{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T03:32:42Z","timestamp":1788406362521,"version":"build-2803163510"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Research Foundation of the Education Bureau of Heibei Province","award":["QN20131046"],"award-info":[{"award-number":["QN20131046"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31401003"],"award-info":[{"award-number":["31401003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Foundation of Administration of Traditional Chinese Medicine of Hebei Province, China","award":["20172017022"],"award-info":[{"award-number":["20172017022"]}]},{"name":"Youth Foundation of Hebei University of Chinese Medicine","award":["QNZ2015003"],"award-info":[{"award-number":["QNZ2015003"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.intimp.2017.03.027","type":"journal-article","created":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T20:03:48Z","timestamp":1491077028000},"page":"95-105","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":62,"special_numbering":"C","title":["Multi-targeted protection of acetaminophen-induced hepatotoxicity in mice by tannic acid"],"prefix":"10.1016","volume":"47","author":[{"given":"Jianping","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiongtao","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenghua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2017.03.027_bb0005","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1002\/hep.20948","article-title":"Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study","volume":"42","author":"Larson","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2017.03.027_bb0010","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.phymed.2009.07.011","article-title":"Acanthoic acid, a diterpene in Acanthopanax koreanum, protects acetaminophen-induced hepatic toxicity in mice","volume":"17","author":"Wu","year":"2010","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2017.03.027_bb0015","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0378-4274(03)00239-X","article-title":"The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity","volume":"144","author":"Jaeschke","year":"2003","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.intimp.2017.03.027_bb0020","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/mutage\/12.4.297","article-title":"Inhibition of the genotoxic effects of heterocyclic amines in human derived hepatoma cells by dietary bioantimutagens","volume":"12","author":"Sanyal","year":"1997","journal-title":"Mutagenesis"},{"key":"10.1016\/j.intimp.2017.03.027_bb0025","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1749-6632.2002.tb02937.x","article-title":"The cardioprotective effect of wine on human blood chemistry","volume":"957","author":"van Velden","year":"2002","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.intimp.2017.03.027_bb0030","doi-asserted-by":"crossref","first-page":"3164","DOI":"10.1021\/jf001378j","article-title":"White wine with red wine-like properties: increased extraction of grape skin polyphenols improves the antioxidant capacity of the derived white wine","volume":"49","author":"Fuhrman","year":"2001","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.intimp.2017.03.027_bb0035","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1111\/j.1478-3231.2008.01776.x","article-title":"Green tea consumption and liver disease: a systematic review","volume":"28","author":"Jin","year":"2008","journal-title":"Liver Int."},{"key":"10.1016\/j.intimp.2017.03.027_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0278-6915(99)00114-3","article-title":"Mutagenicity and antimutagenicity studies of tannic acid and its related compounds","volume":"38","author":"Chen","year":"2000","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.intimp.2017.03.027_bb0045","first-page":"5784","article-title":"Effect of dietary tannic acid on epidermal, lung, and forestomach polycyclic aromatic hydrocarbon metabolism and tumorigenicity in Sencar mice","volume":"49","author":"Athar","year":"1989","journal-title":"Cancer Res."},{"key":"10.1016\/j.intimp.2017.03.027_bb0050","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1002\/ptr.5376","article-title":"Cardioprotective effects of tannic acid on isoproterenol-induced myocardial injury in rats: further insight into \u2018French Paradox\u2019","volume":"29","author":"Hu","year":"2015","journal-title":"Phytother. Res."},{"key":"10.1016\/j.intimp.2017.03.027_bb0055","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1111\/jphp.12527","article-title":"Tannic acid activates the Kv7.4 and Kv7.3\/7.5 K+ channels expressed in HEK293 cells and reduces tension in the rat mesenteric arteries","volume":"68","author":"Zhang","year":"2016","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.intimp.2017.03.027_bb0060","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1002\/ptr.5558","article-title":"New findings on the effects of tannic acid: inhibition of L-type calcium channels, calcium transient and contractility in rat ventricular myocytes","volume":"30","author":"Zhu","year":"2016","journal-title":"Phytother. Res."