{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:03:04Z","timestamp":1792454584225,"version":"4.5.0"},"reference-count":121,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Research Foundation of Xi'an Hong-Hui Hospital","award":["YJ2016015"],"award-info":[{"award-number":["YJ2016015"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.intimp.2016.04.024","type":"journal-article","created":{"date-parts":[[2016,4,29]],"date-time":"2016-04-29T15:29:41Z","timestamp":1461943781000},"page":"118-131","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":124,"special_numbering":"C","title":["Natural products for treatment of bone erosive diseases: The effects and mechanisms on inhibiting osteoclastogenesis and bone resorption"],"prefix":"10.1016","volume":"36","author":[{"given":"Jing","family":"An","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingjun","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2016.04.024_bb0005","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s11154-010-9153-1","article-title":"Cellular mechanisms of bone remodeling","volume":"11","author":"Eriksen","year":"2010","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.intimp.2016.04.024_bb0010","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"Boyle","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2016.04.024_bb0015","first-page":"66","article-title":"Modulation of osteoclast differentiation","volume":"13","author":"Suda","year":"1991","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.intimp.2016.04.024_bb0020","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1196\/annals.1346.020","article-title":"Molecular mechanism of the life and death of the osteoclast","volume":"1068","author":"Tanaka","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.intimp.2016.04.024_bb0025","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.0105-2896.2005.00327.x","article-title":"Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL-RANK signaling system","volume":"208","author":"Tanaka","year":"2005","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.intimp.2016.04.024_bb0030","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/345442a0","article-title":"The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene","volume":"345","author":"Yoshida","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2016.04.024_bb0035","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/16852","article-title":"OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis","volume":"397","author":"Kong","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2016.04.024_bb0040","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1196\/annals.1346.014","article-title":"M-CSF, c-Fms, and signaling in osteoclasts and their precursors","volume":"1068","author":"Ross","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.intimp.2016.04.024_bb0045","doi-asserted-by":"crossref","first-page":"4828","DOI":"10.1073\/pnas.87.12.4828","article-title":"Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op\/op) mouse","volume":"87","author":"Jedrzejczak","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.intimp.2016.04.024_bb0050","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/nri2062","article-title":"Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems","volume":"7","author":"Takayanagi","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0055","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/jcb.21167","article-title":"Molecular analysis of RANKL-independent cell fusion of osteoclast like cells induced by TNF-alpha, lipopolysaccharide, or peptidoglycan","volume":"101","author":"Hotokezaka","year":"2007","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.intimp.2016.04.024_bb0060","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/nrg1122","article-title":"Genetic regulation of osteoclast development and function","volume":"4","author":"Teitelbaum","year":"2003","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.intimp.2016.04.024_bb0065","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1359\/jbmr.2000.15.8.1477","article-title":"Identification and characterization of the new osteoclast progenitor with macrophage phenotypes being able to differentiate into mature osteoclasts","volume":"15","author":"Takeshita","year":"2000","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.intimp.2016.04.024_bb0070","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s774-002-8446-8","article-title":"Comparison of the effects of transdermal estrogen, oral estrogen, and oral estrogen-progestogen therapy on bone mineral density in postmenopausal women","volume":"20","author":"etinkaya","year":"2002","journal-title":"J. Bone Miner. Metab."