{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T19:22:28Z","timestamp":1770837748372,"version":"3.50.1"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570065"],"award-info":[{"award-number":["81570065"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.intimp.2019.03.018","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T12:46:20Z","timestamp":1552999580000},"page":"520-529","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"special_numbering":"C","title":["The protective effect of oleanolic acid on NMDA-induced MLE-12 cells apoptosis and lung injury in mice by activating SIRT1 and reducing NF-\u03baB acetylation"],"prefix":"10.1016","volume":"70","author":[{"given":"Xiang-Ping","family":"Peng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Ting","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-Qiang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.intimp.2019.03.018_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00075198-200102000-00001","article-title":"Neutrophil activation and acute lung injury","volume":"7","author":"Lee","year":"2001","journal-title":"Curr. Opin. Crit. Care"},{"key":"10.1016\/j.intimp.2019.03.018_bb0010","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.intimp.2018.08.023","article-title":"Barbaloin protects against lipopolysaccharide (LPS)-induced acute lung injury by inhibiting the ROS-mediated PI3K\/AKT\/NF-\u03baB pathway","volume":"64","author":"Jiang","year":"2018","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.intimp.2019.03.018_bb0015","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1165\/rcmb.2003-0177OC","article-title":"Ionotropic glutamate receptors in lungs and airways: molecular basis for glutamate toxicity","volume":"30","author":"Dickman","year":"2004","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"4","key":"10.1016\/j.intimp.2019.03.018_bb0020","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.niox.2010.09.004","article-title":"Expression of N-methyl-D-aspartate receptor and its effect on nitric oxide production of rat alveolar macrophages","volume":"23","author":"Shang","year":"2010","journal-title":"Nitric Oxide."},{"issue":"17","key":"10.1016\/j.intimp.2019.03.018_bb0025","doi-asserted-by":"crossref","first-page":"14801","DOI":"10.1074\/jbc.M110557200","article-title":"Neutrophil-derived glutamate regulates vascular endothelial barrier function","volume":"277","author":"Collard","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.intimp.2019.03.018_bb0030","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/S0891-5849(00)00289-6","article-title":"NMDA receptor activation: critical role in oxidant tissue injury","volume":"28","author":"Said","year":"2000","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.intimp.2019.03.018_bb0035","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00350-17","article-title":"N-methyl\u2011d-aspartate (NMDA) receptor blockade prevents neuronal death induced by Zika virus infection","volume":"8","author":"Costa","year":"2017","journal-title":"MBio"},{"issue":"7","key":"10.1016\/j.intimp.2019.03.018_bb0040","doi-asserted-by":"crossref","first-page":"e0132204","DOI":"10.1371\/journal.pone.0132204","article-title":"Blockade of the N-methyl-D-aspartate glutamate receptor ameliorates lipopolysaccharide-induced renal insufficiency","volume":"10","author":"Lin","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2019.03.018_bb0045","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3389\/fncel.2015.00091","article-title":"Researching glutamate - induced cytotoxicity in different cell lines: a comparative\/collective analysis\/study","volume":"9","author":"Kritis","year":"2015","journal-title":"Front. Cell. Neurosci."},{"issue":"3","key":"10.1016\/j.intimp.2019.03.018_bb0050","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20171629","article-title":"Blockade of glutamate receptor ameliorates lipopolysaccharide-induced sepsis through regulation of neuropeptides","volume":"38","author":"Zhe","year":"2018","journal-title":"Biosci. Rep."