{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:46:44Z","timestamp":1792666004123,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670582"],"award-info":[{"award-number":["81670582"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.intimp.2019.106128","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T22:00:08Z","timestamp":1579644008000},"page":"106128","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Resveratrol improves the therapeutic efficacy of bone marrow-derived mesenchymal stem cells in rats with severe acute pancreatitis"],"prefix":"10.1016","volume":"80","author":[{"given":"Dalu","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guodong","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhilong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiang","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingsong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenshun","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2019.106128_b0005","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.pan.2013.07.063","article-title":"evidence-based guidelines for the management of acute pancreatitis","volume":"13","author":"IAP\/APA","year":"2013","journal-title":"Pancreatology"},{"key":"10.1016\/j.intimp.2019.106128_b0010","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S1499-3872(16)60163-7","article-title":"Severe acute pancreatitis: pathogenesis, diagnosis and surgical management","volume":"16","author":"Portelli","year":"2017","journal-title":"Hepatob. Pancreat. Dis."},{"key":"10.1016\/j.intimp.2019.106128_b0015","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0140-6736(14)60649-8","article-title":"Acute pancreatitis","volume":"386","author":"Lankisch","year":"2015","journal-title":"The Lancet"},{"key":"10.1016\/j.intimp.2019.106128_b0020","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1053\/j.gastro.2013.01.075","article-title":"Clinical management of patients with acute pancreatitis","volume":"144","author":"Wu","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.intimp.2019.106128_b0025","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1002\/bjs.4750","article-title":"The continuing challenge of early mortality in acute pancreatitis","volume":"91","author":"Mckay","year":"2010","journal-title":"Brit. J. Surg."},{"key":"10.1016\/j.intimp.2019.106128_b0030","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/MPA.0b013e3182321500","article-title":"Sterile inflammatory response in acute pancreatitis","volume":"41","author":"Rafaz","year":"2012","journal-title":"Pancreas"},{"key":"10.1016\/j.intimp.2019.106128_b0035","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1097\/MPA.0b013e318273066b","article-title":"Effect of serum from patients with severe acute pancreatitis on vascular endothelial permeability","volume":"42","author":"Zheng","year":"2013","journal-title":"Pancreas"},{"key":"10.1016\/j.intimp.2019.106128_b0040","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.intimp.2015.04.026","article-title":"RETRACTED: Resveratrol rescued the TNF-\u03b1-induced impairments of osteogenesis of bone-marrow derived mesenchymal stem cells and inhibited the TNF-\u03b1-activated NF-\u043aB signaling pathway","volume":"26","author":"Zhang","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2019.106128_b0045","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1177\/1535370215598401","article-title":"Resveratrol attenuates renal injury and fibrosis by inhibiting transforming growth factor-\u03b2 pathway on matrix metalloproteinase 7","volume":"241","author":"Xiao","year":"2015","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.intimp.2019.106128_b0050","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1080\/01902140902718197","article-title":"Resveratrol ameliorates lung injury via inhibition of apoptosis in rats with severe acute pancreatitis","volume":"35","author":"Sha","year":"2009","journal-title":"Exp. Lung Res."},{"key":"10.1016\/j.intimp.2019.106128_b0055","doi-asserted-by":"crossref","DOI":"10.1002\/jcb.26772","article-title":"marrow or adipose tissue mesenchymal stem cells: comparison of the therapeutic potentials in mice model of acute liver failure","volume":"119","author":"Zare","year":"2018","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.intimp.2019.106128_b0060","first-page":"325","article-title":"Bone marrow mesenchymal stem cells ameliorate rat acute renal failure by differentiation into renal tubular epithelial-like cells","volume":"22","author":"Hui","year":"2008","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.intimp.2019.106128_b0065","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.3727\/096368915X687499","article-title":"Therapeutic effects of bone marrow-derived mesenchymal stem cells in models of pulmonary and extrapulmonary acute lung injury","volume":"24","author":"Liu","year":"2015","journal-title":"Cell. Transplant."