},{"key":"10.1016\/j.intimp.2016.04.024_bb0075","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.drudis.2013.08.010","article-title":"Is bisphosphonate therapy compromised by the emergence of adverse bone disorders?","volume":"19","author":"Verron","year":"2014","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.intimp.2016.04.024_bb0080","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1126\/science.289.5484.1508","article-title":"Therapeutic approaches to bone diseases","volume":"289","author":"Rodan","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.intimp.2016.04.024_bb0085","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1001\/jama.288.3.321","article-title":"Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial","volume":"288","author":"Rossouw","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.intimp.2016.04.024_bb0090","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1359\/jbmr.0707onj","article-title":"Bisphosphonate-associated osteonecrosis of the jaw: report of a task force of the American Society for Bone and Mineral Research","volume":"22","author":"Chair","year":"2007","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.intimp.2016.04.024_bb0095","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1002\/jbmr.1576","volume":"27","author":"Wu","year":"2012","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.intimp.2016.04.024_bb0100","doi-asserted-by":"crossref","first-page":"5940","DOI":"10.4049\/jimmunol.172.10.5940","article-title":"Curcumin (diferuloylmethane) inhibits receptor activator of NF-kappa B ligand-induced NF-kappa B activation in osteoclast precursors and suppresses osteoclastogenesis","volume":"172","author":"Bharti","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0105","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1124\/mol.109.057877","article-title":"Epigallocatechin-3-gallate inhibits osteoclastogenesis by down-regulating c-Fos expression and suppressing the nuclear factor-\u03baB signal","volume":"77","author":"Lee","year":"2010","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0110","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s00223-008-9139-0","article-title":"Dried plum polyphenols inhibit osteoclastogenesis by downregulating NFATc1 and inflammatory mediators","volume":"82","author":"Bu","year":"2008","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.intimp.2016.04.024_bb0115","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.tim.2007.04.001","article-title":"New aspects of natural products in drug discovery","volume":"15","author":"Lam","year":"2007","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0120","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.drudis.2008.07.004","article-title":"Natural products in drug discovery","volume":"13","author":"Harvey","year":"2008","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.intimp.2016.04.024_bb0125","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1002\/jbmr.1701","article-title":"Protein kinase C-delta deficiency perturbs bone homeostasis by selective uncoupling of cathepsin K secretion and ruffled border formation in osteoclasts","volume":"27","author":"Cremasco","year":"2012","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.intimp.2016.04.024_bb0130","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1074\/jbc.M805280200","article-title":"Cathepsin K activity-dependent regulation of osteoclast actinring formation and bone resorption","volume":"284","author":"Wilson","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2016.04.024_bb0135","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1016\/j.lfs.2006.05.024","article-title":"MMP-9 antisense oligodeoxynucleotide exerts an inhibitory effect on osteoclastic bone resorption by suppressing cell migration","volume":"79","author":"Ishibashi","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2016.04.024_bb0140","doi-asserted-by":"crossref","first-page":"22907","DOI":"10.1074\/jbc.274.33.22907","article-title":"Intracellular fragmentation of bone resorption products by reactive oxygen species generated by osteoclastic tartrate-resistant acid phosphatase","volume":"274","author":"Halleen","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2016.04.024_bb0145","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1359\/jbmr.2003.18.10.1908","article-title":"Potential function for the ROS-generating activity of TRACP","volume":"18","author":"Halleen","year":"2003","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.intimp.2016.04.024_bb0150","doi-asserted-by":"crossref","first-page":"113","DOI":"10.4049\/jimmunol.1002483","article-title":"The role of osteoclast-associated receptor in osteoimmunology","volume":"186","author":"Nemeth","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0155","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/72855","article-title":"Fosl1 is a transcriptional target of c-Fos during osteoclast differentiation","volume":"24","author":"Matsuo","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.intimp.2016.04.024_bb0160","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1126\/science.7939685","article-title":"c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling","volume":"266","author":"Grigoriadis","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.intimp.2016.04.024_bb0165","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1038\/sj.emboj.7600282","article-title":"The Fos-related antigen Fra-1 is an activator of bone matrix formation","volume":"23","author":"Eferl","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.intimp.2016.04.024_bb0170","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S1534-5807(02)00369-6","article-title":"Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling interminal differentiation of osteoclasts","volume":"3","author":"Takayanagi","year":"2002","journal-title":"Dev. Cell"},{"key":"10.1016\/j.intimp.2016.04.024_bb0175","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/jcp.21076","article-title":"Calcium\/calmodulin-dependent kinase activity is required for efficient induction of osteoclast differentiation and bone resorption by receptor activator of nuclear factor kappa B ligand (RANKL)","volume":"212","author":"Ang","year":"2007","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0180","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1124\/mol.58.6.1536","article-title":"Activation