{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:38:59Z","timestamp":1790444339777,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100014137","name":"Shanghai Shenkang Hospital Development Center","doi-asserted-by":"publisher","award":["16CR3086B"],"award-info":[{"award-number":["16CR3086B"]}],"id":[{"id":"10.13039\/501100014137","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670225"],"award-info":[{"award-number":["81670225"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.intimp.2019.106055","type":"journal-article","created":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T19:06:02Z","timestamp":1575659162000},"page":"106055","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":92,"special_numbering":"C","title":["Inhibition of peptidyl arginine deiminase-4 protects against myocardial infarction induced cardiac dysfunction"],"prefix":"10.1016","volume":"78","author":[{"given":"Mingjun","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wengang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Schmull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmin","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"19","key":"10.1016\/j.intimp.2019.106055_b0005","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1161\/CIRCULATIONAHA.107.752113","article-title":"Impact of time of presentation on the care and outcomes of acute myocardial infarction","volume":"117","author":"Jneid","year":"2008","journal-title":"Circulation"},{"issue":"20","key":"10.1016\/j.intimp.2019.106055_b0010","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1056\/NEJMra021498","article-title":"Heart failure","volume":"348","author":"Jessup","year":"2003","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.intimp.2019.106055_b0015","first-page":"236","article-title":"Acute myocardial infarction","volume":"60","author":"Rischpler","year":"2016","journal-title":"Q J. Nucl. Med. Mol. Imaging"},{"issue":"10","key":"10.1016\/j.intimp.2019.106055_b0020","first-page":"27","article-title":"c-kit(+)AT2R(+) bone marrow mononuclear cell subset is a superior subset for cardiac protection after myocardial infarction","volume":"4913515","author":"Du","year":"2016","journal-title":"Stem Cells Int."},{"issue":"4","key":"10.1016\/j.intimp.2019.106055_b0025","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1002\/j.2040-4603.2015.tb00664.x","article-title":"Pathophysiology of myocardial infarction","volume":"5","author":"Frangogiannis","year":"2015","journal-title":"Compr. Physiol."},{"issue":"22","key":"10.1016\/j.intimp.2019.106055_b0030","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1093\/eurheartj\/ehv007","article-title":"Expression of functional tissue factor by neutrophil extracellular traps in culprit artery of acute myocardial infarction","volume":"36","author":"Stakos","year":"2015","journal-title":"Eur. Heart J."},{"issue":"11","key":"10.1016\/j.intimp.2019.106055_b0035","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/nm.2053","article-title":"Extracellular histones are major mediators of death in sepsis","volume":"15","author":"Xu","year":"2009","journal-title":"Nat. Med."},{"issue":"7","key":"10.1016\/j.intimp.2019.106055_b0040","doi-asserted-by":"crossref","DOI":"10.3390\/cells8070716","article-title":"Novel aspects of extracellular vesicles as mediators of cancer-associated thrombosis","volume":"8","author":"Almeida","year":"2019","journal-title":"Cells"},{"issue":"8","key":"10.1016\/j.intimp.2019.106055_b0045","doi-asserted-by":"crossref","first-page":"e99","DOI":"10.1161\/ATVBAHA.117.309580","article-title":"Mitochondrial oxidative stress promotes atherosclerosis and neutrophil extracellular traps in aged mice","volume":"37","author":"Wang","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"2","key":"10.1016\/j.intimp.2019.106055_b0050","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1152\/ajprenal.00254.2016","article-title":"Peptidyl arginine deiminase-4-deficient mice are protected against kidney and liver injury after renal ischemia and reperfusion","volume":"311","author":"Rabadi","year":"2016","journal-title":"Am. J. Physiol. Renal Physiol."},{"issue":"1","key":"10.1016\/j.intimp.2019.106055_b0055","doi-asserted-by":"crossref","first-page":"019","DOI":"10.1038\/s41467-019-09160-7","article-title":"Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia","volume":"10","author":"Perdomo","year":"2019","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.intimp.2019.106055_b0060","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.1002\/jcp.26167","article-title":"Neutrophil extracellular traps in acrolein promoted hepatic ischemia reperfusion injury: therapeutic potential of NOX2 and p38MAPK inhibitors","volume":"233","author":"Arumugam","year":"2018","journal-title":"J. Cell. Physiol."