{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:48:20Z","timestamp":1791388100272,"version":"4.3.3"},"reference-count":109,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.intimp.2019.02.026","type":"journal-article","created":{"date-parts":[[2019,2,23]],"date-time":"2019-02-23T16:32:09Z","timestamp":1550939529000},"page":"156-166","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["Immunomodulatory properties of cimetidine: Its therapeutic potentials for treatment of immune-related diseases"],"prefix":"10.1016","volume":"70","author":[{"given":"Abdollah","family":"Jafarzadeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Nemati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossain","family":"Khorramdelazad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuhair Mohammad","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2019.02.026_bb0005","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/9524075","article-title":"Role of histamine in modulating the immune response and inflammation","volume":"2018","author":"Branco","year":"2018","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.intimp.2019.02.026_bb0010","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3389\/fncel.2014.00120","article-title":"Histamine: a new immunomodulatory player in the neuron-glia crosstalk","volume":"8","author":"Rocha","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.intimp.2019.02.026_bb0015","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.3389\/fimmu.2018.01392","article-title":"Molecular regulation of histamine synthesis","volume":"9","author":"Huang","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0020","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.coi.2017.08.011","article-title":"Immune regulation by histamine and histamine-secreting bacteria","volume":"48","author":"Barcik","year":"2017","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0025","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.jaci.2013.01.013","article-title":"Histamine receptor 2 modifies dendritic cell responses to microbial ligands","volume":"132","author":"Frei","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0030","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1080\/21645515.2016.1191719","article-title":"Cimetidine down-regulates stability of Foxp3 protein via Stub1 in Treg cells","volume":"12","author":"Zhang","year":"2016","journal-title":"Hum. Vaccin. Immunother."},{"key":"10.1016\/j.intimp.2019.02.026_bb0035","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3109\/1547691X.2012.708365","article-title":"Cimetidine enhances delayed-type hypersensitivity responses and serum interleukin (IL)-2, -10, -12, and IL-17 levels after burn injury in an animal model","volume":"10","author":"Jafarzadeh","year":"2013","journal-title":"J. Immunotoxicol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0040","doi-asserted-by":"crossref","first-page":"154","DOI":"10.5114\/aoms.2012.27295","article-title":"T lymphocytes as a target of histamine action","volume":"8","author":"Kmiecik","year":"2012","journal-title":"Arch. Med. Sci."},{"key":"10.1016\/j.intimp.2019.02.026_bb0045","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1189\/jlb.0111017","article-title":"Histamine down-regulates IL-27 production in antigen-presenting cells","volume":"92","author":"Gschwandtner","year":"2012","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0050","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/j.0022-202X.2005.23891.x","article-title":"Histamine induces the generation of monocyte-derived dendritic cells that express CD14 but not CD1a","volume":"125","author":"Katoh","year":"2005","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0055","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1111\/j.1398-9995.1992.tb02385.x","article-title":"Histamine-induced inhibition of neutrophil chemotaxis and T-lymphocyte proliferation in man","volume":"47","author":"Bury","year":"1992","journal-title":"Allergy"},{"key":"10.1016\/j.intimp.2019.02.026_bb0060","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1902\/jop.2005.76.6.998","article-title":"Effect of topical cimetidine rinse on gingival crevicular neutrophil leukocyte function","volume":"76","author":"Van Dyke","year":"2005","journal-title":"J. Periodontol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0065","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1213\/00000539-199907000-00040","article-title":"The effects of cimetidine, ranitidine, and famotidine on human neutrophil functions","volume":"89","author":"Mikawa","year":"1999","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.intimp.2019.02.026_bb0070","first-page":"1576","article-title":"The effect of cimetidine mainly increases CD4+ cells of peripheral blood T lymphocytes","volume":"32","author":"Asakage","year":"2005","journal-title":"Gan To Kagaku Ryoho"},{"key":"10.1016\/j.intimp.2019.02.026_bb0075","first-page":"361","article-title":"Anti-tumor effects of cimetidine on