},{"key":"10.1016\/j.intimp.2019.106128_b0070","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1146\/annurev-bioeng-070909-105309","article-title":"Mesenchymal stem cells as therapeutics","author":"Parekkadan","year":"2010","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"10.1016\/j.intimp.2019.106128_b0075","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1186\/s13287-018-1022-y","article-title":"MicroRNA-9 modified bone marrow-derived mesenchymal stem cells (BMSCs) repair severe acute pancreatitis (SAP) via inducing angiogenesis in rats","volume":"9","author":"Qian","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.intimp.2019.106128_b0080","article-title":"N-Acetylcysteine enhances the therapeutic efficacy of bone marrowderived mesenchymal stem cell transplantation in rats with severe acute pancreatitis","volume":"004","author":"Ma","year":"2019","journal-title":"Pancreatology"},{"key":"10.1016\/j.intimp.2019.106128_b0085","article-title":"Resveratrol improves human umbilical cord-derived mesenchymal stem cells repair for cisplatin-induced acute kidney injury","volume":"10","author":"Zhang","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2019.106128_b0090","doi-asserted-by":"crossref","first-page":"14105","DOI":"10.3390\/ijms140714105","article-title":"Resveratrol inhibits ionising irradiation-induced inflammation in MSCs by activating SIRT1 and limiting NLRP-3 inflammasome activation","volume":"14","author":"Fu","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2019.106128_b0095","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.3892\/mmr.2014.2053","article-title":"The SDF-1\/CXCR4 axis regulates migration of transplanted bone marrow mesenchymal stem cells towards the pancreas in rats with acute pancreatitis","volume":"9","author":"Gong","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.intimp.2019.106128_b0100","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jss.2005.12.032","article-title":"Vascular endothelial growth factor increases in serum and protects against the organ injuries in severe acute pancreatitis","volume":"134","author":"Ueda","year":"2006","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.intimp.2019.106128_b0105","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1002\/jcb.25927","article-title":"Long non-coding RNA MALAT1 promotes proliferation, angiogenesis, and immunosuppressive properties of mesenchymal stem cells by inducing VEGF and IDO","volume":"118","author":"Li","year":"2017","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.intimp.2019.106128_b0110","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.mce.2017.11.009","article-title":"INGAP-PP effects on \u03b2-cell mass and function are related to its positive effect on islet angiogenesis and VEGFA production","volume":"470","author":"Rom\u00e1n","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.intimp.2019.106128_b0115","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.jcyt.2018.11.013","article-title":"Bone marrow\u2013derived mesenchymal stromal cells ameliorate severe acute pancreatitis in rats via hemeoxygenase-1\u2013mediated anti-oxidant and anti-inflammatory effects","volume":"21","author":"Ma","year":"2019","journal-title":"Cytotherapy"},{"key":"10.1016\/j.intimp.2019.106128_b0120","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.lfs.2019.03.019","article-title":"Bone marrow-derived mesenchymal stem cells attenuate severe acute pancreatitis via regulation of microRNA-9 to inhibit necroptosis in rats","volume":"223","author":"Song","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2019.106128_b0125","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1007\/s12013-013-9604-x","article-title":"Resveratrol suppresses microcirculatory disturbance in a rat model of severe acute pancreatitis","volume":"67","author":"Huanchen","year":"2013","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.intimp.2019.106128_b0130","doi-asserted-by":"crossref","DOI":"10.3892\/ijo_00000739","article-title":"Vandetanib alters the protein pattern in malignant glioma and normal brain in the BT4C rat glioma model","author":"Wibom","year":"2010","journal-title":"Int. J. Oncol."},{"issue":"6","key":"10.1016\/j.intimp.2019.106128_b0135","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1038\/sj.bjc.6602108","article-title":"The tyrosine kinase inhibitor ZD6474 inhibits tumour growth in an intracerebral rat glioma model","volume":"91","author":"Sandstr\u00f6m","year":"2004","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.intimp.2019.106128_b0140","article-title":"Antioxidant preconditioning improves the paracrine responsiveness of bone marrow mesenchymal stem cells to diabetic wound fluid","author":"Yashar","year":"2018","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.intimp.2019.106128_b0145","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s00395-013-0333-5","article-title":"Rosuvastatin enhances the therapeutic efficacy of adipose-derived mesenchymal stem cells for myocardial infarction via PI3K\/Akt and MEK\/ERK pathways","volume":"108","author":"Zhang","year":"2013","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.intimp.2019.106128_b0150","first-page":"815","article-title":"Angiopoietin-1 protects mesenchymal stem cells against serum deprivation and hypoxia-induced apoptosis through the PI3K\/Akt pathway","volume":"29","author":"Xian-Bao","year":"2010","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.intimp.2019.106128_b0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/306836","article-title":"Bone marrow-derived mesenchymal stem cells repair necrotic pancreatic tissue and promote angiogenesis by secreting cellular growth factors involved in the SDF-1\u03b1 \/CXCR4 axis in rats","volume":"2015","author":"Qian","year":"2015","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.intimp.2019.106128_b0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/6218798","article-title":"Mechanisms and management of acute pancreatitis","volume":"2018","author":"Garber","year":"2018","journal-title":"Gastroent. Res. Pract."