{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T17:06:42Z","timestamp":1788887202212,"version":"build-2803163510"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.intimp.2017.04.019","type":"journal-article","created":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T01:34:28Z","timestamp":1493775268000},"page":"30-34","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":70,"special_numbering":"C","title":["Baicalin ameliorates chronic unpredictable mild stress-induced depressive behavior: Involving the inhibition of NLRP3 inflammasome activation in rat prefrontal cortex"],"prefix":"10.1016","volume":"48","author":[{"given":"Xiaoxin","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2017.04.019_bb0005","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11011-008-9118-1","article-title":"The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression","volume":"24","author":"Maes","year":"2009","journal-title":"Metab. Brain Dis."},{"issue":"9","key":"10.1016\/j.intimp.2017.04.019_bb0010","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.tins.2008.06.006","article-title":"The HPA axis in major depression: classical theories and new developments","volume":"31","author":"Pariante","year":"2008","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.intimp.2017.04.019_bb0015","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.2174\/138161209788168001","article-title":"Monoaminergic neurotransmission: the history of the discovery of antidepressants from 1950s until today","volume":"15","author":"L\u00f3pez-Mu\u00f1oz","year":"2009","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.intimp.2017.04.019_bb0020","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1517\/14728222.2012.718331","article-title":"Targeting IL-1 in depression","volume":"16","author":"Maes","year":"2012","journal-title":"Expert Opin. Ther. Targets"},{"issue":"1","key":"10.1016\/j.intimp.2017.04.019_bb0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2249.2011.04440.x","article-title":"The NLRP3 inflammasome in health and disease: the good, the bad and the ugly","volume":"166","author":"Menu","year":"2011","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.intimp.2017.04.019_bb0030","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bbi.2012.12.008","article-title":"The inflammasome: pathways linking psychological stress, depression, and systemic illnesses","volume":"31","author":"Iwata","year":"2013","journal-title":"Brain Behav. Immun."},{"issue":"3","key":"10.1016\/j.intimp.2017.04.019_bb0035","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s12035-013-8475-x","article-title":"The NLRP3 inflammasome in Alzheimer's disease","volume":"48","author":"Tan","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.intimp.2017.04.019_bb0040","doi-asserted-by":"crossref","first-page":"370530","DOI":"10.1155\/2014\/370530","article-title":"Chrysophanol inhibits NALP3 inflammasome activation and ameliorates cerebral ischemia\/reperfusion in mice","volume":"2014","author":"Zhang","year":"2014","journal-title":"Mediat. Inflamm."},{"issue":"10","key":"10.1016\/j.intimp.2017.04.019_bb0045","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1007\/s11064-013-1115-z","article-title":"Expression of the NLRP3 inflammasome in cerebral cortex after traumatic brain injury in a rat model","volume":"38","author":"Liu","year":"2013","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.intimp.2017.04.019_bb0050","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.bbi.2013.10.017","article-title":"NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder","volume":"36","author":"Alcocer-G\u00f3mez","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.intimp.2017.04.019_bb0055","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.bbi.2014.04.007","article-title":"Microglial NLRP3 inflammasome activation mediates IL-1\u03b2-related inflammation in prefrontal cortex of depressive rats","volume":"41","author":"Pan","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.intimp.2017.04.019_bb0060","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/cns.12170","article-title":"Involvement of inflammasome activation in lipopolysaccharide-induced mice depressive-like behaviors","volume":"20","author":"Zhang","year":"2014","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.intimp.2017.04.019_bb0065","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.brainres.2011.10.030","article-title":"Baicalin promotes neuronal differentiation of neural stem\/progenitor cells through modulating p-stat3 and bHLH family protein expression","volume":"1429","author":"Li","year":"2012","journal-title":"Brain Res."},{"issue":"4","key":"10.1016\/j.intimp.2017.04.019_bb0070","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.bbrc.2014.07.041","article-title":"Baicalin reverse AMPA receptor expression and neuron apoptosis in chronic unpredictable mild stress rats","volume":"451","author":"Yu","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2017.04.019_bb0075","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.brainres.2010.07.108","article-title":"Neuroprotective effect of baicalin on compression spinal cord injury in rats","volume":"1357","author":"Cao","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.intimp.2017.04.019_bb0080","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.phrs.2006.11.007","article-title":"Baicalin attenuates oxygen-glucose deprivation-induced injury via inhibiting NMDA receptor-mediated 5-lipoxygenase activation in rat cortical neurons","volume":"55","author":"Ge","year":"2007","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.intimp.2017.04.019_bb0085","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.pnpbp.2012.09.007","article-title":"Chronic treatment with baicalin prevents the chronic mild stress-induced depressive-like behavior: involving the inhibition of cyclooxygenase-2 in rat brain","volume":"40","author":"Li","year":"2013","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.intimp.2017.04.019_bb0090","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/cbic.201000570","article-title":"Neuronal differentiation of C17.2 neural stem cells induced by a natural flavonoid, baicalin","volume":"12","author":"Li","year":"2011","journal-title":"Chembiochem"},{"key":"10.1016\/j.intimp.2017.04.019_bb0095","first-page":"166","article-title":"Screening of antidepressant effects of four main flavonoids compounds from Scutellaria baicalensis","volume":"18","author":"Li","year":"2012","journal-title":"Chin. J. Exp. Tradit. Med. Form."