{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:46:18Z","timestamp":1790462778003,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470650"],"award-info":[{"award-number":["81470650"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670841"],"award-info":[{"award-number":["81670841"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7172218"],"award-info":[{"award-number":["7172218"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.intimp.2020.106190","type":"journal-article","created":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T16:52:34Z","timestamp":1578934354000},"page":"106190","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Inhibition of LOX-1 prevents inflammation and photoreceptor cell death in retinal degeneration"],"prefix":"10.1016","volume":"80","author":[{"given":"Xinran","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruilin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiantong","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenna","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.intimp.2020.106190_b0005","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.preteyeres.2004.08.002","article-title":"Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration","volume":"24","author":"Wenzel","year":"2005","journal-title":"Prog. Retin. Eye Res."},{"issue":"4","key":"10.1016\/j.intimp.2020.106190_b0010","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1167\/iovs.18-24398","article-title":"Monomethyl fumarate protects the retina from light-induced retinopathy","volume":"60","author":"Jiang","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"5","key":"10.1016\/j.intimp.2020.106190_b0015","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1189\/jlb.3RI0615-239R","article-title":"Parainflammation, chronic inflammation, and age-related macular degeneration","volume":"98","author":"Chen","year":"2015","journal-title":"J. Leukoc. Biol."},{"issue":"21","key":"10.1016\/j.intimp.2020.106190_b0020","doi-asserted-by":"crossref","first-page":"15326","DOI":"10.1074\/jbc.M112.448712","article-title":"Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal","volume":"288","author":"Kohno","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.intimp.2020.106190_b0025","doi-asserted-by":"crossref","first-page":"e0143952","DOI":"10.1371\/journal.pone.0143952","article-title":"Spatiotemporal Cadence of Macrophage Polarisation in a Model of Light-Induced Retinal Degeneration","volume":"10","author":"Jiao","year":"2015","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1016\/j.intimp.2020.106190_b0030","doi-asserted-by":"crossref","first-page":"17108","DOI":"10.1038\/s41598-017-17400-3","article-title":"Tumor necrosis factor-alpha regulates photoreceptor cell autophagy after retinal detachment","volume":"7","author":"Xie","year":"2017","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.intimp.2020.106190_b0035","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1016\/j.ophtha.2012.07.008","article-title":"Laboratory evidence of sustained chronic inflammatory reaction in retinitis pigmentosa","volume":"120","author":"Yoshida","year":"2013","journal-title":"Ophthalmology"},{"key":"10.1016\/j.intimp.2020.106190_b0040","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.neuroscience.2014.05.065","article-title":"Microglial NADPH oxidase activation mediates rod cell death in the retinal degeneration in rd mice","volume":"275","author":"Zeng","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.intimp.2020.106190_b0045","first-page":"765","article-title":"Expression of CCL2 and its receptor in activation and migration of microglia and monocytes induced by photoreceptor apoptosis","volume":"23","author":"Feng","year":"2017","journal-title":"Mol. Vis."},{"key":"10.1016\/j.intimp.2020.106190_b0050","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2174\/1874196700902010141","article-title":"Peroxisome proliferator-activated receptor expression in murine models and humans with age-related macular degeneration","volume":"2","author":"Herzlich","year":"2009","journal-title":"Open Biol. J."},{"issue":"6","key":"10.1016\/j.intimp.2020.106190_b0055","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1007\/BF03654844","article-title":"The impact of inflammation to the antioxidant defense parameters in AMD patients","volume":"24","author":"Colak","year":"2012","journal-title":"Aging. Clin. Exp. Res."},{"issue":"Pt 1","key":"10.1016\/j.intimp.2020.106190_b0060","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1042\/BJ20051166","article-title":"LOX-1 scavenger receptor mediates calcium-dependent recognition of phosphatidylserine and apoptotic cells","volume":"393","author":"Murphy","year":"2006","journal-title":"Biochem. J."},{"issue":"2","key":"10.1016\/j.intimp.2020.106190_b0065","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.pep.2010.03.021","article-title":"Expression and purification of secreted recombinant hsp60 from eukaryotic cells","volume":"72","author":"Zhou","year":"2010","journal-title":"Protein Expr. Purif."