{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:13:08Z","timestamp":1777389188214,"version":"3.51.4"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81072241"],"award-info":[{"award-number":["81072241"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11635014"],"award-info":[{"award-number":["11635014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31670861"],"award-info":[{"award-number":["31670861"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"military youth funding","award":["15QPN053"],"award-info":[{"award-number":["15QPN053"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1016\/j.intimp.2017.03.013","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T07:46:25Z","timestamp":1489477585000},"page":"178-185","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Radiation-induced decrease of CD8 + dendritic cells contributes to Th1\/Th2 shift"],"prefix":"10.1016","volume":"46","author":[{"given":"Hu","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bailong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojing","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifeng","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qun","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianming","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianguo","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanyong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.intimp.2017.03.013_bb0005","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1093\/jnci\/djs629","article-title":"Combining radiotherapy and cancer immunotherapy: a paradigm shift","volume":"105","author":"Formenti","year":"2013","journal-title":"J. Natl. Cancer Inst."},{"issue":"3 Pt 2","key":"10.1016\/j.intimp.2017.03.013_bb0010","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1038\/jid.2011.411","article-title":"Ionizing radiation: the good, the bad, and the ugly","volume":"132","author":"Ryan","year":"2012","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.intimp.2017.03.013_bb0015","series-title":"Effects of Ionizing Radiation on Immune System, UNSCEAR Reports 2006","author":"UNSCEAR","year":"2006"},{"issue":"6673","key":"10.1016\/j.intimp.2017.03.013_bb0020","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/32588","article-title":"Dendritic cells and the control of immunity","volume":"392","author":"Banchereau","year":"1998","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.intimp.2017.03.013_bb0025","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1038\/nri3712","article-title":"Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny","volume":"14","author":"Guilliams","year":"2014","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2017.03.013_bb0030","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1111\/j.1365-2567.2011.03457.x","article-title":"Complexity of dendritic cell subsets and their function in the host immune system","volume":"133","author":"Kushwah","year":"2011","journal-title":"Immunology"},{"issue":"11","key":"10.1016\/j.intimp.2017.03.013_bb0035","doi-asserted-by":"publisher","first-page":"6037","DOI":"10.4049\/jimmunol.165.11.6037","article-title":"BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood","volume":"165","author":"Dzionek","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2017.03.013_bb0040","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1111\/nyas.12113","article-title":"Human dendritic cells subsets as targets and vectors for therapy","volume":"1284","author":"Klechevsky","year":"2013","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"6","key":"10.1016\/j.intimp.2017.03.013_bb0045","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1084\/jem.20092618","article-title":"Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cells","volume":"207","author":"Poulin","year":"2010","journal-title":"J. Exp. Med."},{"issue":"3","key":"10.1016\/j.intimp.2017.03.013_bb0050","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1111\/j.1365-2249.2007.03576.x","article-title":"BDCA-1+, BDCA-2+ and BDCA-3+ dendritic cells in early human pregnancy decidua","volume":"151","author":"Ban","year":"2008","journal-title":"Clin. Exp. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2017.03.013_bb0055","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/nri746","article-title":"Mouse and human dendritic cell subtypes","volume":"2","author":"Shortman","year":"2002","journal-title":"Nat. Rev. Immunol."},{"issue":"9","key":"10.1016\/j.intimp.2017.03.013_bb0060","doi-asserted-by":"publisher","first-page":"4247","DOI":"10.4049\/jimmunol.1201371","article-title":"Exposure to ionizing radiation induces the migration of cutaneous dendritic cells by a CCR7-dependent mechanism","volume":"189","author":"Cummings","year":"2012","journal-title":"J. Immunol."},{"issue":"8","key":"10.1016\/j.intimp.2017.03.013_bb0065","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1038\/sj.bjc.6602518","article-title":"Immunosuppressive effects of radiation on human dendritic cells: reduced IL-12 production on activation and impairment of naive T-cell priming","volume":"92","author":"Merrick","year":"2005","journal-title":"Br. J. Cancer"},{"issue":"2","key":"10.1016\/j.intimp.2017.03.013_bb0070","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1111\/j.1365-2567.2004.01872.x","article-title":"Irradiation up-regulates CD80 expression through two different mechanisms in spleen B cells, B lymphoma cells, and dendritic cells","volume":"112","author":"Torihata","year":"2004","journal-title":"Immunology"},{"issue":"3","key":"10.1016\/j.intimp.2017.03.013_bb0075","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1073\/pnas.96.3.1036","article-title":"Distinct dendritic cell subsets differentially regulate the class of immune response in vivo","volume":"96","author":"Pulendran","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.intimp.2017.03.013_bb0080","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/79734","article-title":"Dendritic cell regulation of TH1-TH2 development","volume":"1","author":"Moser","year":"2000","journal-title":"Nat. Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2017.03.013_bb0085","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.4049\/jimmunol.167.4.1982","article-title":"CD8- dendritic cell activation status plays an integral role in influencing Th2 response development","volume":"167","author":"MacDonald","year":"2001","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2017.03.013_bb0090","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1080\/09553000500077088","article-title":"Factors effecting the Th2-like immune response after gamma-irradiation: low production of IL-12 heterodimer in antigen-presenting cells and small expression of the IL-12 receptor in T cells","volume":"81","author":"Park","year":"2005","journal-title":"Int. J. Radiat. Biol."},{"issue":"1","key":"10.1016\/j.intimp.2017.03.013_bb0095","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cellimm.2010.10.004","article-title":"Lasting effects of an impairment of Th1-like immune response in gamma-irradiated mice: a resemblance between irradiated mice and aged mice","volume":"267","author":"Park","year":"2011","journal-title":"Cell. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2017.03.013_bb0100","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/09553000701616106","article-title":"Long-lasting alterations of the immune system by ionizing radiation exposure: implications for disease development among atomic bomb survivors","volume":"84","author":"Kusunoki","year":"2008","journal-title":"Int. J. Radiat. Biol."},{"issue":"7","key":"10.1016\/j.intimp.2017.03.013_bb0105","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.1007\/s00216-012-6614-2","article-title":"Correction of peripheral blood mononuclear cell cytosolic protein for hemoglobin contamination","volume":"405","author":"Pluim","year":"2013","journal-title":"Anal. Bioanal. Chem."},{"issue":"2","key":"10.1016\/j.intimp.2017.03.013_bb0110","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1089\/ten.tec.2014.0187","article-title":"Formation of osteoclasts on calcium phosphate bone cements and polystyrene depends on monocyte isolation conditions","volume":"21","author":"Bernhardt","year":"2015","journal-title":"Tissue Eng. Part C Methods"},{"issue":"6","key":"10.1016\/j.intimp.2017.03.013_bb0115","first-page":"515","article-title":"Radioprotective effects of flk2\/flt3 ligand","volume":"26","author":"Hudak","year":"1998","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.intimp.2017.03.013_bb0120","doi-asserted-by":"crossref","first-page":"1181.3","DOI":"10.1096\/fasebj.27.1_supplement.1181.3","article-title":"Radioprotective and Radiomitigative efficacy of Flt3 ligand in a murine model of acute radiation injury","volume":"27","author":"Thomas","year":"2013","journal-title":"FASEB J."},{"issue":"2","key":"10.1016\/j.intimp.2017.03.013_bb0125","doi-asserted-by":"publisher","first-page":"168","DOI":"10.7150\/ijbs.7.168","article-title":"Gamma-ray irradiation impairs dendritic cell migration to CCL19 by down-regulation of CCR7 and induction of cell apoptosis","volume":"7","author":"Liu","year":"2011","journal-title":"Int. J. Biol. Sci."},{"issue":"4","key":"10.1016\/j.intimp.2017.03.013_bb0130","doi-asserted-by":"publisher","first-page":"BR144","DOI":"10.12659\/MSM.882616","article-title":"Hydrogen-rich saline protects immunocytes from radiation-induced apoptosis","volume":"18","author":"Yang","year":"2012","journal-title":"Med. Sci. Monit."},{"issue":"5","key":"10.1016\/j.intimp.2017.03.013_bb0135","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1111\/jcmm.12245","article-title":"Protective effect of hydrogen-rich saline against radiation-induced immune dysfunction","volume":"18","author":"Zhao","year":"2014","journal-title":"J. Cell. Mol. Med."},{"issue":"3","key":"10.1016\/j.intimp.2017.03.013_bb0140","doi-asserted-by":"publisher","first-page":"e91319","DOI":"10.1371\/journal.pone.0091319","article-title":"DNA-damage foci to detect and characterize DNA repair alterations in children treated for pediatric malignancies","volume":"9","author":"Schuler","year":"2014","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.intimp.2017.03.013_bb0145","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1182\/blood.V95.11.3489","article-title":"Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells","volume":"95","author":"McKenna","year":"2000","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.intimp.2017.03.013_bb0150","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/j.0105-2896.2009.00870.x","article-title":"The CD8+ dendritic cell subset","volume":"234","author":"Shortman","year":"2010","journal-title":"Immunol. Rev."},{"issue":"1","key":"10.1016\/j.intimp.2017.03.013_bb0155","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1159\/000350136","article-title":"Whole body irradiation induces cutaneous dendritic cells depletion via NF-kappaB activation","volume":"32","author":"Yang","year":"2013","journal-title":"Cell. Physiol. Biochem."},{"issue":"6","key":"10.1016\/j.intimp.2017.03.013_bb0160","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1084\/jem.20100985","article-title":"Found in translation: the human equivalent of mouse CD8+ dendritic cells","volume":"207","author":"Villadangos","year":"2010","journal-title":"J. Exp. Med."