{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:23:11Z","timestamp":1786990991246,"version":"build-2736575974"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81630084"],"award-info":[{"award-number":["81630084"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471467"],"award-info":[{"award-number":["81471467"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.intimp.2019.01.052","type":"journal-article","created":{"date-parts":[[2019,2,10]],"date-time":"2019-02-10T09:38:28Z","timestamp":1549791508000},"page":"235-244","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Oral cholecalciferol supplementation alleviates lipopolysaccharide-induced preterm delivery partially through regulating placental steroid hormones and prostaglandins in mice"],"prefix":"10.1016","volume":"69","author":[{"given":"Lin","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Hua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-Xiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.intimp.2019.01.052_bb0005","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/S0002-9440(10)63473-6","article-title":"A critical involvement of oxidative stress in acute alcohol-induced hepatic TNF-alpha production","volume":"163","author":"Zhou","year":"2003","journal-title":"Am. J. Pathol."},{"issue":"5","key":"10.1016\/j.intimp.2019.01.052_bb0010","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1016\/0016-5085(95)90708-4","article-title":"Intestinal permeability: an overview","volume":"108","author":"Bjarnason","year":"1995","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.intimp.2019.01.052_bb0015","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1093\/femsre\/fuw007","article-title":"Lipopolysaccharide modification in Gram-negative bacteria during chronic infection","volume":"40","author":"Maldonado","year":"2016","journal-title":"FEMS Microbiol. Rev."},{"issue":"18","key":"10.1016\/j.intimp.2019.01.052_bb0020","doi-asserted-by":"crossref","first-page":"7534","DOI":"10.1073\/pnas.0702279104","article-title":"Nitric oxide mediates prostaglandins' deleterious effect on lipopolysaccharide-triggered murine fetal resorption","volume":"104","author":"Aisemberg","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.intimp.2019.01.052_bb0025","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.4049\/jimmunol.1002679","article-title":"Spontaneous pregnancy loss mediated by abnormal maternal inflammation in rats is linked to deficient uteroplacental perfusion","volume":"186","author":"Renaud","year":"2011","journal-title":"J. Immunol."},{"issue":"11","key":"10.1016\/j.intimp.2019.01.052_bb0030","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1093\/molehr\/gaw050","article-title":"A role for the endocannabinoid system in premature luteal regression and progesterone withdrawal in lipopolysaccharide-induced early pregnancy loss model","volume":"22","author":"Schander","year":"2016","journal-title":"Mol. Hum. Reprod."},{"issue":"1","key":"10.1016\/j.intimp.2019.01.052_bb0035","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/toxsci\/kfn027","article-title":"Reactive oxygen species contribute to lipopolysaccharide-induced teratogens in mice","volume":"103","author":"Zhao","year":"2008","journal-title":"Toxicol. Sci."},{"issue":"2","key":"10.1016\/j.intimp.2019.01.052_bb0040","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.toxlet.2013.10.021","article-title":"Folic acid supplementation during pregnancy protects against lipopolysaccharide-induced neural tube defects in mice","volume":"224","author":"Zhao","year":"2014","journal-title":"Toxicol. Lett."},{"issue":"12","key":"10.1016\/j.intimp.2019.01.052_bb0045","doi-asserted-by":"crossref","first-page":"4762","DOI":"10.4049\/jimmunol.1601331","article-title":"Obeticholic acid protects against lipopolysaccharide-induced fetal death and intrauterine growth restriction through its anti-inflammatory activity","volume":"197","author":"Chen","year":"2016","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2019.01.052_bb0050","doi-asserted-by":"crossref","first-page":"454","DOI":"10.4049\/jimmunol.1103579","article-title":"Zinc supplementation during pregnancy protects against lipopolysaccharide-induced fetal growth restriction and demise through its anti-inflammatory effect","volume":"189","author":"Chen","year":"2012","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2019.01.052_bb0055","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1084\/jem.20130295","article-title":"Inflammation in rat pregnancy inhibits spiral artery remodeling leading to fetal growth restriction and features of preeclampsia","volume":"211","author":"Cotechini","year":"2014","journal-title":"J. Exp. Med."},{"issue":"9","key":"10.1016\/j.intimp.2019.01.052_bb0060","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1016\/j.ajpath.2015.05.015","article-title":"Specific lipopolysaccharide serotypes induce differential maternal and neonatal inflammatory responses in a murine model of preterm labor","volume":"185","author":"Migale","year":"2015","journal-title":"Am. J. Pathol."},{"issue":"1","key":"10.1016\/j.intimp.2019.01.052_bb0065","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1210\/er.2012-1012","article-title":"The roles of vitamin D in skeletal muscle: form, function, and metabolism","volume":"34","author":"Girgis","year":"2013","journal-title":"Endocr. Rev."