{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:17:09Z","timestamp":1770819429304,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271994"],"award-info":[{"award-number":["81271994"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81301550"],"award-info":[{"award-number":["81301550"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371971"],"award-info":[{"award-number":["81371971"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.intimp.2016.09.031","type":"journal-article","created":{"date-parts":[[2016,10,8]],"date-time":"2016-10-08T12:47:46Z","timestamp":1475930866000},"page":"458-465","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Scutellarin inhibits RANKL-mediated osteoclastogenesis and titanium particle-induced osteolysis via suppression of NF-\u03baB and MAPK signaling pathway"],"prefix":"10.1016","volume":"40","author":[{"given":"Shuai","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingcheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianqi","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daxin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jihang","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuguang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2016.09.031_bb0005","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/00003086-200112000-00007","article-title":"Wear and periprosthetic osteolysis: the problem","volume":"393","author":"Harris","year":"2001","journal-title":"Clin. Orthop. Relat. Res."},{"issue":"1","key":"10.1016\/j.intimp.2016.09.031_bb0010","doi-asserted-by":"crossref","first-page":"128","DOI":"10.2106\/JBJS.H.00155","article-title":"The epidemiology of revision total hip arthroplasty in the United States","volume":"91","author":"Bozic","year":"2009","journal-title":"J. Bone Joint Surg."},{"issue":"2","key":"10.1016\/j.intimp.2016.09.031_bb0015","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.smim.2007.11.004","article-title":"Foreign body reaction to biomaterials","volume":"20","author":"Anderson","year":"2008","journal-title":"Semin. Immunol."},{"issue":"18","key":"10.1016\/j.intimp.2016.09.031_bb0020","doi-asserted-by":"crossref","first-page":"7260","DOI":"10.1073\/pnas.87.18.7260","article-title":"Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells","volume":"87","author":"Udagawa","year":"1990","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"5","key":"10.1016\/j.intimp.2016.09.031_bb0025","doi-asserted-by":"crossref","first-page":"575","DOI":"10.2106\/00004623-198365050-00001","article-title":"The synovial-like membrane at the bone-cement interface in loose total hip replacements and its proposed role in bone lysis","volume":"65","author":"Goldring","year":"1983","journal-title":"J. Bone Joint Surg."},{"issue":"4","key":"10.1016\/j.intimp.2016.09.031_bb0030","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/S0883-5403(05)80152-4","article-title":"Cellular mediators secreted by interfacial membranes obtained at revision total hip arthroplasty","volume":"10","author":"Shanbhag","year":"1995","journal-title":"J. Arthroplast."},{"key":"10.1016\/j.intimp.2016.09.031_bb0035","series-title":"Bone Research Protocols","first-page":"129","article-title":"Generating murine osteoclasts from bone marrow","author":"Takahashi","year":"2003"},{"issue":"6","key":"10.1016\/j.intimp.2016.09.031_bb0040","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1080\/15216540500137669","article-title":"RANKing intracellular signaling in osteoclasts","volume":"57","author":"Feng","year":"2005","journal-title":"IUBMB Life"},{"issue":"2","key":"10.1016\/j.intimp.2016.09.031_bb0045","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1055\/s-0028-1088368","article-title":"Protective effects of scutellarin against cerebral ischemia in rats: evidence for inhibition of the apoptosis-inducing factor pathway","volume":"75","author":"Zhang","year":"2009","journal-title":"Planta Med."},{"issue":"3","key":"10.1016\/j.intimp.2016.09.031_bb0050","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.phrs.2004.09.001","article-title":"Effect of scutellarin on nitric oxide production in early stages of neuron damage induced by hydrogen peroxide","volume":"51","author":"Liu","year":"2005","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.intimp.2016.09.031_bb0055","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.bbrc.2010.08.034","article-title":"Scutellarin promotes in vitro angiogenesis in human umbilical vein endothelial cells","volume":"400","author":"Huang","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.intimp.2016.09.031_bb0060","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1097\/FJC.0b013e3180cbd0e7","article-title":"Protective effects of scutellarin and breviscapine on brain and heart ischemia in rats","volume":"50","author":"Lin","year":"2007","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"3","key":"10.1016\/j.intimp.2016.09.031_bb0065","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1111\/j.1476-5381.2010.01070.x","article-title":"Scutellarin alleviates interstitial fibrosis and cardiac dysfunction of infarct rats by inhibiting TGF\u03b2 expression and activation of p38-MAPK and ERK1\/2","volume":"162","author":"Pan","year":"2011","journal-title":"Br. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.intimp.2016.09.031_bb0070","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1080\/10286020903347906","article-title":"Scutellarin protects against lipopolysaccharide-induced acute lung injury via inhibition of NF-$\\kappa$B activation in mice","volume":"12","author":"Tan","year":"2010","journal-title":"J. Asian Nat. Prod. Res."