{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T14:42:57Z","timestamp":1784126577383,"version":"3.55.0"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773982"],"award-info":[{"award-number":["81773982"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573553"],"award-info":[{"award-number":["81573553"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.intimp.2017.12.023","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T15:06:18Z","timestamp":1513955178000},"page":"183-192","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Mogroside IVE attenuates experimental liver fibrosis in mice and inhibits HSC activation through downregulating TLR4-mediated pathways"],"prefix":"10.1016","volume":"55","author":[{"given":"Fengyan","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiguang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuniyoshi","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaofeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2017.12.023_bb0005","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.intimp.2017.12.023_bb0010","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.diff.2016.07.001","article-title":"The characteristics of activated portal fibroblasts\/myofibroblasts in liver fibrosis","volume":"92","author":"Karin","year":"2016","journal-title":"Differentiation"},{"key":"10.1016\/j.intimp.2017.12.023_bb0015","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bpg.2011.02.005","article-title":"Mechanisms of hepatic fibrogenesis","volume":"25","author":"Lee","year":"2011","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"10.1016\/j.intimp.2017.12.023_bb0020","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev-pathol-011110-130246","article-title":"Pathogenesis of liver fibrosis","volume":"6","author":"Hernandez-Gea","year":"2011","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.intimp.2017.12.023_bb0025","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/nm1663","article-title":"TLR4 enhances TGF-\u03b2 signaling and hepatic fibrosis","volume":"13","author":"Seki","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.intimp.2017.12.023_bb0030","doi-asserted-by":"crossref","first-page":"G1318","DOI":"10.1152\/ajpgi.00405.2005","article-title":"LPS signaling enhances hepatic fibrogenesis caused by experimental cholestasis in mice","volume":"290","author":"Isayama","year":"2006","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.intimp.2017.12.023_bb0035","doi-asserted-by":"crossref","unstructured":"Y.H. Paik, R.F. Schwabe, R. Bataller, et al., Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology 37, 1043\u20131055, https:\/\/doi.org\/10.1053\/jhep.2003.50182.","DOI":"10.1053\/jhep.2003.50182"},{"key":"10.1016\/j.intimp.2017.12.023_bb0040","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1055\/s-0030-1255353","article-title":"Toll-like receptor 4 and hepatic fibrogenesis","volume":"30","author":"Pradere","year":"2010","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.intimp.2017.12.023_bb0045","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.3892\/ol.2016.4705","article-title":"Hypoxia-inducible factor-1\u03b1 mediates the toll-like receptor 4 signaling pathway leading to anti-tumor effects in human hepatocellular carcinoma cells under hypoxic conditions","volume":"12","author":"Zhang","year":"2016","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.intimp.2017.12.023_bb0050","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.2353\/ajpath.2007.060887","article-title":"Proangiogenic cytokines as hypoxia- dependent factors stimulating migration of human hepatic stellate cells","volume":"170","author":"Novo","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.intimp.2017.12.023_bb0055","article-title":"Hypoxia-inducible factor-1alpha and MAPK co-regulate activation of hepatic stellate cells upon hypoxia stimulation","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2017.12.023_bb0060","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.jhep.2014.08.025","article-title":"Hypoxia inducible factors in liver disease and hepatocellular carcinoma: current understanding and future directions","volume":"61","author":"Wilson","year":"2014","journal-title":"J. Hepatol."},{"key":"10.1016\/j.intimp.2017.12.023_bb0065","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1478-3231.2010.02347.x","article-title":"Hypoxia-inducible factor-1\u03b1 regulates the expression of genes in hypoxic hepatic stellate cells important for collagen deposition and angiogenesis","volume":"31","author":"Copple","year":"2011","journal-title":"Liver Int."