{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:14:08Z","timestamp":1792786448678,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81401306"],"award-info":[{"award-number":["81401306"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Doctoral Startup Foundation of the Third Affiliated Hospital of Guangzhou Medical University","award":["2014Y02"],"award-info":[{"award-number":["2014Y02"]}],"id":[{"id":"https:\/\/ror.org\/00fb35g87","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"publisher","award":["A2014318"],"award-info":[{"award-number":["A2014318"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.intimp.2016.06.002","type":"journal-article","created":{"date-parts":[[2016,6,15]],"date-time":"2016-06-15T11:37:23Z","timestamp":1465990643000},"page":"233-237","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["TIMP-1 expression induced by IL-32 is mediated through activation of AP-1 signal pathway"],"prefix":"10.1016","volume":"38","author":[{"given":"Haixia","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoquan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingfei","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haizhen","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomou","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2016.06.002_bb0005","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1002\/hep.20528","article-title":"AASLD single-topic research conference on hepatocellular carcinoma: conference proceedings","volume":"40","author":"Sherman","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2016.06.002_bb0010","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1056\/NEJM199306243282508","article-title":"Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies","volume":"328","author":"Friedman","year":"1993","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.intimp.2016.06.002_bb0015","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.cld.2008.07.007","article-title":"The global impact of hepatic fibrosis and end-stage liver disease","volume":"12","author":"Lim","year":"2008","journal-title":"Clin. Liver Dis."},{"key":"10.1016\/j.intimp.2016.06.002_bb0020","doi-asserted-by":"crossref","first-page":"21911","DOI":"10.3390\/ijms160921911","article-title":"Ghrelin attenuates liver fibrosis through regulation of TGF-beta1 expression and autophagy","volume":"16","author":"Mao","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2016.06.002_bb0025","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1053\/j.gastro.2007.02.033","article-title":"Gene expression profiles during hepatic stellate cell activation in culture and in vivo","volume":"132","author":"De Minicis","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.intimp.2016.06.002_bb0030","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0168-8278(01)00260-4","article-title":"Hepatic stellate cell\/myofibroblast subpopulations in fibrotic human and rat livers","volume":"36","author":"Cassiman","year":"2002","journal-title":"J. Hepatol."},{"key":"10.1016\/j.intimp.2016.06.002_bb0035","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1053\/j.gastro.2008.03.003","article-title":"Mechanisms of hepatic fibrogenesis","volume":"134","author":"Friedman","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.intimp.2016.06.002_bb0040","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1111\/bph.12626","article-title":"Glabridin inhibits migration and invasion by transcriptional inhibition of matrix metalloproteinase 9 through modulation of NF-kappaB and AP-1 activity in human liver cancer cells","volume":"171","author":"Hsieh","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.intimp.2016.06.002_bb0045","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/S0168-8278(97)80454-0","article-title":"Tissue inhibitor of metalloproteinase-1 in the liver of patients with chronic liver disease","volume":"26","author":"Murawaki","year":"1997","journal-title":"J. Hepatol."},{"key":"10.1016\/j.intimp.2016.06.002_bb0050","first-page":"1647","article-title":"Tissue inhibitor of metalloproteinase-1 and -2 RNA expression in rat and human liver fibrosis","volume":"150","author":"Herbst","year":"1997","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.intimp.2016.06.002_bb0055","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/j.1751-2980.2012.00629.x","article-title":"Serum levels of tissue inhibitor of metalloproteinase-1 are correlated with liver fibrosis in patients with chronic hepatitis B","volume":"13","author":"Zhu","year":"2012","journal-title":"J. Dig. Dis."},{"key":"10.1016\/j.intimp.2016.06.002_bb0060","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1053\/jhep.2000.20521","article-title":"Tissue inhibitor of metalloproteinases-1 promotes liver fibrosis development in a transgenic mouse model","volume":"32","author":"Yoshiji","year":"2000","journal-title":"Hepatology"},{"issue":"Suppl. 3","key":"10.1016\/j.intimp.2016.06.002_bb0065","doi-asserted-by":"crossref","first-page":"i61","DOI":"10.1136\/ard.2006.058511","article-title":"IL-32, a novel cytokine with a possible role in disease","volume":"65","author":"Dinarello","year":"2006","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.intimp.2016.06.002_bb0070","doi-asserted-by":"crossref","first-page":"557","DOI":"10.4049\/jimmunol.181.1.557","article-title":"Endogenous IL-32 controls cytokine and HIV-1 production","volume":"181","author":"Nold","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2016.06.002_bb0075","doi-asserted-by":"crossref","first-page":"17868","DOI":"10.1074\/jbc.M900368200","article-title":"Interleukin-32 expression in the pancreas","volume":"284","author":"Nishida","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2016.06.002_bb0080","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.jinf.2012.05.009","article-title":"Increased interleukin-32 expression in chronic hepatitis B virus-infected liver","volume":"65","author":"Xu","year":"2012","journal-title":"J. Infect."