{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T09:21:03Z","timestamp":1787908863063,"version":"build-2784847793"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,12,8]],"date-time":"2019-12-08T00:00:00Z","timestamp":1575763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81560712"],"award-info":[{"award-number":["81560712"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81960741"],"award-info":[{"award-number":["81960741"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["LH-2014-7566"],"award-info":[{"award-number":["LH-2014-7566"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2015-6010"],"award-info":[{"award-number":["2015-6010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Joint Fund Project of the Science and Technology Office of Guizhou Province"},{"DOI":"10.13039\/501100010828","name":"Guizhou Provincial Department of Education","doi-asserted-by":"publisher","award":["KY-2015-439"],"award-info":[{"award-number":["KY-2015-439"]}],"id":[{"id":"10.13039\/501100010828","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010828","name":"Guizhou Provincial Department of Education","doi-asserted-by":"publisher","award":["2015019"],"award-info":[{"award-number":["2015019"]}],"id":[{"id":"10.13039\/501100010828","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010828","name":"Guizhou Provincial Department of Education","doi-asserted-by":"publisher","award":["QZYY2017-080"],"award-info":[{"award-number":["QZYY2017-080"]}],"id":[{"id":"10.13039\/501100010828","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guizhou Provincial Administration of Traditional Chinese Medicine"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.intimp.2019.106109","type":"journal-article","created":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T18:23:14Z","timestamp":1576779794000},"page":"106109","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":77,"special_numbering":"C","title":["Asiaticoside nitric oxide gel accelerates diabetic cutaneous ulcers healing by activating Wnt\/\u03b2-catenin signaling pathway"],"prefix":"10.1016","volume":"79","author":[{"given":"Xuqiang","family":"Nie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujun","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiufeng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faming","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.intimp.2019.106109_b0005","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/01.BCR.0000169887.04973.3A","article-title":"Pathophysiology of chronic nonhealing wounds","volume":"26","author":"Medina","year":"2005","journal-title":"J. Burn Care Rehabil."},{"key":"10.1016\/j.intimp.2019.106109_b0010","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/592454","article-title":"Enhanced healing of diabetic wounds by subcutaneous administration of human umbilical cord derived stem cells and their conditioned media","volume":"2013","author":"Shrestha","year":"2013","journal-title":"Int. J. Endocrinology"},{"issue":"3","key":"10.1016\/j.intimp.2019.106109_b0015","doi-asserted-by":"crossref","first-page":"194","DOI":"10.2174\/156720207781387150","article-title":"Vascular injury during elevated glucose can be mitigated by erythropoietin and Wnt signaling","volume":"4","author":"Chong","year":"2007","journal-title":"Curr. Neurovascular Res."},{"issue":"7","key":"10.1016\/j.intimp.2019.106109_b0020","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1002\/ptr.6075","article-title":"Induction of keratinocyte migration by ECa 233 is mediated through FAK\/Akt, ERK, and p38 MAPK signaling","volume":"32","author":"Singkhorn","year":"2018","journal-title":"Phytother. Res."},{"issue":"3","key":"10.1016\/j.intimp.2019.106109_b0025","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1182\/blood.V95.3.952.003k27_952_958","article-title":"Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors","volume":"95","author":"Peichev","year":"2000","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.intimp.2019.106109_b0030","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s00005-007-0027-5","article-title":"Endothelial progenitor cells as a new agent contributing to vascular repair","volume":"55","author":"Miller-Kasprzak","year":"2007","journal-title":"Archivum Immunologiae et Therapiae Experimentalis"},{"issue":"2","key":"10.1016\/j.intimp.2019.106109_b0035","doi-asserted-by":"crossref","DOI":"10.5041\/RMMJ.10038","article-title":"Nitric oxide: the coming of the second messenger","volume":"2","author":"Murad","year":"2011","journal-title":"Rambam Maimonides Med. J."},{"issue":"3","key":"10.1016\/j.intimp.2019.106109_b0040","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1745-7254.2005.00058.x","article-title":"Nitric oxide: a newly discovered function on wound healing","volume":"26","author":"Luo","year":"2005","journal-title":"Acta Pharmacol. Sin."},{"issue":"1","key":"10.1016\/j.intimp.2019.106109_b0045","doi-asserted-by":"crossref","first-page":"H411","DOI":"10.1152\/ajpheart.1996.270.1.H411","article-title":"Nitric oxide mediates mitogenic effect of VEGF on coronary venular endothelium","volume":"270","author":"Morbidelli","year":"1996","journal-title":"Am. J. Physiol.-Heart Circulatory Physiol."