},{"key":"10.1016\/j.intimp.2017.12.023_bb0070","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s10585-010-9360-x","article-title":"Tissue inhibitor of metalloproteinases-1- induced scattered liver metastasis is mediated by hypoxia-inducible factor-1\u03b1","volume":"28","author":"Schelter","year":"2011","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.intimp.2017.12.023_bb0075","doi-asserted-by":"crossref","first-page":"7034","DOI":"10.1039\/C5RA23275A","article-title":"In vitro AMPK activating effect and in vivo pharmacokinetics of mogroside V, a cucurbitane type triterpenoid from Siraitia grosvenorii fruits","volume":"6","author":"Luo","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.intimp.2017.12.023_bb0080","first-page":"1308","article-title":"Mogrol represents a novel leukemia therapeutic, via ERK and STAT3 inhibition","volume":"5","author":"Liu","year":"2015","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.intimp.2017.12.023_bb0085","first-page":"89","article-title":"Chemistry and pharmacology of Siraitia grosvenorii: a review","volume":"12","author":"Li","year":"2014","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.intimp.2017.12.023_bb0090","doi-asserted-by":"crossref","first-page":"729","DOI":"10.3109\/13880209.2013.867451","article-title":"Protective effects and mechanisms of mogroside V acute lung injury in mice","volume":"52","author":"Shi","year":"2014","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.intimp.2017.12.023_bb0095","first-page":"331","article-title":"Effects of mogrosides on proliferation of hepatic stellate cell-T6 and hepatofibrosis-related gene","volume":"44","author":"Wang","year":"2013","journal-title":"Chin. Tradit. Herb. Drug"},{"key":"10.1016\/j.intimp.2017.12.023_bb0100","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.jpba.2015.07.024","article-title":"Exploring in vitro, in vivo metabolism of mogroside V and distribution of its metabolites in rats by HPLC-ESI-IT-TOF-MSn","volume":"115","author":"Xu","year":"2015","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.intimp.2017.12.023_bb0105","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3390\/molecules21020176","article-title":"Metabolites of siamenoside I and their distributions in rats","volume":"21","author":"Yang","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.intimp.2017.12.023_bb0110","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1271\/bbb.90832","article-title":"Digestion and absorption of Siraitia grosvenori triterpenoids in the rat","volume":"74","author":"Murata","year":"2010","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.intimp.2017.12.023_bb0115","first-page":"19","article-title":"Protective effect of mogrosides on carbon tetrachloride-induced hepatic fibrosis rats, Shandong","volume":"52","author":"Xiao","year":"2012","journal-title":"Med. J."},{"key":"10.1016\/j.intimp.2017.12.023_bb0120","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/0168-8278(91)90084-O","article-title":"Classification of chronic viral hepatitis: a need for reassessment","volume":"13","author":"Scheuer","year":"1991","journal-title":"J. Hepatol."},{"key":"10.1016\/j.intimp.2017.12.023_bb0125","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/j.bbagen.2012.06.011","article-title":"Protective role of quercetin against lead-induced inflammatory response in rat kidney through the ROS-mediated MAPKs and NF-\u03baB pathway","volume":"1820","author":"Liu","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.intimp.2017.12.023_bb0130","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.jep.2010.08.025","article-title":"The protective effects of total saponins from Ornithogalum saundersiae (Liliaceae) on acute hepatic failure induced by lipopolysaccharide and d-galactosamine in mice","volume":"132","author":"Wan","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2017.12.023_bb0135","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jep.2015.08.034","article-title":"Preventive effects of Ecliptae Herba extract and its component, ecliptasaponin A, on bleomycin-induced pulmonary fibrosis in mice","volume":"175","author":"You","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2017.12.023_bb0140","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.jhep.2013.12.025","article-title":"Macrophage heterogeneity in liver injury and fibrosis","volume":"6","author":"Tacke","year":"2014","journal-title":"J. Hepatol."},{"key":"10.1016\/j.intimp.2017.12.023_bb0145","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/hep.22950","article-title":"Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis","volume":"50","author":"Karlmark","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2017.12.023_bb0150","doi-asserted-by":"crossref","first-page":"53","DOI":"10.14218\/JCTH.2014.00035","article-title":"Animal models for fibrotic liver diseases: what we have, what we need, and what is under development","volume":"3","author":"Delire","year":"2015","journal-title":"J. Clin. Transl. Hepatol."