hepatocellular carcinomas in diethylnitrosamine-treated rats","volume":"19","author":"Furuta","year":"2008","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.intimp.2019.02.026_bb0080","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3109\/00365529509093275","article-title":"Comparison of immunomodulative effects of the histamine-2 receptor antagonists cimetidine, ranitidine, and famotidine on peripheral blood mononuclear cells in gastric cancer patients","volume":"30","author":"Hahm","year":"1995","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0085","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1684\/ecn.2018.0401","article-title":"Interleukin-18: a regulator of cancer and autoimmune diseases","volume":"28","author":"Esmailbeig","year":"2017","journal-title":"Eur. Cytokine Netw."},{"key":"10.1016\/j.intimp.2019.02.026_bb0090","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1124\/mol.106.025890","article-title":"Cimetidine induces interleukin-18 production through H2-agonist activity in monocytes","volume":"70","author":"Takahashi","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0095","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1111\/all.13227","article-title":"Histamine receptor 2 modifies iNKT cell activity within the inflamed lung","volume":"72","author":"Ferstl","year":"2017","journal-title":"Allergy"},{"key":"10.1016\/j.intimp.2019.02.026_bb0100","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jdiacomp.2006.02.002","article-title":"Effects of histamine 2 receptor antagonists on endothelial-neutrophil adhesion and surface expression of endothelial adhesion molecules induced by high glucose levels","volume":"21","author":"Takeuchi","year":"2007","journal-title":"J. Diabetes Complicat."},{"key":"10.1016\/j.intimp.2019.02.026_bb0105","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.4049\/jimmunol.161.5.2586","article-title":"Histamine potently suppresses human IL-12 and stimulates IL-10 production via H2 receptors","volume":"161","author":"Elenkov","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0110","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1172\/JCI200113930","article-title":"Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization","volume":"108","author":"Mazzoni","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.intimp.2019.02.026_bb0115","doi-asserted-by":"crossref","first-page":"4862","DOI":"10.1016\/j.vaccine.2011.03.091","article-title":"Cimetidine augments Th1\/Th2 dual polarized immune responses to recombinant HBV antigens","volume":"29","author":"Zhang","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.intimp.2019.02.026_bb0120","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/intimm\/dxl121","article-title":"Increased antigen presentation and T(h)1 polarization in genetically histamine-free mice","volume":"19","author":"Jelinek","year":"2007","journal-title":"Int. Immunol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0125","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1365-2567.2006.02326.x","article-title":"Histamine and prostaglandin E up-regulate the production of Th2-attracting chemokines (CCL17 and CCL22) and down-regulate IFN-gamma-induced CXCL10 production by immature human dendritic cells","volume":"117","author":"McIlroy","year":"2006","journal-title":"Immunology"},{"key":"10.1016\/j.intimp.2019.02.026_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/1028415X.2018.1436237","article-title":"Vitamin D down-regulates the expression of some Th17 cell-related cytokines, key inflammatory chemokines, and chemokine receptors in experimental autoimmune encephalomyelitis","author":"Jafarzadeh","year":"2018","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.intimp.2019.02.026_bb0135","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1006\/cimm.1996.0145","article-title":"Dual control of human interleukin-2 and interferon-gamma gene expression by histamine: activation and suppression","volume":"170","author":"Arad","year":"1996","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0140","doi-asserted-by":"crossref","first-page":"4847","DOI":"10.2147\/DDDT.S89792","article-title":"Effects of histamine and its antagonists on murine T-cells and bone marrow-derived dendritic cells","volume":"9","author":"Hu","year":"2015","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.intimp.2019.02.026_bb0145","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0014-2999(96)00987-9","article-title":"Efficacy of a selective histamine H2 receptor agonist, dimaprit, in experimental models of endotoxin shock and hepatitis in mice","volume":"322","author":"Nakamura","year":"1997","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.mehy.2016.03.015","article-title":"Cimetidine as a novel adjunctive treatment for early stage Lyme disease","author":"Shemenski","year":"2016","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.intimp.2019.02.026_bb0155","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0162-3109(98)00057-5","article-title":"Involvement