{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:48:28Z","timestamp":1792712908170,"version":"4.5.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2017M37A1025369"],"award-info":[{"award-number":["2017M37A1025369"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["NRF-2016R1A6A3A11934000"],"award-info":[{"award-number":["NRF-2016R1A6A3A11934000"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.intimp.2019.105738","type":"journal-article","created":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T11:57:40Z","timestamp":1562932660000},"page":"105738","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Inhibition of COX-2 alleviates lumbar spinal stenosis-induced chronic mechanical allodynia in rats"],"prefix":"10.1016","volume":"75","author":[{"given":"Jee Youn","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae Young","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan Sol","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyoung","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Tae","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Yeol","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inchan","family":"Youn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Young","family":"Yune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2019.105738_bb0005","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.3892\/mmr.2013.1723","article-title":"Brain-derived neurotrophic factor expression in dorsal root ganglia of a lumbar spinal stenosis model in rats","volume":"8","author":"Li","year":"2013","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.intimp.2019.105738_bb0010","doi-asserted-by":"crossref","first-page":"E761","DOI":"10.1097\/BRS.0b013e3181e45a6e","article-title":"Evaluation of change in muscle activity as a result of posterior lumbar spine surgery using a dynamic modeling system","volume":"35","author":"Bresnahan","year":"2010","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.intimp.2019.105738_bb0015","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3171\/2009.1.SPINE08288","article-title":"Postoperative outcome after modified unilateral-approach microendoscopic midline decompression for degenerative spinal stenosis","volume":"10","author":"Yagi","year":"2009","journal-title":"J. Neurosurg. Spine"},{"key":"10.1016\/j.intimp.2019.105738_bb0020","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1097\/BRS.0000000000000837","article-title":"A randomized, double-blind, placebo-controlled crossover trial of oxymorphone hydrochloride and propoxyphene\/acetaminophen combination for the treatment of neurogenic claudication associated with lumbar spinal stenosis","volume":"40","author":"Markman","year":"2015","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.intimp.2019.105738_bb0025","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.jpain.2017.12.001","article-title":"Efficacy and safety of oral and transdermal opioid analgesics for musculoskeletal pain in older adults: a systematic review of randomized, placebo-controlled trials","volume":"19","author":"Megale","year":"2018","journal-title":"J. Pain"},{"key":"10.1016\/j.intimp.2019.105738_bb0030","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.2147\/JPR.S182322","article-title":"Interspinous process decompression is associated with a reduction in opioid analgesia in patients with lumbar spinal stenosis","volume":"11","author":"Nunley","year":"2018","journal-title":"J. Pain Res."},{"key":"10.1016\/j.intimp.2019.105738_bb0035","doi-asserted-by":"crossref","first-page":"4308","DOI":"10.1523\/JNEUROSCI.0003-06.2006","article-title":"Activated microglia contribute to the maintenance of chronic pain after spinal cord injury","volume":"26","author":"Hains","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.intimp.2019.105738_bb0040","doi-asserted-by":"crossref","DOI":"10.1126\/stke.2522004re14","article-title":"Cell signaling and the genesis of neuropathic pain","volume":"2004","author":"Ji","year":"2004","journal-title":"Sci. STKE"},{"key":"10.1016\/j.intimp.2019.105738_bb0045","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1523\/JNEUROSCI.0138-07.2007","article-title":"Extracellular signal-regulated kinase-regulated microglia-neuron signaling by prostaglandin E2 contributes to pain after spinal cord injury","volume":"27","author":"Zhao","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.intimp.2019.105738_bb0050","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.expneurol.2012.05.014","article-title":"Inhibition of ROS-induced p38MAPK and ERK activation in microglia by acupuncture relieves neuropathic pain after spinal cord injury in rats","volume":"236","author":"Choi","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.intimp.2019.105738_bb0055","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1016\/j.bbadis.2018.04.006","article-title":"Estrogen alleviates neuropathic pain induced after spinal cord injury by inhibiting microglia and astrocyte activation","volume":"1864","author":"Lee","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.intimp.2019.105738_bb0060","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.pbb.2016.12.013","article-title":"HYP-17, a novel voltage-gated sodium channel blocker, relieves inflammatory and neuropathic pain in rats","volume":"153","author":"Lee","year":"2017","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.intimp.2019.105738_bb0065","doi-asserted-by":"crossref","first-page":"294","DOI":"10.4236\/nm.2012.33034","article-title":"S-Nitrosoglutathione administration ameliorates cauda equina compression injury in rats","volume":"3","author":"Shunmugavel","year":"2012","journal-title":"Neurosci. Med."