{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T17:34:07Z","timestamp":1780508047071,"version":"3.54.1"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Natural Science Foundation Council","award":["81671594"],"award-info":[{"award-number":["81671594"]}]},{"name":"National Natural Science Foundation Council","award":["81571591"],"award-info":[{"award-number":["81571591"]}]},{"DOI":"10.13039\/501100014996","name":"Health and Family Planning Commission of Zhejiang Province","doi-asserted-by":"crossref","award":["2017KY712"],"award-info":[{"award-number":["2017KY712"]}],"id":[{"id":"10.13039\/501100014996","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.intimp.2018.04.048","type":"journal-article","created":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T17:39:41Z","timestamp":1525714781000},"page":"189-193","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Serum human epididymis protein 4 is a predictor for developing nephritis in patients with systemic lupus erythematosus: A prospective cohort study"],"prefix":"10.1016","volume":"60","author":[{"given":"Yingpeng","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanwan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhencheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panying","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renqian","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaixing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.intimp.2018.04.048_bb0005","doi-asserted-by":"crossref","first-page":"233","DOI":"10.5858\/133.2.233","article-title":"Renal disease in systemic lupus erythematosus with emphasis on classification of lupus glomerulonephritis: advances and implications","volume":"133","author":"Seshan","year":"2009","journal-title":"Arch. Pathol. Lab. Med."},{"issue":"5","key":"10.1016\/j.intimp.2018.04.048_bb0010","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1093\/rheumatology\/kep012","article-title":"Renal damage is the most important predictor of mortality within the damage index: data from LUMINA LXIV, a multiethnic US cohort","volume":"48","author":"Danila","year":"2009","journal-title":"Rheumatology (Oxford)"},{"issue":"11","key":"10.1016\/j.intimp.2018.04.048_bb0015","first-page":"2046","article-title":"The benefit of early treatment with immunosuppressive agents in lupus nephritis","volume":"21","author":"Esdaile","year":"1994","journal-title":"J. Rheumatol."},{"issue":"2","key":"10.1016\/j.intimp.2018.04.048_bb0020","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1095\/biolreprod45.2.350","article-title":"A major human epididymis-specific cDNA encodes a protein with sequence homology to extracellular proteinase inhibitors","volume":"45","author":"Kirchhoff","year":"1991","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.intimp.2018.04.048_bb0025","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.cca.2015.03.047","article-title":"HE4 in the differential diagnosis of ovarian masses","volume":"446","author":"Granato","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.intimp.2018.04.048_bb0030","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.cca.2014.08.020","article-title":"Human epididymis protein 4: factors of variation","volume":"438","author":"Ferraro","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.intimp.2018.04.048_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-405211-6.00001-2","article-title":"Human epididymis protein 4 in cancer diagnostics: a promising and reliable tumor marker","volume":"59","author":"Speeckaert","year":"2013","journal-title":"Adv. Clin. Chem."},{"issue":"5","key":"10.1016\/j.intimp.2018.04.048_bb0040","doi-asserted-by":"crossref","first-page":"613","DOI":"10.2217\/bmm.12.70","article-title":"From bench to bedside: discovery of ovarian cancer biomarkers using high-throughput technologies in the past decade","volume":"6","author":"Leung","year":"2012","journal-title":"Biomark. Med"},{"issue":"36","key":"10.1016\/j.intimp.2018.04.048_bb0045","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000007824","article-title":"Potential association between elevated serum human epididymis protein 4 and renal fibrosis: a systemic review and meta-analysis","volume":"96","author":"Chen","year":"2017","journal-title":"Medicine (Baltimore)"},{"issue":"3","key":"10.1016\/j.intimp.2018.04.048_bb0050","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1093\/labmed\/lmx036","article-title":"Human epididymis protein 4 as a potential biomarker of chronic kidney disease in female patients with normal ovarian function","volume":"48","author":"Yuan","year":"2017","journal-title":"Lab. Med."},{"issue":"Pt 4","key":"10.1016\/j.intimp.2018.04.048_bb0055","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1258\/acb.2011.011258","article-title":"Elevated human epididymis protein 4 concentrations in chronic kidney disease","volume":"49","author":"Nagy","year":"2012","journal-title":"Ann. Clin. Biochem."