{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:09:49Z","timestamp":1791230989070,"version":"4.1.0"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Shandong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2010HM068"],"award-info":[{"award-number":["ZR2010HM068"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.intimp.2016.08.028","type":"journal-article","created":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T04:10:25Z","timestamp":1473307825000},"page":"136-143","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Ginsenoside Rb1: The new treatment measure of myasthenia gravis"],"prefix":"10.1016","volume":"41","author":[{"given":"Wei","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Fang","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Kang","family":"Sui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong-Cong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Bin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2016.08.028_bb0005","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1476-9255-9-20","article-title":"Complement regulatory protein Crry deficiency contributes to the antigen specific recall response in experimental autoimmune myasthenia gravis","volume":"9","author":"Soltys","year":"2012","journal-title":"J. Inflamm. (Lond.)"},{"key":"10.1016\/j.intimp.2016.08.028_bb0010","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.mcn.2013.03.005","article-title":"Atorvastatin-modified dendritic cells in vitro ameliorate experimental autoimmune myasthenia gravis by up-regulated Treg cells and shifted Th1\/Th17 to Th2 cytokines","volume":"56","author":"Li","year":"2013","journal-title":"Mol. Cell. Neurosci."},{"issue":"1","key":"10.1016\/j.intimp.2016.08.028_bb0015","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00005-011-0158-6","article-title":"Acetylcholine receptor-induced experimental myasthenia gravis: what have we learned from animal models after three decades?","volume":"60","author":"Baggi","year":"2012","journal-title":"Arch. Immunol. Ther. Exp."},{"issue":"1","key":"10.1016\/j.intimp.2016.08.028_bb0020","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0002-9343(98)00374-X","article-title":"Disorders of neuromuscular junction ion channels","volume":"106","author":"Boonyapisit","year":"1999","journal-title":"Am. J. Med."},{"issue":"4","key":"10.1016\/j.intimp.2016.08.028_bb0025","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.4049\/jimmunol.172.4.2697","article-title":"Breakdown of tolerance to a self-peptide of acetylcholine receptor \u03b1-subunit induces experimental myasthenia gravis in rats","volume":"172","author":"Baggi","year":"2004","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2016.08.028_bb0030","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jneuroim.2008.12.005","article-title":"Administration of bone marrow stromal cells ameliorates experimental autoimmune myasthenia gravis by altering the balance of Th1\/Th2\/Th17\/Treg cell subsets through the secretion of TGF-\u03b2","volume":"207","author":"Kong","year":"2009","journal-title":"J. Neuroimmunol."},{"issue":"5","key":"10.1016\/j.intimp.2016.08.028_bb0035","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1002\/eji.201142088","article-title":"Activation of the adenosine A2A receptor attenuates experimental autoimmune myasthenia gravis severity","volume":"42","author":"Li","year":"2012","journal-title":"Eur. J. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2016.08.028_bb0040","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0165-5728(94)90044-2","article-title":"Acetylcholine receptor-reactive T cells in myasthenia gravis: evidence for the involvement of different subpopulations of T helper cells","volume":"50","author":"Yi","year":"1994","journal-title":"J. Neuroimmunol."},{"issue":"1","key":"10.1016\/j.intimp.2016.08.028_bb0045","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0165-5728(96)00197-X","article-title":"Linomide suppresses both Th1 and Th2 cytokines in experimental autoimmune myasthenia gravis","volume":"73","author":"Zhang","year":"1997","journal-title":"J. Neuroimmunol."},{"issue":"12","key":"10.1016\/j.intimp.2016.08.028_bb0050","doi-asserted-by":"crossref","first-page":"7189","DOI":"10.4049\/jimmunol.162.12.7189","article-title":"Experimental autoimmune myasthenia gravis may occur in the context of a polarized Th1-or Th2-type immune response in rats","volume":"162","author":"Saoudi","year":"1999","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2016.08.028_bb0055","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0165-5728(00)00385-4","article-title":"Suppression of experimental autoimmune myasthenia gravis in IL-10 gene-disrupted mice is associated with reduced B cells and serum cytotoxicity on mouse cell line expressing AChR","volume":"111","author":"Poussin","year":"2000","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.intimp.2016.08.028_bb0060","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0165-5728(96)00197-X","article-title":"Linomide suppresses both Th1 and Th2 