{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:15:26Z","timestamp":1778822126973,"version":"3.51.4"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003089","name":"Centro de Investigaci\u00f3n Cient\u00edfica y de Educaci\u00f3n Superior de Ensenada, Baja California","doi-asserted-by":"publisher","award":["685-107"],"award-info":[{"award-number":["685-107"]}],"id":[{"id":"10.13039\/501100003089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003089","name":"Centro de Investigaci\u00f3n Cient\u00edfica y de Educaci\u00f3n Superior de Ensenada, Baja California","doi-asserted-by":"publisher","award":["615394"],"award-info":[{"award-number":["615394"]}],"id":[{"id":"10.13039\/501100003089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003089","name":"Centro de Investigaci\u00f3n Cient\u00edfica y de Educaci\u00f3n Superior de Ensenada, Baja California","doi-asserted-by":"publisher","award":["299979"],"award-info":[{"award-number":["299979"]}],"id":[{"id":"10.13039\/501100003089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.intimp.2020.106505","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T05:55:15Z","timestamp":1588571715000},"page":"106505","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Venom components of the scorpion Centruroides limpidus modulate cytokine expression by T helper lymphocytes: Identification of ion channel-related toxins by mass spectrometry"],"prefix":"10.1016","volume":"84","author":[{"given":"Juli\u00e1n M.","family":"Cota-Arce","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Zazueta-Favela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"D\u00edaz-Castillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samanta","family":"Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Bern\u00e1ldez-Sarabia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia L.","family":"Caram-Salas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kee W.L.","family":"Dan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galileo","family":"Escobedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexei F.","family":"Licea-Navarro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourival D.","family":"Possani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco A.","family":"De Le\u00f3n-Nava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2020.106505_b0005","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/327470","article-title":"T Helper lymphocyte subsets and plasticity in autoimmunity and cancer: an overview","volume":"2015","author":"Ivanova","year":"2015","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.intimp.2020.106505_b0010","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/184574","article-title":"T. Helper subsets, peripheral plasticity, and the acute phase protein, \u03b11-antitrypsin","volume":"2015","author":"Baranovski","year":"2015","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.intimp.2020.106505_b0015","series-title":"T cell Differentiation","first-page":"18","article-title":"Basic aspects of T helper cell differentiation","author":"Gagliani","year":"2017"},{"key":"10.1016\/j.intimp.2020.106505_b0020","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1182\/blood-2012-09-378653","article-title":"Essentials of Th17 cell commitment and plasticity","volume":"121","author":"Muranski","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.intimp.2020.106505_b0025","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/intimm\/dxw006","article-title":"CD4+ T-cell subsets in inflammatory diseases: Beyond the Th1\/Th2 paradigm","volume":"28","author":"Hirahara","year":"2016","journal-title":"Int. Immunol."},{"key":"10.1016\/j.intimp.2020.106505_b0030","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-08332-9","article-title":"The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells","volume":"10","author":"Perucha","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2020.106505_b0035","series-title":"Clinical Immunology: Principles and Practice","first-page":"235","article-title":"Helper T-cell subsets and control of the inflammatory response","author":"Eagar","year":"2012"},{"key":"10.1016\/j.intimp.2020.106505_b0040","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1146\/annurev-immunol-032414-112212","article-title":"Ion channels in innate and adaptive immunity","volume":"33","author":"Feske","year":"2015","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.intimp.2020.106505_b0045","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.3390\/toxins7051749","article-title":"Toxins targeting the Kv1.3 Channel: potential immunomodulators for autoimmune diseases","volume":"7","author":"Zhao","year":"2015","journal-title":"Toxins (Basel)."},{"key":"10.1016\/j.intimp.2020.106505_b0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/molecules24101846","article-title":"Insulin release mechanism modulated by toxins isolated from animal venoms: from basic research to drug development prospects","volume":"24","author":"Sarmiento","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.intimp.2020.106505_b0055","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.toxicon.2019.06.013","article-title":"Cn29, a novel orphan peptide found in the venom of the scorpion Centruroides noxius: Structure and function","volume":"167","author":"Gurrola","year":"2019","journal-title":"Toxicon"},{"key":"10.1016\/j.intimp.2020.106505_b0060","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11050247","article-title":"Dissecting toxicity: The venom gland transcriptome and the venom proteome of the highly venomous scorpion Centruroides limpidus (Karsch, 1879)","volume":"11","author":"Cid-Uribe","year":"2019","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.intimp.2020.106505_b0065","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.toxicon.2018.11.305","article-title":"Venom content and toxicity regeneration after venom gland depletion by electrostimulation in the scorpion Centruroides limpidus","volume":"157","author":"Carcamo-Noriega","year":"2019","journal-title":"Toxicon"},{"key":"10.1016\/j.intimp.2020.106505_b0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40409-018-0154-y","article-title":"Mass fingerprinting and electrophysiological analysis of the venom from the scorpion Centruroides hirsutipalpus (Scorpiones: Buthidae)","volume":"24","author":"Valdez-Vel\u00e1zquez","year":"2018","journal-title":"J. Venom. Anim. Toxins Incl. Trop. Dis."