of protein kinase A in histamine-mediated inhibition of IL-2 mRNA expression in mouse splenocytes","volume":"41","author":"Poluektova","year":"1999","journal-title":"Immunopharmacology"},{"key":"10.1016\/j.intimp.2019.02.026_bb0160","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/jlb.56.4.495","article-title":"Inhibition of T cell adhesion to extracellular matrix glycoproteins by histamine: a role for mast cell degranulation products","volume":"56","author":"Hershkoviz","year":"1994","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0165","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1124\/jpet.102.036939","article-title":"Histamine h(4) and h(2) receptors control histamine-induced interleukin-16 release from human CD8(+) T cells","volume":"303","author":"Gantner","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.intimp.2019.02.026_bb0170","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.4049\/jimmunol.131.6.2945","article-title":"The role of cyclic AMP in modulating cytotoxic T lymphocytes. II. Sequential changes during culture in responsiveness of cytotoxic lymphocytes to cyclic AMP-active agents","volume":"131","author":"Plaut","year":"1983","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0175","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/35096564","article-title":"Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors","volume":"413","author":"Jutel","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2019.02.026_bb0180","doi-asserted-by":"crossref","first-page":"339","DOI":"10.2332\/allergolint.10-OA-0255","article-title":"Cimetidine enhances antigen-specific IgE and Th2 cytokine production","volume":"60","author":"Arae","year":"2011","journal-title":"Allergol. Int."},{"key":"10.1016\/j.intimp.2019.02.026_bb0185","first-page":"445","article-title":"Cimetidine treatment for viral warts enhances IL-2 and IFN-gamma expression but not IL-18 expression in lesional skin","volume":"13","author":"Mitsuishi","year":"2003","journal-title":"Eur. J. Dermatol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0190","doi-asserted-by":"crossref","first-page":"423","DOI":"10.4049\/jimmunol.130.1.423","article-title":"Modulation of granulomatous hypersensitivity. V. Participation of histamine receptor positive and negative lymphocytes in the granulomatous response of Schistosoma mansoni-infected mice","volume":"130","author":"Weinstock","year":"1983","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0195","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3109\/08923978809041424","article-title":"Immunoregulatory effects of cimetidine: inhibition of suppressor cell effector function in vivo","volume":"10","author":"Kumar","year":"1988","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0200","doi-asserted-by":"crossref","first-page":"3054","DOI":"10.4049\/jimmunol.132.6.3054","article-title":"Inhibition of T suppressor cell expression by histamine type 2 (H2) receptor antagonists","volume":"132","author":"Griswold","year":"1984","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0205","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.bbrc.2008.04.191","article-title":"Cimetidine enhances immune response of HBV DNA vaccination via impairment of the regulatory function of regulatory T cells","volume":"372","author":"Wang","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2019.02.026_bb0210","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/sji.12018","article-title":"Synergistic and additive effects of cimetidine and levamisole on cellular immune responses to hepatitis B virus DNA vaccine in mice","volume":"77","author":"Niu","year":"2013","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0215","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1097\/MIB.0000000000000825","article-title":"Histamine receptor 2 is required to suppress innate immune responses to bacterial ligands in patients with inflammatory bowel disease","volume":"22","author":"Smolinska","year":"2016","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.intimp.2019.02.026_bb0220","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1006\/clin.1994.1174","article-title":"Histamine inhibits immunoglobulin production via histamine H2 receptors without affecting cell growth in human B cells","volume":"73","author":"Fujimoto","year":"1994","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0225","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1159\/000234624","article-title":"The suppressive effect of histamine on anti-DNP antibody production in mice","volume":"86","author":"Okitsu-Negishi","year":"1988","journal-title":"Int. Arch. Allergy Appl. Immunol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0230","first-page":"151","article-title":"The effect of cimetidine on antibody synthesis in vitro and in vivo","volume":"48","author":"Badger","year":"1983","journal-title":"Immunology"},{"key":"10.1016\/j.intimp.2019.02.026_bb0235","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/0090-1229(83)90168-X","article-title":"Cimetidine