},{"issue":"2","key":"10.1016\/j.intimp.2019.03.018_bb0055","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1378\/chest.09-1570","article-title":"N-methyl-D-aspartate glutamate receptor blockade attenuates lung injury associated with experimental sepsis","volume":"137","author":"da CAA","year":"2010","journal-title":"Chest"},{"key":"10.1016\/j.intimp.2019.03.018_bb0060","doi-asserted-by":"crossref","first-page":"L404","DOI":"10.1152\/ajplung.00002.2018","article-title":"NMDA receptor activation inhibits the antifibrotic effect of BM-MSCs on bleomycin-induced pulmonary fibrosis","volume":"315","author":"Li","year":"2018","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.intimp.2019.03.018_bb0065","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1016\/j.biopha.2018.11.002","article-title":"Memantine ameliorates pulmonary inflammation in a mice model of COPD induced by cigarette smoke combined with LPS","volume":"109","author":"Cheng","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.intimp.2019.03.018_bb0070","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1111\/j.1742-7843.2010.00572.x","article-title":"Inhibition of pulmonary surfactants synthesis during N-methyl-D-aspartate-induced lung injury","volume":"107","author":"Shen","year":"2010","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.intimp.2019.03.018_bb0075","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.biopha.2018.10.160","article-title":"Triterpenoids from fruits of Sorbus pohuashanensis inhibit acetaminophen-induced acute liver injury in mice","volume":"109","author":"Yin","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.intimp.2019.03.018_bb0080","first-page":"3641","article-title":"Oleanolic acid protects against oxidative stress-induced human umbilical vein endothelial cell injury by activating AKT\/eNOS signaling","volume":"18","author":"Zhang","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.intimp.2019.03.018_bb0085","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.freeradbiomed.2018.06.003","article-title":"Oleanolic acid attenuates PCBs-induced adiposity and insulin resistance via HNF1b-mediated regulation of redox and PPAR\u03b3 signaling","volume":"124","author":"Su","year":"2018","journal-title":"Free Radic. Biol. Med."},{"issue":"2\u20133","key":"10.1016\/j.intimp.2019.03.018_bb0090","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.resp.2011.07.008","article-title":"Effects of oleanolic acid on pulmonary morphofunctional and biochemical variables in experimental acute lung injury","volume":"179","author":"Santos","year":"2011","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.intimp.2019.03.018_bb0095","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.3892\/mmr.2017.6402","article-title":"Protective effects of oleanolic acid on oxidative stress and the expression of cytokines and collagen by the AKT\/NF-\u03baB pathway in silicotic rats","volume":"15","author":"Peng","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.intimp.2019.03.018_bb0100","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.mce.2017.11.007","article-title":"Oleanonic acid ameliorates pressure overload-induced cardiac hypertrophy in rats: the role of PKC\u03b6-NF-\u03baB pathway","volume":"470","author":"Gao","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"issue":"12","key":"10.1016\/j.intimp.2019.03.018_bb0105","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1002\/ptr.4928","article-title":"Neuroprotective effects of formononetin against NMDA-induced apoptosis in cortical neurons","volume":"27","author":"Tian","year":"2013","journal-title":"Phytother. Res."},{"key":"10.1016\/j.intimp.2019.03.018_bb0110","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/2823454","article-title":"The neuroprotective effects of SIRT1 on NMDA-induced excitotoxicity","volume":"2017","author":"Yang","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.intimp.2019.03.018_bb0115","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.abb.2010.05.003","article-title":"Regulation of SIRT1 in cellular functions: role of polyphenols","volume":"501","author":"Chung","year":"2010","journal-title":"Arch. Biochem. Biophys."},{"issue":"12","key":"10.1016\/j.intimp.2019.03.018_bb0120","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1038\/sj.emboj.7600244","article-title":"Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase","volume":"23","author":"Yeung","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.intimp.2019.03.018_bb0125","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1146\/annurev.biochem.74.082803.133500","article-title":"The biochemistry of sirtuins","volume":"75","author":"Sauve","year":"2006","journal-title":"Annu. Rev. Biochem."},{"issue":"7","key":"10.1016\/j.intimp.2019.03.018_bb0130","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1111\/resp.12558","article-title":"Increases in peripheral SIRT1: a new biological characteristic of asthma","volume":"20","author":"Wang","year":"2015","journal-title":"Respirology"},{"key":"10.1016\/j.intimp.2019.03.018_bb0135","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.pupt.2018.12.001","article-title":"Arbutin attenuates LPS-induced lung injury via Sirt1\/Nrf2\/NF-\u03baBp65 pathway","volume":"54","author":"Ye","year":"2019","journal-title":"Pulm. Pharmacol. Ther."