{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:36:47Z","timestamp":1790397407972,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003569","name":"Ministry of Food and Drug Safety","doi-asserted-by":"publisher","award":["16182MFD416"],"award-info":[{"award-number":["16182MFD416"]}],"id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.intimp.2016.12.021","type":"journal-article","created":{"date-parts":[[2016,12,22]],"date-time":"2016-12-22T21:53:49Z","timestamp":1482443629000},"page":"179-186","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Ponciretin attenuates ethanol-induced gastric damage in mice by inhibiting inflammatory responses"],"prefix":"10.1016","volume":"43","author":[{"given":"Geum-Dan","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2016.12.021_bb0005","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1159\/000090167","article-title":"Alcohol-related diseases of the esophagus and stomach","volume":"23","author":"Franke","year":"2005","journal-title":"Dig. Dis."},{"key":"10.1016\/j.intimp.2016.12.021_bb0010","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.1111\/j.1572-0241.2000.03347.x","article-title":"The effects of alcohol consumption upon the gastrointestinal tract","volume":"95","author":"Bujanda","year":"2000","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.intimp.2016.12.021_bb0015","first-page":"G462","article-title":"Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process","volume":"259","author":"Wallace","year":"1990","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.intimp.2016.12.021_bb0020","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1159\/000171159","article-title":"Effects of ethanol on the gastric mucosa","volume":"5","author":"Guslandi","year":"1987","journal-title":"Dig. Dis."},{"key":"10.1016\/j.intimp.2016.12.021_bb0025","doi-asserted-by":"crossref","first-page":"3831","DOI":"10.2174\/138161212802083707","article-title":"Molecular link mechanisms between inflammation and cancer","volume":"18","author":"Bendramini-Costa","year":"2012","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.intimp.2016.12.021_bb0030","first-page":"9","article-title":"Recent advances in biological therapy for inflammatory bowel disease","volume":"25","author":"Kurtovic","year":"2004","journal-title":"Trop. Gastroenterol."},{"key":"10.1016\/j.intimp.2016.12.021_bb0035","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1006\/cyto.2000.0715","article-title":"Influence of acute alcohol intake and alcohol withdrawal on circulating levels of IL-6, IL-8, IL-10 and IL-12","volume":"12","author":"Gonzalez-Quintela","year":"2000","journal-title":"Cytokine"},{"key":"10.1016\/j.intimp.2016.12.021_bb0040","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1111\/j.1440-1746.2008.05333.x","article-title":"Artemisia asiatica extracts protect against ethanol-induced injury in gastric mucosa of rats","volume":"23","author":"Park","year":"2008","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.intimp.2016.12.021_bb0045","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2174\/0929867013373723","article-title":"Biological properties of citrus flavonoids pertaining to cancer and inflammation","volume":"8","author":"Manthey","year":"2001","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.intimp.2016.12.021_bb0050","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1248\/bpb.30.2345","article-title":"Inhibition of LPS-induced iNOS, COX-2 and cytokines expression by poncirin through the NF-\u03baB inactivation in raw 264.7 macrophage cells","volume":"30","author":"Kim","year":"2007","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.intimp.2016.12.021_bb0055","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1002\/ptr.2840","article-title":"Protective effects of neohesperidin and poncirin isolated from the fruits of Poncirus trifoliata on potential gastric disease","volume":"23","author":"Lee","year":"2009","journal-title":"Phytother. Res."},{"key":"10.1016\/j.intimp.2016.12.021_bb0060","doi-asserted-by":"crossref","first-page":"8684","DOI":"10.3390\/ijms14058684","article-title":"Characterization, purification of Poncirin from edible citrus Ougan (citrus reticulate cv. Suavissima) and its growth inhibitory effect on human gastric cancer cells SGC-7901","volume":"14","author":"Zhu","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2016.12.021_bb0065","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s00774-012-0350-8","article-title":"Poncirin prevents bone loss in glucocorticoid-induced osteoporosis in vivo and in vitro","volume":"30","author":"Yoon","year":"2012","journal-title":"J. Bone Miner. Metab."},{"key":"10.1016\/j.intimp.2016.12.021_bb0070","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jep.2016.05.044","article-title":"Poncirin and its metabolite ponciretin attenuate colitis in mice by inhibiting LPS binding on TLR4 of macrophages and correcting Th17\/Treg imbalance","volume":"189","author":"Kang","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2016.12.021_bb0075","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1055\/s-2005-837746","article-title":"Passive cutaneous anaphylaxis-inhibitory activity of flavanones from Citrus unshiu and Poncirus trifoliata","volume":"71","author":"Park","year":"2005","journal-title":"Planta Med."},{"key":"10.1016\/j.intimp.2016.12.021_bb0080","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1055\/s-2006-960805","article-title":"In vitro anti-Helicobacter pylori activity of some flavonoids and their metabolites","volume":"65","author":"Bae","year":"1999","journal-title":"Planta Med."