{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T18:19:13Z","timestamp":1775672353885,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770609"],"award-info":[{"award-number":["81770609"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University Synergy Innovation Program of Anhui Province","award":["GXXT-2019-045"],"award-info":[{"award-number":["GXXT-2019-045"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.intimp.2020.106374","type":"journal-article","created":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T11:14:06Z","timestamp":1583752446000},"page":"106374","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Dexmedetomidine inhibits the invasion, migration, and inflammation of rheumatoid arthritis fibroblast-like synoviocytes by reducing the expression of NLRC5"],"prefix":"10.1016","volume":"82","author":[{"given":"Ya-Ru","family":"Ji","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Ni","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gao-Lin","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Gen","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Feng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-Hai","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2020.106374_b0005","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0092-8674(00)81109-5","article-title":"Rheumatoid arthritis","volume":"85","author":"Feldmann","year":"1996","journal-title":"Cell."},{"key":"10.1016\/j.intimp.2020.106374_b0010","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s10456-015-9477-2","article-title":"The pathogenic role of angiogenesis in rheumatoid arthritis","volume":"18","author":"Elshabrawy","year":"2015","journal-title":"Angiogenesis"},{"key":"10.1016\/j.intimp.2020.106374_b0015","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1002\/1529-0131(200011)43:11<2531::AID-ANR21>3.0.CO;2-V","article-title":"Modulation of fibroblast-mediated cartilage degradation by articular chondrocytes in rheumatoid arthritis","volume":"43","author":"Pap","year":"2000","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2020.106374_b0020","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/j.1749-6632.1995.tb26675.x","article-title":"TNF alpha is an effective therapeutic target for rheumatoid arthritis","volume":"766","author":"Feldmann","year":"1995","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.intimp.2020.106374_b0025","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.intimp.2019.05.023","article-title":"Sodium tanshinone IIA sulfonate inhibits proliferation, migration, invasion and inflammation in rheumatoid arthritis fibroblast-like synoviocytes","volume":"73","author":"Wang","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2020.106374_b0030","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ejphar.2009.04.026","article-title":"Pyrrolidine dithiocarbamate, a NF-kappaB inhibitor, upregulates MMP-1 and MMP-13 in IL-1beta-stimulated rheumatoid arthritis fibroblast-like synoviocytes","volume":"613","author":"Kim","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2020.106374_b0035","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.1002\/art.23986","article-title":"Antiinflammatory effect of Rho kinase blockade via inhibition of NF-kappaB activation in rheumatoid arthritis","volume":"58","author":"He","year":"2008","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2020.106374_b0040","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1093\/rheumatology\/kem014","article-title":"Anti-malarial agent artesunate inhibits TNF-alpha-induced production of proinflammatory cytokines via inhibition of NF-kappaB and PI3 kinase\/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes","volume":"46","author":"Xu","year":"2007","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.intimp.2020.106374_b0045","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.gene.2016.10.026","article-title":"Expression patterns of NLRC5 and key genes in the STAT1 pathway following infection with Salmonella pullorum","volume":"597","author":"Qiu","year":"2017","journal-title":"Gene"},{"key":"10.1016\/j.intimp.2020.106374_b0050","doi-asserted-by":"crossref","first-page":"e1151593","DOI":"10.1080\/2162402X.2016.1151593","article-title":"NLRC5 elicits antitumor immunity by enhancing processing and presentation of tumor antigens to CD8(+) T lymphocytes","volume":"5","author":"Rodriguez","year":"2016","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.intimp.2020.106374_b0055","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.molimm.2017.08.024","article-title":"NLRC5 promotes cell proliferation via regulating the NF-\u03baB signaling pathway in Rheumatoid arthritis","volume":"91","author":"Liu","year":"2017","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.intimp.2020.106374_b0060","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.cell.2010.03.040","article-title":"NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways","volume":"141","author":"Cui","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2020.106374_b0065","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1136\/annrheumdis-2013-203276","article-title":"Evidence