},{"issue":"9","key":"10.1016\/j.intimp.2019.03.018_bb0140","doi-asserted-by":"crossref","first-page":"L615","DOI":"10.1152\/ajplung.00249.2012","article-title":"SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD","volume":"305","author":"Yao","year":"2013","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.intimp.2019.03.018_bb0145","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1165\/rcmb.2016-0192OC","article-title":"Sirtuin1 protects against systemic sclerosis-related pulmonary fibrosis by decreasing proinflammatory and profibrotic processes","volume":"58","author":"Chu","year":"2018","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"3","key":"10.1016\/j.intimp.2019.03.018_bb0150","doi-asserted-by":"crossref","first-page":"100","DOI":"10.32607\/20758251-2018-10-3-100-102","article-title":"Influence of the activation of NMDA receptors on the resting membrane potential of the postsynaptic cell at the neuromuscular junction","volume":"10","author":"Proskurina","year":"2018","journal-title":"Acta Nat."},{"key":"10.1016\/j.intimp.2019.03.018_bb0155","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1165\/rcmb.2008-0135OC","article-title":"Glutamate mediates hyperoxia-induced newborn rat lung injury through N-methyl-D-aspartate receptors","volume":"40","author":"Wang","year":"2009","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"11","key":"10.1016\/j.intimp.2019.03.018_bb0160","first-page":"1060","article-title":"Mechanism of N-methyl-D-aspartate-induced retinal ganglion cell death","volume":"113","author":"Nakazawa","year":"2009","journal-title":"Nippon Ganka Gakkai Zasshi"},{"key":"10.1016\/j.intimp.2019.03.018_bb0165","doi-asserted-by":"crossref","first-page":"44120","DOI":"10.1038\/srep44120","article-title":"An excessive increase in glutamate contributes to glucose-toxicity in \u03b2-cells via activation of pancreatic NMDA receptors in rodent diabetes","volume":"7","author":"Huang","year":"2017","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.intimp.2019.03.018_bb0170","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1002\/jnr.23329","article-title":"Simvastatin prevents neuroinflammation by inhibiting N-methyl-D-aspartic acid receptor 1 in 6-hydroxydopamine-treated PC12 cells","volume":"92","author":"Yan","year":"2014","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.intimp.2019.03.018_bb0175","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/ppul.20299","article-title":"Role of N-methyl-D-aspartate receptor in hyperoxia-induced lung injury","volume":"40","author":"Tang","year":"2005","journal-title":"Pediatr. Pulmonol."},{"issue":"2","key":"10.1016\/j.intimp.2019.03.018_bb0180","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.intimp.2015.10.024","article-title":"Oleanolic acid ameliorates dextran sodium sulfate-induced colitis in mice by restoring the balance of Th17\/Treg cells and inhibiting NF-kappaB signaling pathway","volume":"29","author":"Kang","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2019.03.018_bb0185","first-page":"1","article-title":"Protective effect of sesamin in lipopolysaccharide-induced mouse model of acute kidney injury via attenuation of oxidative stress, inflammation, and apoptosis","author":"Rousta","year":"2018","journal-title":"Immunopharmacol. Immunotoxicol."},{"issue":"9","key":"10.1016\/j.intimp.2019.03.018_bb0190","doi-asserted-by":"crossref","first-page":"689","DOI":"10.2174\/1871527317666180627120501","article-title":"Oxidative stress: major threat in traumatic brain injury","volume":"17","author":"Khatri","year":"2018","journal-title":"CNS Neurol. Disord. Drug Targets"},{"issue":"5","key":"10.1016\/j.intimp.2019.03.018_bb0195","article-title":"NMDA receptor antagonist attenuates bleomycin-induced acute lung injury","volume":"10","author":"Li","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.intimp.2019.03.018_bb0200","first-page":"12","article-title":"Protective effect of NMDA receptor antagonist memantine on acute lung injury in mice","volume":"39","author":"Ma","year":"2014","journal-title":"Zhong Nan Da Xue Xue Bao Yi Xue Ban"},{"key":"10.1016\/j.intimp.2019.03.018_bb0205","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/MAJ.0b013e318266e8d8","article-title":"N-acetylcysteine-pretreated human embryonic mesenchymal stem cell administration protects against bleomycin-induced lung injury","volume":"346","author":"Wang","year":"2013","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.intimp.2019.03.018_bb0210","doi-asserted-by":"crossref","first-page":"6615","DOI":"10.1002\/jcp.26274","article-title":"miR-34b-5p