},{"issue":"5","key":"10.1016\/j.intimp.2019.01.052_bb0070","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1210\/jc.2014-4407","article-title":"Maternal vitamin D deficiency during pregnancy elevates the risks of small for gestational age and low birth weight infants in Chinese population","volume":"100","author":"Chen","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.intimp.2019.01.052_bb0075","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1093\/humupd\/4.4.389","article-title":"Pregnancy maintenance and the regulation of placental progesterone biosynthesis in the baboon","volume":"4","author":"Henson","year":"1998","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.intimp.2019.01.052_bb0080","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jsbmb.2017.09.010","article-title":"Maternal early pregnancy vitamin D status in relation to low birth weight and small-for-gestational-age offspring","volume":"175","author":"Wang","year":"2018","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"2","key":"10.1016\/j.intimp.2019.01.052_bb0085","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1097\/AOG.0000000000000621","article-title":"Early-pregnancy vitamin D deficiency and risk of preterm birth subtypes","volume":"125","author":"Bodnar","year":"2015","journal-title":"Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.intimp.2019.01.052_bb0090","doi-asserted-by":"crossref","first-page":"3608","DOI":"10.1038\/s41598-018-21944-3","article-title":"Influent factors of gestational vitamin D deficiency and its relation to an increased risk of preterm delivery in Chinese population","volume":"8","author":"Chen","year":"2018","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.intimp.2019.01.052_bb0095","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.3945\/ajcn.115.123752","article-title":"Maternal vitamin D concentrations during pregnancy, fetal growth patterns, and risks of adverse birth outcomes","volume":"103","author":"Miliku","year":"2018","journal-title":"Am. J. Clin. Nutr."},{"issue":"11","key":"10.1016\/j.intimp.2019.01.052_bb0100","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1093\/jn\/123.11.1939","article-title":"AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet","volume":"123","author":"American Institute of Nutrition","year":"1993","journal-title":"J. Nutr."},{"issue":"1","key":"10.1016\/j.intimp.2019.01.052_bb0105","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/toxsci\/kfv036","article-title":"Supplementation with vitamin D3 during pregnancy protects against lipopolysaccharide-induced neural tube defects through improving placental folate transportation","volume":"145","author":"Chen","year":"2015","journal-title":"Toxicol. Sci."},{"issue":"12","key":"10.1016\/j.intimp.2019.01.052_bb0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082713","article-title":"Folic acid protects against lipopolysaccharide-induced preterm delivery and intrauterine growth restriction through its anti-inflammatory effect in mice","volume":"8","author":"Zhao","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2019.01.052_bb0115","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.intimp.2018.11.005","article-title":"Obeticholic acid alleviate lipopolysaccharide-induced acute lung injury via its anti-inflammatory effects in mice","volume":"66","author":"Fei","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2019.01.052_bb0120","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jsbmb.2013.01.015","article-title":"Regulation of progesterone signaling during pregnancy: implications for the use of progestins for the prevention of preterm birth","volume":"139","author":"Byrns","year":"2014","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"1","key":"10.1016\/j.intimp.2019.01.052_bb0125","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1210\/er.2006-0022","article-title":"The molecular control of corpus luteum formation, function, and regression","volume":"28","author":"Stocco","year":"2007","journal-title":"Endocr. Rev."},{"issue":"8","key":"10.1016\/j.intimp.2019.01.052_bb0130","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1210\/me.2002-0056","article-title":"Transcription of cholesterol side-chain cleavage cytochrome P450 in the placenta: activating protein-2 assumes the role of steroidogenic factor-1 by binding to an overlapping promoter element","volume":"16","author":"Ben-Zimra","year":"2002","journal-title":"Mol. Endocrinol."},{"issue":"1","key":"10.1016\/j.intimp.2019.01.052_bb0135","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.mce.2013.09.014","article-title":"Immunolocalization of murine type VI 3\u03b2-hydroxysteroid dehydrogenase in the adrenal gland, testis, skin, and placenta, Mol","volume":"382","author":"Yamamura","year":"2014","journal-title":"Cell Endocrinol."},{"issue":"5","key":"10.1016\/j.intimp.2019.01.052_bb0140","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1507\/endocrj.50.579","article-title":"Differential regulation of estrogen receptor alpha and beta mRNAs in the rat uterus during pregnancy and labor: possible involvement of estrogen receptors in oxytocin receptor regulation","volume":"50","author":"Murata","year":"2003","journal-title":"Endocr. J."},{"issue":"4","key":"10.1016\/j.intimp.2019.01.052_bb0145","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/nm0498-456","article-title":"Local paracrine effects of estradiol are central to parturition in the rhesus monkey","volume":"4","author":"Nathanielsz","year":"1998","journal-title":"Nat. Med."},{"issue":"11","key":"10.1016\/j.intimp.2019.01.052_bb0150","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a023069","article-title":"Molecular regulation of parturition: a myometrial perspective","volume":"5","author":"Renthal","year":"2015","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"3","key":"10.1016\/j.intimp.2019.01.052_bb0155","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1530\/JME-15-0248","article-title":"Interaction of steroid receptor coactivators and estrogen receptors in the human placenta","volume":"56","author":"Kim","year":"2016","journal-title":"J. Mol. Endocrinol."