{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:14:22Z","timestamp":1761585262057,"version":"build-2065373602"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"National Key R&D Program of China","award":["2017YFD0501705","2016YFD0500203"],"award-info":[{"award-number":["2017YFD0501705","2016YFD0500203"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.intimp.2018.07.011","type":"journal-article","created":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T13:19:21Z","timestamp":1533302361000},"page":"119-128","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Influenza virus-like particles composed of conserved influenza proteins and GPI-anchored CCL28\/GM-CSF fusion proteins enhance protective immunity against homologous and heterologous viruses"],"prefix":"10.1016","volume":"63","author":[{"given":"Jing","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiguang","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongmei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongkun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter R.","family":"Wilker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiyang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiecheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanguo","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hualei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianliang","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0979-0526","authenticated-orcid":false,"given":"Songtao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbin","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0760-0503","authenticated-orcid":false,"given":"Yuwei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianzhu","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.intimp.2018.07.011_bb0005","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1001\/jama.292.11.1333","article-title":"Influenza-associated hospitalizations in the United States","volume":"292","author":"Thompson","year":"2004","journal-title":"J. Am. Med. Assoc."},{"issue":"10","key":"10.1016\/j.intimp.2018.07.011_bb0010","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1093\/cid\/cis211","article-title":"Hospitalizations associated with influenza and respiratory syncytial virus in the United States, 1993\u20132008","volume":"54","author":"Zhou","year":"2012","journal-title":"Clin. Infect. Dis."},{"issue":"1","key":"10.1016\/j.intimp.2018.07.011_bb0015","doi-asserted-by":"crossref","first-page":"35","DOI":"10.7774\/cevr.2012.1.1.35","article-title":"Principles underlying rational design of live attenuated influenza vaccines","volume":"1","author":"Jang","year":"2012","journal-title":"Clin. Exp. Vaccin. Res."},{"issue":"3","key":"10.1016\/j.intimp.2018.07.011_bb0020","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nrd4529","article-title":"Advances in the development of influenza virus vaccines","volume":"14","author":"Krammer","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"issue":"1","key":"10.1016\/j.intimp.2018.07.011_bb0025","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3201\/eid1201.051254","article-title":"Influenza pandemics of the 20th century","volume":"12","author":"Kilbourne","year":"2006","journal-title":"Emerg. Infect. Dis. J."},{"issue":"4 Suppl","key":"10.1016\/j.intimp.2018.07.011_bb0030","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.1097\/CCM.0b013e3181ceb25b","article-title":"The 1918 influenza pandemic: lessons for 2009 and the future","volume":"38","author":"Morens","year":"2010","journal-title":"Crit. Care Med."},{"issue":"4","key":"10.1016\/j.intimp.2018.07.011_bb0035","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1586\/erv.09.8","article-title":"Influenza virus-like particle vaccines","volume":"8","author":"Haynes","year":"2009","journal-title":"Expert Rev. Vaccines"},{"issue":"12","key":"10.1016\/j.intimp.2018.07.011_bb0040","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1128\/CVI.05206-11","article-title":"Virus-like particle vaccine containing hemagglutinin confers protection against 2009 H1N1 pandemic influenza","volume":"18","author":"Hossain","year":"2011","journal-title":"Clin. Vaccine Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2018.07.011_bb0045","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.vaccine.2015.11.074","article-title":"Supplemented vaccination with tandem repeat M2e virus-like particles enhances protection against homologous and heterologous HPAI H5 viruses in chickens","volume":"34","author":"Song","year":"2016","journal-title":"Vaccine"},{"key":"10.1016\/j.intimp.2018.07.011_bb0050","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.coviro.2016.03.001","article-title":"Engineering virus-like particles as vaccine platforms","volume":"18","author":"Frietze","year":"2016","journal-title":"Curr. Opin. Virol."