},{"issue":"10","key":"10.1016\/j.intimp.2020.106190_b0070","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1139\/cjpp-2016-0664","article-title":"The role of damage- and pathogen-associated molecular patterns in inflammation-mediated vulnerability of atherosclerotic plaques","volume":"95","author":"Rai","year":"2017","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"4","key":"10.1016\/j.intimp.2020.106190_b0075","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.3390\/jcm3041542","article-title":"Inflammation and cell death in age-related macular degeneration: an immunopathological and ultrastructural model","volume":"3","author":"Ardeljan","year":"2014","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.intimp.2020.106190_b0080","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.intimp.2016.09.027","article-title":"LOX-1 and TLR4 affect each other and regulate the generation of ROS in A. fumigatus keratitis","volume":"40","author":"Gao","year":"2016","journal-title":"Int. Immunopharmacol."},{"issue":"5","key":"10.1016\/j.intimp.2020.106190_b0085","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s10557-011-6342-4","article-title":"LOX-1, oxidative stress and inflammation: a novel mechanism for diabetic cardiovascular complications","volume":"25","author":"Yan","year":"2011","journal-title":"Cardiovasc. Drugs Ther."},{"issue":"4","key":"10.1016\/j.intimp.2020.106190_b0090","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1093\/cvr\/cvu114","article-title":"LOX-1, mtDNA damage, and NLRP3 inflammasome activation in macrophages: implications in atherogenesis","volume":"103","author":"Ding","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.intimp.2020.106190_b0095","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.redox.2017.05.027","article-title":"SIRT1 inhibition causes oxidative stress and inflammation in patients with coronary artery disease","volume":"13","author":"Chan","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2020.106190_b0100","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.mvr.2016.02.006","article-title":"Roles of LOX-1 in microvascular dysfunction","volume":"105","author":"Lubrano","year":"2016","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.intimp.2020.106190_b0105","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.intimp.2019.02.013","article-title":"Microglial LOX-1\/MAPKs\/NF-kappaB positive loop promotes the vicious cycle of neuroinflammation and neural injury","volume":"70","author":"Ge","year":"2019","journal-title":"Int. Immunopharmacol."},{"issue":"7","key":"10.1016\/j.intimp.2020.106190_b0110","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.neuint.2012.07.019","article-title":"Microglial LOX-1 reacts with extracellular HSP60 to bridge neuroinflammation and neurotoxicity","volume":"61","author":"Zhang","year":"2012","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.intimp.2020.106190_b0115","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.neulet.2014.03.061","article-title":"LOX-1 expression and oxidized LDL uptake and toxicity in the HN33 neuronal cell line","volume":"580","author":"Mao","year":"2014","journal-title":"Neurosci. Lett."},{"issue":"8","key":"10.1016\/j.intimp.2020.106190_b0120","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18081744","article-title":"Electronegative Low-Density Lipoprotein L5 Impairs Viability and NGF-Induced Neuronal Differentiation of PC12 Cells via LOX-1","volume":"18","author":"Wang","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2020.106190_b0125","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/s12974-015-0431-4","article-title":"Minocycline counter-regulates pro-inflammatory microglia responses in the retina and protects from degeneration","volume":"12","author":"Scholz","year":"2015","journal-title":"J. Neuroinflammation"},{"issue":"2","key":"10.1016\/j.intimp.2020.106190_b0130","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1159\/000485085","article-title":"Curcumin delays retinal degeneration by regulating microglia activation in the retina of rd1 mice","volume":"44","author":"Wang","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"issue":"4","key":"10.1016\/j.intimp.2020.106190_b0135","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1161\/01.ATV.20.4.1116","article-title":"Upregulation of endothelial receptor for oxidized LDL (LOX-1) by oxidized LDL and implications in apoptosis of human coronary artery endothelial cells: evidence from use of antisense LOX-1 mRNA and chemical inhibitors","volume":"20","author":"Li","year":"2000","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.intimp.2020.106190_b0140","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/1476-511X-9-120","article-title":"Role of LOX-1 and ROS in oxidized low-density lipoprotein induced epithelial-mesenchymal transition of NRK52E","volume":"9","author":"Wang","year":"2010","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.intimp.2020.106190_b0145","article-title":"Wnt5a is involved in LOX-1 and TLR4 induced host inflammatory response in peri-implantitis","author":"Zhang","year":"2019","journal-title":"J. Periodontal Res."},{"issue":"5","key":"10.1016\/j.intimp.2020.106190_b0150","first-page":"450","article-title":"Retinal damage by light in rats","volume":"5","author":"Noell","year":"1966","journal-title":"Invest. Ophthalmol."