{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T08:33:11Z","timestamp":1782721991269,"version":"3.54.5"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2015B020227003"],"award-info":[{"award-number":["2015B020227003"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2015B020226001"],"award-info":[{"award-number":["2015B020226001"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2017B020230004"],"award-info":[{"award-number":["2017B020230004"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2014B020212009"],"award-info":[{"award-number":["2014B020212009"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2014B020226002"],"award-info":[{"award-number":["2014B020226002"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010883","name":"Traditional Chinese Medicine Bureau of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671585"],"award-info":[{"award-number":["81671585"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500102"],"award-info":[{"award-number":["81500102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870121"],"award-info":[{"award-number":["81870121"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370665"],"award-info":[{"award-number":["81370665"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["201803040011"],"award-info":[{"award-number":["201803040011"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["201803040005"],"award-info":[{"award-number":["201803040005"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["201400000003-4"],"award-info":[{"award-number":["201400000003-4"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.intimp.2019.05.048","type":"journal-article","created":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T22:36:01Z","timestamp":1560292561000},"page":"105663","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"special_numbering":"C","title":["Extracellular vesicles from mesenchymal stem cells prevent contact hypersensitivity through the suppression of Tc1 and Th1 cells and expansion of regulatory T cells"],"prefix":"10.1016","volume":"74","author":[{"given":"Liyan","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peilong","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenwei","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suxia","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suijing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyu","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2019.05.048_bb0005","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.jaci.2014.03.009","article-title":"Molecular profiling of contact dermatitis skin identifies allergen-dependent differences in immune response","volume":"134","author":"Dhingra","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.intimp.2019.05.048_bb0010","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1002\/stem.738","article-title":"Human gingiva-derived mesenchymal stromal cells attenuate contact hypersensitivity via prostaglandin E2-dependent mechanisms","volume":"29","author":"Su","year":"2011","journal-title":"Stem Cells"},{"key":"10.1016\/j.intimp.2019.05.048_bb0015","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1756-8722-5-19","article-title":"Clinical applications of mesenchymal stem cells","volume":"5","author":"Wang","year":"2012","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.intimp.2019.05.048_bb0020","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1016\/j.intimp.2010.06.019","article-title":"The immunomodulatory properties of mesenchymal stem cells and their use for immunotherapy","volume":"10","author":"Hoogduijn","year":"2010","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.intimp.2019.05.048_bb0025","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00441-018-02981-w","article-title":"Early injection of human adipose tissue-derived mesenchymal stem cell after inflammation ameliorates dextran sulfate sodium-induced colitis in mice through the induction of M2 macrophages and regulatory T cells","volume":"376","author":"Kawata","year":"2019","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.intimp.2019.05.048_bb0030","doi-asserted-by":"crossref","first-page":"5187","DOI":"10.1038\/s41598-017-04766-7","article-title":"TSG-6 secreted by human adipose tissue-derived mesenchymal stem cells ameliorates DSS-induced colitis by inducing M2 macrophage polarization in mice","volume":"7","author":"Song","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2019.05.048_bb0035","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/scrt216","article-title":"Mesenchymal stem cells generate a CD4+CD25+Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cells","volume":"4","author":"Luz-Crawford","year":"2013","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.intimp.2019.05.048_bb0040","series-title":"Minimal Information for Studies of Extracellular Vesicles 2018 (MISEV2018): A Position Statement of the International Society for Extracellular Vesicles and Update of the MISEV2014 Guidelines","first-page":"1535750","volume":"7","author":"Thery","year":"2018"},{"key":"10.1016\/j.intimp.2019.05.048_bb0045","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.ceb.2004.06.003","article-title":"Exosomes: