\/j.intimp.2016.03.035_bb0110","article-title":"Topical treatment of oral lichen planus with anthocyanins","author":"de Gutierrez E","year":"2014","journal-title":"Med. Oral Patol. Oral Cir. Bucal"},{"key":"10.1016\/j.intimp.2016.03.035_bb0115","doi-asserted-by":"crossref","first-page":"23","DOI":"10.15171\/joddd.2015.005","article-title":"A randomized placebo-controlled double blind clinical trial of quercetin for treatment of oral lichen planus","volume":"9","author":"Amirchaghmaghi","year":"2015","journal-title":"J. Dent. Res. Dent. Clin. Dent. Prosp."},{"key":"10.1016\/j.intimp.2016.03.035_bb0120","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3389\/fphar.2011.00010","article-title":"Anti-inflammatory and immunomodulatory effects of Paeonia lactiflora Pall., a traditional Chinese herbal medicine","volume":"2","author":"He","year":"2011","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2016.03.035_bb0125","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/ptr.5005","article-title":"The beneficial effect of total glucosides of paeony on psoriatic arthritis links to circulating Tregs and Th1 cell function","volume":"28","author":"Wang","year":"2014","journal-title":"Phytother. Res."},{"key":"10.1016\/j.intimp.2016.03.035_bb0130","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s11596-012-0078-7","article-title":"Implications of Th1 and Th17 cells in pathogenesis of oral lichen planus","volume":"32","author":"Xie","year":"2012","journal-title":"J. Huazhong Univ. Sci. Technolog. Med. Sci."},{"key":"10.1016\/j.intimp.2016.03.035_bb0135","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/odi.12094","article-title":"Potential pathogenetic role of Th17, Th0, and Th2 cells in erosive and reticular oral lichen planus","volume":"20","author":"Piccinni","year":"2014","journal-title":"Oral Dis."},{"key":"10.1016\/j.intimp.2016.03.035_bb0140","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.cellimm.2012.12.005","article-title":"Total glucosides of paeony inhibits Th1\/Th17 cells via decreasing dendritic cells activation in rheumatoid arthritis","volume":"280","author":"Lin","year":"2012","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.intimp.2016.03.035_bb0145","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.intimp.2012.07.012","article-title":"Total glucosides of paeony attenuated functional maturation of dendritic cells via blocking TLR4\/5 signaling in vivo","volume":"14","author":"Zhou","year":"2012","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2016.03.035_bb0150","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1601-0825.2009.01516.x","article-title":"Course of oral lichen planus: a retrospective study of 808 northern Italian patients","volume":"15","author":"Carbone","year":"2009","journal-title":"Oral Dis."},{"key":"10.1016\/j.intimp.2016.03.035_bb0155","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1111\/j.1365-4632.2012.05459.x","article-title":"Comparative efficacy of tacrolimus 0.1% ointment and clobetasol propionate 0.05% ointment in oral lichen planus: a randomized double-blind trial","volume":"51","author":"Sonthalia","year":"2012","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.intimp.2016.03.035_bb0160","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1365-2133.2005.06920.x","article-title":"Ciclosporin vs. clobetasol in the topical management of atrophic and erosive oral lichen planus: a double-blind, randomized controlled trial","volume":"154","author":"Conrotto","year":"2006","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.intimp.2016.03.035_bb0165","doi-asserted-by":"crossref","first-page":"378219","DOI":"10.1155\/2013\/378219","article-title":"Total glucosides of paeony capsule plus compound glycyrrhizin tablets for the treatment of severe alopecia areata in children: a randomized controlled trial","volume":"2013","author":"Yang","year":"2013","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.intimp.2016.03.035_bb0170","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/dth.12133","article-title":"Successful treatment of necrobiotic xanthogranuloma with total glucosides of paeony","volume":"27","author":"Li","year":"2014","journal-title":"Dermatol. Ther."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576916301266?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576916301266?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:07:17Z","timestamp":1761584837000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576916301266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":34,"alternative-id":["S1567576916301266"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2016.03.035","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical observation on the treatment of oral lichen planus with total glucosides of paeony capsule combined with corticosteroids","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2016.03.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}