{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T21:02:30Z","timestamp":1792184550655,"version":"4.4.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"JSPS","award":["23602012"],"award-info":[{"award-number":["23602012"]}]},{"name":"JSPS","award":["26460239"],"award-info":[{"award-number":["26460239"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.intimp.2017.01.016","type":"journal-article","created":{"date-parts":[[2017,1,19]],"date-time":"2017-01-19T03:04:33Z","timestamp":1484795073000},"page":"174-182","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":116,"special_numbering":"C","title":["Curcumin ameliorates liver damage and progression of NASH in NASH-HCC mouse model possibly by modulating HMGB1-NF-\u03baB translocation"],"prefix":"10.1016","volume":"44","author":[{"given":"Rejina","family":"Afrin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somasundaram","family":"Arumugam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azizur","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mir Imam Ibne","family":"Wahed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vengadeshprabhu","family":"Karuppagounder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meilei","family":"Harima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizuka","family":"Miyashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Yoneyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyuki","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2017.01.016_bb0005","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1586\/egh.09.35","article-title":"Hepatocellular carcinoma: current trends in worldwide epidemiology, risk factors, diagnosis and therapeutics","volume":"3","author":"Shariff","year":"2009","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.intimp.2017.01.016_bb0010","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/hep.26248","article-title":"Maternal obesity programs offspring nonalcoholic fatty liver disease by innate immune dysfunction in mice","volume":"58","author":"Mouralidarane","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2017.01.016_bb0015","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1002\/ijc.25797","article-title":"Non-alcoholic fatty liver disease progresses to hepatocellular carcinoma in the absence of apparent cirrhosis","volume":"128","author":"Ertle","year":"2011","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.intimp.2017.01.016_bb0020","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s00795-013-0016-1","article-title":"A murine model for non-alcoholic steatohepatitis showing evidence of association between diabetes and hepatocellular carcinoma","volume":"46","author":"Fujii","year":"2013","journal-title":"Med. Mol. Morphol."},{"key":"10.1016\/j.intimp.2017.01.016_bb0025","doi-asserted-by":"crossref","first-page":"149","DOI":"10.5009\/gnl.2012.6.2.149","article-title":"NASH is an inflammatory disorder: pathogenic, prognostic and therapeutic implications","volume":"6","author":"Farrell","year":"2012","journal-title":"Gut Liver"},{"key":"10.1016\/j.intimp.2017.01.016_bb0030","series-title":"Immunity, Inflammation, and Cancer","author":"Grivennikov","year":"2010"},{"key":"10.1016\/j.intimp.2017.01.016_bb0035","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1146\/annurev.immunol.021908.132603","article-title":"HMGB1 and RAGE in inflammation and cancer","volume":"28","author":"Sims","year":"2010","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.intimp.2017.01.016_bb0040","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.molimm.2004.07.023","article-title":"Monocytes promote natural killer cell interferon gamma production in response to the endogenous danger signal HMGB1","volume":"42","author":"DeMarco","year":"2005","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.intimp.2017.01.016_bb0045","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nature00858","article-title":"Release of chromatin protein HMGB1 by necrotic cells triggers inflammation","volume":"418","author":"Scaffidi","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2017.01.016_bb0050","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1084\/jem.20070247","article-title":"HMGB1 release induced by liver ischemia involves Toll-like receptor 4 dependent reactive oxygen species production and calcium-mediated signaling","volume":"204","author":"Tsung","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.intimp.2017.01.016_bb0055","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1084\/jem.20042614","article-title":"The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion","volume":"0","author":"Tsung","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.intimp.2017.01.016_bb0060","doi-asserted-by":"crossref","first-page":"186","DOI":"10.3164\/jcbn.14-75","article-title":"Pruni cortex ameliorates skin inflammation possibly through HMGB1-NF\u03baB pathway in house dust mite induced atopic dermatitis NC\/Nga transgenic mice","volume":"56","author":"Watanabe","year":"2015","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.intimp.2017.01.016_bb0065","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/exd.12685","article-title":"Modulation of HMGB1 translocation and RAGE\/NF\u03baB cascade by quercetin treatment mitigates atopic dermatitis in NC\/Nga transgenic