{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:23:08Z","timestamp":1790022188272,"version":"4.0.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20161069"],"award-info":[{"award-number":["BK20161069"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81902206"],"award-info":[{"award-number":["81902206"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.intimp.2019.106044","type":"journal-article","created":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T11:32:18Z","timestamp":1576668738000},"page":"106044","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Gene delivery of TIPE2 attenuates collagen-induced arthritis by modulating inflammation"],"prefix":"10.1016","volume":"79","author":[{"given":"Jinchun","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.intimp.2019.106044_b0005","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1136\/annrheumdis-2013-204627","article-title":"The global burden of rheumatoid arthritis: estimates from the global burden of disease 2010 study","volume":"73","author":"Cross","year":"2014","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.intimp.2019.106044_b0010","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1146\/annurev.immunol.26.021607.090244","article-title":"Immunity to citrullinated proteins in rheumatoid arthritis","volume":"26","author":"Klareskog","year":"2008","journal-title":"Annu. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2019.106044_b0015","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3109\/08923973.2015.1125917","article-title":"Old and new therapeutics for Rheumatoid Arthritis: in vivo models and drug development","volume":"38","author":"Sardar","year":"2016","journal-title":"Immunopharmacol. Immunotoxicol."},{"issue":"10086","key":"10.1016\/j.intimp.2019.106044_b0020","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1016\/S0140-6736(17)31491-5","article-title":"Novel treatment strategies in rheumatoid arthritis","volume":"389","author":"Burmester","year":"2017","journal-title":"Lancet (London, England)"},{"issue":"11","key":"10.1016\/j.intimp.2019.106044_b0025","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.1002\/art.30524","article-title":"Remission of rheumatoid arthritis in clinical practice: application of the American College of Rheumatology\/European League Against Rheumatism 2011 remission criteria","volume":"63","author":"Shahouri","year":"2011","journal-title":"Arthritis Rheum."},{"issue":"9","key":"10.1016\/j.intimp.2019.106044_b0030","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1007\/s00109-015-1288-9","article-title":"TIPE2 acts as a negative regulator linking NOD2 and inflammatory responses in myocardial ischemia\/reperfusion injury","volume":"93","author":"Zhang","year":"2015","journal-title":"J. Mol. Med. (Berlin, Germany)"},{"issue":"2","key":"10.1016\/j.intimp.2019.106044_b0035","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.bbrc.2018.04.082","article-title":"Egress of murine regulatory T cells from the thymus requires TIPE2","volume":"500","author":"Fan","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.intimp.2019.106044_b0040","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.cell.2008.03.026","article-title":"TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis","volume":"133","author":"Sun","year":"2008","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.intimp.2019.106044_b0045","first-page":"952","article-title":"TIPE2 governs macrophage polarization via negative regulation of mTORC1","volume":"17","author":"Jiang","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.intimp.2019.106044_b0050","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.lfs.2018.11.054","article-title":"Reduced TIPE2 expression is inversely associated with proinflammatory cytokines and positively correlated with bone mineral density in patients with osteoporosis","volume":"216","author":"Jiang","year":"2019","journal-title":"Life Sci."