{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:17:42Z","timestamp":1789708662739,"version":"4.0.1"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.intimp.2019.105730","type":"journal-article","created":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T12:38:04Z","timestamp":1562675884000},"page":"105730","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"special_numbering":"C","title":["Sirolimus as a new drug to treat RIF patients with elevated Th17\/Treg ratio: A double-blind, phase II randomized clinical trial"],"prefix":"10.1016","volume":"74","author":[{"given":"Majid","family":"Ahmadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samaneh","family":"Abdolmohamadi-vahid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahnaz","family":"Ghaebi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanam","family":"Dolati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanaz","family":"Abbaspour-Aghdam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahla","family":"Danaii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katayoun","family":"Berjis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahime","family":"Madadi-Javid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Nouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Homayoon","family":"Siahmansouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohreh","family":"Babaloo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Nouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Yousefi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.intimp.2019.105730_bb0005","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/humrep\/deu292","article-title":"Prevalence of chronic endometritis in repeated unexplained implantation failure and the IVF success rate after antibiotic therapy","volume":"30","author":"Cicinelli","year":"2014","journal-title":"Hum. Reprod."},{"issue":"6","key":"10.1016\/j.intimp.2019.105730_bb0010","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1093\/humrep\/dep011","article-title":"Endometrial secretion analysis identifies a cytokine profile predictive of pregnancy in IVF","volume":"24","author":"Boomsma","year":"2009","journal-title":"Hum. Reprod."},{"issue":"1","key":"10.1016\/j.intimp.2019.105730_bb0015","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1189\/jlb.0708395","article-title":"Embryonic implantation: cytokines, adhesion molecules, and immune cells in establishing an implantation environment","volume":"85","author":"Van Mourik","year":"2009","journal-title":"J. Leukoc. Biol."},{"issue":"7","key":"10.1016\/j.intimp.2019.105730_bb0020","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1093\/humrep\/des134","article-title":"Expression of leukaemia inhibitory factor and interleukin 15 in endometrium of women with recurrent implantation failure after IVF; correlation with the number of endometrial natural killer cells","volume":"27","author":"Mariee","year":"2012","journal-title":"Hum. Reprod."},{"issue":"24","key":"10.1016\/j.intimp.2019.105730_bb0025","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.1016\/S0264-410X(03)00331-1","article-title":"How immune mechanisms are affected by pregnancy","volume":"21","author":"Luppi","year":"2003","journal-title":"Vaccine"},{"issue":"1","key":"10.1016\/j.intimp.2019.105730_bb0030","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jri.2007.02.006","article-title":"Immunosuppressive effect of pregnant mouse serum on allostimulatory activity of dendritic cells","volume":"75","author":"Shojaeian","year":"2007","journal-title":"J. Reprod. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2019.105730_bb0035","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jri.2011.03.006","article-title":"Recent advances in understanding immunology of reproductive failure","volume":"90","author":"Makrigiannakis","year":"2011","journal-title":"J. Reprod. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2019.105730_bb0040","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.critrevonc.2004.09.009","article-title":"Rapamycin: an anti-cancer immunosuppressant?","volume":"56","author":"Law","year":"2005","journal-title":"Crit. Rev. Oncol. Hematol."