mice","volume":"24","author":"Karuppagounder","year":"2015","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.intimp.2017.01.016_bb0070","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1053\/j.gastro.2005.09.004","article-title":"NF-kappaB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis","volume":"129","author":"Dela Pe\u00f1a","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.intimp.2017.01.016_bb0075","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1158\/0008-5472.CAN-14-2147","article-title":"High-mobility group box 1 promotes hepatocellular carcinoma progression through miR-21-mediated matrix metalloproteinase activity","volume":"75","author":"Chen","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.intimp.2017.01.016_bb0080","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1186\/1472-6882-14-457","article-title":"Immunohistochemical and molecular study on the protective effect of curcumin against hepatic toxicity induced by paracetamol in Wistar rats","volume":"14","author":"Soliman","year":"2014","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.intimp.2017.01.016_bb0085","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1124\/mol.107.039818","article-title":"Curcumin protects the rat liver from CCl4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation","volume":"73","author":"Fu","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.intimp.2017.01.016_bb0090","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3109\/10715762.2014.999674","article-title":"Curcumin ameliorates streptozotocin-induced liver damage through modulation of endoplasmic reticulum stress-mediated apoptosis in diabetic rats","volume":"49","author":"Afrin","year":"2015","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.intimp.2017.01.016_bb0095","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.jhep.2015.04.018","article-title":"Curcumin effectively inhibits oncogenic NF-\u03baB signaling and restrains stemness features in liver cancer","volume":"63","author":"Marquardt","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.intimp.2017.01.016_bb0100","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.intimp.2014.12.005","article-title":"Curcumin attenuated acute Propionibacterium acnes-induced liver injury through inhibition of HMGB1 expression in mice","volume":"24","author":"Gu","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2017.01.016_bb0105","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1016\/j.fct.2012.05.050","article-title":"Protective effects of curcumin against hepatic fibrosis induced by carbon tetrachloride: modulation of high-mobility group box 1, Toll-like receptor 4 and 2 expression","volume":"50","author":"Tu","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.intimp.2017.01.016_bb0110","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ejphar.2012.09.050","article-title":"Curcumin inhibits HMGB1 releasing and attenuates concanavalin A-induced hepatitis in mice","volume":"697","author":"Wang","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2017.01.016_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0115922","article-title":"Establishment of a general NAFLD scoring system for rodent models and comparison to human liver pathology","volume":"9","author":"Liang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2017.01.016_bb0120","author":"Lillie"},{"key":"10.1016\/j.intimp.2017.01.016_bb0125","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1002\/mnfr.201200540","article-title":"Curcumin alleviates oxidative stress, inflammation, and renal fibrosis in remnant kidney through the Nrf2-keap1 pathway","volume":"57","author":"Soetikno","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.intimp.2017.01.016_bb0130","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.jhep.2010.04.037","article-title":"Characterization of two F4\/80-positive Kupffer cell subsets by their function and phenotype in mice","volume":"53","author":"Kinoshita","year":"2010","journal-title":"J. Hepatol."},{"key":"10.1016\/j.intimp.2017.01.016_bb0135","doi-asserted-by":"crossref","first-page":"12633","DOI":"10.1074\/jbc.275.17.12633","article-title":"Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-kappa B through an increased production of intracellular reactive oxygen species","volume":"275","author":"Cominacini","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2017.01.016_bb0140","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1111\/j.1440-1746.2008.05543.x","article-title":"Animal models of NASH: getting both pathology and metabolic context right","volume":"23","author":"Larter","year":"2008","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.intimp.2017.01.016_bb0145","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/ajg.2009.715","article-title":"Diabetes and hepatocellular carcinoma: what role does diabetes have in the presence of other known risk factors?","volume":"105","author":"Davila","year":"2010","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.intimp.2017.01.016_bb0150","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1472-6882-6-10","article-title":"Dose escalation of a curcuminoid formulation","volume":"6","author":"Lao","year":"2006","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.intimp.2017.01.016_bb0155","doi-asserted-by":"crossref","first-page":"G433","DOI":"10.1152\/ajpgi.00163.2009","article-title":"Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice","volume":"300","author":"Csak","year":"2011","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.intimp.2017.01.016_bb0160","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.chembiol.2007.03.007","article-title":"Glycyrrhizin binds to high-mobility group box 1 protein and inhibits its cytokine activities","volume":"14","author":"Mollica","year":"2007","journal-title":"Chem. Biol."