},{"issue":"4","key":"10.1016\/j.intimp.2019.01.052_bb0160","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1095\/biolreprod66.4.976","article-title":"Occurrence of estrogen receptor alpha in bovine placentomes throughout mid and late gestation and at parturition","volume":"66","author":"Schuler","year":"2002","journal-title":"Biol. Reprod."},{"issue":"4","key":"10.1016\/j.intimp.2019.01.052_bb0165","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1111\/j.1476-5381.2010.00911.x","article-title":"Dual effect of nitric oxide on uterine prostaglandin synthesis in a murine model of preterm labour","volume":"161","author":"Cella","year":"2010","journal-title":"Br. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.intimp.2019.01.052_bb0170","doi-asserted-by":"crossref","DOI":"10.1111\/aji.12620","article-title":"Vitamin D3 pretreatment protects against lipopolysaccharide-induced early embryo loss through its anti-inflammatory effects","volume":"77","author":"Zhou","year":"2017","journal-title":"Am. J. Reprod. Immunol."},{"issue":"17","key":"10.1016\/j.intimp.2019.01.052_bb0175","doi-asserted-by":"crossref","first-page":"11681","DOI":"10.1074\/jbc.M113.517581","article-title":"Vitamin D inhibits COX-2 expression and inflammatory response by targeting thioesterase superfamily member 4","volume":"289","author":"Wang","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.intimp.2019.01.052_bb0180","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1172\/JCI40051","article-title":"2010. Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice","volume":"120","author":"Hirota","year":"2010","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.intimp.2019.01.052_bb0185","doi-asserted-by":"crossref","first-page":"e12816","DOI":"10.1111\/aji.12816","article-title":"Lipopolysaccharide-induced maternal inflammation induces direct placental injury without alteration in placental blood flow and induces a secondary fetal intestinal injury that persists into adulthood","volume":"79","author":"Fricke","year":"2018","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.intimp.2019.01.052_bb0190","article-title":"Vitamin D3 inhibits lipopolysaccharide-induced placental inflammation through reinforcing interaction between vitamin D receptor and nuclear factor kappa B p65 subunit","volume":"12","author":"Chen","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2019.01.052_bb0195","doi-asserted-by":"crossref","first-page":"18687","DOI":"10.1038\/srep18687","article-title":"Vitamin D3 pretreatment regulates renal inflammatory responses during lipopolysaccharide-induced acute kidney injury","volume":"22","author":"Xu","year":"2015","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.intimp.2019.01.052_bb0200","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1152\/physrev.00014.2015","article-title":"Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects","volume":"96","author":"Christakos","year":"2016","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.intimp.2019.01.052_bb0205","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1194\/jlr.R031534","article-title":"Cytochrome P450-mediated metabolism of vitamin D","volume":"55","author":"Jones","year":"2014","journal-title":"J. Lipid Res."},{"issue":"2","key":"10.1016\/j.intimp.2019.01.052_bb0210","doi-asserted-by":"crossref","first-page":"354","DOI":"10.3945\/ajcn.116.130419","article-title":"Vitamin D status is associated with uteroplacental dysfunction indicated by pre-eclampsia and small-for-gestational-age birth in a large prospective pregnancy cohort in Ireland with low vitamin D status","volume":"104","author":"Kiely","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"issue":"1","key":"10.1016\/j.intimp.2019.01.052_bb0215","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3945\/ajcn.112.037473","article-title":"SWS study group., maternal vitamin D status in pregnancy is associated with adiposity in the offspring: findings from the Southampton Women's survey","volume":"96","author":"Crozier","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"issue":"1","key":"10.1016\/j.intimp.2019.01.052_bb0220","doi-asserted-by":"crossref","first-page":"e167","DOI":"10.1542\/peds.2014-1860","article-title":"Vitamin D in fetal development: findings from a birth cohort study","volume":"135","author":"Hart","year":"2015","journal-title":"Pediatrics"},{"issue":"1","key":"10.1016\/j.intimp.2019.01.052_bb0225","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1067\/mob.2003.112","article-title":"Protective effect of N-acetylcysteine against fetal death and preterm labor induced by maternal inflammation","volume":"188","author":"Buhimschi","year":"2003","journal-title":"Am. J. Obstet. Gynecol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576919300517?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576919300517?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:09:54Z","timestamp":1777619394000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576919300517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":45,"alternative-id":["S1567576919300517"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2019.01.052","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oral cholecalciferol supplementation alleviates lipopolysaccharide-induced preterm delivery partially through regulating placental steroid hormones and prostaglandins in mice","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2019.01.052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}