and the immune response. I. In vivo augmentation of nonspecific and specific immune response","volume":"26","author":"Ershler","year":"1983","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0240","first-page":"244","article-title":"Perioperative cimetidine administration improves systematic immune response and tumor infiltrating lymphocytes in patients with colorectal cancer","volume":"60","author":"Li","year":"2013","journal-title":"Hepato-Gastroenterology"},{"key":"10.1016\/j.intimp.2019.02.026_bb0245","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1080\/21645515.2017.1314874","article-title":"A new therapeutic potential for cancers: one CAR with 2 different engines!","volume":"13","author":"Sheikhi","year":"2017","journal-title":"Hum. Vaccin. Immunother."},{"key":"10.1016\/j.intimp.2019.02.026_bb0250","first-page":"148","article-title":"Whole tumor cell vaccine adjuvants: comparing IL-12 to IL-2 and IL-15","volume":"13","author":"Sheikhi","year":"2016","journal-title":"Iran. J. Immunol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0255","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.31557\/APJCP.2018.19.11.3019","article-title":"Overexpression of regulatory T cell-related markers (FOXP3, CTLA-4 and GITR) by peripheral blood mononuclear cells from patients with breast cancer","volume":"19","author":"Khalife","year":"2018","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.intimp.2019.02.026_bb0260","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.cyto.2018.07.006","article-title":"Serum concentration of interleukin-35 and its association with tumor stages and FOXP3 gene polymorphism in patients with prostate cancer","volume":"113","author":"Chatrabnous","year":"2019","journal-title":"Cytokine"},{"key":"10.1016\/j.intimp.2019.02.026_bb0265","doi-asserted-by":"crossref","first-page":"545","DOI":"10.3233\/CBM-160596","article-title":"Higher circulating levels of chemokine CXCL10 in patients with breast cancer: evaluation of the influences of tumor stage and chemokine gene polymorphism","volume":"16","author":"Jafarzadeh","year":"2016","journal-title":"Cancer Biomark."},{"key":"10.1016\/j.intimp.2019.02.026_bb0270","first-page":"1189","article-title":"Evaluation of the circulating levels of IL-12 and IL-33 in patients with breast cancer: influences of the tumor stages and cytokine gene polymorphisms","volume":"18","author":"Jafarzadeh","year":"2015","journal-title":"Iran. J. Basic Med. Sci."},{"key":"10.1016\/j.intimp.2019.02.026_bb0275","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1007\/s13277-014-2739-6","article-title":"Higher circulating levels of chemokine CCL22 in patients with breast cancer: evaluation of the influences of tumor stage and chemokine gene polymorphism","volume":"36","author":"Jafarzadeh","year":"2015","journal-title":"Tumour Biol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0280","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/JLB.MR0318-097R","article-title":"T lymphocyte subsets in cancer immunity: friends or foes","volume":"105","author":"Chraa","year":"2019","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0285","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.lfs.2016.12.008","article-title":"Antihistamines as promising drugs in cancer therapy","volume":"172","author":"Faustino-Rocha","year":"2017","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2019.02.026_bb0290","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1189\/jlb.3RI0413-217RR","article-title":"Tumor formation and antitumor immunity; the overlooked significance of histamine","volume":"96","author":"Falus","year":"2014","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0295","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.ejps.2011.02.004","article-title":"Cimetidine: an anticancer drug?","volume":"42","author":"Kubecova","year":"2011","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.intimp.2019.02.026_bb0300","first-page":"1293","article-title":"Increase in E-selectin expression in umbilical vein endothelial cells by anticancer drugs and inhibition by cimetidine","volume":"22","author":"Kawase","year":"2009","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.intimp.2019.02.026_bb0305","first-page":"504","article-title":"Effects of perioperative cimetidine administration on peripheral blood lymphocytes and tumor infiltrating lymphocytes in patients with gastrointestinal cancer: results of a randomized controlled clinical trial","volume":"52","author":"Li","year":"2005","journal-title":"Hepato-Gastroenterology"},{"key":"10.1016\/j.intimp.2019.02.026_bb0310","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.molimm.2012.10.035","article-title":"Cimetidine suppresses lung tumor growth in mice through proapoptosis of myeloid-derived suppressor cells","volume":"54","author":"Zheng","year":"2013","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0315","series-title":"Human Papillomavirus and Immunosuppression, Current Problems in Dermatology","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1159\/000357907","volume":"vol. 45","author":"Wieland","year":"2014"},{"key":"10.1016\/j.intimp.2019.02.026_bb0320","article-title":"Cimetidine: a safe treatment option for cutaneous warts in pediatric heart transplant recipients","volume":"6","author":"Das","year":"2018","journal-title":"Med. Sci."