cytokines in experimental autoimmune myasthenia gravis","volume":"73","author":"Zhang","year":"1997","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.intimp.2016.08.028_bb0065","doi-asserted-by":"crossref","unstructured":"Itoh, K.J., et al., The role of IL-10 in human B cell activation, proliferation, and differentiation. J. Neuroimmunol., 154(9): pp. 4341\u20134350.","DOI":"10.4049\/jimmunol.154.9.4341"},{"issue":"1","key":"10.1016\/j.intimp.2016.08.028_bb0070","doi-asserted-by":"crossref","first-page":"604","DOI":"10.4049\/jimmunol.170.1.604","article-title":"Absence of IL-4 facilitates the development of chronic autoimmune myasthenia gravis in C57BL\/6 mice","volume":"170","author":"Ostlie","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2016.08.028_bb0075","first-page":"3444","article-title":"IL 10 acts on the antigen presenting cell to inhibit cytokine production by Th1 cells","volume":"146","author":"David","year":"1995","journal-title":"J. Immunol."},{"issue":"12","key":"10.1016\/j.intimp.2016.08.028_bb0080","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1038\/ni1539","article-title":"TGF- and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell-mediated pathology","volume":"8","author":"MJ","year":"2007","journal-title":"Nat. Immunol."},{"issue":"7","key":"10.1016\/j.intimp.2016.08.028_bb0085","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1002\/eji.200737973","article-title":"CCL2 recruitment of IL-6-producing CD11b+ monocytes to the draining lymph nodes during the initiation of Th17-dependent B cell-mediated autoimmunity","volume":"38","author":"Bai","year":"2008","journal-title":"Eur. J. Immunol."},{"issue":"11","key":"10.1016\/j.intimp.2016.08.028_bb0090","doi-asserted-by":"crossref","first-page":"7072","DOI":"10.4049\/jimmunol.178.11.7072","article-title":"C57BL\/6 mice genetically deficient in IL-12\/IL-23 and IFN-\u03b3 are susceptible to experimental autoimmune myasthenia gravis, suggesting a pathogenic role of non-Th1 cells","volume":"178","author":"Wang","year":"2007","journal-title":"J. Immunol."},{"issue":"10","key":"10.1016\/j.intimp.2016.08.028_bb0095","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1093\/intimm\/dxp095","article-title":"Regulatory T cells: how do they suppress immune responses?","volume":"21","author":"Sakaguchi","year":"2009","journal-title":"Int. Immunol."},{"issue":"7130","key":"10.1016\/j.intimp.2016.08.028_bb0100","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/nature05478","article-title":"FoxP3 occupancy and regulation of key target genes during T-cell stimulation","volume":"445","author":"Marson","year":"2007","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.intimp.2016.08.028_bb0105","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1084\/jem.20031579","article-title":"Loss of functional suppression by CD4+ CD25+ regulatory T cells in patients with multiple sclerosis","volume":"199","author":"Viglietta","year":"2004","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.intimp.2016.08.028_bb0110","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/immu.200390024","article-title":"Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis","volume":"33","author":"Cao","year":"2003","journal-title":"Eur. J. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2016.08.028_bb0115","doi-asserted-by":"crossref","first-page":"164","DOI":"10.4049\/jimmunol.174.1.164","article-title":"Dysfunctional blood and target tissue CD4+ CD25high regulatory T cells in psoriasis: mechanism underlying unrestrained pathogenic effector T cell proliferation","volume":"174","author":"Sugiyama","year":"2005","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2016.08.028_bb0120","doi-asserted-by":"crossref","first-page":"92","DOI":"10.2337\/diabetes.54.1.92","article-title":"Defective suppressor function in CD4+ CD25+ T-cells from patients with type 1 diabetes","volume":"54","author":"Lindley","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.intimp.2016.08.028_bb0125","series-title":"Regulatory T Cells in Multiple Sclerosis\u2013Indications of Impaired Function of Suppressive Capacity and a Role for Chemokines","author":"Edstr\u00f6m","year":"2014"},{"key":"10.1016\/j.intimp.2016.08.028_bb0130","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.biocel.2014.08.014","article-title":"Low-dose splenic radiation inhibits liver tumor development of rats through functional changes in CD4+ CD25+ Treg cells","volume":"55","author":"Wang","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"7","key":"10.1016\/j.intimp.2016.08.028_bb0135","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1182\/blood-2004-03-1040","article-title":"Association of FoxP3 regulatory gene expression with graft-versus-host disease","volume":"104","author":"Miura","year":"2004","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.intimp.2016.08.028_bb0140","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1182\/blood-2003-11-3900","article-title":"Functional defect of regulatory CD4+ CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis","volume":"105","author":"Balandina","year":"2005","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.intimp.2016.08.028_bb0145","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/jnr.20522","article-title":"Decreased FoxP3 levels in multiple sclerosis patients","volume":"81","author":"Huan","year":"2005","journal-title":"J. Neurosci. Res."