},{"issue":"37","key":"10.1016\/j.intimp.2018.07.011_bb0055","doi-asserted-by":"crossref","first-page":"5533","DOI":"10.1016\/j.vaccine.2012.06.043","article-title":"A cell culture-derived whole-virus H5N1 vaccine induces long-lasting cross-clade protective immunity in mice which is augmented by a homologous or heterologous booster vaccination","volume":"30","author":"Sabarth","year":"2012","journal-title":"Vaccine"},{"issue":"7","key":"10.1016\/j.intimp.2018.07.011_bb0060","doi-asserted-by":"crossref","first-page":"3514","DOI":"10.1128\/JVI.02052-06","article-title":"Virus-like particle vaccine induces protective immunity against homologous and heterologous strains of influenza virus","volume":"81","author":"Quan","year":"2007","journal-title":"J. Virol."},{"issue":"4","key":"10.1016\/j.intimp.2018.07.011_bb0065","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.vaccine.2008.11.011","article-title":"Influenza-pseudotyped Gag virus-like particle vaccines provide broad protection against highly pathogenic avian influenza challenge","volume":"27","author":"Haynes","year":"2009","journal-title":"Vaccine"},{"issue":"1","key":"10.1016\/j.intimp.2018.07.011_bb0070","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.vaccine.2012.10.083","article-title":"Virus-like particles as a highly efficient vaccine platform: diversity of targets and production systems and advances in clinical development","volume":"31","author":"Kushnir","year":"2012","journal-title":"Vaccine"},{"issue":"5924","key":"10.1016\/j.intimp.2018.07.011_bb0075","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1126\/science.1171491","article-title":"Antibody recognition of a highly conserved influenza virus epitope","volume":"324","author":"Ekiert","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.intimp.2018.07.011_bb0080","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jconrel.2015.05.278","article-title":"Microneedle patch delivery to the skin of virus-like particles containing heterologous M2e extracellular domains of influenza virus induces broad heterosubtypic cross-protection","volume":"210","author":"Kim","year":"2015","journal-title":"J. Control. Release"},{"issue":"5","key":"10.1016\/j.intimp.2018.07.011_bb0085","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S1473-3099(06)70443-1","article-title":"Cytotoxic T-cell immunity as a target for influenza vaccines","volume":"6","author":"Mullbacher","year":"2006","journal-title":"Lancet Infect. Dis."},{"issue":"5","key":"10.1016\/j.intimp.2018.07.011_bb0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0037786","article-title":"Dissection of influenza a virus M1 protein: pH-dependent oligomerization of N-terminal domain and dimerization of C-terminal domain","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS One"},{"issue":"52","key":"10.1016\/j.intimp.2018.07.011_bb0095","doi-asserted-by":"crossref","first-page":"7658","DOI":"10.1016\/j.vaccine.2012.10.007","article-title":"Adjuvants in influenza vaccines","volume":"30","author":"Tetsutani","year":"2012","journal-title":"Vaccine"},{"issue":"26","key":"10.1016\/j.intimp.2018.07.011_bb0100","doi-asserted-by":"crossref","first-page":"3401","DOI":"10.1016\/j.vaccine.2017.05.010","article-title":"Immunologic evaluation of 10 different adjuvants for use in vaccines for chickens against highly pathogenic avian influenza virus","volume":"35","author":"Lone","year":"2017","journal-title":"Vaccine"},{"issue":"29","key":"10.1016\/j.intimp.2018.07.011_bb0105","doi-asserted-by":"crossref","first-page":"22313","DOI":"10.1074\/jbc.M001461200","article-title":"Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2)","volume":"275","author":"Wang","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.intimp.2018.07.011_bb0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0026979","article-title":"CCL28 induces mucosal homing of HIV-1-specific IgA-secreting plasma cells in mice immunized with HIV-1 virus-like particles","volume":"6","author":"Rainone","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.intimp.2018.07.011_bb0115","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/gt.2009.112","article-title":"Plasmids encoding the mucosal chemokines CCL27 and CCL28 are effective adjuvants in eliciting antigen-specific immunity in vivo","volume":"17","author":"Kutzler","year":"2010","journal-title":"Gene Ther."},{"issue":"4","key":"10.1016\/j.intimp.2018.07.011_bb0120","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.4049\/jimmunol.1300120","article-title":"CCL19 and CCL28 augment mucosal and systemic immune responses to HIV-1 gp140 by mobilizing responsive immunocytes into secondary lymph nodes and mucosal tissue","volume":"191","author":"Hu","year":"2013","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2018.07.011_bb0125","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cyto.2008.12.007","article-title":"Effect of immunological adjuvants: GM-CSF (granulocyte-monocyte colony stimulating, factor) and IL-23 (interleukin-23) on immune responses generated against hepatitis C virus core DNA vaccine","volume":"46","author":"Hartoonian","year":"2009","journal-title":"Cytokine"},{"key":"10.1016\/j.intimp.2018.07.011_bb0130","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/2051-1426-2-11","article-title":"Current status of granulocyte-macrophage colony-stimulating factor in the immunotherapy of melanoma","volume":"2","author":"Kaufman","year":"2014","journal-title":"J. Immunother. Cancer"},{"issue":"2","key":"10.1016\/j.intimp.2018.07.011_bb0135","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1093\/annonc\/mdl158","article-title":"Opposite immune functions of GM-CSF administered as vaccine adjuvant in cancer patients","volume":"18","author":"Parmiani","year":"2007","journal-title":"Ann. Oncol."