{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:04:25Z","timestamp":1790694265495,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100010023","name":"Natural Science Research of Jiangsu Higher Education Institutions of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010023","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008868","name":"Jiangsu Science and Technology Department","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010011","name":"Jiangsu Postdoctoral Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.intimp.2020.106460","type":"journal-article","created":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T06:07:17Z","timestamp":1585807637000},"page":"106460","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Assessment of oral ciprofloxacin impaired gut barrier integrity on gut bacteria in mice"],"prefix":"10.1016","volume":"83","author":[{"given":"Shengyun","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoran","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingshan","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyu","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7415","key":"10.1016\/j.intimp.2020.106460_b0005","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/nature11552","article-title":"Functional interactions between the gut microbiota and host metabolism","volume":"489","author":"Tremaroli","year":"2012","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.intimp.2020.106460_b0010","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nrc.2018.10","article-title":"Gut microbiota injury in allogeneic haematopoietic stem cell transplantation","volume":"18","author":"Shono","year":"2018","journal-title":"Nat. Rev. Cancer"},{"issue":"6289","key":"10.1016\/j.intimp.2020.106460_b0015","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1126\/science.aad9948","article-title":"Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease","volume":"352","author":"Chu","year":"2016","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.intimp.2020.106460_b0020","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1080\/19490976.2017.1284733","article-title":"The gut microbiota of siblings offers insights into microbial pathogenesis of inflammatory bowel disease","volume":"8","author":"Hedin","year":"2017","journal-title":"Gut Microbes"},{"issue":"3","key":"10.1016\/j.intimp.2020.106460_b0025","doi-asserted-by":"crossref","DOI":"10.1111\/sji.12799","article-title":"The imbalance of gut microbiota and its correlation with plasma inflammatory cytokines in pemphigus vulgaris patients","volume":"90","author":"Huang","year":"2019","journal-title":"Scand. J. Immunol."},{"issue":"6","key":"10.1016\/j.intimp.2020.106460_b0030","doi-asserted-by":"crossref","DOI":"10.3390\/nu11061297","article-title":"Lactobacillus acidophilus DDS-1 Modulates Intestinal-Specific Microbiota, Short-Chain Fatty Acid and Immunological Profiles in Aging Mice","volume":"11","author":"Vemuri","year":"2019","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.intimp.2020.106460_b0035","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1073\/pnas.0906112107","article-title":"The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammation","volume":"107","author":"Bansal","year":"2010","journal-title":"PNAS"},{"issue":"11","key":"10.1016\/j.intimp.2020.106460_b0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0080604","article-title":"Commensal bacteria-dependent indole production enhances epithelial barrier function in the colon","volume":"8","author":"Shimada","year":"2013","journal-title":"PLoS ONE"},{"issue":"2","key":"10.1016\/j.intimp.2020.106460_b0045","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.immuni.2013.08.003","article-title":"Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22","volume":"39","author":"Zelante","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2020.106460_b0050","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1080\/19490976.2016.1256525","article-title":"Nutrition and the gut microbiome in the elderly","volume":"8","author":"Salazar","year":"2017","journal-title":"Gut Microbes"},{"issue":"9","key":"10.1016\/j.intimp.2020.106460_b0055","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.3945\/jn.109.104638","article-title":"Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers","volume":"139","author":"Peng","year":"2009","journal-title":"J. Nutr."