},{"issue":"9","key":"10.1016\/j.intimp.2016.08.028_bb0150","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/ni0901-816","article-title":"Regulatory T cells in the control of immune pathology","volume":"2","author":"Maloy","year":"2001","journal-title":"Nat. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2016.08.028_bb0155","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.clim.2004.04.005","article-title":"Increase of circulating CD4+CD25+ T cells in myasthenia gravis patients with stability and thymectomy","volume":"112","author":"Sun","year":"2004","journal-title":"Clin. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2016.08.028_bb0160","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jneuroim.2010.03.016","article-title":"Clinical implication of peripheral CD4+ CD25+ regulatory T cells and Th17 cells in myasthenia gravis patients","volume":"225","author":"Masuda","year":"2010","journal-title":"J. Neuroimmunol."},{"issue":"2","key":"10.1016\/j.intimp.2016.08.028_bb0165","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1254\/jphs.FMJ04001X5","article-title":"Proof of the mysterious efficacy of ginseng: basic and clinical trials: clinical effects of medical ginseng, Korean red ginseng: specifically, its anti-stress action for prevention of disease","volume":"95","author":"Kaneko","year":"2004","journal-title":"J. Pharmacol. Sci."},{"issue":"4","key":"10.1016\/j.intimp.2016.08.028_bb0170","doi-asserted-by":"crossref","first-page":"342","DOI":"10.5142\/jgr.2012.36.4.342","article-title":"Effects of Panax ginseng in neurodegenerative diseases","volume":"36","author":"Cho","year":"2012","journal-title":"J. Ginseng Res."},{"issue":"1","key":"10.1016\/j.intimp.2016.08.028_bb0175","doi-asserted-by":"crossref","first-page":"8","DOI":"10.5142\/jgr.2013.37.8","article-title":"A comprehensive review of the therapeutic and pharmacological effects of ginseng and ginsenosides in central nervous system","volume":"37","author":"Kim","year":"2013","journal-title":"J. Ginseng Res."},{"issue":"5","key":"10.1016\/j.intimp.2016.08.028_bb0180","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1194\/jlr.M035907","article-title":"Ginsenoside Rb1 reduces fatty liver by activating AMP-activated protein kinase in obese rats","volume":"54","author":"Shen","year":"2013","journal-title":"J. Lipid Res."},{"issue":"10","key":"10.1016\/j.intimp.2016.08.028_bb0185","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.2337\/db10-0315","article-title":"Antiobesity and antihyperglycemic effects of ginsenoside Rb1 in rats","volume":"59","author":"Xiong","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.intimp.2016.08.028_bb0190","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.neuroscience.2011.11.070","article-title":"Suppression of local inflammation contributes to the neuroprotective effect of ginsenoside Rb1 in rats with cerebral ischemia","volume":"202","author":"Zhu","year":"2012","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.intimp.2016.08.028_bb0195","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.jep.2010.07.033","article-title":"Ginsenoside Rb1 regulates the expressions of brain-derived neurotrophic factor and caspase-3 and induces neurogenesis in rats with experimental cerebral ischemia","volume":"132","author":"Gao","year":"2010","journal-title":"J. Ethnopharmacol."},{"issue":"11","key":"10.1016\/j.intimp.2016.08.028_bb0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0079399","article-title":"Neuroprotective effects of ginsenoside Rb1 on high glucose-induced neurotoxicity in primary cultured rat hippocampal neurons","volume":"8","author":"Liu","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.intimp.2016.08.028_bb0205","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.jss.2014.04.042","article-title":"Ginsenoside Rb1 improves energy metabolism in the skeletal muscle of an animal model of postoperative fatigue syndrome","volume":"191","author":"Tan","year":"2014","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.intimp.2016.08.028_bb0210","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.ejphar.2014.06.040","article-title":"Ginsenoside Rb1 improves postoperative fatigue syndrome by reducing skeletal muscle oxidative stress through activation of the PI3K\/Akt\/Nrf2 pathway in aged rats","volume":"740","author":"Zhuang","year":"2014","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2016.08.028_bb0215","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.taap.2009.09.009","article-title":"Ginsenoside Rb1 protects against 6-hydroxydopamine-induced oxidative stress by increasing heme oxygenase-1 expression through an estrogen receptor-related PI3K\/Akt\/Nrf2-dependent pathway in human dopaminergic cells","volume":"242","author":"Hwang","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"2","key":"10.1016\/j.intimp.2016.08.028_bb0220","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.jss.2014.04.042","article-title":"Ginsenoside Rb1 improves energy metabolism in the skeletal muscle of an animal model of postoperative fatigue syndrome","volume":"191","author":"Tan","year":"2014","journal-title":"J. Surg. Res."