},{"issue":"3","key":"10.1016\/j.intimp.2018.07.011_bb0140","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1128\/JVI.01692-06","article-title":"Incorporation of glycosylphosphatidylinositol-anchored granulocyte-macrophage colony-stimulating factor or CD40 ligand enhances immunogenicity of chimeric simian immunodeficiency virus-like particles","volume":"81","author":"Skountzou","year":"2007","journal-title":"J. Virol."},{"issue":"28\u201329","key":"10.1016\/j.intimp.2018.07.011_bb0145","doi-asserted-by":"crossref","first-page":"4053","DOI":"10.1016\/S0264-410X(01)00133-5","article-title":"The immune response to a DNA vaccine can be modulated by co-delivery of cytokine genes using a DNA prime-protein boost strategy","volume":"19","author":"Scheerlinck","year":"2001","journal-title":"Vaccine"},{"issue":"3","key":"10.1016\/j.intimp.2018.07.011_bb0150","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/jmv.2148","article-title":"Co-delivery of GM-CSF gene enhances the immune responses of hepatitis C viral core protein-expressing DNA vaccine: role of dendritic cells","volume":"66","author":"Pu","year":"2002","journal-title":"J. Med. Virol."},{"issue":"6","key":"10.1016\/j.intimp.2018.07.011_bb0155","doi-asserted-by":"crossref","first-page":"3102","DOI":"10.4049\/jimmunol.164.6.3102","article-title":"The timing of GM-CSF expression plasmid administration influences the Th1\/Th2 response induced by an HIV-1-specific DNA vaccine","volume":"164","author":"Kusakabe","year":"2000","journal-title":"J. Immunol."},{"issue":"8","key":"10.1016\/j.intimp.2018.07.011_bb0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002847","article-title":"The Ebola virus glycoprotein contributes to but is not sufficient for virulence in vivo","volume":"8","author":"Groseth","year":"2012","journal-title":"PLoS Pathog."},{"issue":"4","key":"10.1016\/j.intimp.2018.07.011_bb0165","doi-asserted-by":"crossref","DOI":"10.3390\/v8040115","article-title":"Intranasal immunization with influenza virus-like particles containing membrane-anchored cholera toxin B or ricin toxin B enhances adaptive immune responses and protection against an antigenically distinct virus","volume":"8","author":"Ji","year":"2016","journal-title":"Viruses"},{"key":"10.1016\/j.intimp.2018.07.011_bb0170","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.virusres.2015.01.007","article-title":"H5N1 influenza virus-like particle vaccine protects mice from heterologous virus challenge better than whole inactivated virus","volume":"200","author":"Ren","year":"2015","journal-title":"Virus Res."},{"issue":"2","key":"10.1016\/j.intimp.2018.07.011_bb0175","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/mt.2012.246","article-title":"Virus-like particles containing multiple M2 extracellular domains confer improved cross-protection against various subtypes of influenza virus","volume":"21","author":"Kim","year":"2013","journal-title":"Mol. Ther."},{"issue":"5","key":"10.1016\/j.intimp.2018.07.011_bb0180","doi-asserted-by":"crossref","first-page":"213","DOI":"10.4110\/in.2015.15.5.213","article-title":"Mechanisms of cross-protection by influenza virus M2-based vaccines","volume":"15","author":"Lee","year":"2015","journal-title":"Immune Netw."},{"issue":"10","key":"10.1016\/j.intimp.2018.07.011_bb0185","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.vaccine.2016.01.028","article-title":"Recombinant M2e outer membrane vesicle vaccines protect against lethal influenza A challenge in BALB\/c mice","volume":"34","author":"Rappazzo","year":"2016","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.intimp.2018.07.011_bb0190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0088340","article-title":"MVA vectors expressing conserved influenza proteins protect mice against lethal challenge with H5N1, H9N2 and H7N1 viruses","volume":"9","author":"Hessel","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.intimp.2018.07.011_bb0195","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0378-1119(91)90171-7","article-title":"Enhanced secretion from insect cells of a foreign protein fused to the honeybee melittin signal peptide","volume":"98","author":"Tessier","year":"1991","journal-title":"Gene"},{"issue":"16","key":"10.1016\/j.intimp.2018.07.011_bb0200","doi-asserted-by":"crossref","first-page":"10969","DOI":"10.1074\/jbc.274.16.10969","article-title":"Identification of the individual residues that determine human CD59 species selective activity","volume":"274","author":"Zhang","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2018.07.011_bb0205","doi-asserted-by":"crossref","DOI":"10.1038\/srep40226","article-title":"Chimeric virus-like particles containing influenza HA antigen and GPI-CCL28 induce long-lasting mucosal immunity against H3N2 viruses","volume":"7","author":"Mohan","year":"2017","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.intimp.2018.07.011_bb0210","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.nano.2015.02.008","article-title":"Protein transfer-mediated surface