{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:21:08Z","timestamp":1790544068853,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31772609"],"award-info":[{"award-number":["31772609"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010038","name":"Earmarked Fund for China Agriculture Research System","doi-asserted-by":"publisher","award":["CARS-36"],"award-info":[{"award-number":["CARS-36"]}],"id":[{"id":"10.13039\/501100010038","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Special Fund Project for Technology Innovation of Hubei Province","award":["2016ABA113"],"award-info":[{"award-number":["2016ABA113"]}]},{"name":"Hubei Provincial Creative Team Project of Agricultural Science and Technology","award":["2007620"],"award-info":[{"award-number":["2007620"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.intimp.2018.10.022","type":"journal-article","created":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T21:21:37Z","timestamp":1539811297000},"page":"303-311","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"special_numbering":"C","title":["Caprylic acid and nonanoic acid upregulate endogenous host defense peptides to enhance intestinal epithelial immunological barrier function via histone deacetylase inhibition"],"prefix":"10.1016","volume":"65","author":[{"given":"Jun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningning","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongkui","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwen","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2018.10.022_bb0005","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/415389a","article-title":"Antimicrobial peptides of multicellular organisms","volume":"415","author":"Zasloff","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2018.10.022_bb0010","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1128\/CMR.00056-05","article-title":"Peptide antimicrobial agents","volume":"19","author":"Jenssen","year":"2006","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.intimp.2018.10.022_bb0015","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1038\/nbt1267","article-title":"Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies","volume":"24","author":"Hancock","year":"2006","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.intimp.2018.10.022_bb0020","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/nchembio.1393","article-title":"Immune modulation by multifaceted cationic host defense (antimicrobial) peptides","volume":"9","author":"Hilchie","year":"2013","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.intimp.2018.10.022_bb0025","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.vetimm.2006.07.012","article-title":"Differential regulation of porcine beta-defensins 1 and 2 upon Salmonella infection in the intestinal epithelial cell line IPI-2I","volume":"114","author":"Veldhuizen","year":"2006","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.intimp.2018.10.022_bb0030","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s00335-005-0158-0","article-title":"Bioinformatic and expression analysis of novel porcine beta-defensins","volume":"17","author":"Sang","year":"2006","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.intimp.2018.10.022_bb0035","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.molimm.2006.03.005","article-title":"Expression of beta-defensins pBD-1 and pBD-2 along the small intestinal tract of the pig: lack of upregulation in vivo upon Salmonella typhimurium infection","volume":"44","author":"Veldhuizen","year":"2007","journal-title":"Mol. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2018.10.022_bb0040","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.aninu.2018.01.003","article-title":"Dietary modulation of endogenous host defense peptide synthesis as an alternative approach to in-feed antibiotics","volume":"4","author":"Robinson","year":"2018","journal-title":"Anim. Nutr."},{"key":"10.1016\/j.intimp.2018.10.022_bb0045","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1615\/CritRevOncog.2015012997","article-title":"Histone deacetylases and mechanisms of regulation of gene expression (histone deacetylases in cancer)","volume":"20","author":"Chen","year":"2015","journal-title":"Crit. Rev. Oncog."},{"key":"10.1016\/j.intimp.2018.10.022_bb0050","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1124\/jpet.114.218768","article-title":"Seizure control by derivatives of medium chain fatty acids associated with the ketogenic diet show novel branching-point structure for enhanced potency","volume":"352","author":"Chang","year":"2015","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.intimp.2018.10.022_bb0055","doi-asserted-by":"crossref","first-page":"3200","DOI":"10.2527\/jas.2012-5673","article-title":"Effects of dietary combinations of organic acids and medium chain fatty acids on the gastrointestinal microbial ecology and bacterial metabolites in the digestive tract of weaning piglets","volume":"91","author":"Zentek","year":"2013","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.intimp.2018.10.022_bb0060","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3168\/jds.S0022-0302(02)74079-4","article-title":"The composition of bovine milk lipids: January 1995 to December 2000","volume":"85","author":"Jensen","year":"2002","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.intimp.2018.10.022_bb0065","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1128\/AAC.45.4.1298-1301.2001","article-title":"Bactericidal activities of milk lipids","volume":"45","author":"Sprong","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.intimp.2018.10.022_bb0070","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1034\/j.1600-0463.2001.d01-131.x","article-title":"Killing of Gram-positive cocci by fatty acids and monoglycerides","volume":"109","author":"Bergsson","year":"2001","journal-title":"APMIS"},{"key":"10.1016\/j.intimp.2018.10.022_bb0075","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1007\/s00253-009-2355-3","article-title":"Antibacterial free fatty acids: activities, mechanisms of action and biotechnological potential","volume":"85","author":"Desbois","year":"2010","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.intimp.2018.10.022_bb0080","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1128\/AEM.58.2.624-629.1992","article-title":"Inhibition of listeria monocytogenes by fatty