},{"key":"10.1016\/j.intimp.2017.12.023_bb0155","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.jcmgh.2015.09.005","article-title":"Role of hypoxia-inducible factors in the development of liver fibrosis","volume":"1","author":"Roth","year":"2015","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.intimp.2017.12.023_bb0160","doi-asserted-by":"crossref","first-page":"G582","DOI":"10.1152\/ajpgi.90368.2008","article-title":"Reduced liver fibrosis in hypoxia-inducible factor-1a-deficient mice","volume":"296","author":"Moon","year":"2009","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.intimp.2017.12.023_bb0165","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.ccr.2012.02.007","article-title":"Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4","volume":"21","author":"Dapito","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.intimp.2017.12.023_bb0170","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nri2079","article-title":"The family of five: TIR-domain containing adaptors in Toll-like receptor signaling","volume":"7","author":"O'Neill","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.intimp.2017.12.023_bb0175","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.cyto.2008.01.006","article-title":"LPS\/TLR4 signal transduction pathway","volume":"42","author":"Lu","year":"2008","journal-title":"Cytokine"},{"key":"10.1016\/j.intimp.2017.12.023_bb0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0153118","article-title":"Characterization of the MMP\/TIMP imbalance and collagen production induced by IL-1\u03b2 or TNF-\u03b1 release from human hepatic stellate cells","volume":"11","author":"Robert","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2017.12.023_bb0185","doi-asserted-by":"crossref","first-page":"7474","DOI":"10.1021\/jf201207m","article-title":"Anti-inflammatory activities of mogrosides from Momordica grosvenori in murine macrophages and a murine ear edema model","volume":"13","author":"Di","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.intimp.2017.12.023_bb0190","first-page":"1492","article-title":"Anti-obesity effects of mogrosides extracted from the fruits of Siraitia grosvenorii (Cucurbitaceae)","volume":"6","author":"Sun","year":"2012","journal-title":"Afr. J. Pharm. Pharmacol"},{"key":"10.1016\/j.intimp.2017.12.023_bb0195","doi-asserted-by":"crossref","first-page":"G571","DOI":"10.1152\/ajpgi.00537.2004","article-title":"Exposure to bacterial cell wall products triggers an inflammatory phenotype in hepatic stellate cells","volume":"289","author":"Brun","year":"2005","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.intimp.2017.12.023_bb0200","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0304-3835(03)00285-4","article-title":"Anticarcinogenic activity of natural sweeteners, cucurbitane glycosides, from Momordica grosvenori","volume":"198","author":"Takasaki","year":"2003","journal-title":"Cancer Lett."},{"key":"10.1016\/j.intimp.2017.12.023_bb0205","first-page":"1252","article-title":"Insulin secretion stimulating effects of mogroside V and fruit extract of Luo Han Kuo (Siraitia grosvenori Swingle) fruit extract","volume":"44","author":"Zhou","year":"2009","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.intimp.2017.12.023_bb0210","doi-asserted-by":"crossref","first-page":"5776","DOI":"10.1016\/j.bmc.2011.08.030","article-title":"Potential AMPK activators of cucurbitane triterpenoids from Siraitia grosvenorii Swingle","volume":"19","author":"Chen","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.intimp.2017.12.023_bb0215","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.canlet.2008.10.046","article-title":"Epidemiology and prevention of hepatocellular carcinoma","volume":"286","author":"Franceschi","year":"2009","journal-title":"Cancer Lett."},{"key":"10.1016\/j.intimp.2017.12.023_bb0220","doi-asserted-by":"crossref","first-page":"8681","DOI":"10.1073\/pnas.82.24.8681","article-title":"Hepatic lipocytes: the principal collagen- producing cells of normal rat liver","volume":"82","author":"Friedman","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.intimp.2017.12.023_bb0225","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S2095-4964(14)60039-X","article-title":"Traditional Chinese medicine for treatment of liver diseases: progress, challenges and opportunities","volume":"12","author":"Zhao","year":"2014","journal-title":"J. Integr. Med."},{"key":"10.1016\/j.intimp.2017.12.023_bb0230","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/j.febslet.2014.04.042","article-title":"Toll like receptor 2 knock-out attenuates carbon tetrachloride (CCl4)-induced liver fibrosis by downregulating MAPK and NF-\u03baB signaling pathways","volume":"588","author":"Ji","year":"2014","journal-title":"FEBS Lett."},{"key":"10.1016\/j.intimp.2017.12.023_bb0235","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.toxlet.2016.06.2102","article-title":"Cucurbitacin E ameliorates hepatic fibrosis in vivo and in vitro through activation of AMPK and blocking mTOR-dependent signaling pathway","volume":"258","author":"Wu","year":"2016","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.intimp.2017.12.023_bb0240","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1093\/clinchem\/43.8.1512","article-title":"Xenobiotic-induced hepatotoxicity: mechanisms of liver injury and methods of monitoring hepatic function","volume":"43","author":"Sturgill","year":"1997","journal-title":"Clin. Chem."},{"key":"10.1016\/j.intimp.2017.12.023_bb0245","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/path.1397","article-title":"Liver extracellular matrix in health and disease","volume":"200","author":"Bedossa","year":"2003","journal-title":"J. Pathol."