},{"issue":"3","key":"10.1016\/j.intimp.2019.106055_b0065","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.autrev.2009.06.002","article-title":"Peptidylarginine deiminase 4 and citrullination in health and disease","volume":"9","author":"Anzilotti","year":"2010","journal-title":"Autoimmun. Rev."},{"issue":"2","key":"10.1016\/j.intimp.2019.106055_b0070","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.biochi.2012.09.029","article-title":"Peptidylarginine deiminase expression and activity in PAD2 knock-out and PAD4-low mice","volume":"95","author":"van Beers","year":"2013","journal-title":"Biochimie"},{"issue":"9","key":"10.1016\/j.intimp.2019.106055_b0075","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1152\/ajprenal.00243.2014","article-title":"Peptidyl arginine deiminase-4 activation exacerbates kidney ischemia-reperfusion injury","volume":"307","author":"Ham","year":"2014","journal-title":"Am. J. Physiol. Renal Physiol."},{"issue":"1","key":"10.1016\/j.intimp.2019.106055_b0080","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1182\/blood-2013-07-514992","article-title":"VWF-mediated leukocyte recruitment with chromatin decondensation by PAD4 increases myocardial ischemia\/reperfusion injury in mice","volume":"123","author":"Savchenko","year":"2014","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.intimp.2019.106055_b0085","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2017.1320009","article-title":"Pharmacological targeting of peptidylarginine deiminase 4 prevents cancer-associated kidney injury in mice","volume":"6","author":"Cedervall","year":"2017","journal-title":"Oncoimmunology"},{"issue":"7847142","key":"10.1016\/j.intimp.2019.106055_b0090","article-title":"Effects of curcumin nanoparticles in isoproterenol-induced myocardial infarction","volume":"7","author":"Boarescu","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"issue":"5","key":"10.1016\/j.intimp.2019.106055_b0095","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1113\/EP085708","article-title":"Treatment with oestrogen-receptor agonists or oxytocin in conjunction with exercise protects against myocardial infarction in ovariectomized rats","volume":"101","author":"Bulut","year":"2016","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.intimp.2019.106055_b0100","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ejphar.2018.04.005","article-title":"Sitagliptin prevents isoproterenol-induced myocardial infarction in rats by modulating nitric oxide synthase enzymes","volume":"829","author":"Ibrahim","year":"2018","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.intimp.2019.106055_b0105","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.kint.2017.08.014","article-title":"Neutrophil peptidyl arginine deiminase-4 has a pivotal role in ischemia\/reperfusion-induced acute kidney injury","volume":"93","author":"Raup-Konsavage","year":"2018","journal-title":"Kidney Int."},{"issue":"2","key":"10.1016\/j.intimp.2019.106055_b0110","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1083\/jcb.200806072","article-title":"Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation","volume":"184","author":"Wang","year":"2009","journal-title":"J. Cell Biol."},{"issue":"360","key":"10.1016\/j.intimp.2019.106055_b0115","article-title":"Activation of PAD4 in NET formation","volume":"3","author":"Rohrbach","year":"2012","journal-title":"Front. Immunol."},{"issue":"9","key":"10.1016\/j.intimp.2019.106055_b0120","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1002\/art.11229","article-title":"Citrullination of synovial proteins in murine models of rheumatoid arthritis","volume":"48","author":"Vossenaar","year":"2003","journal-title":"Arthritis Rheum."},{"issue":"3","key":"10.1016\/j.intimp.2019.106055_b0125","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/ar1697","article-title":"Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity","volume":"7","author":"Lundberg","year":"2005","journal-title":"Arthritis Res. Ther."