},{"key":"10.1016\/j.intimp.2019.02.026_bb0325","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3109\/09546634.2010.500324","article-title":"Systemic treatments for cutaneous warts: a systematic review","volume":"23","author":"Simonart","year":"2012","journal-title":"J. Dermatolog. Treat."},{"key":"10.1016\/j.intimp.2019.02.026_bb0330","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.intimp.2014.07.003","article-title":"Cimetidine effects on the immunosuppression induced by burn injury","volume":"22","author":"Kokhaei","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0335","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/cpmo.25","article-title":"Mouse model of burn wound and infection: thermal (hot air) lesion-induced immunosuppression","volume":"7","author":"Calum","year":"2017","journal-title":"Curr. Protoc. Mouse Biol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0340","first-page":"367","article-title":"Time-dependent changes of immunologic responses after burn injury and immunomodulation by cimetidine and pyrimethamine in an animal model","volume":"23","author":"Jafarzadeh","year":"2010","journal-title":"Pak. J. Pharm. Sci."},{"key":"10.1016\/j.intimp.2019.02.026_bb0345","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0305-4179(03)00203-1","article-title":"Role of histamine receptors in the regulation of edema and circulation postburn","volume":"29","author":"Rantfors","year":"2003","journal-title":"Burns"},{"key":"10.1016\/j.intimp.2019.02.026_bb0350","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/0192-0561(93)90068-A","article-title":"Effect of immunomodulators pyrimethamine and cimetidine on immunosuppression induced by sulfur mustard in mice","volume":"15","author":"Ebtekar","year":"1993","journal-title":"Int. J. Immunopharmacol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0355","unstructured":"B. Gharegozloo, Z.M. Hassan, K.A. S, N. Tavassoli, Effect of immunomodulator pyrimethamine and cimetidine on immunosuppression induced by burn blister fluid, Iran. J. Allergy Asthma Immunol., 3 (2004) 139\u2013143."},{"key":"10.1016\/j.intimp.2019.02.026_bb0360","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/00004630-200107000-00003","article-title":"Burn wound itch control using H1 and H2 antagonists","volume":"22","author":"Baker","year":"2001","journal-title":"J. Burn Care Rehabil."},{"key":"10.1016\/j.intimp.2019.02.026_bb0365","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1096\/fj.02-1008com","article-title":"Histamine enhances TGF-beta1-mediated suppression of Th2 responses","volume":"17","author":"Kunzmann","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.intimp.2019.02.026_bb0370","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1056\/NEJM198202253060804","article-title":"Abnormal histamine-induced suppressor-cell function in atopic subjects","volume":"306","author":"Beer","year":"1982","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.intimp.2019.02.026_bb0375","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1046\/j.1365-2273.1997.d01-294.x","article-title":"The effect of the H2 antagonist cimetidine on the numbers of CD4+ and CD8+ cells in the nasal mucosa of patients with allergic rhinitis","volume":"22","author":"Yang","year":"1997","journal-title":"Clin. Otolaryngol. Allied Sci."},{"key":"10.1016\/j.intimp.2019.02.026_bb0380","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1177\/0192623317735316","article-title":"Bone and the immune system","volume":"45","author":"Weitzmann","year":"2017","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0385","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.coph.2018.03.006","article-title":"Mechanisms and therapeutic targets for bone damage in rheumatoid arthritis, in particular the RANK-RANKL system","volume":"40","author":"Tanaka","year":"2018","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0390","doi-asserted-by":"crossref","first-page":"555","DOI":"10.2131\/jts.32.555","article-title":"A comparative study of histamine activities on differentiation of osteoblasts and osteoclasts","volume":"32","author":"Ikawa","year":"2007","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.intimp.2019.02.026_bb0395","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/joa.12011","article-title":"Increased apoptosis in osteoclasts and decreased RANKL immunoexpression in periodontium of cimetidine-treated rats","volume":"222","author":"Longhini","year":"2013","journal-title":"J. Anat."