{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T18:04:09Z","timestamp":1778781849112,"version":"3.51.4"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31401210"],"award-info":[{"award-number":["31401210"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31571455"],"award-info":[{"award-number":["31571455"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31600653"],"award-info":[{"award-number":["31600653"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270514"],"award-info":[{"award-number":["81270514"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600483"],"award-info":[{"award-number":["81600483"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.intimp.2020.106470","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T12:15:16Z","timestamp":1586952916000},"page":"106470","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["LncRNA-H19 induces hepatic stellate cell activation via upregulating alcohol dehydrogenase III-mediated retinoic acid signals"],"prefix":"10.1016","volume":"84","author":[{"given":"Zhi-Min","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si-Wei","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen-Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Kai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu-Dong","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang-Juan","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan-Zhong","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An-Ping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-Zhong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2020.106470_b0005","doi-asserted-by":"crossref","unstructured":"Y. Nakano, A. Kamiya, H. Sumiyoshi, K. Tsuruya, T. Kagawa, Y. Inagaki, A novel deactivation factor of fibrogenic hepatic stellate cells induces regression of liver fibrosis in mice, Hepatology. (2019).","DOI":"10.1002\/hep.30965"},{"key":"10.1016\/j.intimp.2020.106470_b0010","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/hep.28247","article-title":"A novel role for hepatic stellate cells in pathogenesis of visceral leishmaniasis","volume":"63","author":"Shoukry","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2020.106470_b0015","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1002\/hep.24384","article-title":"Hepatic stellate cells: partners in crime for liver metastases?","volume":"54","author":"Kang","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2020.106470_b0020","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/hep.27645","article-title":"Liver X receptors balance lipid stores in hepatic stellate cells through Rab18, a retinoid responsive lipid droplet protein","volume":"62","author":"O'Mahony","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2020.106470_b0025","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1194\/jlr.M062372","article-title":"ATGL and CGI-58 are lipid droplet proteins of the hepatic stellate cell line HSC-T6","volume":"56","author":"Eichmann","year":"2015","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.intimp.2020.106470_b0030","doi-asserted-by":"crossref","unstructured":"M. Bobowski-Gerard, F.P. Zummo, B. Staels, P. Lefebvre, J. Eeckhoute, Retinoids issued from hepatic stellate cell lipid droplet loss as potential signaling molecules orchestrating a multicellular liver injury response, Cells (2018) 7.","DOI":"10.3390\/cells7090137"},{"issue":"7","key":"10.1016\/j.intimp.2020.106470_b0035","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/labinvest.2016.53","article-title":"Perilipin 5 restores the formation of lipid droplets in activated hepatic stellate cells and inhibits their activation","volume":"96","author":"Lin","year":"2016","journal-title":"Lab. Invest.; J. Tech. Methods Pathol."},{"key":"10.1016\/j.intimp.2020.106470_b0040","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.intimp.2017.06.001","article-title":"Nrf2 induces lipocyte phenotype via a SOCS3-dependent negative feedback loop on JAK2\/STAT3 signaling in hepatic stellate cells","volume":"49","author":"Lu","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2020.106470_b0045","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1007\/s11596-019-2104-5","article-title":"Curcumin recovers intracellular lipid droplet formation through increasing perilipin 5 gene expression in activated hepatic stellate cells in vitro","volume":"39","author":"Han","year":"2019","journal-title":"Curr. Med. Sci."},{"key":"10.1016\/j.intimp.2020.106470_b0050","doi-asserted-by":"crossref","first-page":"116934","DOI":"10.1016\/j.lfs.2019.116934","article-title":"Oroxylin A regulates the turnover of lipid droplet via downregulating adipose triglyceride lipase (ATGL) in hepatic stellate cells","volume":"238","author":"Zhang","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2020.106470_b0055","first-page":"9","article-title":"Hepatic retinyl ester hydrolases and the mobilization of retinyl ester stores","author":"Grumet","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.intimp.2020.106470_b0060","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/S0168-8278(99)80262-1","article-title":"Increased 9,13-di-cis-retinoic acid in rat hepatic fibrosis: implication for a potential link between retinoid loss and TGF-beta mediated fibrogenesis in vivo","volume":"30","author":"Okuno","year":"1999","journal-title":"J. Hepatol."},{"key":"10.1016\/j.intimp.2020.106470_b0065","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1002\/hep.27137","article-title":"Alcohol dehydrogenase III exacerbates liver fibrosis by enhancing stellate cell activation and suppressing natural killer cells in mice","volume":"60","author":"Yi","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2020.106470_b0070","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1002\/hep.29145","article-title":"The role of long noncoding RNA H19 in gender disparity of cholestatic liver injury in multidrug resistance 2 gene knockout mice","volume":"66","author":"Li","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2020.106470_b0075","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1002\/hep.29209","article-title":"H19 promotes cholestatic liver fibrosis by preventing ZEB1-mediated inhibition of epithelial cell adhesion molecule","volume":"66","author":"Song","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2020.106470_b0080","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/hep.30662","article-title":"Cholangiocyte-derived exosomal long noncoding RNA H19 promotes hepatic stellate cell activation and cholestatic liver fibrosis","volume":"70","author":"Liu","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2020.106470_b0085","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1002\/hep.29654","article-title":"Long