{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:32:36Z","timestamp":1789623156195,"version":"build-2803163510"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672094"],"award-info":[{"award-number":["81672094"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972028"],"award-info":[{"award-number":["81972028"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.intimp.2020.106344","type":"journal-article","created":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T17:37:50Z","timestamp":1583516270000},"page":"106344","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["The P2X7 receptor mediates NLRP3-dependent IL-1\u03b2 secretion and promotes phagocytosis in the macrophage response to Treponema pallidum"],"prefix":"10.1016","volume":"82","author":[{"given":"Shi-Lan","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Zhen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man-Li","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Rong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2020.106344_b0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcimb.2019.00220","article-title":"Treponema pallidum Induces the Secretion of HDVSMC Inflammatory Cytokines to Promote the Migration and Adhesion of THP-1 Cells","volume":"9","author":"Gao","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.intimp.2020.106344_b0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.intimp.2019.105744","article-title":"Treponema pallidum enhances human monocyte migration and invasion by dysregulating the MMP\/TIMP balance","volume":"75","author":"Lin","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2020.106344_b0015","doi-asserted-by":"crossref","first-page":"17073","DOI":"10.1038\/nrdp.2017.73","article-title":"Syphilis","volume":"3","author":"Peeling","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.intimp.2020.106344_b0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12865-018-0265-9","article-title":"Treponema pallidum promotes macrophage polarization and activates the NLRP3 inflammasome pathway to induce interleukin-1 beta production","volume":"19","author":"Lin","year":"2018","journal-title":"BMC Immunol."},{"key":"10.1016\/j.intimp.2020.106344_b0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13071-017-2197-2","article-title":"NLRP3 inflammasome activation in murine macrophages caused by Neospora caninum infection","volume":"10","author":"Wang","year":"2017","journal-title":"Parasites Vectors"},{"key":"10.1016\/j.intimp.2020.106344_b0030","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.phrs.2016.11.040","article-title":"Potentiation of hepatic stellate cell activation by extracellular ATP is dependent on P2X7R-mediated NLRP3 inflammasome activation","volume":"117","author":"Jiang","year":"2017","journal-title":"Pharmacol. Res."},{"issue":"4","key":"10.1016\/j.intimp.2020.106344_b0035","doi-asserted-by":"crossref","first-page":"5895","DOI":"10.18632\/oncotarget.13927","article-title":"Extracellular ATP induces apoptosis through P2X7R activation in acute myeloid leukemia cells but not in normal hematopoietic stem cells","volume":"8","author":"Salvestrini","year":"2017","journal-title":"Oncotarget"},{"issue":"8","key":"10.1016\/j.intimp.2020.106344_b0040","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1152\/ajprenal.00203.2014","article-title":"Mitochondrial dysfunction confers albumin-induced NLRP3 inflammasome activation and renal tubular injury","volume":"308","author":"Zhuang","year":"2015","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"10.1016\/j.intimp.2020.106344_b0045","doi-asserted-by":"crossref","first-page":"54290","DOI":"10.18632\/oncotarget.11091","article-title":"NLRP3 inflammasome activation is involved in Ang II-induced kidney damage via mitochondrial dysfunction","author":"Wen","year":"2016","journal-title":"Oncotarget"},{"issue":"11","key":"10.1016\/j.intimp.2020.106344_b0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.ppat.1002212","article-title":"The role of the P2X(7) receptor in infectious diseases","volume":"7","author":"Miller","year":"2011","journal-title":"PLoS Pathog."},{"issue":"6","key":"10.1016\/j.intimp.2020.106344_b0055","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.micinf.2010.03.004","article-title":"Infection, Activation of the P2X receptor triggers the elimination of Toxoplasma gondii tachyzoites from infected macrophages","volume":"12","author":"Corr\u00eaa","year":"2010","journal-title":"Microbes. Infect."