endosomal-derived vesicles shipping extracellular messages","volume":"16","author":"Fevrier","year":"2004","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.intimp.2019.05.048_bb0050","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1038\/sj.leu.2404296","article-title":"Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication","volume":"20","author":"Ratajczak","year":"2006","journal-title":"Leukemia"},{"key":"10.1016\/j.intimp.2019.05.048_bb0055","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1089\/scd.2013.0479","article-title":"Mesenchymal stem cells secrete immunologically active exosomes","volume":"23","author":"Zhang","year":"2014","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.intimp.2019.05.048_bb0060","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s13045-018-0680-7","article-title":"A potent immunomodulatory role of exosomes derived from mesenchymal stromal cells in preventing cGVHD","volume":"11","author":"Lai","year":"2018","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.intimp.2019.05.048_bb0065","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/ACI.0b013e3283088cf9","article-title":"From innate to adaptive immune responses in contact hypersensitivity","volume":"8","author":"Martin","year":"2008","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"10.1016\/j.intimp.2019.05.048_bb0070","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jaci.2012.06.048","article-title":"Atopic dermatitis results in intrinsic barrier and immune abnormalities: implications for contact dermatitis","volume":"131","author":"Gittler","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.intimp.2019.05.048_bb0075","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s10616-012-9528-0","article-title":"Optimization of human umbilical cord mesenchymal stem cell isolation and culture methods","volume":"65","author":"Han","year":"2013","journal-title":"Cytotechnology"},{"key":"10.1016\/j.intimp.2019.05.048_bb0080","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"issue":"1","key":"10.1016\/j.intimp.2019.05.048_bb0085","doi-asserted-by":"crossref","first-page":"3.22.1","DOI":"10.1002\/0471143030.cb0322s30","article-title":"Isolation and characterization of exosomes from cell culture supernatants and biological fluids","volume":"30","author":"Thery","year":"2006","journal-title":"Curr. Protoc. Cell Biol."},{"key":"10.1016\/j.intimp.2019.05.048_bb0090","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1600-0536.1994.tb00650.x","article-title":"Optimization of the mouse ear swelling test for in vivo and in vitro studies of weak contact sensitizers","volume":"30","author":"Garrigue","year":"1994","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.intimp.2019.05.048_bb0095","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/j.ymthe.2017.04.004","article-title":"CXCR5-overexpressing mesenchymal stromal cells exhibit enhanced homing and can decrease contact hypersensitivity","volume":"25","author":"Zhang","year":"2017","journal-title":"Mol. Ther."},{"key":"10.1016\/j.intimp.2019.05.048_bb0100","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.4049\/jimmunol.144.8.3111","article-title":"Phorbol myristate acetate-induced down-modulation of CD4 is dependent on calmodulin and intracellular calcium","volume":"144","author":"Bigby","year":"1990","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2019.05.048_bb0105","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0165-2427(94)90090-6","article-title":"Down-regulation followed by re-expression of equine CD4 molecules in response to phorbol myristate acetate","volume":"42","author":"Zhang","year":"1994","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.intimp.2019.05.048_bb0110","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/1523-1747.ep12874117","article-title":"UVB radiation and DNFB skin painting induce suppressor cells universally in mice","volume":"94","author":"Glass","year":"1990","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.intimp.2019.05.048_bb0115","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.4049\/jimmunol.180.5.3065","article-title":"Phenotypic and functional characterization of ultraviolet radiation-induced regulatory T cells","volume":"180","author":"Maeda","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2019.05.048_bb0120","doi-asserted-by":"crossref","first-page":"6783","DOI":"10.4049\/jimmunol.165.12.6783","article-title":"CD4+ Th1 and CD8+ type 1 cytotoxic T cells both play a crucial role in the full development of contact hypersensitivity","volume":"165","author":"Wang","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2019.05.048_bb0125","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/sj.jid.5700174","article-title":"CD8+ T cells are effector cells of contact dermatitis to common skin allergens in mice","volume":"126","author":"Vocanson","year":"2006","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.intimp.2019.05.048_bb0130","doi-asserted-by":"crossref","first-page":"6467","DOI":"10.1073\/pnas.0501912102","article-title":"Mast cells enhance T cell activation: importance of mast cell-derived