},{"issue":"6","key":"10.1016\/j.intimp.2020.106190_b0155","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1038\/nprot.2017.032","article-title":"Comprehensive analysis of mouse retinal mononuclear phagocytes","volume":"12","author":"Luckoff","year":"2017","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.intimp.2020.106190_b0160","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.neuroscience.2016.10.015","article-title":"Light-induced retinal damage using different light sources, protocols and rat strains reveals LED phototoxicity","volume":"339","author":"Krigel","year":"2016","journal-title":"Neuroscience"},{"issue":"7","key":"10.1016\/j.intimp.2020.106190_b0165","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18071442","article-title":"Early Hippocampal i-LTP and LOX-1 Overexpression Induced by Anoxia: A Potential Role in Neurodegeneration in NPC Mouse Model","volume":"18","author":"Lo Castro","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2020.106190_b0170","doi-asserted-by":"crossref","first-page":"380","DOI":"10.3389\/fncel.2018.00380","article-title":"Cerebrovascular Pathology in Hypertriglyceridemic APOB-100 Transgenic Mice","volume":"12","author":"Hoyk","year":"2018","journal-title":"Front. Cell. Neurosci."},{"issue":"4","key":"10.1016\/j.intimp.2020.106190_b0175","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.bbrc.2012.07.143","article-title":"The new role of LOX-1 in hypertension induced neuronal apoptosis","volume":"425","author":"Li","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.intimp.2020.106190_b0180","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1006\/brbi.1995.1033","article-title":"Interleukin-1 and tumor necrosis factor-alpha synergistically mediate neurotoxicity: involvement of nitric oxide and of N-methyl-D-aspartate receptors","volume":"9","author":"Chao","year":"1995","journal-title":"Brain Behav. Immun."},{"issue":"11","key":"10.1016\/j.intimp.2020.106190_b0185","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1007\/s00011-017-1085-8","article-title":"Interaction of Wip1 and NF-kappaB regulates neuroinflammatory response in astrocytes","volume":"66","author":"Xu","year":"2017","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.intimp.2020.106190_b0190","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev.immunol.14.1.649","article-title":"The NF-kappa B and I kappa B proteins: new discoveries and insights","volume":"14","author":"Baldwin","year":"1996","journal-title":"Annu. Rev. Immunol."},{"issue":"11","key":"10.1016\/j.intimp.2020.106190_b0195","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1161\/CIRCRESAHA.107.149724","article-title":"Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet","volume":"100","author":"Mehta","year":"2007","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.intimp.2020.106190_b0200","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s10787-017-0341-4","article-title":"Inhibitory effects of Dioscin on atherosclerosis and foam cell formation in hyperlipidemia rats","volume":"25","author":"Wang","year":"2017","journal-title":"Inflammopharmacology"},{"issue":"5","key":"10.1016\/j.intimp.2020.106190_b0205","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23051101","article-title":"Ursolic Acid Attenuates Atherosclerosis in ApoE(-\/-) Mice: Role of LOX-1 Mediated by ROS\/NF-kappaB Pathway","volume":"23","author":"Li","year":"2018","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.intimp.2020.106190_b0210","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.joca.2008.06.019","article-title":"Oxidized LDL binding to LOX-1 enhances MCP-1 expression in cultured human articular chondrocytes","volume":"17","author":"Akagi","year":"2009","journal-title":"Osteoarthritis Cartilage"},{"issue":"6","key":"10.1016\/j.intimp.2020.106190_b0215","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1161\/01.ATV.21.6.955","article-title":"Oxidized LDL modulates Bax\/Bcl-2 through the lectinlike Ox-LDL receptor-1 in vascular smooth muscle cells","volume":"21","author":"Kataoka","year":"2001","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.intimp.2020.106190_b0220","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/1742-2094-8-125","article-title":"Curcumin is a potent modulator of microglial gene expression and migration","volume":"8","author":"Karlstetter","year":"2011","journal-title":"J. Neuroinflammation"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576919325962?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576919325962?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T20:20:16Z","timestamp":1744489216000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576919325962"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":44,"alternative-id":["S1567576919325962"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2020.106190","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of LOX-1 prevents inflammation and photoreceptor cell death in retinal degeneration","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2020.106190","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106190"}}