{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:45:26Z","timestamp":1790084726448,"version":"4.0.1"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81501906"],"award-info":[{"award-number":["81501906"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.intimp.2018.05.026","type":"journal-article","created":{"date-parts":[[2018,6,8]],"date-time":"2018-06-08T18:30:46Z","timestamp":1528482646000},"page":"222-230","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"special_numbering":"C","title":["Emodin ameliorates cartilage degradation in osteoarthritis by inhibiting NF-\u03baB and Wnt\/\u03b2-catenin signaling in-vitro and in-vivo"],"prefix":"10.1016","volume":"61","author":[{"given":"Qian-Hai","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Yi","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Er-Man","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Hua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.intimp.2018.05.026_bb0005","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.joca.2014.11.019","article-title":"Current evidence on risk factors for knee osteoarthritis in older adults: a systematic review and meta-analysis","volume":"23","author":"Silverwood","year":"2015","journal-title":"Osteoarthr. Cartil."},{"issue":"3","key":"10.1016\/j.intimp.2018.05.026_bb0010","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/ar2592","article-title":"Cartilage homeostasis in health and rheumatic diseases","volume":"11","author":"Goldring","year":"2009","journal-title":"Arthritis Res. Ther."},{"issue":"1","key":"10.1016\/j.intimp.2018.05.026_bb0015","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.bbapap.2011.06.020","article-title":"Proteases involved in cartilage matrix degradation in osteoarthritis","volume":"1824","author":"Troeberg","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.intimp.2018.05.026_bb0020","doi-asserted-by":"crossref","first-page":"529","DOI":"10.2741\/1817","article-title":"Matrix metalloproteinases: role in arthritis","volume":"11","author":"Burrage","year":"2006","journal-title":"Front. Biosci."},{"issue":"2","key":"10.1016\/j.intimp.2018.05.026_bb0025","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2174\/138945007779940098","article-title":"Molecular targets in osteoarthritis: metalloproteinases and their inhibitors","volume":"8","author":"Burrage","year":"2007","journal-title":"Curr. Drug Targets"},{"issue":"1","key":"10.1016\/j.intimp.2018.05.026_bb0030","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1042\/BJ20151072","article-title":"Anti-ADAMTS5 monoclonal antibodies: implications for aggrecanase inhibition in osteoarthritis","volume":"473","author":"Apte","year":"2016","journal-title":"Biochem. J."},{"issue":"8","key":"10.1016\/j.intimp.2018.05.026_bb0035","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1002\/art.20558","article-title":"Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice","volume":"50","author":"Glasson","year":"2004","journal-title":"Arthritis Rheum."},{"issue":"25","key":"10.1016\/j.intimp.2018.05.026_bb0040","doi-asserted-by":"crossref","first-page":"18294","DOI":"10.1074\/jbc.M701523200","article-title":"Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4","volume":"282","author":"Gendron","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.intimp.2018.05.026_bb0045","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00726-010-0689-x","article-title":"Physiology and pathophysiology of matrix metalloproteases","volume":"41","author":"Klein","year":"2011","journal-title":"Amino Acids"},{"issue":"5","key":"10.1016\/j.intimp.2018.05.026_bb0050","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1002\/art.22526","article-title":"The futility of current approaches to chondroprotection","volume":"56","author":"Felson","year":"2007","journal-title":"Arthritis Rheum."},{"issue":"1","key":"10.1016\/j.intimp.2018.05.026_bb0055","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.fm.2004.01.016","article-title":"Volatile constituents from the leaves of Polygonum cuspidatum S. et Z. and their anti-bacterial activities","volume":"22","author":"Kim","year":"2005","journal-title":"Food Microbiol."},{"key":"10.1016\/j.intimp.2018.05.026_bb0060","doi-asserted-by":"crossref","unstructured":"M.L. Lin, Y.C. Lu, J.G. Chung, S.G. Wang, H.T. Lin, S.E. Kang, C.H. Tang, J.L. Ko, S.S. Chen, Down-regulation of MMP-2 through the p38 MAPK-NF-kappaB-dependent pathway by aloe-emodin leads to inhibition of nasopharyngeal carcinoma cell invasion, Mol. Carcinog. 