{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T12:48:54Z","timestamp":1777294134829,"version":"3.51.4"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"2017 National Undergraduate Training Programs for Innovation and Entrepreneurship","award":["201710366030"],"award-info":[{"award-number":["201710366030"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81273169"],"award-info":[{"award-number":["81273169"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573218"],"award-info":[{"award-number":["81573218"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773514"],"award-info":[{"award-number":["81773514"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Academic and Technical Leaders Foundation of Anhui province","award":["2017D140"],"award-info":[{"award-number":["2017D140"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.intimp.2019.03.026","type":"journal-article","created":{"date-parts":[[2019,3,16]],"date-time":"2019-03-16T07:03:06Z","timestamp":1552719786000},"page":"109-114","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["DNA methylation and transcriptome signature of the IL12B gene in ankylosing spondylitis"],"prefix":"10.1016","volume":"71","author":[{"given":"Xu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jincheng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhipeng","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yubo","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahui","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyi","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengqian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faming","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2019.03.026_bb0005","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1016\/S0140-6736(11)60071-8","article-title":"Spondyloarthritis","volume":"377","author":"Dougados","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.intimp.2019.03.026_bb0010","doi-asserted-by":"crossref","unstructured":"Baeten D, Sieper J, Braun J, et al., Secukinumab, an interleukin-17A inhibitor, in ankylosing spondylitis, NEJM. 373(2015):2534\u201348.","DOI":"10.1056\/NEJMoa1505066"},{"key":"10.1016\/j.intimp.2019.03.026_bb0015","doi-asserted-by":"crossref","unstructured":"Montoya J, Matta NB, Suchon P, et al., Patients with ankylosing spondylitis have been breast fed less often than healthy controls: a case-control retrospective study, Ann. Rheum. Dis. 75(2016):879\u201382.","DOI":"10.1136\/annrheumdis-2015-208187"},{"key":"10.1016\/j.intimp.2019.03.026_bb0020","first-page":"2737","article-title":"Involvement of Notch1\/Hes signaling pathway in ankylosing spondylitis","volume":"8","author":"Xu","year":"2015","journal-title":"Int J Clin Exp Patho."},{"key":"10.1016\/j.intimp.2019.03.026_bb0025","doi-asserted-by":"crossref","unstructured":"Dean LE, Jones GT, MacDonald AG, et al., Global prevalence of ankylosing spondylitis. Rheumatology. 53(2014):650\u20137.","DOI":"10.1093\/rheumatology\/ket387"},{"key":"10.1016\/j.intimp.2019.03.026_bb0030","doi-asserted-by":"crossref","unstructured":"Cai G, Zhang X, Xin L, et al., Associations between vitamin D receptor gene polymorphisms and ankylosing spondylitis in Chinese Han population: a case-control study. Osteoporosis Int. 27(2016):2327\u20132333.","DOI":"10.1007\/s00198-016-3500-3"},{"key":"10.1016\/j.intimp.2019.03.026_bb0035","doi-asserted-by":"crossref","first-page":"7146","DOI":"10.1038\/ncomms8146","article-title":"Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1","volume":"6","author":"Cortes","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2019.03.026_bb0040","doi-asserted-by":"crossref","unstructured":"Cortes A, Gladman D, Raychaudhuri S, et al., Imputation-based analysis of MICA alleles in the susceptibility to ankylosing spondylitis. Ann. Rheum. Dis. 77(2018):1691\u20131692.","DOI":"10.1136\/annrheumdis-2018-213413"},{"key":"10.1016\/j.intimp.2019.03.026_bb0045","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/S0140-6736(07)60635-7","article-title":"Ankylosing spondylitis","volume":"369","author":"Braun","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.intimp.2019.03.026_bb0050","doi-asserted-by":"crossref","unstructured":"Cortes A, Hadler J, Pointon JP, et al., Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci. Nat. Genet. 45(2013):730\u20138.","DOI":"10.1038\/ng.2667"},{"key":"10.1016\/j.intimp.2019.03.026_bb0055","article-title":"Rheumatoid arthritis-associated DNA methylation sites in peripheral blood mononuclear cells","author":"Zhu","year":"2018","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.intimp.2019.03.026_bb0060","doi-asserted-by":"crossref","unstructured":"Nakano K, Whitaker JW, Boyle DL, et al., DNA methylome signature in rheumatoid arthritis. Ann. Rheum. Dis. 72(2013):110\u20137.","DOI":"10.1136\/annrheumdis-2012-201526"},{"key":"10.1016\/j.intimp.2019.03.026_bb0065","doi-asserted-by":"crossref","unstructured":"Zhao M, Zhou Y, Zhu B, et al., IFI44L promoter methylation as a blood biomarker for systemic lupus erythematosus. Ann. Rheum. Dis. 75(2016):1998\u20132006.","DOI":"10.1136\/annrheumdis-2015-208410"},{"key":"10.1016\/j.intimp.2019.03.026_bb0070","doi-asserted-by":"crossref","unstructured":"Ai R, Hammaker D, Boyle DL, et al., Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes. Nat. Commun. 7(2016):11849.","DOI":"10.1038\/ncomms11849"},{"key":"10.1016\/j.intimp.2019.03.026_bb0075","doi-asserted-by":"crossref","unstructured":"Karami J, Mahmoudi M, Amirzargar A, et al., Promoter hypermethylation of BCL11B gene correlates with downregulation of gene transcription in ankylosing spondylitis patients. Genes Immun. 