{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:01:03Z","timestamp":1790355663190,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.intimp.2019.105773","type":"journal-article","created":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T16:31:09Z","timestamp":1563899469000},"page":"105773","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Interleukin-7 promotes CD8+ T cell activity in patients with enterovirus 71 associated encephalitis"],"prefix":"10.1016","volume":"75","author":[{"given":"Xiaojun","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangxi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congcong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2019.105773_bb0005","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S1473-3099(13)70342-6","article-title":"Hand, foot, and mouth disease in China, 2008\u201312: an epidemiological study","volume":"14","author":"Xing","year":"2014","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.intimp.2019.105773_bb0010","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41426-017-0011-z","article-title":"Epidemiological and serological surveillance of hand-foot-and-mouth disease in Shanghai, China, 2012\u20132016","volume":"7","author":"Wang","year":"2018","journal-title":"Emerg Microbes Infect"},{"key":"10.1016\/j.intimp.2019.105773_bb0015","first-page":"512","article-title":"Epidemiologic characteristics of hand, foot, and mouth disease in China from 2006 to 2015","volume":"73","author":"Wang","year":"2016","journal-title":"J. Inf. Secur."},{"key":"10.1016\/j.intimp.2019.105773_bb0020","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1002\/jmv.24200","article-title":"Characterization of severe hand, foot, and mouth disease in Shenzhen, China, 2009\u20132013","volume":"87","author":"Huang","year":"2015","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.intimp.2019.105773_bb0025","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1017\/S0950268809991555","article-title":"Human enterovirus 71 and hand, foot and mouth disease","volume":"138","author":"Wong","year":"2010","journal-title":"Epidemiol. Infect."},{"key":"10.1016\/j.intimp.2019.105773_bb0030","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1136\/jech-2014-203836","article-title":"Enterovirus 71 related severe hand, foot and mouth disease outbreaks in South-East Asia: current situation and ongoing challenges","volume":"68","author":"Sabanathan","year":"2014","journal-title":"J. Epidemiol. Community Health"},{"key":"10.1016\/j.intimp.2019.105773_bb0035","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1093\/ajcp\/aqw089","article-title":"Pathologic studies of fatal encephalomyelitis in children caused by enterovirus 71","volume":"146","author":"Xing","year":"2016","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.intimp.2019.105773_bb0040","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.intimp.2018.04.031","article-title":"Crosstalk between Toll-like receptor 3 and Notch signaling contributes to CD14(+) monocytes activity in enterovirus 71 infected hand, foot, and mouth disease","volume":"60","author":"Hao","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2019.105773_bb0045","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1038\/s41598-018-19988-6","article-title":"Cerebrospinal fluid chemokine patterns in children with enterovirus 71-related encephalitis","volume":"8","author":"Liu","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2019.105773_bb0050","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1089\/jir.2017.0080","article-title":"Interleukin-35 modulates the imbalance between regulatory T cells and T helper 17 cells in enterovirus 71-induced hand, foot, and mouth disease","volume":"37","author":"Huang","year":"2017","journal-title":"J. Interf. Cytokine Res."},{"key":"10.1016\/j.intimp.2019.105773_bb0055","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.immuni.2016.07.006","article-title":"Clarifying the confusion between cytokine and fc receptor \u201ccommon gamma chain\u201d","volume":"45","author":"Brandsma","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2019.105773_bb0060","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.immuni.2019.03.028","article-title":"The gammac family of cytokines: basic biology to therapeutic ramifications","volume":"50","author":"Leonard","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2019.105773_bb0065","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.12688\/f1000research.12202.1","article-title":"The gamma c family of cytokines: fine-tuning signals from IL-2 and IL-21 in the regulation of the immune response","volume":"6","author":"Spolski","year":"2017","journal-title":"F1000Res"},{"key":"10.1016\/j.intimp.2019.105773_bb0070","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1126\/science.1077002","article-title":"A critical role for IL-21 in regulating immunoglobulin production","volume":"298","author":"Ozaki","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.intimp.2019.105773_bb0075","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1002\/eji.201444701","article-title":"OX40 and IL-7 play synergistic roles in the homeostatic proliferation of effector memory CD4(+) T cells","volume":"44","author":"Yamaki","year":"2014","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.intimp.2019.105773_bb0080","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1182\/blood-2015-05-645077","article-title":"Administration of interleukin-7 increases CD4 T cells in idiopathic CD4 lymphocytopenia","volume":"127","author":"Sheikh","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.intimp.2019.105773_bb0085","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/80868","article-title":"Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo","volume":"1","author":"Schluns","year":"2000","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.intimp.2019.105773_bb0090","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/cmi.2014.49","article-title":"Type 1 interferon-induced IL-7 maintains CD8+ T-cell responses and homeostasis by suppressing PD-1 expression in viral hepatitis","volume":"12","author":"Hou","year":"2015","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.intimp.2019.105773_bb0095","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cyto.2017.12.014","article-title":"Interleukin-7 augments CD8(+) T cells function and promotes viral clearance in chronic hepatitis C virus infection","volume":"102","author":"Hou","year":"2018","journal-title":"Cytokine"},{"key":"10.1016\/j.intimp.2019.105773_bb0100","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.cell.2011.01.011","article-title":"IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology","volume":"144","author":"Pellegrini","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2019.105773_bb0105","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.immuni.2017.11.021","article-title":"Transcription factor IRF4 promotes CD8(+) T cell exhaustion and limits the development of memory-like T cells during chronic