},{"issue":"19","key":"10.1016\/j.intimp.2019.106044_b0055","doi-asserted-by":"crossref","first-page":"30781","DOI":"10.18632\/oncotarget.15683","article-title":"Tumor necrosis factor-alpha-induced protein 8-like 2 (TIPE2) is associated with immune phases of patients with chronic hepatitis B","volume":"8","author":"Fan","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.intimp.2019.106044_b0060","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.47","article-title":"MicroRNA-21 regulates T-cell apoptosis by directly targeting the tumor suppressor gene Tipe2","volume":"5","author":"Ruan","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2019.106044_b0065","doi-asserted-by":"crossref","first-page":"11996","DOI":"10.1038\/ncomms11996","article-title":"SARI inhibits angiogenesis and tumour growth of human colon cancer through directly targeting ceruloplasmin","volume":"7","author":"Dai","year":"2016","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.intimp.2019.106044_b0070","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/alr.21984","article-title":"Increased expression of TIPE2 in alternatively activated macrophages is associated with eosinophilic inflammation and disease severity in chronic rhinosinusitis with nasal polyps","volume":"7","author":"Yao","year":"2017","journal-title":"Int. Forum Allergy Rhinol."},{"issue":"4","key":"10.1016\/j.intimp.2019.106044_b0075","first-page":"709","volume":"256","author":"Wang","year":"2018","journal-title":"Ophthalmologie"},{"issue":"6","key":"10.1016\/j.intimp.2019.106044_b0080","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1111\/jgh.13251","article-title":"Decreased expression of TIPE2 contributes to the hyperreactivity of monocyte to Toll-like receptor ligands in primary biliary cirrhosis","volume":"31","author":"Qin","year":"2016","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"6","key":"10.1016\/j.intimp.2019.106044_b0085","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.3892\/or.2016.5192","article-title":"TIPE2 suppresses the tumorigenesis, growth and metastasis of breast cancer via inhibition of the AKT and p38 signaling pathways","volume":"36","author":"Zhang","year":"2016","journal-title":"Oncol. Rep."},{"issue":"1","key":"10.1016\/j.intimp.2019.106044_b0090","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3727\/096504016X14719078133320","article-title":"Tumor Necrosis Factor (TNF)-alpha-Induced Protein 8-like-2 (TIPE2) Inhibits Proliferation and Tumorigenesis in Breast Cancer Cells","volume":"25","author":"Wang","year":"2017","journal-title":"Oncol. Res."},{"issue":"5","key":"10.1016\/j.intimp.2019.106044_b0095","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3727\/096504016X14666990347437","article-title":"TIPE2 overexpression suppresses the proliferation, migration, and invasion in prostate cancer cells by inhibiting PI3K\/Akt signaling pathway","volume":"24","author":"Lu","year":"2016","journal-title":"Oncol. Res."},{"issue":"1","key":"10.1016\/j.intimp.2019.106044_b0100","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1186\/s12885-018-4761-3","article-title":"Knockdown of TIPE2 increases the proliferation in lipopolysaccharide-stimulated gastric cancer cells","volume":"18","author":"Liu","year":"2018","journal-title":"BMC Cancer"},{"issue":"39","key":"10.1016\/j.intimp.2019.106044_b0105","doi-asserted-by":"crossref","first-page":"32546","DOI":"10.1074\/jbc.M112.348755","article-title":"TIPE2, a novel regulator of immunity, protects against experimental stroke","volume":"287","author":"Zhang","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.intimp.2019.106044_b0110","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1159\/000438633","article-title":"TIPE2 alleviates systemic lupus erythematosus through regulating macrophage polarization","volume":"38","author":"Li","year":"2016","journal-title":"Cell. Physiol. Biochem.: Int. J. Exp. Cell. Physiol., Biochem., Pharmacol."},{"issue":"3","key":"10.1016\/j.intimp.2019.106044_b0115","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.4049\/jimmunol.1400415","article-title":"Critical roles of TIPE2 protein in murine experimental colitis","volume":"193","author":"Lou","year":"2014","journal-title":"J. Immunol. (Baltimore, Md.: 1950)"},{"issue":"4","key":"10.1016\/j.intimp.2019.106044_b0120","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/cgt.2016.6","article-title":"Adenovirus-directed expression of TIPE2 suppresses gastric cancer growth via induction of apoptosis and inhibition of AKT and ERK1\/2 signaling","volume":"23","author":"Zhu","year":"2016","journal-title":"Cancer Gene Ther."},{"issue":"4","key":"10.1016\/j.intimp.2019.106044_b0125","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/cgt.2017.3","article-title":"Adenovirus-mediated TIPE2 overexpression inhibits gastric cancer metastasis via reversal of epithelial-mesenchymal transition","volume":"24","author":"Yin","year":"2017","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.intimp.2019.106044_b0130","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.molimm.2017.03.007","article-title":"Gene delivery of TIPE2 inhibits breast cancer development and metastasis via CD8(+) T and NK cell-mediated antitumor responses","volume":"85","author":"Zhang","year":"2017","journal-title":"Mol. Immunol."