},{"issue":"11","key":"10.1016\/j.intimp.2019.105730_bb0045","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nrd3531","article-title":"Rapamycin passes the torch: a new generation of mTOR inhibitors","volume":"10","author":"Benjamin","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"issue":"1","key":"10.1016\/j.intimp.2019.105730_bb0050","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/PL00000199","article-title":"Differential anti-inflammatory effects of immunosuppressive drugs: cyclosporin, rapamycin and FK-506 on inducible nitric oxide synthase, nitric oxide, cyclooxygenase-2 and PGE 2 production","volume":"49","author":"Attur","year":"2000","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.intimp.2019.105730_bb0055","series-title":"Report From the National Transplantation Pregnancy Registry (NTPR): Outcomes of Pregnancy after Transplantation","author":"Coscia","year":"2010"},{"issue":"13","key":"10.1016\/j.intimp.2019.105730_bb0060","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1016\/j.intimp.2007.08.027","article-title":"Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells","volume":"7","author":"Kopf","year":"2007","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2019.105730_bb0065","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/imm.12351","article-title":"The effect of mammalian target of rapamycin inhibition on T helper type 17 and regulatory T cell differentiation in vitro and in vivo in kidney transplant recipients","volume":"144","author":"Kim","year":"2015","journal-title":"Immunology"},{"issue":"6","key":"10.1016\/j.intimp.2019.105730_bb0070","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.immuni.2010.11.024","article-title":"An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness","volume":"33","author":"Procaccini","year":"2010","journal-title":"Immunity"},{"issue":"7","key":"10.1016\/j.intimp.2019.105730_bb0075","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1177\/1933719116675054","article-title":"Maternal T regulatory cell depletion impairs embryo implantation which can be corrected with adoptive T regulatory cell transfer","volume":"24","author":"Heitmann","year":"2017","journal-title":"Reprod. Sci."},{"issue":"5","key":"10.1016\/j.intimp.2019.105730_bb0080","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1093\/humrep\/deu014","article-title":"Adoptive transfer of pregnancy-induced CD4+ CD25+ regulatory T cells reverses the increase in abortion rate caused by interleukin 17 in the CBA\/J\u00d7 BALB\/c mouse model","volume":"29","author":"Wang","year":"2014","journal-title":"Hum. Reprod."},{"issue":"8","key":"10.1016\/j.intimp.2019.105730_bb0085","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.3324\/haematol.2012.074088","article-title":"Differential effects of rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4+ CD25+ FOXP3+ T regulatory cell subpopulations","volume":"98","author":"Scott\u00e0","year":"2013","journal-title":"Haematologica"},{"key":"10.1016\/j.intimp.2019.105730_bb0090","doi-asserted-by":"crossref","DOI":"10.1177\/1933719119828110","article-title":"Rapamycin corrects T regulatory cell depletion and improves embryo implantation and live birth rates in a murine model","author":"Royster","year":"2019","journal-title":"Reprod. Sci."},{"issue":"3","key":"10.1016\/j.intimp.2019.105730_bb0095","doi-asserted-by":"crossref","DOI":"10.1111\/aji.12682","article-title":"Immunosuppressive treatment using tacrolimus promotes pregnancy outcome in infertile women with repeated implantation failures","volume":"78","author":"Nakagawa","year":"2017","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.intimp.2019.105730_bb0100","first-page":"201701129","article-title":"Embryo implantation evolved from an ancestral inflammatory attachment reaction","author":"Griffith","year":"2017","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"6","key":"10.1016\/j.intimp.2019.105730_bb0105","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/S1472-6483(10)61034-6","article-title":"What can the clinician do to improve implantation?","volume":"13","author":"Boomsma","year":"2006","journal-title":"Reprod. BioMed. Online"},{"issue":"1","key":"10.1016\/j.intimp.2019.105730_bb0110","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1530\/jrf.0.0390195","article-title":"The control of implantation","volume":"39","author":"Finn","year":"1974","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.intimp.2019.105730_bb0115","series-title":"Seminars in Reproductive Medicine","first-page":"062","article-title":"The role of growth factors and cytokines during implantation: endocrine and paracrine interactions","author":"Guzeloglu-Kayisli","year":"2009"},{"issue":"5","key":"10.1016\/j.intimp.2019.105730_bb0120","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.fertnstert.2012.03.033","article-title":"Recurrent implantation failure: current update and clinical approach to an ongoing challenge","volume":"97","author":"Laufer","year":"2012","journal-title":"Fertil. Steril."