49(9) (2010) 783\u201397.","DOI":"10.1002\/mc.20652"},{"issue":"1\u20133","key":"10.1016\/j.intimp.2018.05.026_bb0065","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ejphar.2006.09.026","article-title":"Anthraquinone derivative emodin inhibits tumor-associated angiogenesis through inhibition of extracellular signal-regulated kinase 1\/2 phosphorylation","volume":"553","author":"Kaneshiro","year":"2006","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.intimp.2018.05.026_bb0070","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.3390\/ijms13022276","article-title":"Emodin prevents intrahepatic fat accumulation, inflammation and redox status imbalance during diet-induced hepatosteatosis in rats","volume":"13","author":"Alisi","year":"2012","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.intimp.2018.05.026_bb0075","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.ejps.2011.12.012","article-title":"Aloe emodin inhibits colon cancer cell migration\/angiogenesis by downregulating MMP-2\/9, RhoB and VEGF via reduced DNA binding activity of NF-kappaB","volume":"45","author":"Suboj","year":"2012","journal-title":"Eur. J. Pharm. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2018.05.026_bb0080","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3892\/or.2014.3585","article-title":"Inhibitory effect of emodin on migration, invasion and metastasis of human breast cancer MDA-MB-231 cells in vitro and in vivo","volume":"33","author":"Sun","year":"2015","journal-title":"Oncol. Rep."},{"issue":"4","key":"10.1016\/j.intimp.2018.05.026_bb0085","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"3","key":"10.1016\/j.intimp.2018.05.026_bb0090","doi-asserted-by":"crossref","first-page":"523","DOI":"10.2106\/00004623-197153030-00009","article-title":"Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data","volume":"53","author":"Mankin","year":"1971","journal-title":"J. Bone Joint Surg. Am."},{"issue":"5 Suppl","key":"10.1016\/j.intimp.2018.05.026_bb0095","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.1016\/j.pmrj.2012.02.009","article-title":"Pharmaceutical therapy for osteoarthritis","volume":"4","author":"Cheng","year":"2012","journal-title":"PM R"},{"key":"10.1016\/j.intimp.2018.05.026_bb0100","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.intimp.2016.02.014","article-title":"Emodin suppresses LPS-induced inflammation in RAW264.7 cells through a PPARgamma-dependent pathway","volume":"34","author":"Zhu","year":"2016","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.intimp.2018.05.026_bb0105","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.intimp.2014.05.019","article-title":"Emodin inhibits LPS-induced inflammatory response by activating PPAR-gamma in mouse mammary epithelial cells","volume":"21","author":"Yang","year":"2014","journal-title":"Int. Immunopharmacol."},{"issue":"9","key":"10.1016\/j.intimp.2018.05.026_bb0110","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1248\/bpb.34.1432","article-title":"Emodin inhibits proinflammatory responses and inactivates histone deacetylase 1 in hypoxic rheumatoid synoviocytes","volume":"34","author":"Ha","year":"2011","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.intimp.2018.05.026_bb0115","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/690596","article-title":"Anti-inflammatory and antiarthritic activity of anthraquinone derivatives in rodents","volume":"2014","author":"Kshirsagar","year":"2014","journal-title":"Int. J. Inflamm."},{"issue":"6","key":"10.1016\/j.intimp.2018.05.026_bb0120","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1007\/s10753-013-9663-6","article-title":"Therapeutic effect of emodin on collagen-induced arthritis in mice","volume":"36","author":"Zhu","year":"2013","journal-title":"Inflammation"},{"issue":"9","key":"10.1016\/j.intimp.2018.05.026_bb0125","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1093\/rheumatology\/ket178","article-title":"Emodin suppresses inflammatory responses and joint destruction in collagen-induced arthritic mice","volume":"52","author":"Hwang","year":"2013","journal-title":"Rheumatology (Oxford)"},{"issue":"12","key":"10.1016\/j.intimp.2018.05.026_bb0130","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1002\/jcb.23298","article-title":"ADAMTS-4 and ADAMTS-5: key enzymes in osteoarthritis","volume":"112","author":"Verma","year":"2011","journal-title":"J. Cell. Biochem."