},{"key":"10.1016\/j.intimp.2019.105738_bb0070","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/s11481-012-9419-3","article-title":"Simvastatin ameliorates cauda equina compression injury in a rat model of lumbar spinal stenosis","volume":"8","author":"Shunmugavel","year":"2013","journal-title":"J. NeuroImmune Pharmacol."},{"key":"10.1016\/j.intimp.2019.105738_bb0075","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s12974-015-0311-y","article-title":"Oral administration of cytosolic PLA2 inhibitor arachidonyl trifluoromethyl ketone ameliorates cauda equina compression injury in rats","volume":"12","author":"Khan","year":"2015","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.intimp.2019.105738_bb0080","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals","volume":"16","author":"Zimmermann","year":"1983","journal-title":"Pain"},{"key":"10.1016\/j.intimp.2019.105738_bb0085","article-title":"Over-expression of PUMA correlates with the apoptosis of spinal cord cells in rat neuropathic intermittent claudication model","volume":"8","author":"Ma","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2019.105738_bb0090","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1016\/j.bmcl.2014.02.074","article-title":"Synthesis, biological evaluation, and docking analysis of a novel family of 1-methyl-1H-pyrrole-2,5-diones as highly potent and selective cyclooxygenase-2 (COX-2) inhibitors","volume":"24","author":"Kim","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.intimp.2019.105738_bb0095","doi-asserted-by":"crossref","first-page":"7751","DOI":"10.1523\/JNEUROSCI.1661-07.2007","article-title":"Minocycline alleviates death of oligodendrocytes by inhibiting pro-nerve growth factor production in microglia after spinal cord injury","volume":"27","author":"Yune","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.intimp.2019.105738_bb0100","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.brainresrev.2005.11.004","article-title":"Immune and inflammatory mechanisms in neuropathic pain","volume":"51","author":"Moalem","year":"2006","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.intimp.2019.105738_bb0105","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.lfs.2013.10.005","article-title":"Contribution of macrophages to peripheral neuropathic pain pathogenesis","volume":"93","author":"Ristoiu","year":"2013","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2019.105738_bb0110","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.neuroscience.2004.01.003","article-title":"Cyclooxygenase 2 expression in the spared nerve injury model of neuropathic pain","volume":"124","author":"Broom","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.intimp.2019.105738_bb0115","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.neurobiolaging.2008.08.002","article-title":"Injured nerve-derived COX2\/PGE2 contributes to the maintenance of neuropathic pain in aged rats","volume":"31","author":"Ma","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.intimp.2019.105738_bb0120","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ejphar.2006.09.072","article-title":"Intrathecally administered COX-2 but not COX-1 or COX-3 inhibitors attenuate streptozotocin-induced mechanical hyperalgesia in rats","volume":"554","author":"Matsunaga","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2019.105738_bb0125","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neulet.2010.04.069","article-title":"Cyclooxygenase inhibitors suppress the expression of P2X(3) receptors in the DRG and attenuate hyperalgesia following chronic constriction injury in rats","volume":"478","author":"Wang","year":"2010","journal-title":"Neurosci. Lett."},{"issue":"Pt 1","key":"10.1016\/j.intimp.2019.105738_bb0130","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.expneurol.2015.11.001","article-title":"Celecoxib reverts oxaliplatin-induced neuropathic pain through inhibiting PI3K\/Akt2 pathway in the mouse dorsal root ganglion","volume":"275","author":"Jiang","year":"2016","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.intimp.2019.105738_bb0135","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1126\/science.aaf8924","article-title":"Pain regulation by non-neuronal cells and inflammation","volume":"354","author":"Ji","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.intimp.2019.105738_bb0140","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.neuron.2007.07.016","article-title":"Nociceptors\u2014noxious stimulus detectors","volume":"55","author":"Woolf","year":"2007","journal-title":"Neuron"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576919309166?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576919309166?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T21:43:42Z","timestamp":1762551822000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576919309166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":28,"alternative-id":["S1567576919309166"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2019.105738","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of COX-2 alleviates lumbar spinal stenosis-induced chronic mechanical allodynia in rats","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2019.105738","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105738"}}