of c-Jun N-terminal kinase and activator protein1 by receptor activator of nuclear factor kappa B","volume":"58","author":"Lee","year":"2000","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0185","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.yexcr.2006.10.001","article-title":"RANK ligand signaling modulates the matrix metalloproteinase-9 gene expression during osteoclast differentiation","volume":"313","author":"Sundaram","year":"2007","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.intimp.2016.04.024_bb0190","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1084\/jem.20051150","article-title":"Autoamplification of NFATc1 expression determines its essential role in bone homeostasis","volume":"202","author":"Asagiri","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.intimp.2016.04.024_bb0195","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/0092-8674(91)90499-O","article-title":"Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice","volume":"4","author":"Soriano","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2016.04.024_bb0200","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nm1054","article-title":"Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo","volume":"10","author":"Jimi","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.intimp.2016.04.024_bb0205","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1084\/jem.20042081","article-title":"I\u03baB kinase (IKK) \u03b2, but not IKK\u03b1, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss","volume":"201","author":"Ruocco","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.intimp.2016.04.024_bb0210","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/nm1197-1285","article-title":"Osteopetrosis in mice lacking NF-\u03baB1 and NF-\u03baB2","volume":"3","author":"Iotsova","year":"1997","journal-title":"Nat. Med."},{"key":"10.1016\/j.intimp.2016.04.024_bb0215","doi-asserted-by":"crossref","first-page":"35081","DOI":"10.1074\/jbc.C500353200","article-title":"Regulation of the transcriptional activity of c-Fos by ERK. A novel role for the prolyl isomerase PIN1","volume":"280","author":"Monje","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2016.04.024_bb0220","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.biochi.2014.07.003","article-title":"Triptolide, a diterpene, inhibits osteoclastogenesis, induced by RANKL signaling and human cancer cells","volume":"105","author":"Park","year":"2014","journal-title":"Biochimie"},{"key":"10.1016\/j.intimp.2016.04.024_bb0225","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.mce.2014.10.016","article-title":"Triptolide inhibits osteoclast formation, bone resorption, RANKL-mediated NF-\u03baB activation and titanium particle-induced osteolysis in a mouse model","volume":"399","author":"Huang","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0230","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.intimp.2015.10.004","article-title":"17-Hydroxy-jolkinolide a inhibits osteoclast differentiation through suppressing the activation of NF-\u03baB and MAPKs","volume":"29","author":"Wang","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0235","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.bbrc.2014.01.145","article-title":"Jolkinolide B inhibits RANKL-induced osteoclastogenesis by suppressing the activation NF-\u03baB and MAPK signaling pathways","volume":"445","author":"Ma","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2016.04.024_bb0240","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/bph.12463","article-title":"Andrographolide suppresses RANKL-induced osteoclastogenesis in vitro and prevents inflammatory bone loss in vivo","volume":"171","author":"Zhai","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0245","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.intimp.2014.12.012","article-title":"Celastrol attenuates bone erosion in collagen-induced arthritis mice and inhibits osteoclast differentiation and function in RANKL-induced RAW264.7","volume":"24","author":"Gan","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0250","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.bbrc.2014.04.009","article-title":"Curcumol suppresses RANKL-induced osteoclast formation by attenuating the JNK signaling pathway","volume":"447","author":"Yu","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2016.04.024_bb0255","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.bbrc.2013.04.046","article-title":"Sargachromanol G inhibits osteoclastogenesis by suppressing the activation NF-\u03baB and MAPKs in RANKL-induced RAW 264.7 cells","volume":"434","author":"Yoon","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2016.04.024_bb0260","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ejphar.2013.06.002","article-title":"Hispidulin attenuates bone resorption and osteoclastogenesis via the RANKL-induced NF-\u03baB and NFATc1 pathways","volume":"715","author":"Nepal","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0265","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1016\/j.archoralbio.2012.06.012","article-title":"Myricetin suppresses LPS-induced MMP expression in human gingival fibroblasts and inhibits osteoclastogenesis by downregulating NFATc1 in RANKL-induced RAW 264.7 cells","volume":"57","author":"Ko","year":"2012","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0270","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.tiv.2004.05.002","article-title":"Drynariae