},{"key":"10.1016\/j.intimp.2017.12.023_bb0250","article-title":"Dietary supplementation of blueberry juice enhances hepatic expression of metallothionein and attenuates liver fibrosis in rats","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2017.12.023_bb0255","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.intimp.2017.12.023_bb0260","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.4049\/jimmunol.174.4.2037","article-title":"Low TLR4 expression by liver dendritic cells correlates with reduced capacity to activate allogeneic T cells in response to endotoxin","volume":"174","author":"De-Creus","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2017.12.023_bb0265","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.bbrc.2004.10.020","article-title":"LPS-mediated NF-\u03baB activation varies between activated human hepatic stellate cells from different donors","volume":"325","author":"M\u00fchlbauer","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2017.12.023_bb0270","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2010\/192543","article-title":"Toll-like receptor signaling and liver fibrosis","author":"Aoyama","year":"2010","journal-title":"Gastroenterol. Res. Pract."},{"key":"10.1016\/j.intimp.2017.12.023_bb0275","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jss.2013.11.1086","article-title":"The interaction between Toll-like receptor 4 signaling pathway and hypoxia-inducible factor 1\u03b1 in lung ischemia\u2013reperfusion injury","volume":"188","author":"Zhou","year":"2014","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.intimp.2017.12.023_bb0280","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.febslet.2007.12.024","article-title":"LPS-induced toll-like receptor 4 signalling triggers cross-talk of apoptosis signal-regulating kinase 1 (ASK1) and HIF-1alpha protein","volume":"582","author":"Sumbayev","year":"2008","journal-title":"FEBS Lett."},{"key":"10.1016\/j.intimp.2017.12.023_bb0285","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0010983","article-title":"Effects of TLR agonists on the hypoxia-regulated transcription factor HIF-1alpha and dendritic cell maturation under normoxic conditions","volume":"5","author":"Spirig","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2017.12.023_bb0290","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.3748\/wjg.v20.i11.3011","article-title":"Hyperoxia accelerates progression of hepatic fibrosis by up-regulation of transforming growth factor-\u03b2 expression","volume":"20","author":"Lee","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.intimp.2017.12.023_bb0295","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1016\/j.molimm.2008.03.014","article-title":"HIF-1alpha protein is an essential factor for protection of myeloid cells against LPS-induced depletion of ATP and apoptosis that supports toll-like receptor 4-mediated production of IL-6","volume":"45","author":"Lall","year":"2008","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.intimp.2017.12.023_bb0300","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1182\/blood-2003-07-2427","article-title":"Hypoxic gene activation by lipopolysaccharide in macrophages: implication of hypoxia-inducible factor 1alpha","volume":"103","author":"Blouin","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.intimp.2017.12.023_bb0305","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1111\/j.1476-5381.2009.00297.x","article-title":"Analysis of binding site for the novel small-molecule TLR4 signal transduction inhibitor TAK-242 and its therapeutic effect on mouse sepsis model","volume":"157","author":"Takashima","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.intimp.2017.12.023_bb0310","doi-asserted-by":"crossref","first-page":"16309","DOI":"10.1074\/jbc.M710079200","article-title":"Hypoxia-mediated selective mRNA translation by an internal ribosome entry site-independent mechanism","volume":"283","author":"Young","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2017.12.023_bb0315","doi-asserted-by":"crossref","first-page":"8762345","DOI":"10.1155\/2016\/8762345","article-title":"Berberine inhibition of fibrogenesis in a rat model of liver fibrosis and in hepatic stellate cells","volume":"2016","author":"Wang","year":"2016","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.intimp.2017.12.023_bb0320","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1002\/ptr.5833","article-title":"Mogroside IIIE attenuates LPS-induced acute lung injury in mice partly through regulation of the TLR4\/MAPK\/NF-\u03baB axis via AMPK activation","volume":"31","author":"Tao","year":"2017","journal-title":"Phytother. Res."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576917304964?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576917304964?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:09:43Z","timestamp":1761584983000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576917304964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":64,"alternative-id":["S1567576917304964"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2017.12.023","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mogroside IVE attenuates experimental liver fibrosis in mice and inhibits HSC activation through downregulating TLR4-mediated pathways","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2017.12.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}