inhibition attenuates lung inflammation and apoptosis in an LPS-induced acute lung injury mouse model by targeting progranulin","volume":"233","author":"Xie","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.intimp.2019.03.018_bb0215","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.expneurol.2017.12.005","article-title":"The GluN1\/GluN2B NMDA receptor and metabotropic glutamate receptor 1 negative allosteric modulator has enhanced neuroprotection in a rat subarachnoid hemorrhage model","volume":"301","author":"Zhang","year":"2018","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.intimp.2019.03.018_bb0220","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.theriogenology.2017.07.045","article-title":"Bcl-2\/Bax protein and mRNA expression in yak (Bos grunniens) placentomes","volume":"104","author":"Fan","year":"2017","journal-title":"Theriogenology"},{"issue":"2","key":"10.1016\/j.intimp.2019.03.018_bb0225","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.tiv.2013.01.001","article-title":"The neuroprotective effect of praeruptorin C against NMDA-induced apoptosis through down-regulating of GluN2B-containing NMDA receptors","volume":"27","author":"Yang","year":"2013","journal-title":"Toxicol. in Vitro."},{"key":"10.1016\/j.intimp.2019.03.018_bb0230","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.omtn.2018.05.027","article-title":"Ribosomal protein S3 gene silencing protects against cigarette smoke-induced acute lung injury","volume":"12","author":"Dong","year":"2018","journal-title":"Mol. Ther. Nucleic Acids"},{"issue":"5","key":"10.1016\/j.intimp.2019.03.018_bb0235","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1007\/s10753-016-0416-1","article-title":"Protective role of liriodendrin in sepsis-induced acute lung injury","volume":"39","author":"Yang","year":"2016","journal-title":"Inflammation"},{"issue":"3","key":"10.1016\/j.intimp.2019.03.018_bb0240","first-page":"196","article-title":"Attenuation of bleomycin induced lung fibrosis by erdosteine and inhibition of the inducible nitric oxide synthase","volume":"116","author":"Guzel","year":"2015","journal-title":"Bratisl. Lek. Listy"},{"issue":"5","key":"10.1016\/j.intimp.2019.03.018_bb0245","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1159\/000493653","article-title":"Apelin-13 administration protects against LPS-induced acute lung injury by inhibiting NF-\u03baB pathway and NLRP3 Inflammasome activation","volume":"49","author":"Zhang","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"issue":"1","key":"10.1016\/j.intimp.2019.03.018_bb0250","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s10565-010-9168-0","article-title":"Nitric oxide-induced activation of NF-\u03baB-mediated NMDA-induced CTP:phosphocholine cytidylyltransferase alpha expression inhibition in A549 cells","volume":"27","author":"Li","year":"2011","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.intimp.2019.03.018_bb0255","article-title":"Activation of SIRT1 ameliorates LPS-induced lung injury in mice via decreasing endothelial tight junction permeability","author":"Fu","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.intimp.2019.03.018_bb0260","doi-asserted-by":"crossref","DOI":"10.1007\/s12035-019-1472-y","article-title":"Recovery of olfactory function after excitotoxic lesion of the olfactory bulbs is associated with increases in bulbar SIRT1 and SIRT4 expressions","author":"Marin","year":"2019","journal-title":"Mol. Neurobiol."},{"issue":"5","key":"10.1016\/j.intimp.2019.03.018_bb0265","doi-asserted-by":"crossref","first-page":"6023","DOI":"10.1002\/jcp.27187","article-title":"Downregulated microRNA-27b attenuates lipopolysaccharide-induced acute lung injury via activation of NF-E2-related factor 2 and inhibition of nuclear factor \u03baB signaling pathway","volume":"234","author":"Huang","year":"2019","journal-title":"J. Cell. Physiol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576919303315?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576919303315?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T06:42:38Z","timestamp":1565160158000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576919303315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":53,"alternative-id":["S1567576919303315"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2019.03.018","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The protective effect of oleanolic acid on NMDA-induced MLE-12 cells apoptosis and lung injury in mice by activating SIRT1 and reducing NF-\u03baB acetylation","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2019.03.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}