},{"key":"10.1016\/j.intimp.2020.106505_b0075","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.toxicon.2014.11.233","article-title":"Scorpion venom components as potential candidates for drug development","volume":"93","author":"Ortiz","year":"2015","journal-title":"Toxicon"},{"key":"10.1016\/j.intimp.2020.106505_b0080","series-title":"Scorpion Venoms","first-page":"87","article-title":"Scorpion Venom Interactions with the Immune System","author":"Adi-Bessalem","year":"2015"},{"key":"10.1016\/j.intimp.2020.106505_b0085","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.toxicon.2017.11.006","article-title":"Immune drug discovery from venoms","volume":"141","author":"Jimenez","year":"2018","journal-title":"Toxicon"},{"key":"10.1016\/j.intimp.2020.106505_b0090","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/s41423-019-0220-6","article-title":"Helper T cell differentiation","volume":"16","author":"Saravia","year":"2019","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.intimp.2020.106505_b0095","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.toxicon.2016.04.046","article-title":"Comprehensive analysis of venom from the scorpion Centruroides tecomanus reveals compounds with antimicrobial, cytotoxic, and insecticidal activities","volume":"118","author":"Valdez-Velazqu\u00e9z","year":"2016","journal-title":"Toxicon"},{"key":"10.1016\/j.intimp.2020.106505_b0100","doi-asserted-by":"crossref","DOI":"10.3390\/toxins10020051","article-title":"Antimycobacterial activity: a new pharmacological target for conotoxins found in the first reported conotoxin from Conasprella ximenes","volume":"10","author":"Figueroa-Montiel","year":"2018","journal-title":"Toxins"},{"key":"10.1016\/j.intimp.2020.106505_b0105","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s40409-015-0046-3","article-title":"Immunomodulatory activity of Tityus serrulatus scorpion venom on human T lymphocytes","volume":"21","author":"Casella-Martins","year":"2015","journal-title":"J. Venom. Anim. Toxins Incl. Trop. Dis."},{"key":"10.1016\/j.intimp.2020.106505_b0110","first-page":"59","article-title":"Scorpion venom as therapeutic agent - current perspective","volume":"7","author":"Attarde","year":"2016","journal-title":"Int. J. Curr. Pharm. Rev. Res."},{"key":"10.1016\/j.intimp.2020.106505_b0115","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.toxicon.2005.06.001","article-title":"Novel \u03b1-KTx peptides from the venom of the scorpion Centruroides elegans selectively blockade Kv1.3 over IKCa1 K+ channels of T cells","volume":"46","author":"Olamendi-Portugal","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.intimp.2020.106505_b0120","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.toxicon.2016.11.256","article-title":"Comparative proteomic analysis of female and male venoms from the Mexican scorpion Centruroides limpidus: Novel components found","volume":"125","author":"Cid Uribe","year":"2017","journal-title":"Toxicon"},{"key":"10.1016\/j.intimp.2020.106505_b0125","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.toxicon.2017.11.013","article-title":"Venoms of Centruroides and Tityus species from Panama and their main toxic fractions","volume":"141","author":"Salazar","year":"2018","journal-title":"Toxicon"},{"key":"10.1016\/j.intimp.2020.106505_b0130","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/958797","article-title":"Scorpion peptides: Potential use for new drug development","volume":"2013","author":"Hmed","year":"2013","journal-title":"J. Toxicol."},{"key":"10.1016\/j.intimp.2020.106505_b0135","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10989-018-9721-x","article-title":"Scorpion Venom-toxins that aid in drug development: a review","volume":"25","author":"Ghosh","year":"2019","journal-title":"Int. J. Pept. Res. Ther."},{"key":"10.1016\/j.intimp.2020.106505_b0140","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.tips.2004.03.010","article-title":"K+ channels as targets for specific immunomodulation","volume":"25","author":"Chandy","year":"2004","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.intimp.2020.106505_b0145","article-title":"Therapeutic use of scorpion","author":"Petricevich","year":"2013","journal-title":"Venom"},{"key":"10.1016\/j.intimp.2020.106505_b0150","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.7150\/jca.15309","article-title":"Effects of animal venoms and toxins on hallmarks of cancer","volume":"7","author":"Chaisakul","year":"2016","journal-title":"J. Cancer."},{"key":"10.1016\/j.intimp.2020.106505_b0155","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.toxicon.2019.06.219","article-title":"Scorpion envenomation and inflammation: beyond neurotoxic effects","volume":"167","author":"Reis","year":"2019","journal-title":"Toxicon."