},{"key":"10.1016\/j.intimp.2017.03.027_bb0065","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jphs.2015.12.002","article-title":"Ameliorative effects of tannic acid on carbon tetrachloride-induced liver fibrosis in vivo and in vitro","volume":"130","author":"Chu","year":"2016","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.intimp.2017.03.027_bb0070","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0304-3835(01)00678-4","article-title":"Hepatoprotective effects of Platycodon grandiflorum on acetaminophen-induced liver damage in mice","volume":"174","author":"Lee","year":"2001","journal-title":"Cancer Lett."},{"key":"10.1016\/j.intimp.2017.03.027_bb0075","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.intimp.2012.09.013","article-title":"Protective effects of nicotinamide against acetaminophen-induced acute liver injury","volume":"14","author":"Shi","year":"2012","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2017.03.027_bb0080","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/ajcp\/28.1.56","article-title":"A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases","volume":"28","author":"Reitman","year":"1957","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.intimp.2017.03.027_bb0085","doi-asserted-by":"crossref","first-page":"24937","DOI":"10.1016\/S0021-9258(19)73987-8","article-title":"Phorbol esters induce nitric oxide synthase activity in rat hepatocytes. Antagonism with the induction elicited by lipopolysaccharide","volume":"267","author":"Hortelano","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2017.03.027_bb0090","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0022-1759(89)90012-4","article-title":"A sensitive sandwich-enzyme immunoassay for human endothelin","volume":"118","author":"Suzuki","year":"1989","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.intimp.2017.03.027_bb0095","doi-asserted-by":"crossref","first-page":"6049","DOI":"10.1016\/S0021-9258(18)63504-5","article-title":"Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein)","volume":"244","author":"McCord","year":"1969","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2017.03.027_bb0100","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1126\/science.179.4073.588","article-title":"Selenium: biochemical role as a component of glutathione peroxidase","volume":"179","author":"Rotruck","year":"1973","journal-title":"Science"},{"key":"10.1016\/j.intimp.2017.03.027_bb0105","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0021-9258(19)50881-X","article-title":"A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase","volume":"195","author":"Beers","year":"1952","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2017.03.027_bb0110","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.intimp.2017.03.027_bb0115","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.jep.2013.05.028","article-title":"Multitargeted inhibition of hepatic fibrosis in chronic iron-overloaded mice by Salvia miltiorrhiza","volume":"148","author":"Zhang","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2017.03.027_bb0120","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s13105-013-0288-x","article-title":"Protective effects of BML-111 against acetaminophen-induced acute liver injury in mice","volume":"70","author":"El-Agamy","year":"2014","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.intimp.2017.03.027_bb0125","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.jep.2012.10.060","article-title":"Mechanism of protective effects of Danshen against iron overload-induced injury in mice","volume":"145","author":"Gao","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2017.03.027_bb0130","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.jep.2009.10.002","article-title":"Hepatoprotective effects of an active part from Artemisia sacrorum Ledeb. against acetaminophen-induced toxicity in mice","volume":"127","author":"Yuan","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2017.03.027_bb0135","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1055\/s-2008-1073116","article-title":"Acute liver failure: mechanisms of hepatocyte injury and regeneration","volume":"28","author":"Rutherford","year":"2008","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.intimp.2017.03.027_bb0140","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/pds.2162","article-title":"Acetaminophen overdose: a little recognized public health threat","volume":"20","author":"de Achaval","year":"2011","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"10.1016\/j.intimp.2017.03.027_bb0145","first-page":"491","article-title":"Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine","volume":"124","author":"Pradhan","year":"2006","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.intimp.2017.03.027_bb0150","first-page":"300","article-title":"The toxicity of tannic acid administered with the diet","volume":"4","author":"Mitjavila","year":"1971","journal-title":"Eur. J. Toxicol."},{"key":"10.1016\/j.intimp.2017.03.027_bb0155","first-page":"233","article-title":"Influence of sex and dietary casein content upon lethal and liver injurious effect of tannic acid; ineffectiveness of certain so-called liver protecting substances","volume":"3","author":"Korpassy","year":"1952","journal-title":"Acta Physiol. Acad. Sci. Hung."