},{"issue":"3","key":"10.1016\/j.intimp.2017.04.019_bb0100","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/BF00187257","article-title":"Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant","volume":"93","author":"Willner","year":"1987","journal-title":"Psychopharmacology"},{"issue":"1","key":"10.1016\/j.intimp.2017.04.019_bb0105","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.neulet.2007.12.041","article-title":"Prevention of chronic stressinduced depression-like behavior by inducible nitric oxide inhibitor","volume":"433","author":"Wang","year":"2008","journal-title":"Neurosci. Lett."},{"issue":"2","key":"10.1016\/j.intimp.2017.04.019_bb0110","first-page":"327","article-title":"Behavioral despair in mice: a primary screening test for antidepressants","volume":"229","author":"Porsolt","year":"1977","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.intimp.2017.04.019_bb0115","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.pbb.2014.07.015","article-title":"Antidepressant-like effects of salidroside on olfactory bulbectomy-induced pro-inflammatory cytokine production and hyperactivity of HPA axis in rats","volume":"124","author":"Yang","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.intimp.2017.04.019_bb0120","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S1566-2772(03)00086-0","article-title":"Stress models of depression","volume":"3","author":"Vollmayr","year":"2003","journal-title":"Clin. Neurosci. Res."},{"issue":"1","key":"10.1016\/j.intimp.2017.04.019_bb0125","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.fitote.2011.09.017","article-title":"Antidepressant-like effects of the saponins extracted from Chaihu-jia-longgu-muli-tang in a rat unpredictable chronic mild stress model","volume":"83","author":"Li","year":"2012","journal-title":"Fitoterapia"},{"key":"10.1016\/j.intimp.2017.04.019_bb0130","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.brainres.2010.09.095","article-title":"Chronic antidepressant administration alleviates frontal and hippocampal BDNF deficits in CUMS rat","volume":"1366","author":"Zhang","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.intimp.2017.04.019_bb0135","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s11920-011-0232-0","article-title":"Is depression an inflammatory disorder?","volume":"13","author":"Raison","year":"2011","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.intimp.2017.04.019_bb0140","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1073\/pnas.0708092105","article-title":"IL-1\u03b2 is an essential mediator of the antineurogenic and anhedonic effects of stress","volume":"105","author":"Koo","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.intimp.2017.04.019_bb0145","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/mp.2009.91","article-title":"Stress and IL-1beta contribute to the development of depressive-like behavior following peripheral nerve injury","volume":"15","author":"Norman","year":"2010","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.intimp.2017.04.019_bb0150","first-page":"18(8)","article-title":"NLRP3 inflammasome mediates chronic mild stress-induced depression in mice via neuroinflammation","author":"Zhang","year":"2015","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2017.04.019_bb0155","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13567-016-0359-4","article-title":"Baicalin suppresses NLRP3 inflammasome and nuclear factor-kappa B (NF-\u03baB) signaling during Haemophilus parasuis infection","volume":"47","author":"Fu","year":"2016","journal-title":"Vet. Res."},{"issue":"3","key":"10.1016\/j.intimp.2017.04.019_bb0160","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1177\/1753425916631032","article-title":"The anti-inflammatory effects of baicalin through suppression of NLRP3 inflammasome pathway in LPS-challenged piglet mononuclear phagocytes","volume":"22","author":"Ye","year":"2016","journal-title":"Innate Immun."},{"issue":"9","key":"10.1016\/j.intimp.2017.04.019_bb0165","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1017\/S1461145714000285","article-title":"Iptakalim confers an antidepressant effect in a chronic mild stress model of depression through regulating neuro-inflammation and neurogenesis","volume":"17","author":"Lu","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576917301534?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576917301534?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,2]],"date-time":"2018-09-02T01:28:15Z","timestamp":1535851695000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576917301534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":33,"alternative-id":["S1567576917301534"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2017.04.019","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Baicalin ameliorates chronic unpredictable mild stress-induced depressive behavior: Involving the inhibition of NLRP3 inflammasome activation in rat prefrontal cortex","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2017.04.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}