},{"issue":"1","key":"10.1016\/j.intimp.2019.106109_b0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1089-8603(02)00002-2","article-title":"Nitric oxide and wound repair: role of cytokines?","volume":"7","author":"Schwentker","year":"2002","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.intimp.2019.106109_b0055","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/895857","article-title":"Antinociceptive activities and the mechanisms of anti-inflammation of asiatic acid in mice","volume":"2011","author":"Huang","year":"2011","journal-title":"Evidence-Based Complementary Alternative Med."},{"key":"10.1016\/j.intimp.2019.106109_b0060","doi-asserted-by":"crossref","DOI":"10.1111\/joa.12784","article-title":"VEGF, FGF-2 and TGF\u03b2 expression in the normal and regenerating epidermis of geckos: implications for epidermal homeostasis and wound healing in reptiles","author":"Subramaniam","year":"2018","journal-title":"J. Anat."},{"key":"10.1016\/j.intimp.2019.106109_b0065","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s10456-014-9455-0","article-title":"Tipping off endothelial tubes: nitric oxide drives tip cells","volume":"18","author":"Priya","year":"2015","journal-title":"Angiogenesis"},{"key":"10.1016\/j.intimp.2019.106109_b0070","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.actbio.2017.03.011","article-title":"Functional poly(\u03b5-caprolactone)\/chitosan dressings with nitric oxide-releasing property improve wound healing","volume":"54","author":"Zhou","year":"2017","journal-title":"Acta Biomater."},{"issue":"Pt B","key":"10.1016\/j.intimp.2019.106109_b0075","first-page":"624","article-title":"Nitric oxide-releasing polymer incorporated ointment for cutaneous wound healing","volume":"220","author":"Im","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.intimp.2019.106109_b0080","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.actbio.2017.12.005","article-title":"Nitric oxide-releasing injectable hydrogels with high antibacterial activity through in situ formation of peroxynitrite","volume":"67","author":"Hoang Thi","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.intimp.2019.106109_b0085","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ejps.2018.11.034","article-title":"Physicochemical parameters of NO-containing gas flow affect wound healing therapy. An experimental study","volume":"128","author":"Shekhter","year":"2019","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.intimp.2019.106109_b0090","doi-asserted-by":"crossref","first-page":"S162","DOI":"10.1093\/clinids\/21.Supplement_2.S162","article-title":"NO inhibitions: antimicrobial properties of nitric oxide","volume":"21(Supplement_2)","author":"De Groote","year":"1995","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.intimp.2019.106109_b0095","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/9525624","article-title":"A prospective randomized, controlled, bouble-blind trial of the efficacy using centella cream for scar improvement","volume":"2018","author":"Jenwitheesuk","year":"2018","journal-title":"Evid. Based Complement. Alternat. Med."},{"issue":"4","key":"10.1016\/j.intimp.2019.106109_b0100","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1007\/BF02977683","article-title":"Advanced formulation and pharmacological activity of hydrogel of the titrated extract of C. asiatica","volume":"28","author":"Hong","year":"2005","journal-title":"Arch. Pharm. Res."},{"issue":"1","key":"10.1016\/j.intimp.2019.106109_b0105","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/s12906-019-2625-2","article-title":"Pharmacological properties of Centella asiatica hydrogel in accelerating wound healing in rabbits","volume":"19","author":"Sh Ahmed","year":"2019","journal-title":"BMC Complement Altern. Med."},{"issue":"3","key":"10.1016\/j.intimp.2019.106109_b0110","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1002\/term.1992","article-title":"Wound-healing effect of electrospun gelatin nanofibres containing Centella asiatica extract in a rat model","volume":"11","author":"Yao","year":"2017","journal-title":"J. Tissue Eng. Regen. Med."},{"issue":"1","key":"10.1016\/j.intimp.2019.106109_b0115","doi-asserted-by":"crossref","first-page":"10","DOI":"10.4103\/0971-6580.172251","article-title":"Preclinical safety assessment of standardized extract of Centella asiatica (L.) urban leaves","volume":"22","author":"Deshpande","year":"2015","journal-title":"Toxicol. Int."},{"key":"10.1016\/j.intimp.2019.106109_b0120","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jep.2017.02.040","article-title":"Ethnobotanical survey of herbal tea plants from the traditional markets in Chaoshan, China","volume":"205","author":"Li","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2019.106109_b0125","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.intimp.2017.07.005","article-title":"Asiatic acid inhibits LPS-induced inflammatory response in human gingival fibroblasts","volume":"50","author":"Hao","year":"2017","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2019.106109_b0130","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jconrel.2012.05.050","article-title":"Improved in vitro and in vivo collagen biosynthesis by asiaticoside-loaded ultradeformable vesicles","volume":"162","author":"Paolino","year":"2012","journal-title":"J. Control. Release."