18(2017):170\u2013175.","DOI":"10.1038\/gene.2017.17"},{"key":"10.1016\/j.intimp.2019.03.026_bb0080","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s13075-018-1616-x","article-title":"Elevated levels of plasma symmetric dimethylarginine and increased arginase activity as potential indicators of cardiovascular comorbidity in rheumatoid arthritis","volume":"20","author":"Chandrasekharan","year":"2018","journal-title":"Arthritis Res Ther."},{"key":"10.1016\/j.intimp.2019.03.026_bb0085","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13075-017-1276-2","article-title":"DNA methylation mediates genotype and smoking interaction in the development of anti-citrullinated peptide antibody-positive rheumatoid arthritis","volume":"19","author":"Meng","year":"2017","journal-title":"Arthritis Res Ther."},{"key":"10.1016\/j.intimp.2019.03.026_bb0090","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s13075-017-1382-1","article-title":"Genome-wide DNA methylation profile analysis identifies differentially methylated loci associated with ankylosis spondylitis","volume":"19","author":"Hao","year":"2017","journal-title":"Arthritis Res Ther."},{"key":"10.1016\/j.intimp.2019.03.026_bb0095","doi-asserted-by":"crossref","unstructured":"Lai NS, Chou JL, Chen GC, et al., Association between cytokines and methylation of SOCS-1 in serum of patients with ankylosing spondylitis. Mol. Biol. Rep. 41(2014):3773\u201380.","DOI":"10.1007\/s11033-014-3242-2"},{"key":"10.1016\/j.intimp.2019.03.026_bb0100","doi-asserted-by":"crossref","unstructured":"Aslani S, Mahmoudi M, Garshasbi M, et al., Evaluation of DNMT1 gene expression profile and methylation of its promoter region in patients with ankylosing spondylitis. Clin. Rheumatol. 35(2016):2723\u20132731.","DOI":"10.1007\/s10067-016-3403-x"},{"key":"10.1016\/j.intimp.2019.03.026_bb0105","article-title":"Association study of IL-12B polymorphisms susceptibility with ankylosing spondylitis in mainland Han population","volume":"10","author":"Zhang","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2019.03.026_bb0110","doi-asserted-by":"crossref","unstructured":"Ivanova M, Manolova I, Miteva L, et al., Genetic variations in the IL-12B gene in association with IL-23 and IL-12p40 serum levels in ankylosing spondylitis. Rheumatol. Int. 2018. doi: https:\/\/doi.org\/10.1007\/s00296-018-4204-0","DOI":"10.1007\/s00296-018-4204-0"},{"key":"10.1016\/j.intimp.2019.03.026_bb0115","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/RHU.0000000000000610","article-title":"The diagnostic and prognostic role of interleukin 12B and interleukin 6R gene polymorphism in patients with ankylosing spondylitis","volume":"24","author":"Ruan","year":"2018","journal-title":"J. Clin. Rheumatol."},{"key":"10.1016\/j.intimp.2019.03.026_bb0120","doi-asserted-by":"crossref","unstructured":"Wong RH, Wei JC, Huang CH, et al., Association of IL-12B genetic polymorphism with the susceptibility and disease severity of ankylosing spondylitis. J. Rheumatol. 39(2012):135\u201340.","DOI":"10.3899\/jrheum.110613"},{"key":"10.1016\/j.intimp.2019.03.026_bb0125","doi-asserted-by":"crossref","unstructured":"Chen L, Ridley A, Hammitzsch A, et al., Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis. Ann. Rheum. Dis. 75(2016):916\u201323.","DOI":"10.1136\/annrheumdis-2014-206996"},{"key":"10.1016\/j.intimp.2019.03.026_bb0130","doi-asserted-by":"crossref","unstructured":"Costantino F, Talpin A, Said-Nahal R, et al., A family-based genome-wide association study reveals an association of spondyloarthritis with MAPK14. Ann. Rheum. Dis. 76(2017):310\u2013314.","DOI":"10.1136\/annrheumdis-2016-209449"},{"key":"10.1016\/j.intimp.2019.03.026_bb0135","doi-asserted-by":"crossref","unstructured":"Coffre M, Roumier M, Rybczynska M, et al., Combinatorial control of Th17 and Th1 cell functions by genetic variations in genes associated with the interleukin-23 signaling pathway in spondyloarthritis. Arthritis Rheum. 65(2013):1510\u201321.","DOI":"10.1002\/art.37936"},{"key":"10.1016\/j.intimp.2019.03.026_bb0140","doi-asserted-by":"crossref","unstructured":"Jadon D, Tillett W, Wallis D, et al., Exploring ankylosing spondylitis-associated ERAP1, IL23R and IL12B gene polymorphisms in subphenotypes of psoriatic arthritis. Rheumatology. 52(2013):261\u20136.","DOI":"10.1093\/rheumatology\/kes254"},{"key":"10.1016\/j.intimp.2019.03.026_bb0145","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/sj.gene.6363720","article-title":"Complete primary structure, chromosomal localisation, and definition of polymorphisms of the gene encoding the human interleukin-12 p40 subunit","volume":"1","author":"Huang","year":"2000","journal-title":"Genes Immun."},{"key":"10.1016\/j.intimp.2019.03.026_bb0150","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1006\/geno.1994.1636","article-title":"High-resolution physical mapping of human 5q31-q33 using three methods: radiation hybrid mapping, interphase fluorescence in situ hybridization, and pulsed-field gel electrophoresis","volume":"24","author":"Warrington","year":"1994","journal-title":"Genomics"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576919300633?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576919300633?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:15:09Z","timestamp":1761585309000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576919300633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":30,"alternative-id":["S1567576919300633"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2019.03.026","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DNA methylation and transcriptome signature of the IL12B gene in ankylosing spondylitis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2019.03.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}