engineering to adjuvantate virus-like nanoparticles for enhanced anti-viral immune responses","volume":"11","author":"Patel","year":"2015","journal-title":"Nanomedicine"},{"key":"10.1016\/j.intimp.2018.07.011_bb0215","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jconrel.2016.05.021","article-title":"Co-delivery of GPI-anchored CCL28 and influenza HA in chimeric virus-like particles induces cross-protective immunity against H3N2 viruses","volume":"233","author":"Mohan","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.intimp.2018.07.011_bb0220","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.virusres.2014.09.018","article-title":"Incorporation of conserved nucleoprotein into influenza virus-like particles could provoke a broad protective immune response in BALB\/c mice and chickens","volume":"195","author":"Xue","year":"2015","journal-title":"Virus Res."},{"issue":"3","key":"10.1016\/j.intimp.2018.07.011_bb0225","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.chom.2017.02.007","article-title":"Generation of a live attenuated influenza vaccine that elicits broad protection in mice and ferrets","volume":"21","author":"Wang","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.intimp.2018.07.011_bb0230","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2015.00169","article-title":"Incorporation of membrane-anchored flagellin or Escherichia coli heat-labile enterotoxin B subunit enhances the innmunogenicity of rabies virus-like particles in mice and dogs","volume":"6","author":"Qi","year":"2015","journal-title":"Front. Microbiol."},{"issue":"21","key":"10.1016\/j.intimp.2018.07.011_bb0235","doi-asserted-by":"crossref","first-page":"4283","DOI":"10.1016\/j.vaccine.2007.02.059","article-title":"Evaluation of influenza virus-like particles and Novasome adjuvant as candidate vaccine for avian influenza","volume":"25","author":"Pushko","year":"2007","journal-title":"Vaccine"},{"issue":"9","key":"10.1016\/j.intimp.2018.07.011_bb0240","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.0030360","article-title":"Live, attenuated influenza A H5N1 candidate vaccines provide broad cross-protection in mice and ferrets","volume":"3","author":"Suguitan","year":"2006","journal-title":"PLoS Med."},{"issue":"6","key":"10.1016\/j.intimp.2018.07.011_bb0245","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.vaccine.2017.12.053","article-title":"A virus-like particle vaccine candidate for influenza A virus based on multiple conserved antigens presented on hepatitis B tandem core particles","volume":"36","author":"Ramirez","year":"2018","journal-title":"Vaccine"},{"key":"10.1016\/j.intimp.2018.07.011_bb0250","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2017.01730","article-title":"Cross-protective efficacy of influenza virus M2e containing virus-like particles is superior to hemagglutinin vaccines and variable depending on the genetic backgrounds of mice","volume":"8","author":"Kim","year":"2017","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2018.07.011_bb0255","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0190868","article-title":"Intranasal vaccination with M2e5x virus-like particles induces humoral and cellular immune responses conferring cross-protection against heterosubtypic influenza viruses","volume":"13","author":"Lee","year":"2018","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.intimp.2018.07.011_bb0260","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.1128\/JVI.77.6.3615-3623.2003","article-title":"Enhancement of mucosal immunization with virus-like particles of simian immunodeficiency virus","volume":"77","author":"Kang","year":"2003","journal-title":"J. Virol."},{"issue":"11","key":"10.1016\/j.intimp.2018.07.011_bb0265","doi-asserted-by":"crossref","first-page":"5726","DOI":"10.1128\/JVI.00207-09","article-title":"Intranasal vaccination with 1918 influenza virus-like particles protects mice and ferrets from lethal 1918 and H5N1 influenza virus challenge","volume":"83","author":"Perrone","year":"2009","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.intimp.2018.07.011_bb0270","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009161","article-title":"Virus-like particle vaccine protects against 2009 H1N1 pandemic influenza virus in mice","volume":"5","author":"Quan","year":"2010","journal-title":"PLoS One"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576918303370?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576918303370?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:09:36Z","timestamp":1761584976000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576918303370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":54,"alternative-id":["S1567576918303370"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2018.07.011","relation":{},"ISSN":["1567-5769"],"issn-type":[{"type":"print","value":"1567-5769"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Influenza virus-like particles composed of conserved influenza proteins and GPI-anchored CCL28\/GM-CSF fusion proteins enhance protective immunity against homologous and heterologous viruses","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2018.07.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}