},{"issue":"2","key":"10.1016\/j.intimp.2019.106109_b0135","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3109\/03008209009152427","article-title":"Stimulation of collagen synthesis in fibroblast cultures by a triterpene extracted from Centella asiatica","volume":"24","author":"Maquart","year":"1990","journal-title":"Connect. Tissue Res."},{"issue":"13","key":"10.1016\/j.intimp.2019.106109_b0140","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.phymed.2012.08.002","article-title":"Asiaticoside enhances normal human skin cell migration, attachment and growth in vitro wound healing model","volume":"19","author":"Lee","year":"2012","journal-title":"Phytomedicine"},{"issue":"1\u20132","key":"10.1016\/j.intimp.2019.106109_b0145","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.ijpharm.2015.05.058","article-title":"Mechanical properties and in vivo healing evaluation of a novel Centella asiatica-loaded hydrocolloid wound dressing","volume":"490","author":"Jin","year":"2015","journal-title":"Int. J. Pharm."},{"issue":"11","key":"10.1016\/j.intimp.2019.106109_b0150","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1111\/j.1365-4632.2004.02047.x","article-title":"Asiaticoside induction for cell-cycle progression, proliferation and collagen synthesis in human dermal fibroblasts","volume":"43","author":"Lu","year":"2004","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.intimp.2019.106109_b0155","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.biopha.2018.05.156","article-title":"Comparison of three different extracts of Centella asiatica for anti-amnesic, antioxidant and anticholinergic activities: in vitro and in vivo study","volume":"105","author":"Arora","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2019.106109_b0160","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.biopha.2016.06.016","article-title":"Preparation of asiaticoside-loaded coaxially electrospinning nanofibers and their effect on deep partial-thickness burn injury","volume":"83","author":"Zhu","year":"2016","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.intimp.2019.106109_b0165","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/(SICI)1099-1573(199902)13:1<50::AID-PTR368>3.0.CO;2-V","article-title":"Asiaticoside-induced elevation of antioxidant levels in healing wounds","volume":"13","author":"Shukla","year":"1999","journal-title":"Phytother. Res."},{"issue":"2\u20133","key":"10.1016\/j.intimp.2019.106109_b0170","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.ejphar.2008.02.036","article-title":"Facilitating action of asiaticoside at low doses on burn wound repair and its mechanism","volume":"584","author":"Kimura","year":"2008","journal-title":"Eur. J. Pharmacol."},{"issue":"8","key":"10.1016\/j.intimp.2019.106109_b0175","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1007\/s11064-017-2245-5","article-title":"Transient cerebral ischemia alters GSK-3\u03b2 and p-GSK-3\u03b2 immunoreactivity in pyramidal neurons and induces p-GSK-3\u03b2 expression in astrocytes in the gerbil hippocampal CA1 area","volume":"42","author":"Chen","year":"2017","journal-title":"Neurochem. Res."},{"issue":"3","key":"10.1016\/j.intimp.2019.106109_b0185","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.niox.2005.01.006","article-title":"A direct nitric oxide gas delivery system for bacterial and mammalian cell cultures","volume":"12","author":"Ghaffari","year":"2005","journal-title":"Nitric Oxide"},{"issue":"6","key":"10.1016\/j.intimp.2019.106109_b0190","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.cell.2017.05.016","article-title":"Wnt\/\u03b2-Catenin Signaling, Disease, and Emerging Therapeutic Modalities","volume":"169","author":"Nusse","year":"2017","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.intimp.2019.106109_b0195","first-page":"214","article-title":"Does treatment affect the levels of serum interleukin-6, interleukin-8 and procalcitonin in diabetic foot infection? A pilot study","volume":"26","author":"Altay","year":"2012","journal-title":"Aesthetic Plast. Surg."},{"issue":"18","key":"10.1016\/j.intimp.2019.106109_b0200","doi-asserted-by":"crossref","first-page":"4152","DOI":"10.1021\/jf5007165","article-title":"Docosahexaenoic acid inhibits vascular endothelial growth factor (VEGF)-induced cell migration via the GPR120\/PP2A\/ERK1\/2\/eNOS signaling pathway in human umbilical vein endothelial cells","volume":"62","author":"Chao","year":"2014","journal-title":"J. Agric. Food. Chem."},{"issue":"7","key":"10.1016\/j.intimp.2019.106109_b9000","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.2337\/diabetes.54.7.2143","article-title":"Tissue factor as a link between wounding and tissue repair","volume":"54","author":"Chen","year":"2005","journal-title":"Diabetes"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576919308938?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576919308938?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T18:42:02Z","timestamp":1727289722000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576919308938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":40,"alternative-id":["S1567576919308938"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2019.106109","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Asiaticoside nitric oxide gel accelerates diabetic cutaneous ulcers healing by activating Wnt\/\u03b2-catenin signaling pathway","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2019.106109","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106109"}}