of NLRP3-inflammasome activation in rheumatoid arthritis (RA); genetic variants within the NLRP3-inflammasome complex in relation to susceptibility to RA and response to anti-TNF treatment","volume":"73","author":"Mathews","year":"2014","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.intimp.2020.106374_b0070","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nm.2279","article-title":"The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance","volume":"17","author":"Vandanmagsar","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.intimp.2020.106374_b0075","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s00011-013-0604-5","article-title":"Effects of dexmedetomidine on early and late cytokines during polymicrobial sepsis in mice","volume":"62","author":"Xu","year":"2013","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.intimp.2020.106374_b0080","first-page":"5040","article-title":"Dexmedetomidine alleviates LPS-induced septic cardiomyopathy via the cholinergic anti-inflammatory pathway in mice","volume":"9","author":"Kong","year":"2017","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.intimp.2020.106374_b0085","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/aps.2010.32","article-title":"Dexmedetomidine blocks thermal hyperalgesia and spinal glial activation in rat model of monoarthritis","volume":"31","author":"Xu","year":"2010","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.intimp.2020.106374_b0090","first-page":"4910","article-title":"Anti-nociceptive effect of dexmedetomidine in a rat model of monoarthritis via suppression of the TLR4\/NF-\u03baB p65 pathway","volume":"14","author":"Ji","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.intimp.2020.106374_b0095","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/s41419-019-1416-5","article-title":"Dexmedetomidine inhibits astrocyte pyroptosis and subsequently protects the brain in in vitro and in vivo models of sepsis","volume":"10","author":"Sun","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2020.106374_b0100","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.biopha.2018.04.150","article-title":"Taurine enhances the protective effect of Dexmedetomidine on sepsis-induced acute lung injury via balancing the immunological system","volume":"103","author":"Zhao","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2020.106374_b0105","first-page":"1472","article-title":"Pretreatment with dexmedetomidine ameliorates renal inflammation and oxidative stress in rats with lipopolysaccharide-induced sepsis and acute kidney injury","volume":"35","author":"Chen","year":"2015","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"10.1016\/j.intimp.2020.106374_b0110","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1002\/art.22791","article-title":"Freund's complete adjuvant induces arthritis in mice lacking a functional interferon-gamma receptor by triggering tumor necrosis factor alpha-driven osteoclastogenesis","volume":"56","author":"Geboes","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2020.106374_b0115","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1007\/s10753-014-9967-1","article-title":"Anti-inflammatory effects of vitamin E on adjuvant-induced arthritis in rats","volume":"38","author":"Rossato","year":"2015","journal-title":"Inflammation"},{"key":"10.1016\/j.intimp.2020.106374_b0120","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3109\/14397595.2014.903595","article-title":"Association of polymorphisms in SPARC and NLRP2 genes with rheumatoid arthritis in a Chinese Han population","volume":"25","author":"Yang","year":"2015","journal-title":"Mod. Rheumatol."},{"key":"10.1016\/j.intimp.2020.106374_b0125","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S1995-7645(14)60145-0","article-title":"Role of NLRP3 and NLRP1 inflammasomes signaling pathways in pathogenesis of rheumatoid arthritis","volume":"7","author":"Wang","year":"2014","journal-title":"Asian Pac. J. Trop. Med."},{"key":"10.1016\/j.intimp.2020.106374_b0130","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.immuni.2009.02.006","article-title":"The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1","volume":"30","author":"Thomas","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2020.106374_b0135","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.jbspin.2015.10.007","article-title":"MicroRNA-20a negatively regulates expression of NLRP3-inflammasome by targeting TXNIP in adjuvant-induced arthritis fibroblast-like synoviocytes","volume":"83","author":"Li","year":"2016","journal-title":"Joint Bone Spine."