},{"key":"10.1016\/j.intimp.2020.106505_b0160","series-title":"Mouse Models of Innate Immunity: Methods and Protocols","first-page":"75","article-title":"In vitro differentiation of effector CD4+ T helper cell subsets","author":"Read","year":"2019"},{"key":"10.1016\/j.intimp.2020.106505_b0165","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.toxicon.2015.09.029","article-title":"Induction of IL-12 from human monocytes after stimulation with Androctonus crassicauda scorpion venom","volume":"106","author":"Saadi","year":"2015","journal-title":"Toxicon"},{"key":"10.1016\/j.intimp.2020.106505_b0170","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.toxicon.2015.04.007","article-title":"Hemiscorpius lepturus venom induces expression and production of interluckin-12 in human monocytes","volume":"100","author":"Hadaddezfuli","year":"2015","journal-title":"Toxicon"},{"key":"10.1016\/j.intimp.2020.106505_b0175","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11020063","article-title":"Serotherapy against voltage-gated sodium channel-targeting \u03b1-toxins from Androctonus scorpion venom","volume":"11","author":"Martin-Eauclaire","year":"2019","journal-title":"Toxins"},{"key":"10.1016\/j.intimp.2020.106505_b0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/MI\/2006\/54273","article-title":"Balance between pro- and anti-inflammatory cytokines in mice treated with Centruroides noxius scorpion venom","volume":"2006","author":"Petricevich","year":"2006","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.intimp.2020.106505_b0185","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.toxicon.2017.01.007","article-title":"Selected scorpion toxin exposures induce cytokine release in human peripheral blood mononuclear cells","volume":"127","author":"Corzo","year":"2017","journal-title":"Toxicon."},{"key":"10.1016\/j.intimp.2020.106505_b0190","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/mi.2010.8","article-title":"IL-10 production by CD4+ effector T cells: a mechanism for self-regulation","volume":"3","author":"Jankovic","year":"2010","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.intimp.2020.106505_b0195","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.4049\/jimmunol.180.9.5771","article-title":"IL- 10: the master regulator of immunity to infection","volume":"180","author":"Couper","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2020.106505_b0200","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.immuni.2019.03.020","article-title":"IL-10 family cytokines IL-10 and IL-22: from basic science to clinical translation","volume":"50","author":"Ouyang","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2020.106505_b0205","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1600-065X.2009.00816.x","article-title":"The functional network of ion channels in T lymphocytes","volume":"231","author":"Cahalan","year":"2009","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.intimp.2020.106505_b0210","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/nri3233","article-title":"Ion channels and transporters in lymphocyte function and immunity","volume":"12","author":"Feske","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.intimp.2020.106505_b0215","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/ni.2379","article-title":"A voltage-gated sodium channel is essential for the positive selection of CD4+ T cells","volume":"13","author":"Lo","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.intimp.2020.106505_b0220","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/s41577-018-0110-7","article-title":"Calcium signalling in T cells","volume":"19","author":"Trebak","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.intimp.2020.106505_b0225","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.bbamcr.2018.04.001","article-title":"Profiling calcium signals of in vitro polarized human effector CD4+ T cells","volume":"1865","author":"Kircher","year":"2018","journal-title":"Biochim. Biophys. Acta - Mol. Cell Res."},{"key":"10.1016\/j.intimp.2020.106505_b0230","doi-asserted-by":"crossref","first-page":"4440","DOI":"10.4049\/jimmunol.1002860","article-title":"Sensitivity and resistance to regulation by IL-4 during Th17 maturation","volume":"187","author":"Cooney","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2020.106505_b0235","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aab3142","article-title":"TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma","volume":"7","author":"Choy","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.intimp.2020.106505_b0240","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0066486","article-title":"Mass fingerprinting of the venom and transcriptome of venom gland of scorpion Centruroides tecomanus","volume":"8","author":"Valdez-Vel\u00e1zquez","year":"2013","journal-title":"PLoS One."},{"key":"10.1016\/j.intimp.2020.106505_b0245","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.bbrc.2015.01.103","article-title":"Identification and functional characterization of voltage-gated sodium channels in lymphocytes","volume":"458","author":"Huang","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.intimp.2020.106505_b0250","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0170102","article-title":"T Cell subset and stimulation strength-dependent modulation of T cell activation by Kv1.3 blockers","volume":"12","author":"Fung-Leung","year":"2017","journal-title":"PLoS ONE"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692030268X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692030268X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:50:26Z","timestamp":1778820626000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156757692030268X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":50,"alternative-id":["S156757692030268X"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2020.106505","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Venom components of the scorpion Centruroides limpidus modulate cytokine expression by T helper lymphocytes: Identification of ion channel-related toxins by mass spectrometry","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2020.106505","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106505"}}