acids and monoglycerides","volume":"58","author":"Wang","year":"1992","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.intimp.2018.10.022_bb0085","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/BF02931506","article-title":"Susceptibility of Escherichia coli to C2-C18 fatty acids","volume":"48","author":"Marounek","year":"2003","journal-title":"Folia Microbiol. (Praha)"},{"key":"10.1016\/j.intimp.2018.10.022_bb0090","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/BF02931402","article-title":"In vitro effect of C2-C18 fatty acids on Salmonellas","volume":"49","author":"Skrivanova","year":"2004","journal-title":"Folia Microbiol. (Praha)"},{"key":"10.1016\/j.intimp.2018.10.022_bb0095","doi-asserted-by":"crossref","first-page":"6591","DOI":"10.1007\/s11033-014-3543-5","article-title":"The role of epithelial tight junctions involved in pathogen infections","volume":"41","author":"Lu","year":"2014","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.intimp.2018.10.022_bb0100","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1002\/mnfr.201500992","article-title":"Green tea polyphenol epigallocatechin-3-gallate improves epithelial barrier function by inducing the production of antimicrobial peptide pBD-1 and pBD-2 in monolayers of porcine intestinal epithelial IPEC-J2 cells","volume":"60","author":"Wan","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.intimp.2018.10.022_bb0105","doi-asserted-by":"crossref","DOI":"10.1038\/srep17651","article-title":"Specific immunotherapy in combination with Clostridium butyricum inhibits allergic inflammation in the mouse intestine","volume":"5","author":"Shi","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2018.10.022_bb0110","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1136\/gut.45.6.911","article-title":"Defensins and innate host defence of the gastrointestinal tract","volume":"45","author":"Bevins","year":"1999","journal-title":"Gut"},{"key":"10.1016\/j.intimp.2018.10.022_bb0115","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.molimm.2007.06.001","article-title":"Porcine beta-defensin 2 displays broad antimicrobial activity against pathogenic intestinal bacteria","volume":"45","author":"Veldhuizen","year":"2008","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.intimp.2018.10.022_bb0120","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1055\/s-0030-1262879","article-title":"Pathophysiology of typical hemolytic uremic syndrome","volume":"36","author":"Karpman","year":"2010","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1016\/j.intimp.2018.10.022_bb0125","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1128\/IAI.74.4.2338-2352.2006","article-title":"The host defense peptide beta-defensin 1 confers protection against Bordetella pertussis in newborn piglets","volume":"74","author":"Elahi","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.intimp.2018.10.022_bb0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0049558","article-title":"Modulation of antimicrobial host defense peptide gene expression by free fatty acids","volume":"7","author":"Sunkara","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2018.10.022_bb0135","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.peptides.2013.10.008","article-title":"Differential regulation of human cathelicidin LL-37 by free fatty acids and their analogs","volume":"50","author":"Jiang","year":"2013","journal-title":"Peptides"},{"key":"10.1016\/j.intimp.2018.10.022_bb0140","article-title":"Induction of porcine host defense peptide gene expression by short-chain fatty acids and their analogs","volume":"8","author":"Zeng","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2018.10.022_bb0145","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.intimp.2018.03.014","article-title":"Blend of organic acids and medium chain fatty acids prevents the inflammatory response and intestinal barrier dysfunction in mice challenged with enterohemorrhagic Escherichia coli O157:H7","volume":"58","author":"Wang","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2018.10.022_bb0150","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.gene.2005.09.010","article-title":"Acetylation and deacetylation of non-histone proteins","volume":"363","author":"Glozak","year":"2005","journal-title":"Gene"},{"key":"10.1016\/j.intimp.2018.10.022_bb0155","doi-asserted-by":"crossref","DOI":"10.1038\/srep27070","article-title":"Butyrate upregulates endogenous host defense peptides to enhance disease resistance in piglets via histone deacetylase inhibition","volume":"6","author":"Xiong","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2018.10.022_bb0160","doi-asserted-by":"crossref","first-page":"8028","DOI":"10.1128\/JVI.00722-14","article-title":"Activation and repression of Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus lytic cycles by short- and medium-chain fatty acids","volume":"88","author":"Gorres","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.intimp.2018.10.022_bb0165","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1186\/1471-2164-13-424","article-title":"H3K9 and H3K14 acetylation co-occur at many gene regulatory elements, while H3K14ac marks a subset of inactive inducible promoters in mouse embryonic stem cells","volume":"13","author":"Karmodiya","year":"2012","journal-title":"BMC Genomics"},{"key":"10.1016\/j.intimp.2018.10.022_bb0170","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1042\/BJ20090870","article-title":"Binding of the CHD4 PHD2 finger to histone H3 is modulated by covalent modifications","volume":"423","author":"Musselman","year":"2009","journal-title":"Biochem. J."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576918308877?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576918308877?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T10:08:12Z","timestamp":1605262092000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576918308877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":34,"alternative-id":["S1567576918308877"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2018.10.022","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Caprylic acid and nonanoic acid upregulate endogenous host defense peptides to enhance intestinal epithelial immunological barrier function via histone deacetylase inhibition","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2018.10.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}