Rhizoma promotes osteoblast differentiation and mineralization in MC3T3-E1 cells through regulation of bone morphogenetic protein-2, alkaline phosphatase, type I collagen and collagenase-1","volume":"18","author":"Jeong","year":"2004","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.intimp.2016.04.024_bb0275","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.chembiol.2007.06.010","article-title":"A triterpene glycoside from black cohosh that inhibits osteoclastogenesis by modulating RANKL and TNF\u03b1 signaling pathways","volume":"14","author":"Qiu","year":"2007","journal-title":"Chem. Biol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0280","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1016\/j.fct.2012.02.019","article-title":"Ginsenoside Rb1 inhibits osteoclastogenesis by modulating NF-\u03baB and MAPKs pathways","volume":"50","author":"Cheng","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0285","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.intimp.2015.01.010","article-title":"Saikosaponin a inhibits RANKL-induced osteoclastogenesis by suppressing NF-\u03baB and MAPK pathways","volume":"25","author":"Zhou","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0290","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.intimp.2009.03.001","article-title":"Caffeic acid phenethyl ester inhibits osteoclastogenesis by suppressing NF\u03baB and downregulating NFATc1 and c-Fos","volume":"9","author":"Ha","year":"2009","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0295","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.phymed.2015.08.013","article-title":"Citrus limonoid nomilin inhibits osteoclastogenesis in vitro by suppression of NFATc1 and MAPK signaling pathways","volume":"22","author":"Kimira","year":"2015","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2016.04.024_bb0300","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.bbrc.2011.10.073","article-title":"The plant limonoid 7-oxo-deacetoxygedunin inhibits RANKL-induced osteoclastogenesis by suppressing activation of the NF-\u03baB and MAPK pathways","volume":"415","author":"Wisutsitthiwong","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2016.04.024_bb0305","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.bbrc.2014.05.034","article-title":"Schisantherin A suppresses osteoclast formation and wear particle-induced osteolysis via modulating RANKL signaling pathways","volume":"449","author":"He","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2016.04.024_bb0310","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.bone.2009.10.042","article-title":"Inhibition of osteoclast differentiation and bone resorption by rotenone, through down-regulation of RANKL-induced c-Fos and NFATc1 expression","volume":"46","author":"Kwak","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.intimp.2016.04.024_bb0315","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.bcp.2014.06.009","article-title":"Hypericin suppresses osteoclast formation and wear particle-induced osteolysis via modulating ERK signalling pathway","volume":"90","author":"Ouyang","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0320","doi-asserted-by":"crossref","first-page":"17660","DOI":"10.1074\/jbc.M311032200","article-title":"Src kinase activity is essential for osteoclast function","volume":"279","author":"Miyazaki","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2016.04.024_bb0325","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1083\/jcb.200209098","article-title":"Regulation of cytochrome c oxidase activity by c-Src in osteoclasts","volume":"160","author":"Miyazaki","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0330","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/S1097-2765(00)80232-4","article-title":"TRANCE, a TNF family member, activates Akt\/PKB through a signaling complex involving TRAF6 and c-Src","volume":"4","author":"Wong","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1016\/j.intimp.2016.04.024_bb0335","doi-asserted-by":"crossref","first-page":"163","DOI":"10.4049\/jimmunol.1101254","article-title":"Akt induces osteoclast differentiation through regulating the GSK3\u03b2\/NFATc1 signaling cascade","volume":"188","author":"Moon","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0340","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1101\/gad.1089403","article-title":"Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2","volume":"17","author":"Peng","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.intimp.2016.04.024_bb0345","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0001058","article-title":"Akt1 in osteoblasts and osteoclasts controls bone remodeling","volume":"2","author":"Kawamura","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2016.04.024_bb0350","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1016\/j.bcp.2008.03.007","article-title":"Bavachalcone inhibits osteoclast differentiation through suppression of NFATc1 induction by RANKL","volume":"75","author":"Park","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0355","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.intimp.2014.03.001","article-title":"9-Hydroxy-6.7-dimethoxydalbergiquinol inhibits osteoclast differentiation through down-regulation of Akt, c-Fos and NFATc1","volume":"20","author":"Kim","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0360","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ejphar.2010.03.023","article-title":"Inhibition of osteoclastogenic differentiation by Ikarisoside A in RAW 