},{"issue":"42","key":"10.1016\/j.intimp.2018.04.048_bb0060","doi-asserted-by":"crossref","first-page":"67748","DOI":"10.18632\/oncotarget.11682","article-title":"Elevated serum concentrations of HE4 as a novel biomarker of disease severity and renal fibrosis in kidney disease","volume":"7","author":"Wan","year":"2016","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.intimp.2018.04.048_bb0065","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jchf.2012.11.005","article-title":"The WAP four-disulfide core domain protein HE4: a novel biomarker for heart failure","volume":"1","author":"de Boer","year":"2013","journal-title":"JACC Heart. Fail."},{"issue":"1","key":"10.1016\/j.intimp.2018.04.048_bb0070","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.cardfail.2016.05.002","article-title":"HE4 serum levels are associated with heart failure severity in patients with chronic heart failure","volume":"23","author":"Piek","year":"2017","journal-title":"J. Card. Fail."},{"issue":"6","key":"10.1016\/j.intimp.2018.04.048_bb0075","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1002\/jcla.21954","article-title":"Human epididymis protein 4: a novel biomarker for lupus nephritis and chronic kidney disease in systemic lupus erythematosus","volume":"30","author":"Yang","year":"2016","journal-title":"J. Clin. Lab. Anal."},{"issue":"9","key":"10.1016\/j.intimp.2018.04.048_bb0080","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1002\/art.1780400928","article-title":"Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus","volume":"40","author":"Hochberg","year":"1997","journal-title":"Arthritis Rheum."},{"issue":"6","key":"10.1016\/j.intimp.2018.04.048_bb0085","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/art.1780350606","article-title":"Derivation of the SLEDAI. A disease activity index for lupus patients. The committee on prognosis studies in SLE","volume":"35","author":"Bombardier","year":"1992","journal-title":"Arthritis Rheum."},{"issue":"9035","key":"10.1016\/j.intimp.2018.04.048_bb0090","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/S0140-6736(96)03032-2","article-title":"Plasma homocysteine as a risk factor for atherothrombotic events in systemic lupus erythematosus","volume":"348","author":"Petri","year":"1996","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.intimp.2018.04.048_bb0095","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1136\/annrheumdis-2012-201940","article-title":"Joint European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association (EULAR\/ERA-EDTA) recommendations for the management of adult and paediatric lupus nephritis","volume":"71","author":"Bertsias","year":"2012","journal-title":"Ann. Rheum. Dis."},{"issue":"3","key":"10.1016\/j.intimp.2018.04.048_bb0100","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.chest.2016.04.006","article-title":"Human epididymis protein 4: a novel serum inflammatory biomarker in cystic fibrosis","volume":"150","author":"Nagy","year":"2016","journal-title":"Chest"},{"issue":"17","key":"10.1016\/j.intimp.2018.04.048_bb0105","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1038\/sj.onc.1205363","article-title":"The putative ovarian tumour marker gene HE4 (WFDC2), is expressed in normal tissues and undergoes complex alternative splicing to yield multiple protein isoforms","volume":"21","author":"Bingle","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.intimp.2018.04.048_bb0110","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/1465-9921-7-61","article-title":"WFDC2 (HE4): a potential role in the innate immunity of the oral cavity and respiratory tract and the development of adenocarcinomas of the lung","volume":"7","author":"Bingle","year":"2006","journal-title":"Respir. Res."},{"issue":"6","key":"10.1016\/j.intimp.2018.04.048_bb0115","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/modpathol.3800612","article-title":"Comprehensive analysis of HE4 expression in normal and malignant human tissues","volume":"19","author":"Galgano","year":"2006","journal-title":"Mod. Pathol."},{"issue":"2","key":"10.1016\/j.intimp.2018.04.048_bb0120","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nm.2989","article-title":"Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis","volume":"19","author":"LeBleu","year":"2013","journal-title":"Nat. Med."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576918301991?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576918301991?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T15:19:41Z","timestamp":1661181581000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576918301991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":24,"alternative-id":["S1567576918301991"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2018.04.048","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum human epididymis protein 4 is a predictor for developing nephritis in patients with systemic lupus erythematosus: A prospective cohort study","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2018.04.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}