},{"key":"10.1016\/j.intimp.2016.06.002_bb0085","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1002\/hep.24285","article-title":"Interleukin-32: a new proinflammatory cytokine involved in hepatitis C virus-related liver inflammation and fibrosis","volume":"53","author":"Moschen","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2016.06.002_bb0090","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.virol.2015.02.015","article-title":"Novel expression and regulation of TIMP-1 in Epstein Barr virus-infected cells and its impact on cell survival","volume":"481","author":"Lin","year":"2015","journal-title":"Virology"},{"issue":"Pt 2","key":"10.1016\/j.intimp.2016.06.002_bb0095","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1042\/bj3240611","article-title":"Transcriptional activity of the human tissue inhibitor of metalloproteinases 1 (TIMP-1) gene in fibroblasts involves elements in the promoter, exon 1 and intron 1","volume":"324","author":"Clark","year":"1997","journal-title":"Biochem. J."},{"key":"10.1016\/j.intimp.2016.06.002_bb0100","doi-asserted-by":"crossref","first-page":"5533","DOI":"10.1074\/jbc.M114.598011","article-title":"Adiponectin reduces hepatic stellate cell migration by promoting tissue inhibitor of metalloproteinase-1 (TIMP-1) secretion","volume":"290","author":"Ramezani-Moghadam","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2016.06.002_bb0105","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.jhep.2007.02.003","article-title":"Expression of MMPs and TIMPs in liver fibrosis \u2014 a systematic review with special emphasis on anti-fibrotic strategies","volume":"46","author":"Hemmann","year":"2007","journal-title":"J. Hepatol."},{"key":"10.1016\/j.intimp.2016.06.002_bb0110","doi-asserted-by":"crossref","first-page":"G1083","DOI":"10.1152\/ajpgi.00568.2005","article-title":"Mechanisms of liver Injury. II. Mechanisms of neutrophil-induced liver cell injury during hepatic ischemia-reperfusion and other acute inflammatory conditions","volume":"290","author":"Jaeschke","year":"2006","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.intimp.2016.06.002_bb0115","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.molimm.2011.03.012","article-title":"Interleukin-32 expression induced by hepatitis B virus protein X is mediated through activation of NF-kappaB","volume":"48","author":"Pan","year":"2011","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.intimp.2016.06.002_bb0120","doi-asserted-by":"crossref","first-page":"12159","DOI":"10.1074\/jbc.M109.067629","article-title":"Hepatitis B virus protein X-induced expression of the CXC chemokine IP-10 is mediated through activation of NF-kappaB and increases migration of leukocytes","volume":"285","author":"Zhou","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2016.06.002_bb0125","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.virol.2008.11.042","article-title":"HBx protein induces expression of MIG and increases migration of leukocytes through activation of NF-kappaB","volume":"385","author":"Xia","year":"2009","journal-title":"Virology"},{"key":"10.1016\/j.intimp.2016.06.002_bb0130","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1365-2893.2005.00540.x","article-title":"Gene expression profile of T-cell-specific chemokines in human hepatocyte-derived cells: evidence for a synergistic inducer effect of cytokines and hepatitis C virus proteins","volume":"12","author":"Apolinario","year":"2005","journal-title":"J. Viral Hepat."},{"key":"10.1016\/j.intimp.2016.06.002_bb0135","first-page":"131","article-title":"Interleukin-32: a cytokine and inducer of TNFalpha","volume":"22","author":"Kim","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2016.06.002_bb0140","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1172\/JCI1018","article-title":"Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors","volume":"102","author":"Iredale","year":"1998","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.intimp.2016.06.002_bb0145","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1053\/gast.1996.v110.pm8608892","article-title":"Expression of tissue inhibitor of metalloproteinases 1 and 2 is increased in fibrotic human liver","volume":"110","author":"Benyon","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.intimp.2016.06.002_bb0150","doi-asserted-by":"crossref","first-page":"e84071","DOI":"10.1371\/journal.pone.0084071","article-title":"Gene expression profiling of early hepatic stellate cell activation reveals a role for Igfbp3 in cell migration","volume":"8","author":"Mannaerts","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2016.06.002_bb0155","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/labinvest.2008.127","article-title":"PTK787\/ZK22258 attenuates stellate cell activation and hepatic fibrosis in vivo by inhibiting VEGF signaling","volume":"89","author":"Liu","year":"2009","journal-title":"Lab. Investig."},{"key":"10.1016\/j.intimp.2016.06.002_bb0160","doi-asserted-by":"crossref","first-page":"3515","DOI":"10.1073\/pnas.0712381105","article-title":"Interleukin-32 induces the differentiation of monocytes into macrophage-like cells","volume":"105","author":"Netea","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576916302272?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576916302272?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T17:48:55Z","timestamp":1748972935000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576916302272"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":32,"alternative-id":["S1567576916302272"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2016.06.002","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TIMP-1 expression induced by IL-32 is mediated through activation of AP-1 signal pathway","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2016.06.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}