},{"issue":"6","key":"10.1016\/j.intimp.2019.106044_b0135","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/cmi.2017.4","article-title":"Regulation of inflammation and tumorigenesis by the TIPE family of phospholipid transfer proteins","volume":"14","author":"Goldsmith","year":"2017","journal-title":"Cell. Mol. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2019.106044_b0140","doi-asserted-by":"crossref","first-page":"13319","DOI":"10.1038\/s41598-017-13825-y","article-title":"TIPE2 negatively regulates mycoplasma pneumonia-triggered immune response via MAPK signaling pathway","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2019.106044_b0145","doi-asserted-by":"crossref","unstructured":"Z.Z. Yao, A.X. Hu, X.S. Liu, DUSP19 regulates IL-1beta-induced apoptosis and MMPs expression in rat chondrocytes through JAK2\/STAT3 signaling pathway, Biomed. Pharmacother. = Biomed. Pharmacother. 96 (2017) 1209-1215.","DOI":"10.1016\/j.biopha.2017.11.097"},{"key":"10.1016\/j.intimp.2019.106044_b0150","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.chemosphere.2018.02.137","article-title":"Effect of perfluorooctane sulphonate-induced Kupffer cell activation on hepatocyte proliferation through the NF-kappaB\/TNF-alpha\/IL-6-dependent pathway","volume":"200","author":"Han","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.intimp.2019.106044_b0155","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.neuro.2018.03.003","article-title":"Per fl uorooctanesulfonate induces neuroinflammation through the secretion of TNF-alpha mediated by the JAK2\/STAT3 pathway","volume":"66","author":"Chen","year":"2018","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.intimp.2019.106044_b0160","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.neuro.2017.04.001","article-title":"Manganese exposure facilitates microglial JAK2-STAT3 signaling and consequent secretion of TNF-a and IL-1beta to promote neuronal death","volume":"64","author":"Yin","year":"2018","journal-title":"Neurotoxicology"},{"issue":"11","key":"10.1016\/j.intimp.2019.106044_b0165","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1111\/jcmm.12353","article-title":"Decreased expression of microRNA-21 correlates with the imbalance of Th17 and Treg cells in patients with rheumatoid arthritis","volume":"18","author":"Dong","year":"2014","journal-title":"J. Cell Mol. Med."},{"issue":"2","key":"10.1016\/j.intimp.2019.106044_b0170","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1111\/jcmm.13414","article-title":"CDK7 inhibition suppresses rheumatoid arthritis inflammation via blockage of NF-kappaB activation and IL-1beta\/IL-6 secretion","volume":"22","author":"Hong","year":"2018","journal-title":"J. Cell Mol. Med."},{"issue":"3","key":"10.1016\/j.intimp.2019.106044_b0175","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1111\/jcmm.12988","article-title":"Pannexin3 inhibits TNF-alpha-induced inflammatory response by suppressing NF-kappaB signalling pathway in human dental pulp cells","volume":"21","author":"Song","year":"2017","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.intimp.2019.106044_b0180","doi-asserted-by":"crossref","first-page":"5958429","DOI":"10.1155\/2017\/5958429","article-title":"Proinflammatory cytokines IL-6 and TNF-alpha increased telomerase activity through NF-kappaB\/STAT1\/STAT3 activation, and withaferin A inhibited the signaling in colorectal cancer cells","volume":"2017","author":"Chung","year":"2017","journal-title":"Mediators Inflamm."},{"issue":"5","key":"10.1016\/j.intimp.2019.106044_b0185","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23051062","article-title":"Tryptanthrin protects mice against dextran sulfate sodium-induced colitis through inhibition of TNF-alpha\/NF-kappaB and IL-6\/STAT3 pathways","volume":"23","author":"Wang","year":"2018","journal-title":"Molecules (Basel, Switzerland)"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576919307490?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576919307490?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T18:41:52Z","timestamp":1727289712000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576919307490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":37,"alternative-id":["S1567576919307490"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2019.106044","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gene delivery of TIPE2 attenuates collagen-induced arthritis by modulating inflammation","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2019.106044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106044"}}