},{"key":"10.1016\/j.intimp.2020.106460_b0060","series-title":"Ciprofloxacin","author":"Thai","year":"2019"},{"issue":"5","key":"10.1016\/j.intimp.2020.106460_b0065","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1128\/AAC.47.5.1681-1688.2003","article-title":"Surveillance for antimicrobial susceptibility among clinical isolates of Pseudomonas aeruginosa and Acinetobacter baumannii from hospitalized patients in the United States, 1998 to 2001","volume":"47","author":"Karlowsky","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"issue":"5","key":"10.1016\/j.intimp.2020.106460_b0070","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1093\/jac\/48.5.740","article-title":"Detection of decreased in vitro susceptibility to ciprofloxacin in Salmonella enterica serotypes Typhi and Paratyphi A","volume":"48","author":"Threlfall","year":"2001","journal-title":"J. Antimicrobial Chemotherapy"},{"issue":"7413","key":"10.1016\/j.intimp.2020.106460_b0075","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nature11400","article-title":"Antibiotics in early life alter the murine colonic microbiome and adiposity","volume":"488","author":"Cho","year":"2012","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.intimp.2020.106460_b0080","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1084\/jem.20130084","article-title":"The Nlrp3 inflammasome regulates acute graft-versus-host disease","volume":"210","author":"Jankovic","year":"2013","journal-title":"J. Exp. Med."},{"issue":"24","key":"10.1016\/j.intimp.2020.106460_b0085","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1016\/j.bbmt.2018.07.026","article-title":"Loss of NLRP3 Function Alleviates Murine Hepatic Graft-versus-Host Disease","volume":"12","author":"Zhu","year":"2018","journal-title":"Biol. Blood Marrow Transplant."},{"issue":"5","key":"10.1016\/j.intimp.2020.106460_b0090","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/ismej.2009.153","article-title":"Experimental factors affecting PCR-based estimates of microbial species richness and evenness","volume":"4","author":"Engelbrektson","year":"2010","journal-title":"Isme J."},{"issue":"10","key":"10.1016\/j.intimp.2020.106460_b0095","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1038\/ismej.2014.50","article-title":"Deterministic processes guide long-term synchronised population dynamics in replicate anaerobic digesters","volume":"8","author":"Vanwonterghem","year":"2014","journal-title":"Isme J."},{"key":"10.1016\/j.intimp.2020.106460_b0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejsobi.2016.02.004","article-title":"Effect of biochar additions to soil on nitrogen leaching, microbial biomass and bacterial community structure","volume":"74","author":"Xu","year":"2016","journal-title":"Eur. J. Soil Biol."},{"issue":"16","key":"10.1016\/j.intimp.2020.106460_b0105","doi-asserted-by":"crossref","first-page":"5261","DOI":"10.1128\/AEM.00062-07","article-title":"Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy","volume":"73","author":"Wang","year":"2007","journal-title":"Appl. Environ. Microb."},{"issue":"D1","key":"10.1016\/j.intimp.2020.106460_b0110","doi-asserted-by":"crossref","first-page":"D590","DOI":"10.1093\/nar\/gks1219","article-title":"The SILVA ribosomal RNA gene database project: improved data processing and web-based tools","volume":"41","author":"Quast","year":"2013","journal-title":"Nucl. Acids Res."},{"issue":"13","key":"10.1016\/j.intimp.2020.106460_b0115","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1081\/JLC-100100472","article-title":"An improved HPLC method for the analysis of organic acids, carbohydrates, and alcohols in grape musts and wines","volume":"23","author":"Castellari","year":"2000","journal-title":"J. Liq. Chromatogr. R T"},{"issue":"1","key":"10.1016\/j.intimp.2020.106460_b0120","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1093\/toxsci\/kfw150","article-title":"From the Cover: exposure to oral antibiotics induces Gut Microbiota dysbiosis associated with lipid metabolism dysfunction and low-grade inflammation in mice","volume":"154","author":"Jin","year":"2016","journal-title":"Toxicol. Sci.: Off. J. Soc. Toxicol."},{"issue":"1","key":"10.1016\/j.intimp.2020.106460_b0125","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1128\/IAI.00929-09","article-title":"Precarious balance: Th17 cells in host defense","volume":"78","author":"Peck","year":"2010","journal-title":"Infect. Immun."},{"issue":"5","key":"10.1016\/j.intimp.2020.106460_b0130","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/ni.2025","article-title":"Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22","volume":"12","author":"Sonnenberg","year":"2011","journal-title":"Nat. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2020.106460_b0135","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/cmi.2010.21","article-title":"Interleukin-17 and its expanding biological functions","volume":"7","author":"Xu","year":"2010","journal-title":"Cell Mol. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2020.106460_b0140","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.immuni.2016.02.007","article-title":"Intestinal interleukin-17 receptor signaling mediates reciprocal control of the Gut Microbiota and autoimmune inflammation","volume":"44","author":"Kumar","year":"2016","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.intimp.2020.106460_b0145","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nri3349","article-title":"Innate lymphoid cells\u2013how did we miss them?","volume":"13","author":"Walker","year":"2013","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2020.106460_b0150","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1159\/000452356","article-title":"Microbiota Plays a Key Role in Non-Steroidal Anti-Inflammatory Drug-Induced Small Intestinal Damage","volume":"95","author":"Otani","year":"2017","journal-title":"Digestion"},{"issue":"2","key":"10.1016\/j.intimp.2020.106460_b0155","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1084\/jem.20111703","article-title":"Microbiota-induced IL-1beta, but not IL-6, is critical for the development of steady-state TH17 cells in the intestine","volume":"209","author":"Shaw","year":"2012","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.intimp.2020.106460_b0160","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1038\/s41467-017-01917-2","article-title":"Remodelling of the gut microbiota by hyperactive NLRP3 induces regulatory T cells to maintain homeostasis","volume":"8","author":"Yao","year":"2017","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.intimp.2020.106460_b0165","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.3382\/ps\/pez279","article-title":"Effects of sodium butyrate on intestinal health and gut microbiota composition during intestinal inflammation progression in broilers","volume":"98","author":"Zou","year":"2019","journal-title":"Poult. Sci."},{"issue":"7","key":"10.1016\/j.intimp.2020.106460_b0170","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1182\/blood-2014-02-554725","article-title":"The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation","volume":"124","author":"Taur","year":"2014","journal-title":"Blood"},{"issue":"5728","key":"10.1016\/j.intimp.2020.106460_b0175","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1126\/science.1110591","article-title":"Diversity of the human intestinal microbial flora","volume":"308","author":"Eckburg","year":"2005","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.intimp.2020.106460_b0180","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.cell.2011.04.022","article-title":"NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis","volume":"145","author":"Elinav","year":"2011","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.intimp.2020.106460_b0185","doi-asserted-by":"crossref","first-page":"e00692","DOI":"10.1128\/mBio.00692-13","article-title":"The gut microbiome modulates colon tumorigenesis","volume":"4","author":"Zackular","year":"2013","journal-title":"mBio"},{"issue":"7216","key":"10.1016\/j.intimp.2020.106460_b0190","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1038\/nature07336","article-title":"Innate immunity and intestinal microbiota in the development of Type 1 diabetes","volume":"455","author":"Wen","year":"2008","journal-title":"Nature"},{"issue":"7195","key":"10.1016\/j.intimp.2020.106460_b0195","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/nature07008","article-title":"A microbial symbiosis factor prevents intestinal inflammatory disease","volume":"453","author":"Mazmanian","year":"2008","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.intimp.2020.106460_b0200","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1182\/blood-2008-08-172155","article-title":"IL-17 contributes to CD4-mediated graft-versus-host disease","volume":"113","author":"Kappel","year":"2009","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.intimp.2020.106460_b0205","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/nm.3892","article-title":"Innate lymphoid cells in the initiation, regulation and resolution of inflammation","volume":"21","author":"Sonnenberg","year":"2015","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.intimp.2020.106460_b0210","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/eji.201040793","article-title":"IL-17-producing T cells contribute to acute graft-versus-host disease in patients undergoing unmanipulated blood and marrow transplantation","volume":"41","author":"Zhao","year":"2011","journal-title":"Eur. J. Immunol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576919326426?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576919326426?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:18:09Z","timestamp":1761585489000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576919326426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":42,"alternative-id":["S1567576919326426"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2020.106460","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessment of oral ciprofloxacin impaired gut barrier integrity on gut bacteria in mice","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2020.106460","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106460"}}