TNF","volume":"102","author":"Nakae","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"e1282","key":"10.1016\/j.intimp.2019.05.048_bb0135","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.jaci.2009.03.022","article-title":"CD4+CD25+ regulatory T cells suppress contact hypersensitivity reactions through a CD39, adenosine-dependent mechanism","volume":"123","author":"Ring","year":"2009","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.intimp.2019.05.048_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2009.10.025","article-title":"Gap junctions between regulatory T cells and dendritic cells prevent sensitization of CD8(+) T cells","volume":"125","author":"Ring","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.intimp.2019.05.048_bb0145","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.imlet.2012.06.001","article-title":"Microvesicles derived from mesenchymal stem cells: potent organelles for induction of tolerogenic signaling","volume":"147","author":"Mokarizadeh","year":"2012","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.intimp.2019.05.048_bb0150","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.stemcr.2017.04.008","article-title":"MSC-derived extracellular vesicles attenuate immune responses in two autoimmune murine models: type 1 diabetes and uveoretinitis","volume":"8","author":"Shigemoto-Kuroda","year":"2017","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.intimp.2019.05.048_bb0155","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/leu.2014.41","article-title":"MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease","volume":"28","author":"Kordelas","year":"2014","journal-title":"Leukemia"},{"key":"10.1016\/j.intimp.2019.05.048_bb0160","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/nature15376","article-title":"Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth","volume":"527","author":"Zhang","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2019.05.048_bb0165","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.cell.2017.08.035","article-title":"Adipose tissue macrophage-derived exosomal miRNAs can modulate in vivo and in vitro insulin sensitivity","volume":"171","author":"Ying","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2019.05.048_bb0170","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/cdd.2017.31","article-title":"Interactions between Th1 cells and Tregs affect regulation of hepatic fibrosis in biliary atresia through the IFN-gamma\/STAT1 pathway","volume":"24","author":"Wen","year":"2017","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.intimp.2019.05.048_bb0175","series-title":"Regulatory T Cells Trigger Effector T Cell DNA Damage and Senescence Caused by Metabolic Competition","first-page":"249","volume":"9","author":"Liu","year":"2018"},{"key":"10.1016\/j.intimp.2019.05.048_bb0180","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1111\/jcmm.13201","article-title":"miR-181a and miR-150 regulate dendritic cell immune inflammatory responses and cardiomyocyte apoptosis via targeting JAK1-STAT1\/c-Fos pathway","volume":"21","author":"Zhu","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.intimp.2019.05.048_bb0185","series-title":"miR-146a Controls Immune Response in the Melanoma Microenvironment","first-page":"183","volume":"79","author":"Mastroianni","year":"2019"},{"key":"10.1016\/j.intimp.2019.05.048_bb0190","series-title":"Multiple Myeloma-derived Exosomes Regulate the Functions of Mesenchymal Stem Cells Partially Via Modulating miR-21 and miR-146a","first-page":"9012152","volume":"2017","author":"Cheng","year":"2017"},{"key":"10.1016\/j.intimp.2019.05.048_bb0195","series-title":"Exosome-mediated miR-146a Transfer Suppresses Type I Interferon Response and Facilitates EV71 Infection","first-page":"e1006611","volume":"13","author":"Fu","year":"2017"},{"key":"10.1016\/j.intimp.2019.05.048_bb0200","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.semcancer.2011.12.010","article-title":"MicroRNAs and STAT interplay","volume":"22","author":"Kohanbash","year":"2012","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.intimp.2019.05.048_bb0205","doi-asserted-by":"crossref","first-page":"E3536","DOI":"10.1073\/pnas.1703920114","article-title":"Intranasal MSC-derived A1-exosomes ease inflammation, and prevent abnormal neurogenesis and memory dysfunction after status epilepticus","volume":"114","author":"Long","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576919306241?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576919306241?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:11:54Z","timestamp":1761585114000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576919306241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":41,"alternative-id":["S1567576919306241"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2019.05.048","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Extracellular vesicles from mesenchymal stem cells prevent contact hypersensitivity through the suppression of Tc1 and Th1 cells and expansion of regulatory T cells","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2019.05.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105663"}}