},{"issue":"5","key":"10.1016\/j.intimp.2019.106055_b0130","doi-asserted-by":"crossref","first-page":"F809","DOI":"10.1152\/ajprenal.00569.2017","article-title":"Divergent roles for kidney proximal tubule and granulocyte PAD4 in ischemic AKI","volume":"314","author":"Li","year":"2018","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"10.1016\/j.intimp.2019.106055_b0135","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.ejphar.2018.07.005","article-title":"Inhibition of peptidylarginine deiminase alleviates LPS-induced pulmonary dysfunction and improves survival in a mouse model of lethal endotoxemia","volume":"833","author":"Liang","year":"2018","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.intimp.2019.106055_b0140","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/jnc.12744","article-title":"Peptidylarginine deiminases: novel drug targets for prevention of neuronal damage following hypoxic ischemic insult (HI) in neonates","volume":"130","author":"Lange","year":"2014","journal-title":"J. Neurochem."},{"issue":"3","key":"10.1016\/j.intimp.2019.106055_b0145","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1093\/eurjhf\/hfq196","article-title":"Proteomic analysis of myocardial tissue from the border zone during early stage post-infarct remodelling in rats","volume":"13","author":"Xiang","year":"2011","journal-title":"Eur. J. Heart Fail."},{"issue":"5","key":"10.1016\/j.intimp.2019.106055_b0150","doi-asserted-by":"crossref","first-page":"019","DOI":"10.1007\/s00395-019-0740-3","article-title":"Neutrophil extracellular traps and fibrocytes in ST-segment elevation myocardial infarction","volume":"114","author":"Hofbauer","year":"2019","journal-title":"Basic Res. Cardiol."},{"issue":"6","key":"10.1016\/j.intimp.2019.106055_b0155","doi-asserted-by":"crossref","first-page":"014","DOI":"10.1007\/s00395-014-0444-7","article-title":"Inflammation revisited: inflammation versus resolution of inflammation following myocardial infarction","volume":"109","author":"Kain","year":"2014","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.intimp.2019.106055_b0160","doi-asserted-by":"crossref","unstructured":"Zhou, Z., et al., Excessive Neutrophil Extracellular Trap Formation Aggravates Acute Myocardial Infarction Injury in Apolipoprotein E Deficiency Mice via the ROS-Dependent Pathway. Oxid Med Cell Longev, 2019. 21(1209307).","DOI":"10.1155\/2019\/1209307"},{"issue":"3","key":"10.1016\/j.intimp.2019.106055_b0165","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/s41385-019-0139-3","article-title":"PAD4-dependent NETs generation are indispensable for intestinal clearance of Citrobacter rodentium","volume":"12","author":"Saha","year":"2019","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.intimp.2019.106055_b0170","doi-asserted-by":"crossref","unstructured":"Yahagi, A., et al., IL-6-PAD4 axis in the earliest phase of arthritis in knock-in gp130F759 mice, a model for rheumatoid arthritis. RMD Open, 2019. 5(2): p. 2018-000853.","DOI":"10.1136\/rmdopen-2018-000853"},{"issue":"10","key":"10.1016\/j.intimp.2019.106055_b0175","article-title":"Peptidylarginine deiminase 4: a nuclear button triggering neutrophil extracellular traps in inflammatory diseases and aging","volume":"20","author":"Wong","year":"2018","journal-title":"FASEB J."},{"issue":"2","key":"10.1016\/j.intimp.2019.106055_b0180","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1161\/01.CIR.95.2.320","article-title":"Apoptosis in human acute myocardial infarction","volume":"95","author":"Saraste","year":"1997","journal-title":"Circulation"},{"issue":"7203","key":"10.1016\/j.intimp.2019.106055_b0185","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/nature07201","article-title":"Origin and physiological roles of inflammation","volume":"454","author":"Medzhitov","year":"2008","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.intimp.2019.106055_b0190","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/nchembio.1735","article-title":"Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation","volume":"11","author":"Lewis","year":"2015","journal-title":"Nat. Chem. Biol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757691932288X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757691932288X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:14:17Z","timestamp":1761585257000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156757691932288X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":38,"alternative-id":["S156757691932288X"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2019.106055","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of peptidyl arginine deiminase-4 protects against myocardial infarction induced cardiac dysfunction","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2019.106055","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106055"}}