},{"key":"10.1016\/j.intimp.2019.02.026_bb0400","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1902\/jop.2013.130453","article-title":"Cimetidine reduces alveolar bone loss in induced periodontitis in rat molars","volume":"85","author":"Longhini","year":"2014","journal-title":"J. Periodontol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0405","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.3389\/fimmu.2018.01561","article-title":"Hepatitis B virus adaptation to the CD8+ T cell response: consequences for host and pathogen","volume":"9","author":"Lumley","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0410","first-page":"233","article-title":"Human leukocyte antigens influence the antibody response to hepatitis B vaccine","volume":"14","author":"Jafarzadeh","year":"2015","journal-title":"Iran. J. Allergy Asthma Immunol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0415","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1046\/j.1365-2249.2003.02093.x","article-title":"The antibody response to HBs antigen is regulated by coordinated Th1 and Th2 cytokine production in healthy neonates","volume":"131","author":"Jafarzadeh","year":"2003","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0420","doi-asserted-by":"crossref","first-page":"4544","DOI":"10.1016\/S0264-410X(01)00183-9","article-title":"High seroprotection rate induced by low doses of a recombinant hepatitis B vaccine in healthy Iranian neonates","volume":"19","author":"Shokri","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.intimp.2019.02.026_bb0425","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.vaccine.2007.10.044","article-title":"Low dose revaccination induces robust protective anti-HBs antibody response in the majority of healthy non-responder neonates","volume":"26","author":"Jafarzadeh","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.intimp.2019.02.026_bb0430","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.4161\/hv.28517","article-title":"Cimetidine synergizes with Praziquantel to enhance the immune response of HBV DNA vaccine via activating cytotoxic CD8(+) T cell","volume":"10","author":"Xie","year":"2014","journal-title":"Hum. Vaccin. Immunother."},{"key":"10.1016\/j.intimp.2019.02.026_bb0435","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/pim.12087","article-title":"Immunology of human schistosomiasis","volume":"36","author":"Colley","year":"2014","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0440","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1007\/s00281-012-0341-9","article-title":"Induction and regulation of pathogenic Th17 cell responses in schistosomiasis","volume":"34","author":"Larkin","year":"2012","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0445","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.4269\/ajtmh.17-0966","article-title":"Functional studies of T regulatory lymphocytes in human schistosomiasis in Western Kenya","volume":"98","author":"Ondigo","year":"2018","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.intimp.2019.02.026_bb0450","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.exppara.2011.05.012","article-title":"Cimetidine enhances the protective effect of GST DNA vaccine against Schistosoma japonicum","volume":"128","author":"Li","year":"2011","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0455","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/S0264-410X(96)00311-8","article-title":"A randomized, placebo-controlled study of oral cimetidine as an immunopotentiator of parenteral immunization with a group B meningococcal vaccine","volume":"15","author":"Drabick","year":"1997","journal-title":"Vaccine"},{"key":"10.1016\/j.intimp.2019.02.026_bb0460","first-page":"99","article-title":"Study on immune response in BALB\/c mice induced by ROP2 protein of Toxoplasma gondii with cimetidine","volume":"31","author":"Chen","year":"2013","journal-title":"Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi"},{"key":"10.1016\/j.intimp.2019.02.026_bb0465","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.xphs.2016.08.019","article-title":"The slow relaxation dynamics in the amorphous pharmaceutical drugs cimetidine, nizatidine, and famotidine","volume":"105","author":"Viciosa","year":"2016","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.intimp.2019.02.026_bb0470","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.3389\/fimmu.2018.01894","article-title":"Ranitidine inhibition of breast tumor growth is B cell dependent and associated with an enhanced antitumor antibody response","volume":"9","author":"Rogers","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0475","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2016.1151591","article-title":"Ranitidine modifies myeloid cell populations and inhibits breast tumor development and spread in mice","volume":"5","author":"Vila-Leahey","year":"2016","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.intimp.2019.02.026_bb0480","first-page":"242","article-title":"Histamine type-2 receptor antagonist immune modulation. II. Cimetidine and ranitidine increase interleukin-2 