264.7 cells via JNK and NF-\u03baB signaling pathways","volume":"636","author":"Choi","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0365","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1016\/j.fct.2008.08.016","article-title":"Baicalein inhibits osteoclast differentiation and induces mature osteoclast apoptosis","volume":"46","author":"Kim","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0370","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.fct.2013.08.047","article-title":"Xanthohumol modulates the expression of osteoclast-specific genes during osteoclastogenesis in RAW264.7 cells","volume":"62","author":"Suh","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0375","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0088974","article-title":"Anti-osteoclastogenic activity of praeruptorin A via inhibition of p38\/Akt-c-Fos-NFATc1 signaling and PLC\u03b3-independent Ca2+ oscillation","volume":"9","author":"Yeon","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2016.04.024_bb0380","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ejphar.2007.11.013","article-title":"Berberine inhibits RANKL-induced osteoclast formation and survival through suppressing the NF-\u03baB and Akt pathways","volume":"580","author":"Hu","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0385","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.bbrc.2013.12.029","article-title":"Dioscin inhibits osteoclast differentiation and bone resorption though down-regulating the Akt signaling cascades","volume":"443","author":"Qu","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2016.04.024_bb0390","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/j.bcp.2003.12.031","article-title":"Inhibition of osteoclast differentiation and bone resorption by tanshinone IIA isolated from Salvia miltiorrhiza Bunge","volume":"67","author":"Kim","year":"2004","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0395","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.phymed.2014.10.008","article-title":"Mollugin from Rubea cordifolia suppresses receptor activator of nuclear factor-\u03ba B ligand induced osteoclastogenesis and bone resorbing activity in vitro and prevents lipopolysaccharide-induced bone loss in vivo","volume":"22","author":"Baek","year":"2015","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2016.04.024_bb0400","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1042\/BJ20150151","article-title":"Gambogic acid inhibits osteoclast formation and ovariectomy-induced osteoporosis by suppressing the JNK, p38 and Akt signalling pathways","volume":"469","author":"Ma","year":"2015","journal-title":"Biochem. J."},{"key":"10.1016\/j.intimp.2016.04.024_bb0405","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.bone.2015.02.017","article-title":"Leonurine hydrochloride inhibits osteoclastogenesis and prevents osteoporosis associated with estrogen deficiency by inhibiting the NF-\u03baB and PI3K\/Akt signaling pathways","volume":"75","author":"Yuan","year":"2015","journal-title":"Bone"},{"key":"10.1016\/j.intimp.2016.04.024_bb0410","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.1749-6632.2009.05217.x","article-title":"PLCgamma2: where bone and immune cells find their common ground","volume":"1192","author":"Faccio","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.intimp.2016.04.024_bb0415","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.tibs.2005.10.005","article-title":"Phospholipase C-gamma: diverse roles in receptor-mediated calcium signaling","volume":"30","author":"Patterson","year":"2005","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.intimp.2016.04.024_bb0420","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.bone.2013.12.013","article-title":"Oleanolic acid acetate inhibits osteoclast differentiation by downregulating PLC\u03b32-Ca2+-NFATc1 signaling, and suppresses bone loss in mice","volume":"60","author":"Kim","year":"2014","journal-title":"Bone"},{"key":"10.1016\/j.intimp.2016.04.024_bb0425","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ejphar.2012.02.026","article-title":"Arctigenin suppresses receptor activator of nuclear factor \u03baB ligand(RANKL)-mediated osteoclast differentiation in bone marrow-derived macrophages","volume":"682","author":"Kim","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0430","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1182\/blood-2004-09-3662","article-title":"A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation","volume":"106","author":"Lee","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.intimp.2016.04.024_bb0435","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00044.2005","article-title":"The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology","volume":"87","author":"Bedard","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.intimp.2016.04.024_bb0440","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jep.2010.05.063","article-title":"Drynaria fortunei J. Sm. Promotes osteoblast maturation by inducing differentiation-related gene expression and protecting against oxidative stress-induced apoptotic insults","volume":"131","author":"Hung","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0445","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.bbrc.2010.09.053","article-title":"Resveratrol prevents RANKL-induced osteoclast differentiation of murine osteoclast progenitor RAW 264.7 cells through inhibition of ROS