},{"issue":"46","key":"10.1016\/j.intimp.2016.08.028_bb0225","doi-asserted-by":"crossref","first-page":"5411","DOI":"10.1016\/j.vaccine.2005.04.007","article-title":"The Rb1 fraction of ginseng elicits a balanced Th1 and Th2 immune response","volume":"23","author":"Rivera","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.intimp.2016.08.028_bb0230","first-page":"1","article-title":"Ginsenoside-Rb1\/-Rg1 alleviate experimental autoimmune encephalomyelitis by suppressing Th1 and Th17 cells and upregulating regulatory T cells","author":"Lee","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.intimp.2016.08.028_bb0235","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/748964","article-title":"Korean red ginseng saponin fraction rich in ginsenoside-Rb1, Rc and Rb2 attenuates the severity of mouse collagen-induced arthritis","volume":"2014","author":"Endale","year":"2014","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.intimp.2016.08.028_bb0240","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1084\/jem.141.6.1365","article-title":"Experimental autoimmune myasthenia: a model of myasthenia gravis in rats and guinea pigs","volume":"141","author":"Lennon","year":"1975","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.intimp.2016.08.028_bb0245","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/ptr.4966","article-title":"Animal studies on medicinal herbs: predictability, dose conversion and potential value","volume":"28","author":"Wojcikowski","year":"2014","journal-title":"Phytother. Res."},{"issue":"1","key":"10.1016\/j.intimp.2016.08.028_bb0250","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0165-5728(98)00262-8","article-title":"Interleukin-4 deficiency facilitates development of experimental myasthenia gravis and precludes its prevention by nasal administration of CD4+ epitope sequences of the acetylcholine receptor","volume":"95","author":"Karachunski","year":"1999","journal-title":"J. Neuroimmunol."},{"issue":"10","key":"10.1016\/j.intimp.2016.08.028_bb0255","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1093\/intimm\/12.10.1381","article-title":"Tumor necrosis factor receptor-1 is critically involved in the development of experimental autoimmune myasthenia gravis","volume":"12","author":"Wang","year":"2000","journal-title":"Int. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2016.08.028_bb0260","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/intimm\/10.5.703","article-title":"IL-6-deficient mice are resistant to the induction of experimental autoimmune encephalomyelitis provoked by myelin oligodendrocyte glycoprotein","volume":"10","author":"Okuda","year":"1998","journal-title":"Int. Immunol."},{"issue":"6","key":"10.1016\/j.intimp.2016.08.028_bb0265","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/nm1585","article-title":"TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27\/STAT1","volume":"13","author":"Amadi-Obi","year":"2007","journal-title":"Nat. Med."},{"issue":"7198","key":"10.1016\/j.intimp.2016.08.028_bb0270","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/nature07036","article-title":"Induction and effector functions of TH17 cells","volume":"453","author":"Bettelli","year":"2008","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.intimp.2016.08.028_bb0275","doi-asserted-by":"crossref","first-page":"6173","DOI":"10.4049\/jimmunol.171.11.6173","article-title":"Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice","volume":"171","author":"Nakae","year":"2003","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2016.08.028_bb0280","doi-asserted-by":"crossref","first-page":"566","DOI":"10.4049\/jimmunol.177.1.566","article-title":"IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis","volume":"177","author":"Komiyama","year":"2006","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2016.08.028_bb0285","doi-asserted-by":"crossref","first-page":"409","DOI":"10.4049\/jimmunol.161.1.409","article-title":"Enhancing effect of IL-17 on IL-1-induced IL-6 and leukemia inhibitory factor production by rheumatoid arthritis synoviocytes and its regulation by Th2 cytokines","volume":"161","author":"Chabaud","year":"1998","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2016.08.028_bb0290","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/BOR.0b013e328304b6b5","article-title":"IL-17 and the Th17 lineage in systemic lupus erythematosus","volume":"20","author":"Garrett-Sinha","year":"2008","journal-title":"Curr. Opin. Rheumatol."