},{"key":"10.1016\/j.intimp.2019.106128_b0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00535-004-1505-8","article-title":"Significance of apoptotic cell death in systemic complications with severe acute pancreatitis","volume":"40","author":"Takeyama","year":"2005","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.intimp.2019.106128_b0170","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/01.shk.0000191413.94461.b0","article-title":"Acute pancreatitis: models, markers and mediators","volume":"24","author":"Granger","year":"2005","journal-title":"Shock"},{"key":"10.1016\/j.intimp.2019.106128_b0180","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1053\/j.gastro.2010.11.047","article-title":"Human bone marrow-derived clonal mesenchymal stem cells inhibit inflammation and reduce acute pancreatitis in rats","volume":"140","author":"Kyung Hee","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.intimp.2019.106128_b0190","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.biomaterials.2016.03.020","article-title":"Insight on stem cell preconditioning and instructive biomaterials to enhance cell adhesion, retention, and engraftment for tissue repair","volume":"90","author":"Shafiq","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.intimp.2019.106128_b0195","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.7150\/thno.15412","article-title":"Melatonin treatment improves mesenchymal stem cells therapy by preserving stemness during long-term in vitro expansion","volume":"6","author":"Shuai","year":"2016","journal-title":"Theranostics"},{"key":"10.1016\/j.intimp.2019.106128_b0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/9737483","article-title":"Anti-diabetic effects of resveratrol; the way forward in its clinical utility","volume":"2016","author":"Oyenihia","year":"2016","journal-title":"J. Diab. Res."},{"key":"10.1016\/j.intimp.2019.106128_b0205","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3390\/nu8050250","article-title":"Resveratrol and cardiovascular diseases","volume":"8","author":"Bonnefontrousselot","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.intimp.2019.106128_b0210","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.bbadis.2015.01.012","article-title":"Lifespan and healthspan extension by resveratrol","volume":"1852","author":"Bhullar","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.intimp.2019.106128_b0215","doi-asserted-by":"crossref","first-page":"643763","DOI":"10.1155\/2015\/643763","article-title":"Anti-inflammatory and organ-protective effects of resveratrol in trauma-hemorrhagic injury","volume":"2015","author":"Liu","year":"2015","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.intimp.2019.106128_b0220","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ijdevneu.2016.01.005","article-title":"Resveratrol augments therapeutic efficiency of mouse bone marrow","volume":"49","author":"Wang","year":"2016","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.intimp.2019.106128_b0225","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3109\/08880018.2012.762962","article-title":"Resveratrol and adipose-derived mesenchymal stem cells are effective in the prevention and treatment of doxorubicin cardiotoxicity in rats","volume":"30","author":"Pinarli","year":"2013","journal-title":"Pediatr. Hematol. Oncol."},{"key":"10.1016\/j.intimp.2019.106128_b0230","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.intimp.2018.12.063","article-title":"Effects of palmitate and astaxanthin on cell viability and proinflammatory characteristics of mesenchymal stem cells","volume":"68","author":"Yaghooti","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2019.106128_b0235","doi-asserted-by":"crossref","first-page":"C317","DOI":"10.1152\/ajpcell.00415.2008","article-title":"Role of HIF-1\u03b1 and VEGF in human mesenchymal stem cell proliferation by 17\u03b2-estradiol: involvement of PKC, PI3K\/Akt, and MAPKs","volume":"296","author":"Yun","year":"2009","journal-title":"Am. J. Physiol.-Cell. Ph."},{"key":"10.1016\/j.intimp.2019.106128_b0240","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-018-0861-x","article-title":"Long noncoding RNA H19 upregulates vascular endothelial growth factor A to enhance mesenchymal stem cells survival and angiogenic capacity by inhibiting miR-199a-5p","volume":"9","author":"Hou","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.intimp.2019.106128_b0245","first-page":"1","article-title":"Vascular endothelial growth factor: molecular and biological aspects","volume":"237","author":"Ferrara","year":"1999","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.intimp.2019.106128_b0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1756-9966-28-141","article-title":"marrow mesenchymal stem cells from leukemia patients inhibit growth and apoptosis in serum-deprived K562 cells","volume":"28","author":"Wei","year":"2009","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.intimp.2019.106128_b0255","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/ncb2679","article-title":"Spatial regulation of VEGF receptor endocytosis in angiogenesis","volume":"15","author":"Masanori","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.intimp.2019.106128_b0260","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jcyt.2012.11.007","article-title":"Effect of umbilical cord mesenchymal stem cells on treatment of severe acute pancreatitis in rats","volume":"15","author":"Yang","year":"2013","journal-title":"Cytotherapy"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576919319976?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576919319976?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T23:03:09Z","timestamp":1744498989000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576919319976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":50,"alternative-id":["S1567576919319976"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2019.106128","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Resveratrol improves the therapeutic efficacy of bone marrow-derived mesenchymal stem cells in rats with severe acute pancreatitis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2019.106128","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106128"}}