},{"issue":"4","key":"10.1016\/j.intimp.2019.105730_bb0125","article-title":"Evidence-based update: immunological evaluation of recurrent implantation failure","volume":"1","author":"Garc\u00eda-Segovia","year":"2016","journal-title":"Reproductive Immunology: Open Access"},{"key":"10.1016\/j.intimp.2019.105730_bb0130","first-page":"28","article-title":"Decreased peripheral blood CD4+ CD25bright T cells in women with repeated implantation failures after in vitro fertilization and embryo transfer","volume":"23","author":"Chen","year":"2009","journal-title":"Formos. J. Rheumatol"},{"issue":"5","key":"10.1016\/j.intimp.2019.105730_bb0135","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1600-0897.2010.00921.x","article-title":"Study on the relationship between Th17 cells and unexplained recurrent spontaneous abortion","volume":"65","author":"Liu","year":"2011","journal-title":"Am. J. Reprod. Immunol."},{"issue":"11","key":"10.1016\/j.intimp.2019.105730_bb0140","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1093\/humrep\/der301","article-title":"An imbalance in interleukin-17-producing T and Foxp3+ regulatory T cells in women with idiopathic recurrent pregnancy loss","volume":"26","author":"Lee","year":"2011","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.intimp.2019.105730_bb0145","unstructured":"S. Abdolrahim, n.d. T Regulatory (Treg)\/T Helper 17 Imbalance with Emphasis on Treg Factors during Implantation Window in Unexplained Recurrent Spontaneous Miscarriage."},{"issue":"2","key":"10.1016\/j.intimp.2019.105730_bb0150","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.1600-0897.2012.01153.x","article-title":"An increase of Treg cells in the peripheral blood is associated with a better in vitro fertilization treatment outcome","volume":"68","author":"Zhou","year":"2012","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.intimp.2019.105730_bb0155","unstructured":"S. Rajaei, A.H. Zarnani, M. Jeddi-Tehrani, M. Tavakoli, A. Mohammadzadeh, A. Dabbagh, M. Mirahmadian, Cytokine profile in the endometrium of normal fertile and women with repeated implantation failure, Iranian Journal of Immunology 8(4) (2011) 201."},{"key":"10.1016\/j.intimp.2019.105730_bb0160","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/j.biopha.2016.10.062","article-title":"Novel immunotherapeutic approaches for treatment of infertility","volume":"84","author":"Abdolmohammadi-Vahid","year":"2016","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.intimp.2019.105730_bb0165","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/aji.12338","article-title":"Immunosuppression with tacrolimus improved reproductive outcome of women with repeated implantation failure and elevated peripheral blood TH1\/TH2 cell ratios","volume":"73","author":"Nakagawa","year":"2015","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.intimp.2019.105730_bb0170","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.biopha.2017.06.001","article-title":"Effect of intravenous immunoglobulin on Th1 and Th2 lymphocytes and improvement of pregnancy outcome in recurrent pregnancy loss (RPL)","volume":"92","author":"Ahmadi","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2019.105730_bb0175","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.imlet.2017.10.003","article-title":"Intravenous immunoglobulin (IVIG) treatment modulates peripheral blood Th17 and regulatory T cells in recurrent miscarriage patients: non randomized, open-label clinical trial","volume":"192","author":"Ahmadi","year":"2017","journal-title":"Immunol. Lett."},{"issue":"6","key":"10.1016\/j.intimp.2019.105730_bb0180","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1080\/19396368.2017.1390007","article-title":"Regulatory T cells improve pregnancy rate in RIF patients after additional IVIG treatment","volume":"63","author":"Ahmadi","year":"2017","journal-title":"Syst Biol Reprod Med"},{"issue":"2","key":"10.1016\/j.intimp.2019.105730_bb0185","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1074\/jbc.270.2.815","article-title":"Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells","volume":"270","author":"Sabers","year":"1995","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.intimp.2019.105730_bb0190","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S1097-2765(02)00636-6","article-title":"Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control","volume":"10","author":"Loewith","year":"2002","journal-title":"Mol. Cell"},{"issue":"2","key":"10.1016\/j.intimp.2019.105730_bb0195","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0092-8674(02)00808-5","article-title":"mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery","volume":"110","author":"Kim","year":"2002","journal-title":"Cell"},{"issue":"s17","key":"10.1016\/j.intimp.2019.105730_bb0200","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1399-0012.2006.00598.x","article-title":"The role and value of sirolimus administration in kidney and liver transplantation","volume":"20","author":"Mehrabi","year":"2006","journal-title":"Clin. Transpl."},{"issue":"9","key":"10.1016\/j.intimp.2019.105730_bb0205","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nri1435","article-title":"Tolerance, not immunity, crucially depends on IL-2","volume":"4","author":"Malek","year":"2004","journal-title":"Nat. Rev. Immunol."