},{"issue":"1","key":"10.1016\/j.intimp.2016.08.028_bb0295","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.imlet.2008.11.015","article-title":"The role of FoxP3+ CD4+ CD25 hi Tregs in the pathogenesis of myasthenia gravis","volume":"122","author":"Zhang","year":"2009","journal-title":"Immunol. Lett."},{"issue":"4","key":"10.1016\/j.intimp.2016.08.028_bb0300","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/ni904","article-title":"FoxP3 programs the development and function of CD4+ CD25+ regulatory T cells","volume":"4","author":"Fontenot","year":"2003","journal-title":"Nat. Immunol."},{"issue":"5609","key":"10.1016\/j.intimp.2016.08.028_bb0305","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.1079490","article-title":"Control of regulatory T cell development by the transcription factor FoxP3","volume":"299","author":"Hori","year":"2003","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.intimp.2016.08.028_bb0310","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1002\/eji.200939792","article-title":"Expansion of regulatory T cells via IL-2\/anti-IL-2 mAb complexes suppresses experimental myasthenia","volume":"40","author":"Liu","year":"2010","journal-title":"Eur. J. Immunol."},{"issue":"7090","key":"10.1016\/j.intimp.2016.08.028_bb0315","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature04754","article-title":"Transforming growth factor-beta induces development of the T(H)17 lineage","volume":"441","author":"Mangan","year":"2006","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.intimp.2016.08.028_bb0320","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1084\/jem.20030152","article-title":"Conversion of peripheral CD4+CD25\u2212 naive T cells to CD4+CD25+ regulatory T cells by TGF-\u03b2 induction of transcription factor FoxP3","volume":"198","author":"Chen","year":"2003","journal-title":"J. Exp. Med."},{"issue":"6","key":"10.1016\/j.intimp.2016.08.028_bb0325","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/ni.1607","article-title":"A critical function for TGF-\u03b2 signaling in the development of natural CD4+CD25+FoxP3+ regulatory T cells","volume":"9","author":"Liu","year":"2008","journal-title":"Nat. Immunol."},{"issue":"9","key":"10.1016\/j.intimp.2016.08.028_bb0330","doi-asserted-by":"crossref","first-page":"4773","DOI":"10.4049\/jimmunol.165.9.4773","article-title":"Cutting edge: TGF- inhibits Th type 2 development through inhibition of GATA-3 expression","volume":"165","author":"Gorelik","year":"2000","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.intimp.2016.08.028_bb0335","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/ni1261","article-title":"A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17","volume":"11","author":"Park","year":"2005","journal-title":"Nat. Immunol."},{"issue":"11","key":"10.1016\/j.intimp.2016.08.028_bb0340","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/ni1254","article-title":"Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages","volume":"6","author":"Harrington","year":"2005","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2016.08.028_bb0345","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/eji.200838748","article-title":"TGF-beta indirectly favors the development of human Th17 cells by inhibiting Th1 cells","volume":"39","author":"Santarlasci","year":"2009","journal-title":"Eur. J. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2016.08.028_bb0350","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.immuni.2009.04.010","article-title":"Mechanisms of FoxP3+ T regulatory cell-mediated suppression","volume":"30","author":"Shevach","year":"2009","journal-title":"Immunity"},{"issue":"10","key":"10.1016\/j.intimp.2016.08.028_bb0355","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1007\/s00221-015-4352-3","article-title":"Protective effect of ginsenoside Rb1 on integrity of blood-brain barrier following cerebral ischemia","volume":"233","author":"Chen","year":"2015","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.intimp.2016.08.028_bb0360","article-title":"Ginsenoside Rb1 preconditioning enhances eNOS expression and attenuates myocardial ischemia\/reperfusion injury in diabetic rats","volume":"2011","author":"Xia","year":"2011","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.intimp.2016.08.028_bb0365","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/334255a0","article-title":"Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells","volume":"334","author":"Stevens","year":"1988","journal-title":"Nature"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576916303563?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576916303563?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T20:38:40Z","timestamp":1692477520000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576916303563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":73,"alternative-id":["S1567576916303563"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2016.08.028","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ginsenoside Rb1: The new treatment measure of myasthenia gravis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2016.08.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}