production","volume":"401","author":"He","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2016.04.024_bb0450","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.bcp.2007.06.044","article-title":"Inhibition of osteoclast differentiation and bone resorption by sauchinone","volume":"74","author":"Han","year":"2007","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0455","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.yexcr.2014.12.018","article-title":"Scoparone attenuates RANKL-induced osteoclastic differentiation through controlling reactive oxygen species production and scavenging","volume":"331","author":"Lee","year":"2015","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.intimp.2016.04.024_bb0460","doi-asserted-by":"crossref","first-page":"10605","DOI":"10.3390\/ijms150610605","article-title":"Genistein inhibits osteoclastic differentiation of RAW 264.7 cells via regulation of ROS production and scavenging","volume":"15","author":"Lee","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2016.04.024_bb0465","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1254\/jphs.12243FP","article-title":"Fisetin inhibits osteoclastogenesis through prevention of RANKL induced ROS production by Nrf2-mediated up-regulation of phase II antioxidant enzymes","volume":"121","author":"Sakai","year":"2013","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.intimp.2016.04.024_bb0470","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.bbrc.2007.06.023","article-title":"Bacterial lipopolysaccharide induces osteoclast formation in RAW 264.7 macrophage cells","volume":"360","author":"Islam","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2016.04.024_bb0475","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1600-0773.1998.tb01429.x","article-title":"Effect of stem cell factor, interleukin-6, nitric oxide and transforming growth factor-beta on the osteoclast differentiation induced by 1 alpha,25-(OH)2D3 in primary murine bone marrow cultures","volume":"82","author":"Chae","year":"1998","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0480","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00774-007-0808-2","article-title":"Selective cyclooxygenase-2 inhibitor prevents reduction of trabecular bone mass in collagen-induced arthritic mice in association with suppression of RANKL\/OPG ratio and IL-6 mRNA expression in synovial tissues but not in bone marrow cells","volume":"26","author":"Taketa","year":"2008","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.intimp.2016.04.024_bb0485","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.3899\/jrheum.081321","article-title":"The tumor necrosis factor-{alpha}-blocking agent infliximab inhibits interleukin 1beta (IL-1beta) and IL-6 gene expression in human osteoblastic cells","volume":"36","author":"E","year":"2009","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0490","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ejphar.2012.08.013","article-title":"The natural flavonoid galangin inhibits osteoclastic bone destruction and osteoclastogenesis by suppressing NF-\u03baB in collagen-induced arthritis and bone marrow-derived macrophages","volume":"698","author":"Huh","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0495","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.intimp.2015.09.018","article-title":"Inhibitory effect of brazilin on osteoclast differentiation and its mechanism of action","volume":"29","author":"Kim","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0500","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.phymed.2010.04.003","article-title":"Icariin inhibits osteoclast differentiation and bone resorption by suppression of MAPKs\/NF-\u03baB regulated HIF-1\u03b1 and PGE2 synthesis","volume":"18","author":"Hsieh","year":"2011","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2016.04.024_bb0505","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1016\/j.febslet.2011.07.046","article-title":"Naringin abrogates osteoclastogenesis and bone resorption via the inhibition of RANKL-induced NF-\u03baB and ERK activation","volume":"585","author":"Ang","year":"2011","journal-title":"FEBS Lett."},{"key":"10.1016\/j.intimp.2016.04.024_bb0510","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/8756-3282(90)90082-A","article-title":"A band of F-actin containing podosomes is involved in bone resorption by osteoclasts","volume":"11","author":"Kanehisa","year":"1990","journal-title":"Bone"},{"key":"10.1016\/j.intimp.2016.04.024_bb0515","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1359\/jbmr.2001.16.7.1248","article-title":"Organization of cytoskeletal F-actin, G-actin, and gelsolin in the adhesion structures in cultured osteoclast","volume":"16","author":"Akisaka","year":"2001","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.intimp.2016.04.024_bb0520","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1749-6632.2011.06283.x","article-title":"The osteoclast and its unique cytoskeleton","volume":"1240","author":"Teitelbaum","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.intimp.2016.04.024_bb0525","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1084\/jem.20050645","article-title":"DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells","volume":"202","author":"Yagi","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.intimp.2016.04.024_bb0530","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1210\/me.2007-0237","article-title":"NFATc1 induces osteoclast fusion via upregulation of Atp6v0d2 and the dendritic cell-specific transmembrane protein (DC-STAMP)","volume":"22","author":"Kim","year":"2008","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0535","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.cellbi.2008.04.017","article-title":"Licochalcone A inhibits the formation and bone resorptive activity of osteoclasts","volume":"32","author":"Kim","year":"2008","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.intimp.2016.04.024_bb0540","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jnutbio.2009.11.002","article-title":"The effects of luteolin on osteoclast differentiation, function in vitro and ovariectomy-induced bone loss","volume":"22","author":"Kim","year":"2011","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.intimp.2016.04.024_bb0545","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.bcp.2014.10.019","article-title":"Myricetin prevents titanium particle-induced osteolysis in vivo and inhibits RANKL-induced osteoclastogenesis in vitro","volume":"93","author":"Wu","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0550","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.bbrc.2015.09.093","article-title":"Tenuigenin inhibits RANKL-induced osteoclastogenesis by down-regulating NF-\u03baB activation and suppresses bone loss in vivo","volume":"466","author":"Yang","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2016.04.024_bb0555","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.ejphar.2010.10.048","article-title":"Harmine, a \u03b2-carboline alkaloid, inhibits osteoclast differentiation and bone resorption in vitro and in vivo","volume":"650","author":"Yonezawa","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0560","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.bone.2011.04.003","article-title":"The small molecule harmine regulates NFATc1 and Id2 expression in osteoclast progenitor cells","volume":"49","author":"Egusa","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.intimp.2016.04.024_bb0565","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.bbrc.2012.12.051","article-title":"Sanguinarine inhibits osteoclast formation and bone resorption via suppressing RANKL-induced activation of NF-\u03baB and ERK signaling pathways","volume":"430","author":"Li","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2016.04.024_bb0570","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.bbrc.2015.04.034","article-title":"Esculetin attenuates receptor activator of nuclear factor kappa-B ligand-mediated osteoclast differentiation through c-Fos\/nuclear factor of activated T-cells c1 signaling pathway","volume":"461","author":"Baek","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2016.04.024_bb0575","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.bone.2015.07.023","article-title":"Decursin inhibits osteoclastogenesis by downregulating NFATc1 and blocking fusion of pre-osteoclasts","volume":"81","author":"Kim","year":"2015","journal-title":"Bone"},{"key":"10.1016\/j.intimp.2016.04.024_bb0580","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.ejphar.2013.10.027","article-title":"Inhibitory effects of obovatol on osteoclast differentiation and bone resorption","volume":"723","author":"Kim","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0585","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.biochi.2015.02.002","article-title":"Inhibitory effects of ursolic acid on osteoclastogenesis and titanium particle-induced osteolysis are mediated primarily via suppression of NF-kB signaling","volume":"111","author":"Jiang","year":"2015","journal-title":"Biochimie"},{"key":"10.1016\/j.intimp.2016.04.024_bb0590","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1016\/j.bbrc.2004.10.197","article-title":"Furosin, an ellagitannin, suppresses RANKL-induced osteoclast differentiation and function through inhibition of MAP kinase activation and actin ring formation","volume":"325","author":"Park","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2016.04.024_bb0595","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.bcp.2010.04.014","article-title":"Alisol-B, a novel phyto-steroid, suppresses the RANKL-induced osteoclast formation and prevents bone loss in mice","volume":"80","author":"Lee","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0600","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.intimp.2010.08.017","article-title":"Gymnasterkoreayne F inhibits osteoclast formation by suppressing NFATc1 and DC-STAMP expression","volume":"10","author":"Kim","year":"2010","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2016.04.024_bb0605","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ejphar.2015.10.053","article-title":"Myristoleic acid inhibits osteoclast formation and bone resorption by suppressing the RANKL activation of Src and Pyk2","volume":"768","author":"Kwon","year":"2015","journal-title":"Eur. J. Pharmacol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576916301588?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576916301588?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T16:24:21Z","timestamp":1536769461000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576916301588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":121,"alternative-id":["S1567576916301588"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2016.04.024","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Natural products for treatment of bone erosive diseases: The effects and mechanisms on inhibiting osteoclastogenesis and bone resorption","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2016.04.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}