},{"issue":"5","key":"10.1016\/j.intimp.2018.05.026_bb0135","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1186\/s13075-014-0429-9","article-title":"Current and emerging therapeutic strategies for preventing inflammation and aggrecanase-mediated cartilage destruction in arthritis","volume":"16","author":"Dancevic","year":"2014","journal-title":"Arthritis Res. Ther."},{"issue":"2","key":"10.1016\/j.intimp.2018.05.026_bb0140","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.intimp.2013.06.027","article-title":"Vorinostat, a HDAC inhibitor, showed anti-osteoarthritic activities through inhibition of iNOS and MMP expression, p38 and ERK phosphorylation and blocking NF-kappaB nuclear translocation","volume":"17","author":"Zhong","year":"2013","journal-title":"Int. Immunopharmacol."},{"issue":"12","key":"10.1016\/j.intimp.2018.05.026_bb0145","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1002\/art.38188","article-title":"MicroRNA-127-5p regulates matrix metalloproteinase 13 expression and interleukin-1beta-induced catabolic effects in human chondrocytes","volume":"65","author":"Park","year":"2013","journal-title":"Arthritis Rheum."},{"issue":"8","key":"10.1016\/j.intimp.2018.05.026_bb0150","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1002\/art.34425","article-title":"A Wnt\/beta-catenin negative feedback loop inhibits interleukin-1-induced matrix metalloproteinase expression in human articular chondrocytes","volume":"64","author":"Ma","year":"2012","journal-title":"Arthritis Rheum."},{"issue":"6","key":"10.1016\/j.intimp.2018.05.026_bb0155","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1053\/joca.2001.0427","article-title":"The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation","volume":"9","author":"Tortorella","year":"2001","journal-title":"Osteoarthr. Cartil."},{"issue":"25","key":"10.1016\/j.intimp.2018.05.026_bb0160","doi-asserted-by":"crossref","first-page":"22201","DOI":"10.1074\/jbc.M200431200","article-title":"Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage","volume":"277","author":"Malfait","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.intimp.2018.05.026_bb0165","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/art.22334","article-title":"Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5","volume":"56","author":"Song","year":"2007","journal-title":"Arthritis Rheum."},{"issue":"11","key":"10.1016\/j.intimp.2018.05.026_bb0170","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1002\/art.23027","article-title":"Double-knockout of ADAMTS-4 and ADAMTS-5 in mice results in physiologically normal animals and prevents the progression of osteoarthritis","volume":"56","author":"Majumdar","year":"2007","journal-title":"Arthritis Rheum."},{"issue":"Suppl 3","key":"10.1016\/j.intimp.2018.05.026_bb0175","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1186\/ar572","article-title":"Matrix metalloproteinases in arthritic disease","volume":"4","author":"Murphy","year":"2002","journal-title":"Arthritis Res."},{"issue":"1","key":"10.1016\/j.intimp.2018.05.026_bb0180","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2174\/138920108783497659","article-title":"Joint diseases and matrix metalloproteinases: a role for MMP-13","volume":"9","author":"Takaishi","year":"2008","journal-title":"Curr. Pharm. Biotechnol."},{"issue":"10","key":"10.1016\/j.intimp.2018.05.026_bb0185","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1016\/j.ajpath.2016.06.010","article-title":"Histone deacetylase inhibitor vorinostat (SAHA) suppresses IL-1beta-induced matrix metallopeptidase-13 expression by inhibiting IL-6 in osteoarthritis chondrocyte","volume":"186","author":"Makki","year":"2016","journal-title":"Am. J. Pathol."},{"issue":"44","key":"10.1016\/j.intimp.2018.05.026_bb0190","doi-asserted-by":"crossref","first-page":"8877","DOI":"10.1021\/bi301228d","article-title":"Development of a neutralizing antibody specific for the active form of matrix metalloproteinase-13","volume":"51","author":"Naito","year":"2012","journal-title":"Biochemistry"},{"issue":"5","key":"10.1016\/j.intimp.2018.05.026_bb0195","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1002\/jcb.20239","article-title":"Production of the chemokine eotaxin-1 in osteoarthritis and its role in cartilage degradation","volume":"93","author":"Hsu","year":"2004","journal-title":"J. Cell. Biochem."},{"issue":"3","key":"10.1016\/j.intimp.2018.05.026_bb0200","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/S1471-4892(01)00055-8","article-title":"The inhibition of metalloproteinases as a therapeutic target in rheumatoid arthritis and osteoarthritis","volume":"1","author":"Bigg","year":"2001","journal-title":"Curr. Opin. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2018.05.026_bb0205","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/art.10706","article-title":"Induction of matrix metalloproteinase 1 gene expression is regulated by inflammation-responsive transcription factor SAF-1 in osteoarthritis","volume":"48","author":"Ray","year":"2003","journal-title":"Arthritis Rheum."},{"issue":"4","key":"10.1016\/j.intimp.2018.05.026_bb0210","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1136\/ard.2002.001461","article-title":"Carboxymethylated chitin reduces MMP-1 expression in rabbit ACLT osteoarthritic cartilage","volume":"63","author":"Hongbin","year":"2004","journal-title":"Ann. Rheum. Dis."},{"issue":"11","key":"10.1016\/j.intimp.2018.05.026_bb0215","doi-asserted-by":"crossref","first-page":"3530","DOI":"10.1002\/art.23958","article-title":"Inhibition of interleukin-1beta-induced matrix metalloproteinases 1 and 13 production in human osteoarthritic chondrocytes by prostaglandin D2","volume":"58","author":"Zayed","year":"2008","journal-title":"Arthritis Rheum."},{"issue":"5","key":"10.1016\/j.intimp.2018.05.026_bb0220","doi-asserted-by":"crossref","first-page":"599","DOI":"10.2174\/138945010791011938","article-title":"NF-kappaB signaling: multiple angles to target OA","volume":"11","author":"Marcu","year":"2010","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.intimp.2018.05.026_bb0225","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.molimm.2018.02.008","article-title":"Emodin attenuates titanium particle-induced osteolysis and RANKL-mediated osteoclastogenesis through the suppression of IKK phosphorylation","volume":"96","author":"Li","year":"2018","journal-title":"Mol. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2018.05.026_bb0230","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3109\/10799893.2013.863919","article-title":"WNT signaling and chondrocytes: from cell fate determination to osteoarthritis physiopathology","volume":"34","author":"Sassi","year":"2014","journal-title":"J. Recept. Signal Transduct. Res."},{"issue":"1","key":"10.1016\/j.intimp.2018.05.026_bb0235","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3109\/10520295.2013.819123","article-title":"The roles of canonical and non-canonical Wnt signaling in human de-differentiated articular chondrocytes","volume":"89","author":"Sassi","year":"2014","journal-title":"Biotech. Histochem."},{"issue":"10","key":"10.1016\/j.intimp.2018.05.026_bb0240","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/ncprheum0904","article-title":"Wnt-beta-catenin signaling in the pathogenesis of osteoarthritis","volume":"4","author":"Corr","year":"2008","journal-title":"Nat. Clin. Pract. Rheumatol."},{"issue":"3","key":"10.1016\/j.intimp.2018.05.026_bb0245","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/labinvest.3700747","article-title":"Wnt\/beta-catenin signaling stimulates matrix catabolic genes and activity in articular chondrocytes: its possible role in joint degeneration","volume":"88","author":"Yuasa","year":"2008","journal-title":"Lab. Investig."},{"key":"10.1016\/j.intimp.2018.05.026_bb0250","doi-asserted-by":"crossref","unstructured":"W.J. Li, L.P. Tang, Y. Xiong, W.P. Chen, X.D. Zhou, Q.H. Ding, L.D. Wu, A possible mechanism in DHEA-mediated protection against osteoarthritis, Steroids 89 (2014) 20\u20136.","DOI":"10.1016\/j.steroids.2014.07.011"},{"issue":"Suppl 3","key":"10.1016\/j.intimp.2018.05.026_bb0255","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1016\/j.joca.2010.05.029","article-title":"The OARSI histopathology initiative \u2014 recommendations for histological assessments of osteoarthritis in the rabbit","volume":"18","author":"Laverty","year":"2010","journal-title":"Osteoarthr. Cartil."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576918302376?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576918302376?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,19]],"date-time":"2019-10-19T03:38:40Z","timestamp":1571456320000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576918302376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":51,"alternative-id":["S1567576918302376"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2018.05.026","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Emodin ameliorates cartilage degradation in osteoarthritis by inhibiting NF-\u03baB and Wnt\/\u03b2-catenin signaling in-vitro and in-vivo","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2018.05.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}