},{"issue":"26","key":"10.1016\/j.intimp.2020.106344_b0060","doi-asserted-by":"crossref","first-page":"18810","DOI":"10.1074\/jbc.M610762200","article-title":"Differential Requirement of P2X7 Receptor and Intracellular K+ for Caspase-1 Activation Induced by Intracellular and Extracellular Bacteria","volume":"282","author":"Franchi","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2020.106344_b0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12879-018-2993-0","article-title":"Development of tissue inflammation accompanied by NLRP3 inflammasome activation in rabbits infected with Treponema pallidum strain Nichols","volume":"18","author":"Lin","year":"2018","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.intimp.2020.106344_b0070","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.intimp.2018.03.040","article-title":"Akt, mTOR and NF-\u03baB pathway activation in Treponema pallidum stimulates M1 macrophages","volume":"59","author":"Lin","year":"2018","journal-title":"Int. Immunopharmacol."},{"issue":"8","key":"10.1016\/j.intimp.2020.106344_b0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0182768","article-title":"Whole genome sequence of the Treponema pallidum subsp pallidum strain Amoy: An Asian isolate highly similar to SS14","volume":"12","author":"Tong","year":"2017","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.intimp.2020.106344_b0080","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1073\/pnas.1714645115","article-title":"Pyruvate cycle increases aminoglycoside efficacy and provides respiratory energy in bacteria","volume":"115","author":"Su","year":"2018","journal-title":"PNAS"},{"issue":"1","key":"10.1016\/j.intimp.2020.106344_b0085","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/infdis\/165.1.69","article-title":"Macrophage-mediated killing of opsonized Treponema-Pallidum","volume":"165","author":"Bakerzander","year":"1992","journal-title":"J. Infect. Dis."},{"issue":"8","key":"10.1016\/j.intimp.2020.106344_b0090","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1093\/infdis\/jiv591","article-title":"Reduced Treponema pallidum-specific opsonic antibody activity in HIV-infected patients with Syphilis","volume":"213","author":"Marra","year":"2016","journal-title":"J. Infect. Dis."},{"issue":"4","key":"10.1016\/j.intimp.2020.106344_b0095","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1128\/IAI.01666-06","article-title":"Phagocytosis of Borrelia burgdorferi and Treponema pallidum potentiates innate immune activation and induces gamma interferon production","volume":"75","author":"Moore","year":"2007","journal-title":"Infect. Immun."},{"issue":"1","key":"10.1016\/j.intimp.2020.106344_b0100","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1136\/sextrans-2016-052681","article-title":"Robust pro-inflammatory immune response is associated with serological cure in patients with syphilis: an observational study","volume":"93","author":"Pastuszczak","year":"2017","journal-title":"Sexually Transmitted Infect."},{"key":"10.1016\/j.intimp.2020.106344_b0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2017.00123","article-title":"The P2X7 Receptor-Interleukin-1 Liaison","volume":"8","author":"Giuliani","year":"2017","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2020.106344_b0110","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1600-065X.2011.01046.x","article-title":"The inflammasome: an integrated view","volume":"243","author":"Gross","year":"2011","journal-title":"Immunol. Rev."},{"issue":"7381","key":"10.1016\/j.intimp.2020.106344_b0115","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nature10759","article-title":"Inflammasomes in health and disease","volume":"481","author":"Strowig","year":"2012","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.intimp.2020.106344_b0120","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s12026-018-8988-5","article-title":"Phagocytosis and oxycytosis: two arms of human innate immunity","volume":"66","author":"Minasyan","year":"2018","journal-title":"Immunol. Res."},{"issue":"3","key":"10.1016\/j.intimp.2020.106344_b0125","first-page":"547","article-title":"Autophagy Enhances Bacterial Clearance during P. aeruginosa Lung Infection","volume":"8","author":"Junkins","year":"2014","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.intimp.2020.106344_b0130","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1128\/IAI.00945-15","article-title":"Pseudomonas aeruginosa triggers macrophage autophagy to escape intracellular killing by activation of the NLRP3 Inflammasome","volume":"84","author":"Deng","year":"2016","journal-title":"Infect. Immun."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576919330966?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576919330966?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T16:34:16Z","timestamp":1727454856000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576919330966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":26,"alternative-id":["S1567576919330966"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2020.106344","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The P2X7 receptor mediates NLRP3-dependent IL-1\u03b2 secretion and promotes phagocytosis in the macrophage response to Treponema pallidum","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2020.106344","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106344"}}