},{"key":"10.1016\/j.intimp.2016.12.021_bb0085","doi-asserted-by":"crossref","first-page":"13260","DOI":"10.3390\/molecules181113260","article-title":"Isosakuranetin-5-O-rutinoside: a new flavanone with antidepressant activity isolated from Salvia elegans Vahl","volume":"18","author":"Gonz\u00e1lez-Cortazar","year":"2013","journal-title":"Molecules"},{"key":"10.1016\/j.intimp.2016.12.021_bb0090","article-title":"Irisolidone attenuates ethanol-induced gastric injury in mice by inhibiting the infiltration of neutrophils","author":"Kang","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.intimp.2016.12.021_bb0095","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1046\/j.1365-2036.1999.00476.x","article-title":"Mouse model of Helicobacter pylori infection: studies of gastric function and ulcer healing","volume":"13","author":"Konturek","year":"1999","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.intimp.2016.12.021_bb0100","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.intimp.2014.04.021","article-title":"Lactobacillus plantarum CLP-0611 ameliorates colitis in mice by polarizing M1 to M2-like macrophages","volume":"21","author":"Jang","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2016.12.021_bb0105","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.phymed.2016.01.002","article-title":"Neomangiferin modulates the Th17\/Treg balance and ameliorates colitis in mice","volume":"23","author":"Lim","year":"2016","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2016.12.021_bb0110","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.intimp.2016.03.004","article-title":"Mangiferin corrects the imbalance of Th17\/Treg cells in mice with TNBS-induced colitis","volume":"34","author":"Lim","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2016.12.021_bb0115","doi-asserted-by":"crossref","first-page":"684","DOI":"10.3109\/00365521.2011.560678","article-title":"Klebsiella pneumoniae increases the risk of inflammation and colitis in a murine model of intestinal bowel disease","volume":"46","author":"Lee","year":"2011","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.intimp.2016.12.021_bb0120","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.cellimm.2012.10.001","article-title":"Kalopanaxsaponin B inhibits LPS-induced inflammation by inhibiting IRAK1 kinase","volume":"279","author":"Joh","year":"2012","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.intimp.2016.12.021_bb0125","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/0006-291X(83)91627-3","article-title":"Differential distribution of distinct forms of myeloperoxidase in different azurophilic granule subpopulations from human neutrophils","volume":"114","author":"Kinkade","year":"1983","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2016.12.021_bb0130","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1248\/bpb.22.422","article-title":"Anti-helicobacter pylori activity of the metabolites of poncirin from Poncirus trifoliata by human intestinal bacteria","volume":"22","author":"Kim","year":"1999","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.intimp.2016.12.021_bb0135","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201600517","article-title":"Irisolidone attenuates ethanol-induced gastric injury in mice by inhibiting the infiltration of neutrophils","author":"Kang","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.intimp.2016.12.021_bb0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0071762","article-title":"Ellagitannins from Rubus berries for the control of gastric inflammation: in vitro and in vivo studies","volume":"8","author":"Sangiovanni","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2016.12.021_bb0145","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.mrfmmm.2005.03.027","article-title":"Protective effects of green tea polyphenol extracts against ethanol-induced gastric mucosal damages in rats: stress-responsive transcription factors and MAP kinases as potential targets","volume":"579","author":"Lee","year":"2005","journal-title":"Mutat. Res."},{"key":"10.1016\/j.intimp.2016.12.021_bb0150","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.jep.2013.12.009","article-title":"Src are major pharmacological targets of a Cerbera manghas methanol extract with kaempferol-based anti-inflammatory activity","volume":"151","author":"Jeong","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2016.12.021_bb0155","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1023\/B:DDAS.0000020490.34220.6d","article-title":"Preventive effect of the flavonoid, wogonin, against ethanol-induced gastric mucosal damage in rats","volume":"49","author":"Park","year":"2004","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.intimp.2016.12.021_bb0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0076894","article-title":"Role of an indole-thiazolidine molecule PPAR pan-agonist and COX inhibitor on inflammation and microcirculatory damage in acute gastric lesions","volume":"8","author":"Santin","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2016.12.021_bb0165","doi-asserted-by":"crossref","first-page":"5462","DOI":"10.1016\/j.bmcl.2010.07.094","article-title":"Identification of 3',4',5'-trimethoxychalcone analogues as potent inhibitors of helicobacter pylori-induced inflammation in human gastric epithelial cells","volume":"20","author":"Lai","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.intimp.2016.12.021_bb0170","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1007\/s12272-011-0915-4","article-title":"The effect of quercetin-3-O-\u03b2-D-glucuronopyranoside on indomethacin-induced gastric damage in rats via induction of mucus secretion and down-regulation of ICAM-1 expression","volume":"34","author":"Yan","year":"2011","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.intimp.2016.12.021_bb0175","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.bbagen.2015.01.008","article-title":"Morin protects gastric mucosa from nonsteroidal anti-inflammatory drug, indomethacin induced inflammatory damage and apoptosis by modulating NF-\u03baB pathway","volume":"1850","author":"Sinha","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.intimp.2016.12.021_bb0180","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/j.1083-4389.2004.00281.x","article-title":"Protective mechanism of epigallocatechin-3-gallate against helicobacter pylori-induced gastric epithelial cytotoxicity via the blockage of TLR-4 signaling","volume":"9","author":"Lee","year":"2004","journal-title":"Helicobacter"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576916305227?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576916305227?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T17:51:44Z","timestamp":1536169904000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576916305227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":36,"alternative-id":["S1567576916305227"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2016.12.021","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ponciretin attenuates ethanol-induced gastric damage in mice by inhibiting inflammatory responses","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2016.12.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}