},{"key":"10.1016\/j.intimp.2020.106374_b0140","doi-asserted-by":"crossref","first-page":"18509","DOI":"10.1002\/jcb.29173","article-title":"Dexmedetomidine alleviates lipopolysaccharide-induced acute kidney injury by inhibiting the NLRP3 inflammasome activation via regulating the TLR4\/NOX4\/NF-\u03baB pathway","volume":"120","author":"Yao","year":"2019","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.intimp.2020.106374_b0145","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1159\/000479609","article-title":"Dexmedetomidine alleviates hyperoxia-induced acute lung injury via inhibiting NLRP3 inflammasome activation","volume":"42","author":"Zhang","year":"2017","journal-title":"Cell Physiol. Biochem."},{"key":"10.1016\/j.intimp.2020.106374_b0150","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/j.1365-2567.2009.03174.x","article-title":"Expression and function of the NALP3 inflammasome in rheumatoid synovium","volume":"129","author":"Kolly","year":"2010","journal-title":"Immunology"},{"key":"10.1016\/j.intimp.2020.106374_b0155","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.canlet.2018.11.024","article-title":"NLRC5 mediates cell proliferation, migration, and invasion by regulating the Wnt\/\u03b2-catenin signalling pathway in clear cell renal cell carcinoma","volume":"444","author":"Wang","year":"2019","journal-title":"Cancer Lett."},{"key":"10.1016\/j.intimp.2020.106374_b0160","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.canlet.2016.03.006","article-title":"NLRC5 regulates cell proliferation, migration and invasion in hepatocellular carcinoma by targeting the Wnt\/\u03b2-catenin signaling pathway","volume":"376","author":"Peng","year":"2016","journal-title":"Cancer Lett."},{"key":"10.1016\/j.intimp.2020.106374_b0165","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1080\/13880209.2019.1651874","article-title":"Dexmedetomidine inhibits the NF-\u03baB pathway and NLRP3 inflammasome to attenuate papain-induced osteoarthritis in rats","volume":"57","author":"Cheng","year":"2019","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.intimp.2020.106374_b0170","doi-asserted-by":"crossref","first-page":"4655","DOI":"10.12659\/MSM.915503","article-title":"Effect of dexmedetomidine-mediated insulin-like growth factor 2 (IGF2) signal pathway on immune function and invasion and migration of cancer cells in rats with ovarian cancer","volume":"25","author":"Tian","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.intimp.2020.106374_b0175","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3727\/096504017X14982578608217","article-title":"Dexmedetomidine inhibits osteosarcoma cell proliferation and migration, and promotes apoptosis by regulating miR-520a-3p","volume":"26","author":"Wang","year":"2018","journal-title":"Oncol. Res."},{"key":"10.1016\/j.intimp.2020.106374_b0180","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1189\/jlb.0502256","article-title":"NF-kappaB-dependent lymphocyte hyperadhesiveness to synovial fibroblasts by hypoxia and reoxygenation: potential role in rheumatoid arthritis","volume":"73","author":"Han","year":"2003","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.intimp.2020.106374_b0185","doi-asserted-by":"crossref","DOI":"10.1136\/ard.61.suppl_2.ii13","article-title":"Is NF-kappaB a useful therapeutic target in rheumatoid arthritis?","volume":"61","author":"Feldmann","year":"2002","journal-title":"Ann. Rheumatic Diseases"},{"key":"10.1016\/j.intimp.2020.106374_b0190","doi-asserted-by":"crossref","first-page":"R120","DOI":"10.1186\/ar1038","article-title":"IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-kappaB- and PI3-kinase\/Akt-dependent pathways","volume":"6","author":"Hwang","year":"2004","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.intimp.2020.106374_b0195","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1136\/ard.61.12.1047","article-title":"Receptor activator NF-kappaB ligand (RANKL) expression in synovial tissue from patients with rheumatoid arthritis, spondyloarthropathy, osteoarthritis, and from normal patients: semiquantitative and quantitative analysis","volume":"61","author":"Crotti","year":"2002","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.intimp.2020.106374_b0200","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1096\/fj.201700511RR","article-title":"NLRC5 deficiency ameliorates diabetic nephropathy through alleviating inflammation","volume":"32","author":"Luan","year":"2018","journal-title":"FASEB J."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576919329431?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576919329431?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T16:34:09Z","timestamp":1727454849000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576919329431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":40,"alternative-id":["S1567576919329431"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2020.106374","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dexmedetomidine inhibits the invasion, migration, and inflammation of rheumatoid arthritis fibroblast-like synoviocytes by reducing the expression of NLRC5","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2020.106374","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106374"}}