},{"key":"10.1016\/j.intimp.2017.03.027_bb0160","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1016\/j.fct.2008.03.012","article-title":"Invivo studies on evaluation of potential toxicity of unspent tannins using albino rats (Rattusnorvegicus)","volume":"46","author":"Sudha","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.intimp.2017.03.027_bb0165","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3109\/03602539208996298","article-title":"Molecular aspects of paracetamol-induced hepatotoxicity and its mechanism-based prevention","volume":"24","author":"Vermeulen","year":"1992","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.intimp.2017.03.027_bb0170","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jhep.2004.09.015","article-title":"Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice","volume":"42","author":"Masubuchi","year":"2005","journal-title":"J. Hepatol."},{"key":"10.1016\/j.intimp.2017.03.027_bb0175","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/jbt.20042","article-title":"Diverse antioxidants protect against acetaminophen hepatotoxicity","volume":"18","author":"Oz","year":"2004","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.intimp.2017.03.027_bb0180","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3109\/03602532.2011.602688","article-title":"Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity","volume":"44","author":"Jaeschke","year":"2012","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.intimp.2017.03.027_bb0185","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/toxsci\/65.2.166","article-title":"Mechanisms of hepatotoxicity","volume":"65","author":"Jaeschke","year":"2002","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.intimp.2017.03.027_bb0190","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1021\/tx9800349","article-title":"Nitrotyrosine-protein adducts in hepatic centrilobular areas following toxic doses of acetaminophen in mice","volume":"11","author":"Hinson","year":"1998","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.intimp.2017.03.027_bb0195","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jep.2014.12.013","article-title":"Protective effects of Penthorum chinense Pursh against chronic ethanol-induced liver injury in mice","volume":"161","author":"Cao","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2017.03.027_bb0200","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0027-5107(00)00019-1","article-title":"Hydroperoxide-induced DNA damage and mutations","volume":"450","author":"Termini","year":"2000","journal-title":"Mutat. Res."},{"key":"10.1016\/j.intimp.2017.03.027_bb0205","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.fct.2007.09.095","article-title":"Curcumin attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2-mediated induction of heme oxygenase-1","volume":"46","author":"Farombi","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.intimp.2017.03.027_bb0210","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1016\/j.freeradbiomed.2008.02.006","article-title":"Polymeric black tea polyphenols induce phase II enzymes via Nrf2 in mouse liver and lungs","volume":"44","author":"Patel","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.intimp.2017.03.027_bb0215","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jhep.2007.02.008","article-title":"Quercetin protects human hepatocytes from ethanol-derived oxidative stress by inducing heme oxygenase-1 via the MAPK\/Nrf2 pathways","volume":"47","author":"Yao","year":"2007","journal-title":"J. Hepatol."},{"key":"10.1016\/j.intimp.2017.03.027_bb0220","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1053\/j.gastro.2008.01.011","article-title":"Nuclear factor-eythroid 2-related factor 2 prevents alcohol-induced fulminant liver injury","volume":"134","author":"Lamle","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.intimp.2017.03.027_bb0225","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.taap.2012.05.010","article-title":"Role of Nrf2 in preventing ethanol-induced oxidative stress and lipid accumulation","volume":"262","author":"Wu","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.intimp.2017.03.027_bb0230","first-page":"59","article-title":"Ethanol extract of ganoderma lucidum augments cellular anti-oxidant defense through activation of Nrf2\/HO-1","volume":"19","author":"Lee","year":"2016","journal-title":"Aust. J. Pharm."},{"key":"10.1016\/j.intimp.2017.03.027_bb0235","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.fct.2014.04.026","article-title":"Quinocetone-induced Nrf2\/HO-1 pathway suppression aggravates hepatocyte damage of Sprague-Dawley rats","volume":"69","author":"Yu","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.intimp.2017.03.027_bb0240","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1177\/019262339602400206","article-title":"Histopathology of acetaminophen-induced liver changes: role of interleukin 1 alpha and tumor necrosis factor alpha","volume":"24","author":"Blazka","year":"1996","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.intimp.2017.03.027_bb0245","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1006\/taap.1995.1125","article-title":"Role of proinflammatory cytokines in acetaminophen hepatotoxicity","volume":"133","author":"Blazka","year":"1995","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.intimp.2017.03.027_bb0250","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1074-7613(00)80307-6","article-title":"TGF beta 1 inhibits NF-kappa B\/Rel activity inducing apoptosis of B cells: transcriptional activation of I kappa B alpha","volume":"5","author":"Arsura","year":"1996","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2017.03.027_bb0255","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/wsbm.30","article-title":"NF-kappaB signaling","volume":"1","author":"O'Dea","year":"2009","journal-title":"Wiley Interdiscip. Rev. Syst. Biol. Med."