},{"issue":"10","key":"10.1016\/j.intimp.2017.03.013_bb0165","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/S0167-5699(00)01712-6","article-title":"Transcriptional regulation of Th1\/Th2 polarization","volume":"21","author":"Rengarajan","year":"2000","journal-title":"Immunol. Today"},{"issue":"34","key":"10.1016\/j.intimp.2017.03.013_bb0170","doi-asserted-by":"publisher","first-page":"21597","DOI":"10.1074\/jbc.272.34.21597","article-title":"Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene","volume":"272","author":"Zhang","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.intimp.2017.03.013_bb0175","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1016\/j.immuni.2012.09.007","article-title":"The transcription factor T-bet is induced by multiple pathways and prevents an endogenous Th2 cell program during Th1 cell responses","volume":"37","author":"Zhu","year":"2012","journal-title":"Immunity"},{"issue":"12","key":"10.1016\/j.intimp.2017.03.013_bb0180","doi-asserted-by":"publisher","first-page":"7732","DOI":"10.4049\/jimmunol.0902707","article-title":"Langerin+ CD8alpha+ dendritic cells are critical for cross-priming and IL-12 production in response to systemic antigens","volume":"183","author":"Farrand","year":"2009","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2017.03.013_bb0185","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.4049\/jimmunol.167.3.1423","article-title":"IL-12 induction by a TH1-inducing adjuvant in vivo: dendritic cell subsets and regulation by IL-10","volume":"167","author":"Huang","year":"2001","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2017.03.013_bb0190","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1667\/RR3340","article-title":"Radiation-induced increase in plasma Flt3 ligand concentration in mice: evidence for the implication of several cell types","volume":"163","author":"Prat","year":"2005","journal-title":"Radiat. Res."},{"issue":"8","key":"10.1016\/j.intimp.2017.03.013_bb0195","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1080\/09553000802029928","article-title":"Bone marrow stromal cells spontaneously produce Flt3-ligand: influence of ionizing radiations and cytokine stimulation","volume":"84","author":"Bertho","year":"2008","journal-title":"Int. J. Radiat. Biol."},{"issue":"3","key":"10.1016\/j.intimp.2017.03.013_bb0200","doi-asserted-by":"publisher","first-page":"e58558","DOI":"10.1371\/journal.pone.0058558","article-title":"Correlation of plasma FL expression with bone marrow irradiation dose","volume":"8","author":"Sproull","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.intimp.2017.03.013_bb0205","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/S0360-3016(03)00584-4","article-title":"Plasma Flt-3 ligand concentration correlated with radiation-induced bone marrow damage during local fractionated radiotherapy","volume":"57","author":"Huchet","year":"2003","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"6","key":"10.1016\/j.intimp.2017.03.013_bb0210","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1080\/09553000110043711","article-title":"Level of Flt3-ligand in plasma: a possible new bio-indicator for radiation-induced aplasia","volume":"77","author":"Bertho","year":"2001","journal-title":"Int. J. Radiat. Biol."},{"issue":"4","key":"10.1016\/j.intimp.2017.03.013_bb0215","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1084\/jem.181.4.1357","article-title":"The FLT3 ligand potently and directly stimulates the growth and expansion of primitive murine bone marrow progenitor cells in vitro: synergistic interactions with interleukin (IL) 11, IL-12, and other hematopoietic growth factors","volume":"181","author":"Jacobsen","year":"1995","journal-title":"J. Exp. Med."},{"issue":"6","key":"10.1016\/j.intimp.2017.03.013_bb0220","doi-asserted-by":"publisher","first-page":"3666","DOI":"10.4049\/jimmunol.1001934","article-title":"IL-10 controls cystatin C synthesis and blood concentration in response to inflammation through regulation of IFN regulatory factor 8 expression","volume":"186","author":"Xu","year":"2011","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2017.03.013_bb0225","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/j.immuni.2014.04.016","article-title":"Development and function of dendritic cell subsets","volume":"40","author":"Mildner","year":"2014","journal-title":"Immunity"},{"issue":"7","key":"10.1016\/j.intimp.2017.03.013_bb0230","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1038\/nri1127","article-title":"Origin, precursors and differentiation of mouse dendritic cells","volume":"3","author":"Ardavin","year":"2003","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2017.03.013_bb0235","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1182\/blood.V99.3.999","article-title":"CD8\u03b1+ dendritic cells originate from the CD8\u03b1\u2212 dendritic cell subset by a maturation process involving CD8\u03b1, DEC-205, and CD24 up-regulation","volume":"99","author":"del Hoyo","year":"2002","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.intimp.2017.03.013_bb0240","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1182\/blood-2002-10-3186","article-title":"CD8\u03b1+ mouse spleen dendritic cells do not originate from the CD8\u03b1-dendritic cell subset","volume":"102","author":"Naik","year":"2003","journal-title":"Blood"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576917301030?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576917301030?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T00:05:31Z","timestamp":1658793931000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576917301030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":48,"alternative-id":["S1567576917301030"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2017.03.013","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Radiation-induced decrease of CD8+ dendritic cells contributes to Th1\/Th2 shift","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2017.03.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}