},{"key":"10.1016\/j.intimp.2017.01.016_bb0165","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10620-006-3177-0","article-title":"A long-term glycyrrhizin injection therapy reduces hepatocellular carcinogenesis rate in patients with interferon-resistant active chronic hepatitis C: a cohort study of 1249 patients","volume":"51","author":"Ikeda","year":"2006","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.intimp.2017.01.016_bb0170","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/carcin\/20.1.59","article-title":"Inhibition of hepatocellular carcinoma by glycyrrhizin in diethylnitrosamine-treated mice","volume":"20","author":"Shiota","year":"1999","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.intimp.2017.01.016_bb0175","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.4049\/jimmunol.170.7.3890","article-title":"IFN-gamma induces high mobility group box 1 protein release partly through a TNF-dependent mechanism","volume":"170","author":"Rendon-Mitchell","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2017.01.016_bb0180","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1126\/science.285.5425.248","article-title":"HMG-1 as a late mediator of endotoxin lethality in mice","volume":"285","author":"Wang","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.intimp.2017.01.016_bb0185","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nrgastro.2013.183","article-title":"NAFLD, NASH and liver cancer","volume":"10","author":"Michelotti","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.intimp.2017.01.016_bb0190","doi-asserted-by":"crossref","first-page":"S54","DOI":"10.1002\/hep.21060","article-title":"The liver as an immunological organ","volume":"43","author":"Racanelli","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2017.01.016_bb0195","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.bbrc.2005.08.070","article-title":"Increased expression of PPARgamma in high fat diet-induced liver steatosis in mice","volume":"336","author":"Inoue","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2017.01.016_bb0200","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1002\/hep.25880","article-title":"Analysis of the role of hepatic PPAR\u03b3 expression during mouse liver regeneration","volume":"56","author":"Gazit","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2017.01.016_bb0205","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1089\/ars.2010.3356","article-title":"High-mobility group box 1, oxidative stress, and disease","volume":"14","author":"Tang","year":"2016","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.intimp.2017.01.016_bb0210","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1007\/s10753-013-9704-1","article-title":"High mobility group box 1 (HMGB1) mediates high-glucose-induced calcification in vascular smooth muscle cells of saphenous veins","volume":"36","author":"Wang","year":"2013","journal-title":"Inflammation"},{"key":"10.1016\/j.intimp.2017.01.016_bb0215","article-title":"Liver injury attenuation by curcumin in a rat NASH model: an Nrf2 activation-mediated effect?","author":"Li","year":"2014","journal-title":"Ir. J. Med. Sci."},{"key":"10.1016\/j.intimp.2017.01.016_bb0220","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/j.freeradbiomed.2010.09.006","article-title":"Oxidative stress, inflammation, and cancer: how are they linked?","volume":"49","author":"Reuter","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.intimp.2017.01.016_bb0225","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1172\/JCI117857","article-title":"Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis","volume":"95","author":"Warren","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.intimp.2017.01.016_bb0230","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0016-5085(03)00689-9","article-title":"Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma","volume":"125","author":"Capurro","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.intimp.2017.01.016_bb0235","first-page":"299","article-title":"Significance of des-gamma-carboxy prothrombin production in hepatocellular carcinoma","volume":"63","author":"Fujikawa","year":"2009","journal-title":"Acta Med. Okayama"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576917300243?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576917300243?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T00:58:32Z","timestamp":1536109112000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576917300243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":47,"alternative-id":["S1567576917300243"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2017.01.016","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Curcumin ameliorates liver damage and progression of NASH in NASH-HCC mouse model possibly by modulating HMGB1-NF-\u03baB translocation","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2017.01.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}