},{"key":"10.1016\/j.intimp.2017.03.027_bb0260","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.taap.2005.06.024","article-title":"Distinct roles of NF-kappaB p50 in the regulation of acetaminophen-induced inflammatory mediator production and hepatotoxicity","volume":"211","author":"Dambach","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.intimp.2017.03.027_bb0265","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.jpedsurg.2005.12.025","article-title":"Increased expression of c-fos and c-jun in the rat small intestinal epithelium after ischemia-reperfusion injury: a possible correlation with the proliferation or apoptosis of intestinal epithelial cells","volume":"41","author":"Shima","year":"2006","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.intimp.2017.03.027_bb0270","first-page":"197","article-title":"Preconditioning effects on expression of proto-oncogenes c-fos and c-jun after hepatic ischemia\/reperfusion in rats","volume":"4","author":"Xiao","year":"2005","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"key":"10.1016\/j.intimp.2017.03.027_bb0275","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.4049\/jimmunol.169.2.1007","article-title":"Intercellular adhesion molecule (ICAM)-1, but not ICAM-2, activates RhoA and stimulates c-fos and rhoA transcription in endothelial cells","volume":"169","author":"Thompson","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2017.03.027_bb0280","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/hep.510270222","article-title":"Cellular localization of endothelin-1 and increased production in liver injury in the rat: potential for autocrine and paracrine effects on stellate cells","volume":"27","author":"Rockey","year":"1998","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2017.03.027_bb0285","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.fct.2010.11.041","article-title":"Modulation of Bax\/Bcl-2 and caspases by probiotics during acetaminophen induced apoptosis in primary hepatocytes","volume":"49","author":"Sharma","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.intimp.2017.03.027_bb0290","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.tiv.2006.05.005","article-title":"Cadmium-induced apoptosis in rat hepatocytes does not necessarily involve caspase-dependent pathways","volume":"20","author":"Pham","year":"2006","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.intimp.2017.03.027_bb0295","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/35037710","article-title":"The biochemistry of apoptosis","volume":"407","author":"Hengartner","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2017.03.027_bb0300","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0092-8674(04)00046-7","article-title":"Cell death: critical control points","volume":"116","author":"Danial","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2017.03.027_bb0305","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.cbi.2014.10.016","article-title":"Free radicals, reactive oxygen species, oxidative stress and its classification","volume":"224","author":"Lushchak","year":"2014","journal-title":"Chem. Biol. Interact."},{"issue":"Suppl","key":"10.1016\/j.intimp.2017.03.027_bb0310","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1016\/j.toxlet.2012.03.285","article-title":"Hepatoprotective role of Polygonum bistorta and tannic acid on APAP treated rats","volume":"211","author":"Mittal","year":"2012","journal-title":"Toxicol. Lett."},{"issue":"Suppl. 2","key":"10.1016\/j.intimp.2017.03.027_bb0315","first-page":"S310","article-title":"Tannins: current knowledge of food sources, intake, bioavailability and biological effects","volume":"53","author":"Serrano","year":"2009","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.intimp.2017.03.027_bb0320","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/jat.2550120307","article-title":"Tannin content of tea and coffee","volume":"12","author":"Savolainen","year":"1992","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.intimp.2017.03.027_bb0325","doi-asserted-by":"crossref","first-page":"2980","DOI":"10.1007\/s10620-008-0239-5","article-title":"Green-tea polyphenols downregulate cyclooxygenase and Bcl-2 activity in acetaminophen-induced hepatotoxicity","volume":"53","author":"Oz","year":"2008","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.intimp.2017.03.027_bb0330","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.3748\/wjg.15.1829","article-title":"Protective effect of tea polyphenols against paracetamol-induced hepatotoxicity in mice is significantly correlated with cytochrome P450 suppression","volume":"15","author":"Chen","year":"2009","journal-title":"World J. Gastroenterol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576917301285?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576917301285?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:08:24Z","timestamp":1761584904000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576917301285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":66,"alternative-id":["S1567576917301285"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2017.03.027","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multi-targeted protection of acetaminophen-induced hepatotoxicity in mice by tannic acid","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2017.03.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}