},{"issue":"9","key":"10.1016\/j.intimp.2019.105730_bb0210","doi-asserted-by":"crossref","first-page":"5287","DOI":"10.4049\/jimmunol.172.9.5287","article-title":"Distinct IL-2 receptor signaling pattern in CD4+ CD25+ regulatory T cells","volume":"172","author":"Bensinger","year":"2004","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2019.105730_bb0215","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1182\/blood-2006-02-004747","article-title":"IL-2 regulates FOXP3 expression in human CD4+ CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo","volume":"108","author":"Zorn","year":"2006","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.intimp.2019.105730_bb0220","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/ni.2005","article-title":"The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2","volume":"12","author":"Delgoffe","year":"2011","journal-title":"Nat. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2019.105730_bb0225","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1002\/eji.201041073","article-title":"Integrated T-cell receptor and costimulatory signals determine TGF-\u03b2-dependent differentiation and maintenance of Foxp3+ regulatory T cells","volume":"41","author":"Gabry\u0161ov\u00e1","year":"2011","journal-title":"Eur. J. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2019.105730_bb0230","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1084\/jem.20071477","article-title":"The AKT\u2013mTOR axis regulates de novo differentiation of CD4+ Foxp3+ cells","volume":"205","author":"Haxhinasto","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.intimp.2019.105730_bb0235","doi-asserted-by":"crossref","first-page":"8698","DOI":"10.1038\/ncomms9698","article-title":"Ndrg1 is a T-cell clonal anergy factor negatively regulated by CD28 costimulation and interleukin-2","volume":"6","author":"Oh","year":"2015","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.intimp.2019.105730_bb0240","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.4049\/jimmunol.176.5.2730","article-title":"Prolonged TCR\/CD28 engagement drives IL-2-independent T cell clonal expansion through signaling mediated by the mammalian target of rapamycin","volume":"176","author":"Colombetti","year":"2006","journal-title":"J. Immunol."},{"issue":"11","key":"10.1016\/j.intimp.2019.105730_bb0245","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.healun.2009.07.009","article-title":"Everolimus but not mycophenolate mofetil therapy is associated with soluble HLA-G expression in heart transplant patients","volume":"28","author":"Sheshgiri","year":"2009","journal-title":"J. Heart Lung Transplant."},{"key":"10.1016\/j.intimp.2019.105730_bb0250","doi-asserted-by":"crossref","unstructured":"H. Margoles, V. Gomez-Lobo, J. Veis, M. Sherman, J. Moore Jr, Successful maternal and fetal outcome in a kidney transplant patient with everolimus exposure throughout pregnancy: a case report, Transplant. Proc., Elsevier, 2014, pp. 281\u2013283.","DOI":"10.1016\/j.transproceed.2013.09.029"},{"issue":"2","key":"10.1016\/j.intimp.2019.105730_bb0255","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1053\/j.ajkd.2012.05.012","article-title":"Pregnancy in a kidney transplant patient treated with everolimus","volume":"60","author":"Carta","year":"2012","journal-title":"Am. J. Kidney Dis."},{"issue":"1","key":"10.1016\/j.intimp.2019.105730_bb0260","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/acel.12405","article-title":"Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system","volume":"15","author":"Arriola Apelo","year":"2016","journal-title":"Aging Cell"},{"issue":"4","key":"10.1016\/j.intimp.2019.105730_bb0265","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0092684","article-title":"Beneficial metabolic effects of rapamycin are associated with enhanced regulatory cells in diet-induced obese mice","volume":"9","author":"Makki","year":"2014","journal-title":"PLoS One"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576919307957?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576919307957?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:18:24Z","timestamp":1761585504000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576919307957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":53,"alternative-id":["S1567576919307957"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2019.105730","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sirolimus as a new drug to treat RIF patients with elevated Th17\/Treg ratio: A double-blind, phase II randomized clinical trial","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2019.105730","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105730"}}