infection","volume":"47","author":"Man","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2019.105773_bb0110","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.immuni.2016.07.008","article-title":"Bioenergetic insufficiencies due to metabolic alterations regulated by the inhibitory receptor PD-1 are an early driver of CD8(+) T cell exhaustion","volume":"45","author":"Bengsch","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2019.105773_bb0115","doi-asserted-by":"crossref","first-page":"6281","DOI":"10.1128\/JVI.00464-14","article-title":"Animal model of respiratory syncytial virus: CD8+ T cells cause a cytokine storm that is chemically tractable by sphingosine-1-phosphate 1 receptor agonist therapy","volume":"88","author":"Walsh","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.intimp.2019.105773_bb0120","doi-asserted-by":"crossref","DOI":"10.4161\/21624011.2014.954893","article-title":"A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines","volume":"3","author":"Boegel","year":"2014","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.intimp.2019.105773_bb0125","doi-asserted-by":"crossref","first-page":"287","DOI":"10.4049\/jimmunol.0902761","article-title":"CD8(+) T cell control of hepatitis B virus replication: direct comparison between cytolytic and noncytolytic functions","volume":"184","author":"Phillips","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2019.105773_bb0130","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/1348-0421.12227","article-title":"Cerebrospinal fluid Th1\/Th2 cytokine profiles in children with enterovirus 71-associated meningoencephalitis","volume":"59","author":"Li","year":"2015","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.intimp.2019.105773_bb0135","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/ni.2494","article-title":"IL-7 signaling must be intermittent, not continuous, during CD8(+) T cell homeostasis to promote cell survival instead of cell death","volume":"14","author":"Kimura","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.intimp.2019.105773_bb0140","article-title":"Interleukin-7 enhances anti-tumor activity of CD8(+) T cells in patients with hepatocellular carcinoma","author":"Teng","year":"2018","journal-title":"Cytokine"},{"key":"10.1016\/j.intimp.2019.105773_bb0145","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nri2970","article-title":"Harnessing the biology of IL-7 for therapeutic application","volume":"11","author":"Mackall","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.intimp.2019.105773_bb0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0050199","article-title":"Interleukin-7, but not thymic stromal lymphopoietin, plays a key role in the T cell response to influenza A virus","volume":"7","author":"Plumb","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2019.105773_bb0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002636","article-title":"Treatment with IL-7 prevents the decline of circulating CD4+ T cells during the acute phase of SIV infection in rhesus macaques","volume":"8","author":"Vassena","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.intimp.2019.105773_bb0160","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1002\/jmv.23929","article-title":"Serum cytokine profiles of children with human enterovirus 71-associated hand, foot, and mouth disease","volume":"86","author":"Han","year":"2014","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.intimp.2019.105773_bb0165","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0111193","article-title":"Expression of the IL-7 receptor alpha-chain is down regulated on the surface of CD4 T-cells by the HIV-1 Tat protein","volume":"9","author":"McLaughlin","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2019.105773_bb0170","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1084\/jem.189.10.1555","article-title":"Noncytopathic clearance of lymphocytic choriomeningitis virus from the hepatocyte","volume":"189","author":"Guidotti","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.intimp.2019.105773_bb0175","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1006\/viro.2000.0442","article-title":"Cytokine-mediated control of viral infections","volume":"273","author":"Guidotti","year":"2000","journal-title":"Virology"},{"key":"10.1016\/j.intimp.2019.105773_bb0180","doi-asserted-by":"crossref","first-page":"472","DOI":"10.3389\/fcimb.2017.00472","article-title":"Interleukin-35 suppresses antiviral immune response in chronic hepatitis B virus infection","volume":"7","author":"Shao","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.intimp.2019.105773_bb0185","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.biopha.2017.10.143","article-title":"Notch signaling pathway dampens tumor-infiltrating CD8(+) T cells activity in patients with colorectal carcinoma","volume":"97","author":"Yu","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2019.105773_bb0190","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1159\/000491615","article-title":"Interleukin-35 suppresses the antitumor activity of T cells in patients with non-small cell lung Cancer","volume":"47","author":"Wang","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.intimp.2019.105773_bb0195","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.intimp.2018.07.033","article-title":"Notch signaling pathway suppresses CD8(+) T cells activity in patients with lung adenocarcinoma","volume":"63","author":"Li","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2019.105773_bb0200","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1158\/1078-0432.CCR-13-1016","article-title":"Interleukin-7 mediates selective expansion of tumor-redirected cytotoxic T lymphocytes (CTLs) without enhancement of regulatory T-cell inhibition","volume":"20","author":"Perna","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.intimp.2019.105773_bb0205","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/sj.jid.5700001","article-title":"Cytotoxic T cells","volume":"126","author":"Andersen","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.intimp.2019.105773_bb0210","doi-asserted-by":"crossref","first-page":"5123","DOI":"10.1182\/blood-2010-12-323154","article-title":"Immunotherapeutic effects of IL-7 during a chronic viral infection in mice","volume":"117","author":"Nanjappa","year":"2011","journal-title":"Blood"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757691930966X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757691930966X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T07:16:31Z","timestamp":1749539791000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156757691930966X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":42,"alternative-id":["S156757691930966X"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2019.105773","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interleukin-7 promotes CD8+ T cell activity in patients with enterovirus 71 associated encephalitis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2019.105773","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105773"}}