production","volume":"102","author":"Gifford","year":"1987","journal-title":"Surgery"},{"key":"10.1016\/j.intimp.2019.02.026_bb0485","first-page":"577","article-title":"Ranitidine improves certain cellular immune responses in asymptomatic HIV-infected individuals","volume":"4","author":"Nielson","year":"1991","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"10.1016\/j.intimp.2019.02.026_bb0490","first-page":"1902","article-title":"Improved vaccination response during ranitidine treatment, and increased plasma histamine concentrations, in patients with B cell chronic lymphocytic leukemia","volume":"9","author":"Jurlander","year":"1995","journal-title":"Leukemia"},{"key":"10.1016\/j.intimp.2019.02.026_bb0495","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1097\/00005537-200102000-00009","article-title":"Changes in serum interferon-gamma, interleukin-4, and interleukin-12 cytokine levels in anti-histamine type 2-treated allergic rhinitis patients","volume":"111","author":"Testa","year":"2001","journal-title":"Laryngoscope"},{"key":"10.1016\/j.intimp.2019.02.026_bb0500","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/S0748-7983(95)97120-3","article-title":"Effect of ranitidine and low-dose interleukin-2 in vitro on NK-cell activity in peripheral blood from patients with liver metastases from colorectal cancer","volume":"21","author":"Nielsen","year":"1995","journal-title":"Eur. J. Surg. Oncol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0505","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1741-7015-10-57","article-title":"Potential immunological consequences of pharmacological suppression of gastric acid production in patients with multiple sclerosis","volume":"10","author":"Biswas","year":"2012","journal-title":"BMC Med."},{"key":"10.1016\/j.intimp.2019.02.026_bb0510","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1124\/jpet.102.042515","article-title":"Histamine inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production in an intercellular adhesion molecule-1- and B7.1-dependent manner","volume":"304","author":"Morichika","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.intimp.2019.02.026_bb0515","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00535-009-0019-9","article-title":"Cytokine responses of intraepithelial lymphocytes are regulated by histamine H(2) receptor","volume":"44","author":"Takagaki","year":"2009","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0520","doi-asserted-by":"crossref","first-page":"461","DOI":"10.4161\/hv.27165","article-title":"Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge","volume":"10","author":"Wang","year":"2014","journal-title":"Hum. Vaccin. Immunother."},{"key":"10.1016\/j.intimp.2019.02.026_bb0525","first-page":"460","article-title":"Cimetidine reduces impairment of cellular immunity after transcatheter arterial embolization in patients with hepatocellular carcinoma","volume":"50","author":"Nishiguchi","year":"2003","journal-title":"Hepato-Gastroenterology"},{"key":"10.1016\/j.intimp.2019.02.026_bb0530","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1038\/sj.bjc.6600233","article-title":"Cimetidine modulates the antigen presenting capacity of dendritic cells from colorectal cancer patients","volume":"86","author":"Kubota","year":"2002","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.intimp.2019.02.026_bb0535","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0192-0561(96)00044-6","article-title":"Comparison of antiproliferative effects of 1-histamine-2 receptor antagonists, cimetidine, ranitidine, and famotidine, in gastric cancer cells","volume":"18","author":"Hahm","year":"1996","journal-title":"Int. J. Immunopharmacol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0540","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1472-8206.2009.00810.x","article-title":"Hepatoprotective, antinociceptive and antioxidant activities of cimetidine, ranitidine and famotidine as histamine H2 receptor antagonists","volume":"25","author":"Ahmadi","year":"2011","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.intimp.2019.02.026_bb0545","first-page":"673","article-title":"Cimetidine induces apoptosis of human salivary gland tumor cells","volume":"17","author":"Fukuda","year":"2007","journal-title":"Oncol. Rep."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576918313092?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576918313092?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T22:20:28Z","timestamp":1694643628000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576918313092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":109,"alternative-id":["S1567576918313092"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2019.02.026","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunomodulatory properties of cimetidine: Its therapeutic potentials for treatment of immune-related diseases","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2019.02.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}