noncoding RNA H19 interacts with polypyrimidine tract-binding protein 1 to reprogram hepatic lipid homeostasis","volume":"67","author":"Liu","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2020.106470_b0090","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.freeradbiomed.2016.10.498","article-title":"ROS-JNK1\/2-dependent activation of autophagy is required for the induction of anti-inflammatory effect of dihydroartemisinin in liver fibrosis","volume":"101","author":"Zhang","year":"2016","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.intimp.2020.106470_b0095","doi-asserted-by":"crossref","first-page":"e2886","DOI":"10.1038\/cddis.2017.255","article-title":"Interaction between autophagy and senescence is required for dihydroartemisinin to alleviate liver fibrosis","volume":"8","author":"Zhang","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2020.106470_b0100","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.intimp.2016.03.011","article-title":"Dihydroartemisinin alleviates bile duct ligation-induced liver fibrosis and hepatic stellate cell activation by interfering with the PDGF-\u03b2R\/ERK signaling pathway","volume":"34","author":"Chen","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2020.106470_b0105","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/iub.1478","article-title":"Dihydroartemisinin prevents liver fibrosis in bile duct ligated rats by inducing hepatic stellate cell apoptosis through modulating the PI3K\/Akt pathway","volume":"68","author":"Chen","year":"2016","journal-title":"IUBMB Life"},{"key":"10.1016\/j.intimp.2020.106470_b0110","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.redox.2018.09.007","article-title":"Curcumol induces RIPK1\/RIPK3 complex-dependent necroptosis via JNK1\/2-ROS signaling in hepatic stellate cells","volume":"19","author":"Jia","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2020.106470_b0115","doi-asserted-by":"crossref","first-page":"610","DOI":"10.7150\/thno.22237","article-title":"Ligand activation of ppargamma by ligustrazine suppresses pericyte functions of hepatic stellate cells via SMRT-mediated transrepression of HIF-1alpha","volume":"8","author":"Zhang","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.intimp.2020.106470_b0120","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.toxlet.2018.07.013","article-title":"DNMT1 controls LncRNA H19\/ERK signal pathway in hepatic stellate cell activation and fibrosis","volume":"295","author":"Yang","year":"2018","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.intimp.2020.106470_b0125","doi-asserted-by":"crossref","DOI":"10.1242\/dev.167502","article-title":"Retinoic acid signaling pathways","volume":"146","author":"Ghyselinck","year":"2019","journal-title":"Development"},{"key":"10.1016\/j.intimp.2020.106470_b0130","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00210-018-01598-8","article-title":"Enhancement of tumor suppressor RAR-beta protein expression by cationic liposomal-ATRA treatment in benzo(a)pyrene-induced lung cancer mice model","volume":"392","author":"Viswanathan","year":"2019","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"10.1016\/j.intimp.2020.106470_b0135","first-page":"467","article-title":"Hepatic stellate cell lipid droplets: a specialized lipid droplet for retinoid storage","volume":"1791","author":"Blaner","year":"2009","journal-title":"BBA"},{"key":"10.1016\/j.intimp.2020.106470_b0140","doi-asserted-by":"crossref","first-page":"15007","DOI":"10.1002\/jcb.28762","article-title":"The retinol-retinoic acid metabolic pathway is impaired in the lumbar spine of a rat model of congenital kyphoscoliosis","volume":"120","author":"Sonoda","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.intimp.2020.106470_b0145","doi-asserted-by":"crossref","first-page":"10845","DOI":"10.1038\/ncomms10845","article-title":"ALDH1A1 provides a source of meiosis-inducing retinoic acid in mouse fetal ovaries","volume":"7","author":"Bowles","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2020.106470_b0150","doi-asserted-by":"crossref","first-page":"5337","DOI":"10.1073\/pnas.082093299","article-title":"Stimulation of retinoic acid production and growth by ubiquitously expressed alcohol dehydrogenase Adh3","volume":"99","author":"Molotkov","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.intimp.2020.106470_b0155","doi-asserted-by":"crossref","first-page":"G809","DOI":"10.1152\/ajpgi.00212.2007","article-title":"Retinoic acid signaling sensitizes hepatic stellate cells to NK cell killing via upregulation of NK cell activating ligand RAE1","volume":"293","author":"Radaeva","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.intimp.2020.106470_b0160","doi-asserted-by":"crossref","first-page":"9698","DOI":"10.1002\/jcp.27656","article-title":"H19\/miR-148a\/USP4 axis facilitates liver fibrosis by enhancing TGF-beta signaling in both hepatic stellate cells and hepatocytes","volume":"234","author":"Zhu","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.intimp.2020.106470_b0165","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/hep.29838","article-title":"Cholangiocyte-derived exosomal long noncoding RNA H19 promotes cholestatic liver injury in mouse and humans","volume":"68","author":"Li","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2020.106470_b0170","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1002\/hep.30698","article-title":"Long noncoding RNA H19 contributes to cholangiocyte proliferation and cholestatic liver fibrosis in biliary atresia","volume":"70","author":"Xiao","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2020.106470_b0175","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.biopha.2017.11.010","article-title":"Dihydroartemisinin inhibits ER stress-mediated mitochondrial pathway to attenuate hepatocyte lipoapoptosis via blocking the activation of the PI3K\/Akt pathway","volume":"97","author":"Chen","year":"2018","journal-title":"Biomedicine & Pharmacotherapy = Biomed. Pharmacotherapie"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576919330346?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576919330346?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T21:44:18Z","timestamp":1762551858000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576919330346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":35,"alternative-id":["S1567576919330346"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2020.106470","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LncRNA-H19 induces hepatic stellate cell activation via upregulating alcohol dehydrogenase III-mediated retinoic acid signals","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2020.106470","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106470"}}