},{"issue":"06","key":"10.1016\/j.intimp.2016.09.031_bb0075","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1142\/S0192415X11009494","article-title":"Scutellarin attenuates human-neutrophil-elastase-induced mucus production by inhibiting the PKC-ERK signaling pathway in vitro and in vivo","volume":"39","author":"Jiang","year":"2011","journal-title":"Am. J. Chin. Med."},{"issue":"3","key":"10.1016\/j.intimp.2016.09.031_bb0080","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.bbrc.2012.12.051","article-title":"Sanguinarine inhibits osteoclast formation and bone resorption via suppressing RANKL-induced activation of NF-\u03baB and ERK signaling pathways","volume":"430","author":"Li","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.intimp.2016.09.031_bb0085","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1006\/jsre.2000.5949","article-title":"Hypericin and photodynamic therapy decreases human pancreatic cancer in vitro and in vivo","volume":"93","author":"Liu","year":"2000","journal-title":"J. Surg. Res."},{"issue":"5","key":"10.1016\/j.intimp.2016.09.031_bb0090","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1007\/s00223-007-9077-2","article-title":"Particle-induced osteolysis in three-dimensional micro-computed tomography","volume":"81","author":"Wedemeyer","year":"2007","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.intimp.2016.09.031_bb0095","series-title":"Guide for the Care and Use of Laboratory Animals","author":"Care IOLA","year":"1985"},{"issue":"4","key":"10.1016\/j.intimp.2016.09.031_bb0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0034132","article-title":"Prevention of wear particle-induced osteolysis by a novel V-ATPase inhibitor saliphenylhalamide through inhibition of osteoclast bone resorption","volume":"7","author":"Qin","year":"2012","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.intimp.2016.09.031_bb0105","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.bcp.2014.06.009","article-title":"Hypericin suppresses osteoclast formation and wear particle-induced osteolysis via modulating ERK signalling pathway","volume":"90","author":"Ouyang","year":"2014","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.intimp.2016.09.031_bb0110","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.1016\/S0092-8674(02)00703-1","article-title":"Missing pieces in the NF-\u03baB puzzle","volume":"109","author":"Ghosh","year":"2002","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.intimp.2016.09.031_bb0115","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1172\/JCI200419657","article-title":"Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation","volume":"114","author":"Ikeda","year":"2004","journal-title":"J. Clin. Invest."},{"issue":"42","key":"10.1016\/j.intimp.2016.09.031_bb0135","doi-asserted-by":"crossref","first-page":"35081","DOI":"10.1074\/jbc.C500353200","article-title":"Regulation of the transcriptional activity of c-Fos by ERK A novel role for the prolyl isomerase PIN1","volume":"280","author":"Monje","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.intimp.2016.09.031_bb0140","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.archoralbio.2004.11.016","article-title":"Osteoclast diseases and dental abnormalities","volume":"50","author":"Helfrich","year":"2005","journal-title":"Arch. Oral Biol."},{"issue":"1","key":"10.1016\/j.intimp.2016.09.031_bb0145","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.11607\/jomi.te40","article-title":"The deception and fallacies of sponsored randomized prospective double-blinded clinical trials: the bisphosphonate research example","volume":"29","author":"Marx","year":"2013","journal-title":"Int. J. Oral Maxillofac. Implants"},{"key":"10.1016\/j.intimp.2016.09.031_bb0150","author":"Hiligsmann"},{"issue":"4","key":"10.1016\/j.intimp.2016.09.031_bb0155","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1074\/jbc.M805280200","article-title":"Cathepsin K activity-dependent regulation of osteoclast actin ring formation and bone resorption","volume":"284","author":"Wilson","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"6937","key":"10.1016\/j.intimp.2016.09.031_bb0160","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"Boyle","year":"2003","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.intimp.2016.09.031_bb0165","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/j.1399-0004.2010.01619.x","article-title":"Bone resorption in syndromes of the Ras\/MAPK pathway","volume":"80","author":"Stevenson","year":"2011","journal-title":"Clin. Genet."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576916304052?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576916304052?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T20:55:36Z","timestamp":1536353736000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576916304052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":30,"alternative-id":["S1567576916304052"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2016.09.031","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Scutellarin inhibits RANKL-mediated osteoclastogenesis and titanium particle-induced osteolysis via suppression of NF-\u03baB and MAPK signaling pathway","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2016.09.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}